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Cortico Subcortical Dynamics In Parkinsons Disease
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Book Synopsis Cortico-Subcortical Dynamics in Parkinson’s Disease by : Kuei-Yuan Tseng
Download or read book Cortico-Subcortical Dynamics in Parkinson’s Disease written by Kuei-Yuan Tseng and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input–output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3–5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.
Book Synopsis Cortico-Subcortical Dynamics in Parkinson’s Disease by : Kuei-Yuan Tseng
Download or read book Cortico-Subcortical Dynamics in Parkinson’s Disease written by Kuei-Yuan Tseng and published by Humana Press. This book was released on 2009-05-21 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input–output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3–5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.
Book Synopsis Subcortical-cortical Network Dynamics in the Human Brain by : Mahsa Malekmohammadi
Download or read book Subcortical-cortical Network Dynamics in the Human Brain written by Mahsa Malekmohammadi and published by . This book was released on 2015 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cerebral cortex is connected to various subcortical structures such as the thalamus and the basal ganglia (BG). The diffuse yet specific patterns of structural connectivity of the thalamus with the cortex suggest thalamocortical connectivity could play an important role in addressing the binding problem. Previous research has established the presence of BG oscillations and their link to functional and pathological connectivity states to the cortical structures. Considering the topographically organized connections between thalamus, BG and the cortex it has been proposed that disruptions to normal oscillatory activity within the cortico-BG-thalamocortical circuits may partly account for the pathophysiology of Parkinson's disease (PD) . Using simultaneous invasive recordings of cortical and thalamic electrophysiological activity in two awake and spontaneously behaving human subjects, we provide direct evidence of thalamic regulation of cortical activity through a mechanism of phase-amplitude coupling (PAC). Specifically, we show that cortical PAC between the [theta] phase and [beta] amplitude is spatially dependent on and time variant with the magnitude of thalamocortical [theta] coherence. Moreover, using causality analysis and MR diffusion tractrography, we provide evidence that thalamic [theta] activity drives cortical [theta] oscillations and PAC across structures via structurally constrained pathways. In PD, pathologic oscillatory activity, particularly in the [beta] band, is present in BG and motor cortex. The role of these [beta] oscillations in modulating activity at a network level have not been thoroughly characterized. Using simultaneously recorded cortical and pallidal local field potentials in 20 patients with PD undergoing deep brain stimulation surgery, we confirm increased [beta] activity and [beta]-[gamma] PAC in motor cortical areas. The cortical [beta] band is highly coherent with [beta] activity in the motor region of the GPi where local [beta]-[gamma] and [beta]-(200-300Hz) PAC and cross-site pallido-cortical PAC were observed. Contralateral movement significantly decreased pallido-cortical coherence and PAC as well as local cortical PAC, but did not completely eliminate this coupling, possibly manifesting a deficiency in the diseased BG to disentrain the motor network during action. These results shed light on the dynamic nature of pallidocortical coupling, suggesting [beta] oscillations reverberate through the motor network and modulate activity at a network level.
Book Synopsis Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-Cortical System by : Erwin B. Montgomery Jr.
Download or read book Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-Cortical System written by Erwin B. Montgomery Jr. and published by Elsevier. This book was released on 2023-06-30 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-thalamic-cortical system that causes neurological disorders like Parkinson's disease. While there have been remarkable advances in the understanding of the anatomy, physiology and chemistry of these systems, there remains a significant degree of inconsistency and incompleteness between facts and advancements. This book introduces the novel concepts of nonlinear complex systems and their connection to Parkinsonism as well as hyperkinetic disorders. The actual mechanisms underlying the motor disorders of Parkinson's disease at the level of the lower motor neuron are also discussed.
Book Synopsis Computational Neuroscience Models of the Basal Ganglia by : V. Srinivasa Chakravarthy
Download or read book Computational Neuroscience Models of the Basal Ganglia written by V. Srinivasa Chakravarthy and published by Springer. This book was released on 2018-03-21 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a compendium of the aforementioned subclass of models of Basal Ganglia, which presents some the key existent theories of Basal Ganglia function. The book presents computational models of basal ganglia-related disorders, including Parkinson’s disease, schizophrenia, and addiction. Importantly, it highlights the applications of understanding the role of the basal ganglia to treat neurological and psychiatric disorders. The purpose of the present book is to amend and expand on James Houk’s book (MIT press; ASIN: B010BF4U9K) by providing a comprehensive overview on computational models of the basal ganglia. This book caters to researchers and academics from the area of computational cognitive neuroscience.
