Continuous Flow Fast Atom Bombardment and Electrospray Ionization Mass Spectrometry in Natural Products Research

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ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.:/5 (358 download)

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Book Synopsis Continuous Flow Fast Atom Bombardment and Electrospray Ionization Mass Spectrometry in Natural Products Research by : Katarzyna Janota

Download or read book Continuous Flow Fast Atom Bombardment and Electrospray Ionization Mass Spectrometry in Natural Products Research written by Katarzyna Janota and published by . This book was released on 1995 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous flow fast atom bombardment (CF-FAB) has been applied as a liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) interface in natural products research. Initial studies concentrated on characterization of the interface, optimization of operational parameters and sensitivity assessment. Using a CF-FAB interface, femtomole quantities of different classes of compounds were detected, which is two orders of magnitude more sensitive than by standard FAB. Later, CF-FAB was applied to the analysis of didemnin, streptovaricin, and ecteinascidin mixtures in isocratic and/or gradient modes. The first application led to the discovery of acyclo-desHIP-didemnin A in a mixture of didemnins, cyclic peptides of potent antitumor and antiviral activity. Although related to didemnins, the linear peptide was biologically inactive. The second application project involved streptovaricins, secondary metabolites of Streptomyces spectabilis. In the streptovaricin mixture, besides streptovaricins, protostreptovaricins III and IV were detected by LC/CF-FABMS. The presence of protostreptovaricins in the streptovaricin complex confirmed the biosynthetic pathway proposed for streptovaricin C. Even though these precursors were known previously, they were not observed as components of the mixture by standard FABMS. When ecteinascidins were analyzed by LC/CF-FABMS, the most significant difference was the amount of structural information generated in the low mass range in comparison to the standard FAB spectra. The hydrates of structurally significant fragment ions were observed when the background was subtracted. The use of a CF-FAB interface was extended to on-line high resolution mass measurements of different components in the mixture. Mass measurements were within the range of acceptable error. On-line LC/CF-FABMS/MS was performed on the ecteinascidin mixture using B/E linked scans. Observed ions were then classified as group-characteristic or compound-specific. Finally, CF-FAB was compared to electrospray ionization (ESI) as an LC/MS and LC/MS/MS interface with respect to sensitivity and structural information. In the selected ion chromatogram mode, the sensitivity of CF-FAB is comparable to that of LC/ESIMS. However, identification of unknowns is more feasible by LC/ESIMS than by LC/CF-FABMS. Also, the daughter ion mass spectra can be produced even on trace amounts by LC/ESIMS/MS and are of better quality than by LC/CF-FABMS/MS. In LC/ESIMS/MS, similar structural information is obtained; however, the main difference is the relative intensities of the fragment ions. Several new ecteinascidins were observed by LC/ESIMS. Their structures are proposed on the basis of LC/ESIMS/MS data.

Continuous-Flow Fast Atom Bombardment Mass Spectrometry

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ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Continuous-Flow Fast Atom Bombardment Mass Spectrometry by : R. M. Caprioli

Download or read book Continuous-Flow Fast Atom Bombardment Mass Spectrometry written by R. M. Caprioli and published by . This book was released on 1990-12-31 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on presentations made at a workshop on Continuous Flow Fast Atom Bombardment held in Annapolis, Maryland, in November, 1989. Expanded and edited, the papers presented at the workshop form a compact volume reflecting recent advances in a number of key areas in the field of continuous flow fast atom bombardment mass spectrometry. Topics cover non-aqueous applications, biological process monitoring, trace analysis, and design and operational conditions.

Ionization Methods in Organic Mass Spectrometry

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Publisher : Royal Society of Chemistry
ISBN 13 : 184755119X
Total Pages : 188 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Ionization Methods in Organic Mass Spectrometry by : Alison E Ashcroft

Download or read book Ionization Methods in Organic Mass Spectrometry written by Alison E Ashcroft and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ionization Methods in Organic Mass Spectrometry is a basic practical guide for scientists of all disciplines who wish to analyse samples by organic mass spectrometry. Concentrating on instrumental operation, this book gives step-by-step instructions on how to set up, and how to achieve the best results, using a range of ionization methods, including atmospheric pressure chemical ionization, electrospray ionization and matrix assisted laser desorption ionization. Ionization Methods in Organic Mass Spectrometry will enable a beginner, or practitioner with limited experience, to choose the most appropriate ionization technique in application areas such as biomolecules, drugs and metabolites, pesticides, polymers and many other organic compounds. It will be a valuable practical guide for technicians, graduates, students or researchers - or indeed anyone new to practical organic mass spectrometry.

