Conformational And Colloidal Stability Of Macromolecules In Aqueous Salt Solutions

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Conformational and Colloidal Stability of Macromolecules in Aqueous Salt Solutions

Author : Bradley Allen Rogers
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (113 download)

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Book Synopsis Conformational and Colloidal Stability of Macromolecules in Aqueous Salt Solutions by : Bradley Allen Rogers

Download or read book Conformational and Colloidal Stability of Macromolecules in Aqueous Salt Solutions written by Bradley Allen Rogers and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The conformational and colloidal stability of proteins in aqueous solutions are critical to the function of biological cells and the shelf-life of biopharmaceutical drug products. These properties of protein macromolecules are strongly influenced by cosolutes in the solution, including inorganic salt ions and non-ionic crowding agents. The intrinsic and cosolute-modulated properties of proteins are governed by specific interactions between proteins, water, and cosolutes. Herein, the non-covalent interactions that drive two phenomena are explored, including anion-induced denaturation of proteins and the liquid-liquid phase separation of therapeutic antibody solutions. In the first aim, protein folding is mimicked by thermoresponsive polymers model systems that undergo hydrophobic collapse upon heating. A combination of light scattering measurements as well as vibrational and nuclear magnetic resonance spectroscopies on these thermoresponsive polymers reveal that the structure of water-water hydrogen bonding at hydrophobic surfaces can modulate the binding affinity of weakly hydrated anions over several orders of magnitude. In the second aim, the colloidal phase separation of concentrated antibody formulations is imaged by dark-field microscopy on a temperature gradient microfluidics platform. This platform facilitates high-throughput measurements of phase separation across a range of temperatures and solution conditions, simultaneously. Analysis of the dark-field images over time reveals that the phase separation is a multistep reaction. Collectively, this work provides novel insights into the conformational and colloidal stability of proteins, which advance the current understanding of protein behavior in biological and biotechnological solutions.

Albumin: Structure, Function and Uses

Author : Victor M. Rosenoer
Publisher : Elsevier
ISBN 13 : 1483156885
Total Pages : 427 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Albumin: Structure, Function and Uses by : Victor M. Rosenoer

Download or read book Albumin: Structure, Function and Uses written by Victor M. Rosenoer and published by Elsevier. This book was released on 2014-05-18 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Albumin Structure, Function and Uses reviews the many facets of serum albumin, including its history and evolutionary development, structure and function, synthesis, degradation, distribution and transport, and metabolic behavior. The use, misuse, and abuse of albumin in the treatment of disease are also discussed. This book is comprised of 17 chapters and begins with a commentary on how albumin is used, misused, and abused in the treatment of disease such as peptic ulcer, and a description of the real indications for its use. Concepts in albumin purification are then examined, along with the amino acid sequence of serum albumin and some aspects of its structure and conformational properties. Subsequent chapters explore the phylogenetics of albumin; albumin binding sites; clinical implications of drug-albumin interaction; genetics of human serum albumin; and hepatic synthesis of export proteins. Albumin catabolism and intracellular transport are also considered, together with surgical and clinical aspects of albumin metabolism. This monograph should be a useful resource for biochemists and clinicians.

Supramolecular Assemblies Based on Electrostatic Interactions

Author : M. Ali Aboudzadeh
Publisher : Springer Nature
ISBN 13 : 3031006577
Total Pages : 404 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Supramolecular Assemblies Based on Electrostatic Interactions by : M. Ali Aboudzadeh

Download or read book Supramolecular Assemblies Based on Electrostatic Interactions written by M. Ali Aboudzadeh and published by Springer Nature. This book was released on 2022-05-21 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents recent advances and current knowledge in the field of supramolecular assemblies based on electrostatic interactions. The flexibility and simplicity of constructing assemblies is explained via several examples, illustrations, figures, case studies, and historical perspectives. Moreover, as there is an increasing demand for the use of theoretical and computational models of the interaction strengths for assisting with the experimental studies, one chapter specifically focuses on the "modelling'' of supramolecular assemblies. Finally, various aspects of the recent advances of the field as well as potential future opportunities are discussed, with the goal being to stimulate critical discussions among the community and to encourage further discovery. This volume aims to inspire and guide fellow scientists and students working in this field and thus it provides a great tool for all researchers, graduates and professionals specializing on the topic.

