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Author : Natalia Colocci
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.:/5 (437 download)
Download or read book Cooperative Oligonucleotide-directed Triple Helix Formation at Adjacent DNA Sites written by Natalia Colocci and published by . This book was released on 1996 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Scott F. Singleton
Publisher :
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.:/5 (437 download)
Download or read book The Thermodynamics of Oligonucleotide-directed Triple Helix Formation at Single DNA Sites written by Scott F. Singleton and published by . This book was released on 1995 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Claude Malvy
Publisher : Springer Science & Business Media
ISBN 13 : 9780792384182
Total Pages : 332 pages
Book Rating : 4.3/5 (841 download)
Download or read book Triple Helix Forming Oligonucleotides written by Claude Malvy and published by Springer Science & Business Media. This book was released on 1999-02-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.
Author : Valery N. Soyfer
Publisher : Springer Science & Business Media
ISBN 13 : 1461239729
Total Pages : 373 pages
Book Rating : 4.4/5 (612 download)
Download or read book Triple-Helical Nucleic Acids written by Valery N. Soyfer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.
Author : Claude Malvy
Publisher : Springer Science & Business Media
ISBN 13 : 1461551773
Total Pages : 296 pages
Book Rating : 4.4/5 (615 download)
Download or read book Triple Helix Forming Oligonucleotides written by Claude Malvy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.
Author : Thomas J. Povsic
Publisher :
ISBN 13 :
Total Pages : 566 pages
Book Rating : 4.:/5 (437 download)
Download or read book Oligonucleotide Directed Sequence Specific Recognition and Alkylation of Double Helical DNA by Triple Helix Formation written by Thomas J. Povsic and published by . This book was released on 1992 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. S. Koh
Publisher :
ISBN 13 :
Total Pages : 16 pages
Book Rating : 4.:/5 (227 download)
Download or read book Design of Novel Bases on Recognition of GC Base Pairs of DNA by Oligonucleotide Directed Triple Helix Formation written by J. S. Koh and published by . This book was released on 1991 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: The binding of pyrimidine oligonucleotides containing cytosine at single sites on double helical DNA by triple helix formation is sensitive to pH. An important factor is the required protonation of the cytosine N-3 in the third strand to enable the formation of two Hoogsteen hydrogen bonds (G+GC triplet). Because oligonucleotide specificity could provide a method for artificial repression of viral and pathogenic diseases, it is desirable to design and synthesize a novel base that could bind GC base pairs strongly and selectively over a wide range of intracellular pH. The novel base, N-1-15-O-(bis(4-methoxyphenyl)phenylmethyl-2-deoxy-BETA-D-erythro-pentofuranosyl-4,7-dihydro-3-methyl-7-oxo-1H-pyrazolo-4,3-DLPYRIMI-DINE-5-YL-2-methyl-propanamide (P1) was designed, synthesized and incorporated within a pyrimidine oligonucleotide and shown to recognize GC base pairs as selectively and strongly as C. Oligonucleotides containing P1 bases show the same specificity as C but with less pH sensitivity in triple helix formation. P1 does not require protonation in triple helix formation. Such specificity allows binding at a 15 base pairs site in plasmid DNA (pH7.8) and a 16 base pairs site in the 3' long terminal repeat (LTR) of HIV DNA(pH 7.4).
Author : Zutao YU
Publisher : Springer Nature
ISBN 13 : 9811544239
Total Pages : 145 pages
Book Rating : 4.8/5 (115 download)
Download or read book Artificial Assemblies with Cooperative DNA Recognition written by Zutao YU and published by Springer Nature. This book was released on 2020-05-09 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole–imidazole polyamides (PIPs). PIPs represent the best-characterized class of small molecule DNA binders that can be modified to bind with any predetermined DNA sequence and regulate gene expression patterns in a transgene-free and cost-effective manner. PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability. In recent years, there have been numerous novel studies on the applications of these biological tools; this research is thoroughly reviewed in the first chapter. There are several critical issues, however, that impede the further broad study of PIPs, which greatly concern the author. For instance, the short PIP version has an excessively hi^10 bp; this significantly decreases cell permeability. Moreover, the conventional binding strategy for PIP design cannot apply to flexible DNA binding—for example, the DNA-binding mode of a transcription factor pair. In this book, the author describes the development of three kinds of cooperative DNA-binding systems that help resolve the current highly problematic issues concerning PIPs. These three systems offer a range of significant advantages, such as favorable sequence selectivity, long recognition sequence, higher binding affinity, and a flexible gap distance. Released at a critical juncture in the application of PIPs, this book will greatly facilitate their use as therapeutic drugs in the treatment of cancer and hereditary diseases, and in regenerative medicine.
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Publisher :
ISBN 13 :
Total Pages : 1484 pages
Book Rating : 4.:/5 (31 download)
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Author : Jacob S. Lai
Publisher :
ISBN 13 :
Total Pages : 798 pages
Book Rating : 4.F/5 ( download)
Download or read book Nonnatural Fluorinated Deoxyribonucleoside Analogues written by Jacob S. Lai and published by . This book was released on 2005 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ramaswamy H. Sarma
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)
Download or read book Structure & Methods written by Ramaswamy H. Sarma and published by . This book was released on 1990 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 1158 pages
Book Rating : 4.X/5 (6 download)
Download or read book Nucleic Acids Abstracts written by and published by . This book was released on 1997 with total page 1158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 604 pages
Book Rating : 4.F/5 ( download)
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ISBN 13 :
Total Pages : 896 pages
Book Rating : 4.3/5 (91 download)
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1995 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 1840 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 1628 pages
Book Rating : 4.3/5 (91 download)
Download or read book Applied Science & Technology Index written by and published by . This book was released on 1996 with total page 1628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