Continuous-flow Fast Atom Bombardment Liquid Chromatography-mass Spectrometry in Bioanalysis

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ISBN 13 : 9789514232282
Total Pages : 62 pages
Book Rating : 4.2/5 (322 download)

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Book Synopsis Continuous-flow Fast Atom Bombardment Liquid Chromatography-mass Spectrometry in Bioanalysis by : Paula S. Kokkonen

Download or read book Continuous-flow Fast Atom Bombardment Liquid Chromatography-mass Spectrometry in Bioanalysis written by Paula S. Kokkonen and published by . This book was released on 1991 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Electrochemically Assisted Fast Atom Bombardment Mass Spectrometry

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ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Electrochemically Assisted Fast Atom Bombardment Mass Spectrometry by : Lawrence Richard Phillips

Download or read book Electrochemically Assisted Fast Atom Bombardment Mass Spectrometry written by Lawrence Richard Phillips and published by . This book was released on 1988 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Encyclopedia of Mass Spectrometry

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Publisher : Elsevier Science
ISBN 13 : 9780080438016
Total Pages : 1040 pages
Book Rating : 4.4/5 (38 download)

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Book Synopsis The Encyclopedia of Mass Spectrometry by : Michael L. Gross

Download or read book The Encyclopedia of Mass Spectrometry written by Michael L. Gross and published by Elsevier Science. This book was released on 2006-12-21 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 6: Ionization Methods captures the story of molecular ionization and its phenomenal evolution that makes mass spectrometry the powerful method it is today. Chapters 1 and 2 cover fundamentals and various issues that are common to all ionization (e.g., accurate mass, isotope clusters, and derivatization). Chapters 3-9 acknowledge that some ionization methods are appropriate for gas-phase molecules and others for molecules that are in the solid or liquid states. Chapters 3-6 cover gas-phase molecules, dividing the subject into: (1) ionization of gas-phase molecules by particles (e.g., EI), (2) ionization by photons, (3) ionization by ion-molecule and molecule-molecule reactions (e.g., APCI and DART), and ionization in Strong electric fields (i.e., Electrohydrodynamic and Field Ionization/Desorption). "Ionization in a Strong Electric Field" illustrates the transition to ionization of molecules in the solid or liquid states, covered in Chapters 7-9: (1) spray methods for ionization (e.g., electrospray), (2) desorption ionization by particle bombardment (e.g., FAB), and (3) desorption by photons (e.g., MALDI). Electrospray and MALDI also lead to applications in biophysical chemistry, the theme of Chapter 10. Chapter 11 reconsiders ionization from the view of choosing an ionization method. The range of subjects is from ionization of organic and biomolecules to the study of microorganisms.

The Encyclopedia of Mass Spectrometry

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Publisher : Elsevier Science
ISBN 13 : 9780080438016
Total Pages : 1040 pages
Book Rating : 4.4/5 (38 download)

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Book Synopsis The Encyclopedia of Mass Spectrometry by : Michael L. Gross

Download or read book The Encyclopedia of Mass Spectrometry written by Michael L. Gross and published by Elsevier Science. This book was released on 2006-12-21 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 6: Ionization Methods captures the story of molecular ionization and its phenomenal evolution that makes mass spectrometry the powerful method it is today. Chapters 1 and 2 cover fundamentals and various issues that are common to all ionization (e.g., accurate mass, isotope clusters, and derivatization). Chapters 3-9 acknowledge that some ionization methods are appropriate for gas-phase molecules and others for molecules that are in the solid or liquid states. Chapters 3-6 cover gas-phase molecules, dividing the subject into: (1) ionization of gas-phase molecules by particles (e.g., EI), (2) ionization by photons, (3) ionization by ion-molecule and molecule-molecule reactions (e.g., APCI and DART), and ionization in Strong electric fields (i.e., Electrohydrodynamic and Field Ionization/Desorption). "Ionization in a Strong Electric Field" illustrates the transition to ionization of molecules in the solid or liquid states, covered in Chapters 7-9: (1) spray methods for ionization (e.g., electrospray), (2) desorption ionization by particle bombardment (e.g., FAB), and (3) desorption by photons (e.g., MALDI). Electrospray and MALDI also lead to applications in biophysical chemistry, the theme of Chapter 10. Chapter 11 reconsiders ionization from the view of choosing an ionization method. The range of subjects is from ionization of organic and biomolecules to the study of microorganisms.

Electrospray and MALDI Mass Spectrometry

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Publisher : John Wiley & Sons
ISBN 13 : 1118211553
Total Pages : 900 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Electrospray and MALDI Mass Spectrometry by : Richard B. Cole

Download or read book Electrospray and MALDI Mass Spectrometry written by Richard B. Cole and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.

