Controlling Cardiac Arrhythmias By Lengthening Repolarization

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Cardiac Repolarization

Author : Ihor Gussak
Publisher : Springer Science & Business Media
ISBN 13 : 1592593623
Total Pages : 549 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cardiac Repolarization by : Ihor Gussak

Download or read book Cardiac Repolarization written by Ihor Gussak and published by Springer Science & Business Media. This book was released on 2003-03-13 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias

Author : Peter Taggart
Publisher : Frontiers Media SA
ISBN 13 : 2889662160
Total Pages : 133 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias by : Peter Taggart

Download or read book Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias written by Peter Taggart and published by Frontiers Media SA. This book was released on 2020-12-11 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Acquired Long QT Syndrome

Author : A. John Camm
Publisher : John Wiley & Sons
ISBN 13 : 1405146168
Total Pages : 208 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Acquired Long QT Syndrome by : A. John Camm

Download or read book Acquired Long QT Syndrome written by A. John Camm and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.

Pharmacology and Therapeutics for Dentistry - E-Book

Author : John A. Yagiela
Publisher : Elsevier Health Sciences
ISBN 13 : 0323078249
Total Pages : 957 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Pharmacology and Therapeutics for Dentistry - E-Book by : John A. Yagiela

Download or read book Pharmacology and Therapeutics for Dentistry - E-Book written by John A. Yagiela and published by Elsevier Health Sciences. This book was released on 2010-03-12 with total page 957 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient's health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you're concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. - An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. - Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. - The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. - The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. - Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. - Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. - Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. - New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. - A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. - An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. - Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

Cardiology Explained

Author : Euan A. Ashley
Publisher : Remedica
ISBN 13 : 1901346226
Total Pages : 258 pages
Book Rating : 4.9/5 (13 download)

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Book Synopsis Cardiology Explained by : Euan A. Ashley

Download or read book Cardiology Explained written by Euan A. Ashley and published by Remedica. This book was released on 2004 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

The Brugada Syndrome

Author : Charles Antzelevitch
Publisher : John Wiley & Sons
ISBN 13 : 1405146818
Total Pages : 248 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis The Brugada Syndrome by : Charles Antzelevitch

Download or read book The Brugada Syndrome written by Charles Antzelevitch and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, the cellular basis for sudden death, the BrugadaSyndrome, has largely remained an unknown to modernarrhythmologists and cardiologists, particularly in the absence ofany structural heart disease. Detailed observations of age-groups,especially the young, families and populations where sudden deathfrequently occurs, and improved understanding of its contributoryfactors and mechanisms are, however, showing the way forward. This addition to the Clinical Approaches to Tachyarrhythmias(CATA) Series, written by the investigators who discovered andprobed the Brugada Syndrome, discusses the history, etiology,pathology and clinical manifestations of sudden death. Fromdiagnosis, prognosis, to therapeutic approaches using the latest incathater ablation techniques, electrophysiological surgery, andgenetic appraisal, the work is a testimony to the author'sinvestigation. Using clinical cases in Thailand and Laos, theyfurther unravel the syndrome's molecular mechanisms, studyingrelated syndromes, such as the long-QT syndrome, infant death, andarryhthmogenic right ventricular cardiomyopathy. By being informed of the electrophysiological abnormalities thatcontribute to familial and genetic diseases, physicians,cardiologists and all those who care for patients with cardiacarrhythmias will be better able to identify and treat patients inwhom the Brugada Syndrome may strike next.

Anesthetic Pharmacology

Author : Alex S. Evers
Publisher : Cambridge University Press
ISBN 13 : 1139497022
Total Pages : 2902 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Anesthetic Pharmacology by : Alex S. Evers

Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

J Wave Syndromes

Author : Charles Antzelevitch
Publisher : Springer
ISBN 13 : 3319315781
Total Pages : 342 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis J Wave Syndromes by : Charles Antzelevitch

Download or read book J Wave Syndromes written by Charles Antzelevitch and published by Springer. This book was released on 2016-06-27 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.

Ventricular Arrhythmias

Author : John M. Miller
Publisher :
ISBN 13 : 9781416062752
Total Pages : 0 pages
Book Rating : 4.0/5 (627 download)

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Book Synopsis Ventricular Arrhythmias by : John M. Miller

Download or read book Ventricular Arrhythmias written by John M. Miller and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ventricular arrhythmias cause most cases of sudden cardiac death, which is the leading cause of death in the US. This issue reviews the causes of arrhythmias and the promising new drugs and devices to treat arrhythmias.