Book Synopsis Deep Brain Stimulation for Parkinson's Disease by : Gordon H. Baltuch
Download or read book Deep Brain Stimulation for Parkinson's Disease written by Gordon H. Baltuch and published by CRC Press. This book was released on 2007-03-19 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's
Book Synopsis Balance Dysfunction in Parkinson’s Disease by : Martina Mancini
Download or read book Balance Dysfunction in Parkinson’s Disease written by Martina Mancini and published by Academic Press. This book was released on 2019-09-14 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory postural adjustments in preparation for voluntary movements, and dynamic balance control during walking and turning. In addition, the book's authors summarize the effects of levodopa, deep brain stimulation, and rehabilitation intervention for each balance domain. This book is recommended for anyone interested in how and why balance control is affected by PD. Provides the first comprehensive review of research to date on balance dysfunctions in Parkinson's disease Discusses how to translate current neuroscience research into practice regarding neural control of balance Provides evidence on the effects of current interventions on balance control
Book Synopsis Event-Related Dynamics of Brain Oscillations by : Christa Neuper
Download or read book Event-Related Dynamics of Brain Oscillations written by Christa Neuper and published by Elsevier. This book was released on 2006-12-03 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on brain oscillations and event-related electroencephalography (EEG) and event-related (de-) synchronization (ERD/ERS) in particular became a rapidly growing field in the last decades. A large number of laboratories worldwide are using ERD/ERS to study cognitive and motor brain function and the importance of this tool in neurocognitive research is widely recognized. This book is a summary of the most current research, methods, and applications of the study of event-related dynamics of brain oscillations. Facing the rapid progress in this field, it brings together, on the one side, fundamental questions of the underlying events, which still remain to be clarified and, on the other side, some of the most significant novel findings, which point to the key topics for future research. In particular, the chapters of this volume cover the neurophysiological fundamentals and models (Section I), new methodological approaches (Section II), current ERD research related to cognitive (Section III) and sensorimotor brain function (Section IV), invasive approaches and clinical applications (Section V), and novel developments of EEG-based brain-computer interfaces and neurofeedback (Section IV).
Book Synopsis Marsden's Book of Movement Disorders by : Ivan Donaldson
Download or read book Marsden's Book of Movement Disorders written by Ivan Donaldson and published by Oxford University Press. This book was released on 2012-03-29 with total page 1512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.
Book Synopsis The Orexin System. Basic Science and Role in Sleep Pathology by : M.A. Steiner
Download or read book The Orexin System. Basic Science and Role in Sleep Pathology written by M.A. Steiner and published by Karger Medical and Scientific Publishers. This book was released on 2021-05-28 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.
Book Synopsis Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic by : Daniela Andres
Download or read book Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic written by Daniela Andres and published by Frontiers Media SA. This book was released on 2017-10-31 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders.
Book Synopsis Multiscale Models of Brain Disorders by : Vassilis Cutsuridis
Download or read book Multiscale Models of Brain Disorders written by Vassilis Cutsuridis and published by Springer Nature. This book was released on 2019-10-11 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.
Book Synopsis Culture, Mind, and Brain by : Laurence J. Kirmayer
Download or read book Culture, Mind, and Brain written by Laurence J. Kirmayer and published by Cambridge University Press. This book was released on 2020-09-24 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent neuroscience research makes it clear that human biology is cultural biology - we develop and live our lives in socially constructed worlds that vary widely in their structure values, and institutions. This integrative volume brings together interdisciplinary perspectives from the human, social, and biological sciences to explore culture, mind, and brain interactions and their impact on personal and societal issues. Contributors provide a fresh look at emerging concepts, models, and applications of the co-constitution of culture, mind, and brain. Chapters survey the latest theoretical and methodological insights alongside the challenges in this area, and describe how these new ideas are being applied in the sciences, humanities, arts, mental health, and everyday life. Readers will gain new appreciation of the ways in which our unique biology and cultural diversity shape behavior and experience, and our ongoing adaptation to a constantly changing world.