Soviet Progress in Chemistry

Author :
Publisher :
ISBN 13 :
Total Pages : 746 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Soviet Progress in Chemistry by :

Download or read book Soviet Progress in Chemistry written by and published by . This book was released on 1982 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 1378 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1977 with total page 1378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biophysics for the Life Sciences

Author : Norma Allewell
Publisher : Springer Science & Business Media
ISBN 13 : 1461485487
Total Pages : 401 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Molecular Biophysics for the Life Sciences by : Norma Allewell

Download or read book Molecular Biophysics for the Life Sciences written by Norma Allewell and published by Springer Science & Business Media. This book was released on 2013-09-28 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution. It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions. Reviews of research on three disparate biomolecular machines—DNA helicases, ATP synthases, and myosin--illustrate how the combination of theory and experiment leads to new insights and new questions.

Specific Ion Effects

Author : Werner Kunz
Publisher : World Scientific
ISBN 13 : 9814271586
Total Pages : 347 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Specific Ion Effects by : Werner Kunz

Download or read book Specific Ion Effects written by Werner Kunz and published by World Scientific. This book was released on 2010 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific ion effects are important in numerous fields of science and technology. This book summarizes the main ideas that came up over the years. It presents the efforts of theoreticians and supports it by the experimental results stemming from various techniques.

Handbook of Crystal Growth

Author : Tatau Nishinaga
Publisher : Elsevier
ISBN 13 : 0444593764
Total Pages : 1216 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Handbook of Crystal Growth by : Tatau Nishinaga

Download or read book Handbook of Crystal Growth written by Tatau Nishinaga and published by Elsevier. This book was released on 2014-11-04 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume IAHandbook of Crystal Growth, 2nd Edition (Fundamentals: Thermodynamics and Kinetics) Volume IA addresses the present status of crystal growth science, and provides scientific tools for the following volumes: Volume II (Bulk Crystal Growth) and III (Thin Film Growth and Epitaxy). Volume IA highlights thermodynamics and kinetics. After historical introduction of the crystal growth, phase equilibria, defect thermodynamics, stoichiometry, and shape of crystal and structure of melt are described. Then, the most fundamental and basic aspects of crystal growth are presented, along with the theories of nucleation and growth kinetics. In addition, the simulations of crystal growth by Monte Carlo, ab initio-based approach and colloidal assembly are thoroughly investigated. Volume IBHandbook of Crystal Growth, 2nd Edition (Fundamentals: Transport and Stability) Volume IB discusses pattern formation, a typical problem in crystal growth. In addition, an introduction to morphological stability is given and the phase-field model is explained with comparison to experiments. The field of nanocrystal growth is rapidly expanding and here the growth from vapor is presented as an example. For the advancement of life science, the crystal growth of protein and other biological molecules is indispensable and biological crystallization in nature gives many hints for their crystal growth. Another subject discussed is pharmaceutical crystal growth. To understand the crystal growth, in situ observation is extremely powerful. The observation techniques are demonstrated. Volume IA Explores phase equilibria, defect thermodynamics of Si, stoichiometry of oxides and atomistic structure of melt and alloys Explains basic ideas to understand crystal growth, equilibrium shape of crystal, rough-smooth transition of step and surface, nucleation and growth mechanisms Focuses on simulation of crystal growth by classical Monte Carlo, ab-initio based quantum mechanical approach, kinetic Monte Carlo and phase field model. Controlled colloidal assembly is presented as an experimental model for crystal growth. Volume IIB Describes morphological stability theory and phase-field model and comparison to experiments of dendritic growth Presents nanocrystal growth in vapor as well as protein crystal growth and biological crystallization Interprets mass production of pharmaceutical crystals to be understood as ordinary crystal growth and explains crystallization of chiral molecules Demonstrates in situ observation of crystal growth in vapor, solution and melt on the ground and in space