Ambient Ionization Mass Spectrometry

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Publisher : Royal Society of Chemistry
ISBN 13 : 1782628029
Total Pages : 529 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Ambient Ionization Mass Spectrometry by : Marek Domin

Download or read book Ambient Ionization Mass Spectrometry written by Marek Domin and published by Royal Society of Chemistry. This book was released on 2014-11-14 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.

Bioassay Methods in Natural Product Research and Drug Development

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Publisher : Springer Science & Business Media
ISBN 13 : 9401148104
Total Pages : 203 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Bioassay Methods in Natural Product Research and Drug Development by : Lars Bohlin

Download or read book Bioassay Methods in Natural Product Research and Drug Development written by Lars Bohlin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Studies on the Desorption Ionization Mechanism in Fast Atom Bombardment Mass Spectrometry

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Publisher :
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4.:/5 (73 download)

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Book Synopsis Studies on the Desorption Ionization Mechanism in Fast Atom Bombardment Mass Spectrometry by : Angelina Morales

Download or read book Studies on the Desorption Ionization Mechanism in Fast Atom Bombardment Mass Spectrometry written by Angelina Morales and published by . This book was released on 1990 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Expanding Role of Mass Spectrometry in Biotechnology

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ISBN 13 : 9780974245126
Total Pages : 0 pages
Book Rating : 4.2/5 (451 download)

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Book Synopsis The Expanding Role of Mass Spectrometry in Biotechnology by : Gary Siuzdak

Download or read book The Expanding Role of Mass Spectrometry in Biotechnology written by Gary Siuzdak and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the basic concepts in mass spectrometry as well as advanced topics including protein identification/protein structural analysis, carbohydrate and oligonucleotide analysis. Topics also include pharmacokinetics, high throughput screening, and the recent development of mass spectrometry in clinical diagnosis.

Mass Spectrometry in Medicinal Chemistry

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Publisher : John Wiley & Sons
ISBN 13 : 352761091X
Total Pages : 460 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Mass Spectrometry in Medicinal Chemistry by : Klaus Wanner

Download or read book Mass Spectrometry in Medicinal Chemistry written by Klaus Wanner and published by John Wiley & Sons. This book was released on 2007-06-27 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

Mechanism Studies of Fast Atom Bombardment Mass Spectrometry

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ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (299 download)

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Book Synopsis Mechanism Studies of Fast Atom Bombardment Mass Spectrometry by : Jian Yin

Download or read book Mechanism Studies of Fast Atom Bombardment Mass Spectrometry written by Jian Yin and published by . This book was released on 1993 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Encyclopedia of Spectroscopy and Spectrometry

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Publisher : Academic Press
ISBN 13 : 0080922171
Total Pages : 7207 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Encyclopedia of Spectroscopy and Spectrometry by :

Download or read book Encyclopedia of Spectroscopy and Spectrometry written by and published by Academic Press. This book was released on 2010-04-09 with total page 7207 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of the Encyclopedia of Spectroscopy and Spectrometry pulls key information into a single source for quick access to answers and/or in-depth examination of topics. "SPEC-2" covers theory, methods, and applications for researchers, students, and professionals—combining proven techniques and new insights for comprehensive coverage of the field. The content is available in print and online via ScienceDirect, the latter of which offers optimal flexibility, accessibility, and usability through anytime, anywhere access for multiple users and superior search functionality. No other work gives analytical and physical (bio)chemists such unprecedented access to the literature. With 30% new content, SPEC-2 maintains the "authoritative, balanced coverage" of the original work while also breaking new ground in spectroscopic research. Incorporates more than 150 color figures, 5,000 references, and 300 articles (30% of which are new), for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Features a new co-editor: David Koppenaal of Pacific Northwest National Laboratory, Washington, USA, whose work in atomic mass spectrometry has been recognized internationally

Advances in Fast Atom Bombardment Mass Spectrometry

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ISBN 13 :
Total Pages : 342 pages
Book Rating : 4.:/5 (156 download)

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Book Synopsis Advances in Fast Atom Bombardment Mass Spectrometry by : Mark Elliott Hemling

Download or read book Advances in Fast Atom Bombardment Mass Spectrometry written by Mark Elliott Hemling and published by . This book was released on 1986 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fast Atom Bombardment and Electron Impact Mass Spectrometry Studies of Some Aryltin Compounds and Ferrocenes

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Fast Atom Bombardment and Electron Impact Mass Spectrometry Studies of Some Aryltin Compounds and Ferrocenes by : Yongchong Luo

Download or read book Fast Atom Bombardment and Electron Impact Mass Spectrometry Studies of Some Aryltin Compounds and Ferrocenes written by Yongchong Luo and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: