Conformation Analysis Of Proteins

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Prediction of Protein Structure and the Principles of Protein Conformation

Author : G.D. Fasman
Publisher : Springer Science & Business Media
ISBN 13 : 1461315719
Total Pages : 796 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Prediction of Protein Structure and the Principles of Protein Conformation by : G.D. Fasman

Download or read book Prediction of Protein Structure and the Principles of Protein Conformation written by G.D. Fasman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.

Protein Conformation

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470514159
Total Pages : 282 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Protein Conformation by : Derek J. Chadwick

Download or read book Protein Conformation written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.

Circular Dichroism and the Conformational Analysis of Biomolecules

Author : G.D. Fasman
Publisher : Springer Science & Business Media
ISBN 13 : 1475725086
Total Pages : 739 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Circular Dichroism and the Conformational Analysis of Biomolecules by : G.D. Fasman

Download or read book Circular Dichroism and the Conformational Analysis of Biomolecules written by G.D. Fasman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''Excellent and very timely....It will undoubtedly become a standard reference for the application of circular dichroism (CD) to biomolecules.'' --- Quarterly Review of Biology, March 1997 ''[T]estament to the book's utility is the fact that during the course of my review I had to 'rescue' it from the desks of graduate students on an almost daily basis. In summary, this is a great book.'' --- American Scientist ''Well documented chapters provide a very good insight into the problems surrounding the conformation of biomacromolecules...An indispensible source of information.'' --- Nahrung, 42(2), 1998 Renowned experts present the first state-of-the-art description of circular dichroism spectroscopy (CD). Chapters present in-depth discussions of the history of the field, the theory of CD for application to globular proteins, membrane proteins, peptides, nucleic acids and their interactions, carbohydrates, and instrumentation. Discussions also feature new techniques using synchrotron radiation, vibrational Raman optical activity, and vibrational CD. More than 250 illustrations supplement the text.

Protein Structure and Function

Author : Gregory A. Petsko
Publisher : New Science Press
ISBN 13 : 0878936637
Total Pages : 220 pages
Book Rating : 4.8/5 (789 download)

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Book Synopsis Protein Structure and Function by : Gregory A. Petsko

Download or read book Protein Structure and Function written by Gregory A. Petsko and published by New Science Press. This book was released on 2004 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each title in the 'Primers in Biology' series is constructed on a modular principle that is intended to make them easy to teach from, to learn from, and to use for reference.

Conformation analysis of proteins

Author : Michael Levitt
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (258 download)

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Book Synopsis Conformation analysis of proteins by : Michael Levitt

Download or read book Conformation analysis of proteins written by Michael Levitt and published by . This book was released on 1972 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Conformation in Biology and Drug Design

Author : Sidney Udenfriend
Publisher : Elsevier
ISBN 13 : 1483218007
Total Pages : 516 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Conformation in Biology and Drug Design by : Sidney Udenfriend

Download or read book Conformation in Biology and Drug Design written by Sidney Udenfriend and published by Elsevier. This book was released on 2014-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.

Conformation in Fibrous Proteins and Related Synthetic Polypeptides

Author : R Fraser
Publisher : Elsevier
ISBN 13 : 0323143997
Total Pages : 649 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Conformation in Fibrous Proteins and Related Synthetic Polypeptides by : R Fraser

Download or read book Conformation in Fibrous Proteins and Related Synthetic Polypeptides written by R Fraser and published by Elsevier. This book was released on 2012-12-02 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conformation in Fibrous Proteins: And Related Synthetic Polypeptides provides a comprehensive and critical account of conformation in fibrous proteins and synthetic polypeptides in the solid state. Physical methods of determining conformation are discussed, and relevant results from studies of synthetic polypeptides and fibrous proteins are presented. Comprised of 18 chapters divided into three sections, this book opens with a discussion on the theory and technique of X-ray diffraction applicable to the study of conformation in fibrous materials, along with electron diffraction, electron microscopy, optical diffraction, and infrared spectrophotometry. The procedures used for conformation analysis and prediction are also outlined. The following chapters consider optimization techniques and other methods for elucidating conformation in fibrous proteins and synthetic polypeptides; the use of synthetic polypeptides as models of fibrous proteins; and conformation in fibrous proteins such as silks, collagens, myofibrillar proteins, and keratins. This monograph will be a valuable source of information for molecular biologists.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Conformational Dynamics