Polymerized Ionic Liquids

Author : Ali Eftekhari
Publisher : Royal Society of Chemistry
ISBN 13 : 1782629602
Total Pages : 564 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Polymerized Ionic Liquids by : Ali Eftekhari

Download or read book Polymerized Ionic Liquids written by Ali Eftekhari and published by Royal Society of Chemistry. This book was released on 2017-09-18 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series covers the fundamentals and applications of different smart material systems from renowned international experts.

Maro Polymer Notes

Author :
Publisher :
ISBN 13 :
Total Pages : 446 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Maro Polymer Notes by :

Download or read book Maro Polymer Notes written by and published by . This book was released on 1995 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Colloids and the Depletion Interaction

Author : Henk N.W. Lekkerkerker
Publisher : Springer Science & Business Media
ISBN 13 : 9400712227
Total Pages : 245 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Colloids and the Depletion Interaction by : Henk N.W. Lekkerkerker

Download or read book Colloids and the Depletion Interaction written by Henk N.W. Lekkerkerker and published by Springer Science & Business Media. This book was released on 2011-05-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colloids are submicron particles that are ubiquitous in nature (milk, clay, blood) and industrial products (paints, drilling fluids, food). In recent decades it has become clear that adding depletants such as polymers or small colloids to colloidal dispersions allows one to tune the interactions between the colloids and in this way control the stability, structure and rheological properties of colloidal dispersions. This book offers a concise introduction to the fundamentals of depletion effects and their influence on the phase behavior of colloidal dispersions. Throughout the book, conceptual explanations are accompanied by experimental and computer simulation results. From the review by Kurt Binder: "They have succeeded in writing a monograph that is a very well balanced compromise between a very pedagogic introduction, suitable for students and other newcomers, and reviews of the advanced research trends in the field. Thus each chapter contains many and up to date references, but in the initial sections of the chapters, there are suggested exercises which will help the interested reader to recapitulate the main points of the treatment and to deepen his understanding of the subject. Only elementary knowledge of statistical thermodynamics is needed as a background for understanding the derivations presented in this book; thus this text is suitable also for advanced teaching purposes, useful of courses which deal with the physics for soft condensed matter. There does not yet exist any other book with a similar scope..... The readability of this book is furthermore enhanced by a list of symbols, and index of keywords, and last not least by a large number of figures, including many pedagogic sketches which were specifically prepared for this book. Thus, this book promises to be very useful for students and related applied sciences alike." Eur. Phys. J. E (2015) 38: 73

Colloids

Author : Mohamed Nageeb Rashed
Publisher : BoD – Books on Demand
ISBN 13 : 183962969X
Total Pages : 234 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Colloids by : Mohamed Nageeb Rashed

Download or read book Colloids written by Mohamed Nageeb Rashed and published by BoD – Books on Demand. This book was released on 2021-09-08 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colloids are submicron particles that are ubiquitous in both natural and industrial products. Colloids and colloidal systems play a significant role in human health as well as commercial and industrial situations. Colloids have important applications in medicine, sewage disposal, water purification, mining, photography, electroplating, agriculture, and more.This book gathers recent research from experts in the field of colloids and discusses several aspects of colloid morphology, synthesis, and applications. The book is divided into three sections that cover different techniques for the synthesis of colloids, the structure, dynamic and stability of colloids, and applications of colloidal particles, respectively.