Book Synopsis Recent Advances in Parkinson's Disease by :
Download or read book Recent Advances in Parkinson's Disease written by and published by Elsevier. This book was released on 2020-04-16 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields
Book Synopsis The Cognitive Neuropsychiatry of Parkinson's Disease by : Patrick McNamara
Download or read book The Cognitive Neuropsychiatry of Parkinson's Disease written by Patrick McNamara and published by MIT Press. This book was released on 2011-08-26 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A detailed examination of the major neuropsychiatric syndromes of Parkinson's disease and a cognitive theory that accounts for their neurology and phenomenology. Patients with Parkinson's disease (PD) suffer most visibly with such motor deficits as tremor and rigidity and less obviously with a range of nonmotor symptoms, including autonomic dysfunction, mood disorders, and cognitive impairment. The neuropsychiatric disturbances of PD can be as disabling as its motor disorders; but they have only recently begun to be studied intensively by clinicians and scientists. In this book, Patrick McNamara examines the major neuropsychiatric syndromes of PD in detail and offers a cognitive theory that accounts for both their neurology and their phenomenology. McNamara offers an up-to-date review of current knowledge of such neuropsychiatric manifestations of PD as cognitive deficits, personality changes, speech and language symptoms, sleep disorders, apathy, psychosis, and dementia. He argues that the cognitive, mood, and personality symptoms of PD stem from the weakening or suppression of the agentic aspects of the self. McNamara's study may well lead to improved treatment for Parkinson's patients. But its overarching goal is to arrive at a better understanding of the human mind and its breakdown patterns in patients with PD. The human mind-brain is an elaborate and complex structure patched together to produce what we call the self. When we observe the disruption of the self structure that occurs with the various neuropsychiatric disorders associated with PD, McNamara argues, we get a glimpse into the inner workings of the most spectacular structure of the self: the agentic self, the self that acts.
Book Synopsis The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders by : David F. Cechetto
Download or read book The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders written by David F. Cechetto and published by Academic Press. This book was released on 2016-10-14 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer’s Disease, Parkinson’s, addiction, and cardiovascular dysregulation. Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value. Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvement Presents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentally Provides expert commentary and a perspective on future trends at the end of each chapter Addresses translational advances and promising therapeutic options Includes references to key articles for additional detailed study
Book Synopsis The Neuropsychology of Psychopathology by : Chad A. Noggle, PhD, ABN
Download or read book The Neuropsychology of Psychopathology written by Chad A. Noggle, PhD, ABN and published by Springer Publishing Company. This book was released on 2012-11-26 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This clinical reference book presents state-of-the-science knowledge about the neurobiology and genetics of the major mental disorders and how this corresponds with their psychiatric features and neuropsychological traits. The text demonstrates how the application of neuropsychology to these disorders provides a more comprehensive foundation for greater accuracy in assessment, diagnosis, and treatment. The book focuses on the neuropathological and pathophysiological basis of the various symptoms, emphasizing the biological basis of each disorder. This approach stresses the importance of looking at the other functional impacts of these manifestations (for example, cognitive deficits secondary to depression). The text compares adult versus child presentation of psychiatric disorders and covers the major forms of psychopathology including ADHD; Learning Disabilities; Pervasive Developmental Disorders; Mood, Anxiety, Personality, and Schizophrenic Disorders; Cortical and Subcortical Dementias; and Delirium. The book is written for clinical professionals to increase diagnostic accuracy and intervention success and to provide a way to approach psychopathologies as disorders of the neurological system. Key Features: Provides state-of-the-science knowledge about the application of neuropsychological practice to the major forms of psychopathology Examines neurological and neuropsychological features of the major forms of psychopathology Demonstrates how the application of neurobiology and genetics to psychiatric disorders can increase accuracy of assessment, diagnosis, and treatment Considers adult versus child presentation of psychiatric disorders