Dispersion of Ventricular Repolarization

Author : S. Bertil Olsson
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)

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Book Synopsis Dispersion of Ventricular Repolarization by : S. Bertil Olsson

Download or read book Dispersion of Ventricular Repolarization written by S. Bertil Olsson and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

ABC of Clinical Electrocardiography

Author : Francis Morris
Publisher : John Wiley & Sons
ISBN 13 : 1444312499
Total Pages : 112 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis ABC of Clinical Electrocardiography by : Francis Morris

Download or read book ABC of Clinical Electrocardiography written by Francis Morris and published by John Wiley & Sons. This book was released on 2009-04-15 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrocardiography is an essential tool in diagnosing cardiacdisorders. This second edition of the ABC of ClinicalElectrocardiography allows readers to become familiar with the widerange of patterns seen in the electrocardiogram in clinicalpractice and covers the fundamentals of ECG interpretation andanalysis. Fully revised and updated, this edition includes a self-assessmentsection to aid revision and check comprehension, clear anatomicaldiagrams to illustrate key points and a larger format to show12-lead ECGs clearly and without truncation. Edited and written by leading experts, the ABC of ClinicalElectrocardiography is a valuable text for anyone managing patientswith heart disorders, both in general practice and in hospitals.Junior doctors and nurses, especially those working in cardiologyand emergency departments, as well as medical students, will findthis a vaulable introduction to the understanding of this keyclinical tool.

Antiarrhythmic Drugs

Author : Antoni Martínez-Rubio
Publisher : Springer Nature
ISBN 13 : 3030348938
Total Pages : 433 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Antiarrhythmic Drugs by : Antoni Martínez-Rubio

Download or read book Antiarrhythmic Drugs written by Antoni Martínez-Rubio and published by Springer Nature. This book was released on 2020-02-03 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis.

Electrocardiographic Imaging

Author : Maria S. Guillem
Publisher : Frontiers Media SA
ISBN 13 : 2889636712
Total Pages : 178 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Electrocardiographic Imaging by : Maria S. Guillem

Download or read book Electrocardiographic Imaging written by Maria S. Guillem and published by Frontiers Media SA. This book was released on 2020-04-17 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrical activity in the myocardium coordinates the contraction of the heart, and its knowledge could lead to a better understanding, diagnosis, and treatment of cardiac diseases. This electrical activity generates an electromagnetic field that propagates outside the heart and reaches the human torso surface, where it can be easily measured. Classical electrocardiography aims to interpret the 12-lead electrocardiogram (ECG) to determine cardiac activity and support the diagnosis of cardiac pathologies such as arrhythmias, altered activations, and ischemia. More recently, a higher number of leads is used to reconstruct a more detailed quantitative description of the electrical activity in the heart by solving the so-called inverse problem of electrocardiography. This technique is known as ECG imaging. Today, clinical applications of ECG imaging are showing promising results in guiding a variety of electrophysiological interventions such as catheter ablation of atrial fibrillation and ventricular tachycardia. However, in order to promote the adoption of ECG imaging in the routine clinical practice, further research is required regarding more accurate mathematical methods, further scientific validation under different preclinical scenarios and a more extensive clinical validation

Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence

Author : World Health Organization. Department of Mental Health and Substance Abuse
Publisher : World Health Organization
ISBN 13 : 9241547545
Total Pages : 133 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence by : World Health Organization. Department of Mental Health and Substance Abuse

Download or read book Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence written by World Health Organization. Department of Mental Health and Substance Abuse and published by World Health Organization. This book was released on 2009 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: "These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv

Comprehensive Electrocardiology

Author : Peter W. Macfarlane
Publisher : Springer Science & Business Media
ISBN 13 : 1848820453
Total Pages : 2310 pages
Book Rating : 4.8/5 (488 download)

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Book Synopsis Comprehensive Electrocardiology by : Peter W. Macfarlane

Download or read book Comprehensive Electrocardiology written by Peter W. Macfarlane and published by Springer Science & Business Media. This book was released on 2010-11-05 with total page 2310 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition of the classic complete reference book for cardiologists and trainee cardiologists on the theory and practice of electrocardiography, one of the key modalities used for evaluating cardiology patients and deciding on appropriate management strategies.

Novel Therapeutic Targets for Antiarrhythmic Drugs

Author : George Edward Billman
Publisher : John Wiley & Sons
ISBN 13 : 9780470561409
Total Pages : 608 pages
Book Rating : 4.5/5 (614 download)

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Book Synopsis Novel Therapeutic Targets for Antiarrhythmic Drugs by : George Edward Billman

Download or read book Novel Therapeutic Targets for Antiarrhythmic Drugs written by George Edward Billman and published by John Wiley & Sons. This book was released on 2010-01-05 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Profiles potential treatment approaches for cardiac arrhythmias Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.

Voltage Gated Sodium Channels

Author : Peter C. Ruben
Publisher : Springer Science & Business Media
ISBN 13 : 3642415881
Total Pages : 328 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.