Colloid Stability

Author : Chemical Society (Great Britain). Faraday Division
Publisher :
ISBN 13 :
Total Pages : 364 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Colloid Stability by : Chemical Society (Great Britain). Faraday Division

Download or read book Colloid Stability written by Chemical Society (Great Britain). Faraday Division and published by . This book was released on 1978 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Flocs in Water Treatment

Author : David H. Bache
Publisher : IWA Publishing
ISBN 13 : 1843390639
Total Pages : 309 pages
Book Rating : 4.8/5 (433 download)

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Book Synopsis Flocs in Water Treatment by : David H. Bache

Download or read book Flocs in Water Treatment written by David H. Bache and published by IWA Publishing. This book was released on 2007-11-08 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flocs in Water Treatment is the first of its kind - serving as a valuable aide-mémoire for scientists, process engineers and other professionals engaged in water treatment. The framework described in Flocs in Water Treatment can also be applied to aggregated solids found both in the natural environment, and within a broad range of industries. Flocs (aggregated solid matter) resulting from the combined influence of coagulation and flocculation play a vital role in solid-liquid separation processes. The design and operation of water treatment plants demands a proper understanding of the ways in which flocs affect treatment systems and how their properties can be manipulated to increase treatment efficiency. Flocs in Water Treatment provides a comprehensive account of the ways in which flocs are formed, their characterization, and how they behave in practice. Flocs are complex entities, whose properties defy easy description and measurement. In spite of this, the authors provide a clear and discerning account of the current state of knowledge; this is rooted in science and draws on many disciplines. Based on their experiences in research and the workings of full scale treatment plants, the authors offer candid advice on tasks such as the measurement of floc properties and guidance on problems involving the use of chemicals for controlling floc properties within treatment systems.

Densities of Aqueous Solutions of Inorganic Substances

Author : Otakar Söhnel
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (49 download)

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Book Synopsis Densities of Aqueous Solutions of Inorganic Substances by : Otakar Söhnel

Download or read book Densities of Aqueous Solutions of Inorganic Substances written by Otakar Söhnel and published by Elsevier Publishing Company. This book was released on 1985 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polyampholytes

Author : Sarkyt E. Kudaibergenov
Publisher : Springer Science & Business Media
ISBN 13 : 9780306467813
Total Pages : 232 pages
Book Rating : 4.4/5 (678 download)

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Book Synopsis Polyampholytes by : Sarkyt E. Kudaibergenov

Download or read book Polyampholytes written by Sarkyt E. Kudaibergenov and published by Springer Science & Business Media. This book was released on 2002-04-30 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the synthesis, characterization and application aspects of linear and crosslinked synthetic polyampholytes - simple model of biopolymers - starting from the 1950's. The synthetic strategy of "annealed", "quenched" and "zwitterionic" polyampholytes, the properties of polyampholytes in solutions and in gel state are considered. The complexation ability of polyampholytes with respect to transition metal ions, ionic surfactants, dyes and organic probes polyelectrolytes, proteins and colloid particles is discussed. Stimuli-sensitive behavior of various amphoteric gel and membrane systems demonstrating rhythmically phenomenon similar to that of heart beat, deformation, oscillation or self-oscillation phenomena stimulated by temperature, pH and electric field are illustrated. Catalytic properties of synthetic polyampholytes simulating the function of enzymes are also considered.

The Engineering Index Annual

Author :
Publisher :
ISBN 13 :
Total Pages : 2264 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis The Engineering Index Annual by :

Download or read book The Engineering Index Annual written by and published by . This book was released on 1992 with total page 2264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its creation in 1884, Engineering Index has covered virtually every major engineering innovation from around the world. It serves as the historical record of virtually every major engineering innovation of the 20th century. Recent content is a vital resource for current awareness, new production information, technological forecasting and competitive intelligence. The world?s most comprehensive interdisciplinary engineering database, Engineering Index contains over 10.7 million records. Each year, over 500,000 new abstracts are added from over 5,000 scholarly journals, trade magazines, and conference proceedings. Coverage spans over 175 engineering disciplines from over 80 countries. Updated weekly.