Author : Ke-li Han
Publisher : Springer Science & Business Media
ISBN 13 : 3319029703
Total Pages : 488 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Protein Conformational Dynamics by : Ke-li Han

Download or read book Protein Conformational Dynamics written by Ke-li Han and published by Springer Science & Business Media. This book was released on 2014-01-20 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.

Protein Conformation

Author : Linda B. Roswell
Publisher : Nova Publishers
ISBN 13 : 9781604562194
Total Pages : 280 pages
Book Rating : 4.5/5 (621 download)

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Book Synopsis Protein Conformation by : Linda B. Roswell

Download or read book Protein Conformation written by Linda B. Roswell and published by Nova Publishers. This book was released on 2008 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein structure is the characteristic 3-dimensional shape of a protein, imposed upon it by the secondary and tertiary structure of the peptide chain. This stage in the structure of a protein describes the highest level of organisation in overall structure assumed by multimeric proteins (aggregates of more than one polypeptide chain). This is the fourth folding level of protein building. This new book presents the latest research in the field.

Methods in Protein Structure and Stability Analysis: Conformational stability, size, shape, and surface of protein molecules

Author : Vladimir N. Uversky
Publisher : Nova Publishers
ISBN 13 : 9781600217043
Total Pages : 414 pages
Book Rating : 4.2/5 (17 download)

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Book Synopsis Methods in Protein Structure and Stability Analysis: Conformational stability, size, shape, and surface of protein molecules by : Vladimir N. Uversky

Download or read book Methods in Protein Structure and Stability Analysis: Conformational stability, size, shape, and surface of protein molecules written by Vladimir N. Uversky and published by Nova Publishers. This book was released on 2007 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein research is a frontier field in science. Proteins are widely distributed in plants and animals and are the principal constituents of the protoplasm of all cells, and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved throughout the body, and in photosynthesis. This book gathers new leading-edge research from throughout the world in this exciting and exploding field of research.

Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides

Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527631852
Total Pages : 508 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides by :

Download or read book Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides written by and published by John Wiley & Sons. This book was released on 2013-02-13 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the last of five books in the Amino Acids, Peptidesand Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series tocover this important topic in organic and biochemistry. Drawingupon the combined expertise of the international "who's who" inamino acid research, these volumes represent a real benchmark foramino acid chemistry, providing a comprehensive discussion of theoccurrence, uses and applications of amino acids and, by extension,their polymeric forms, peptides and proteins. The practical value of each volume is heightened by theinclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry,Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides Volume 5 of this series presents a wealth of methods to analyzeamino acids and peptides. Classical approaches are described, suchas X-ray analysis, chromatographic methods, NMR, AFM, massspectrometry and 2D-gel electrophoresis, as well as newerapproaches, including Surface Plasmon Resonance and arraytechnologies. Originally planned as a six volume series, Amino Acids,Peptides and Proteins in Organic Chemistry now completes withfive volumes but remains comprehensive in both scope andcoverage. ahref="http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527335463.html"Furtherinformation about the 5 Volume Set and purchasing details can beviewed here./a

Instrumental Analysis of Intrinsically Disordered Proteins

Author : Vladimir Uversky
Publisher : John Wiley & Sons
ISBN 13 : 0470602600
Total Pages : 792 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Instrumental Analysis of Intrinsically Disordered Proteins by : Vladimir Uversky

Download or read book Instrumental Analysis of Intrinsically Disordered Proteins written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2011-01-31 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Invitation to Protein Sequence Analysis Through Probability and Information

Author : Daniel J. Graham
Publisher : CRC Press
ISBN 13 : 0429647883
Total Pages : 230 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Invitation to Protein Sequence Analysis Through Probability and Information by : Daniel J. Graham

Download or read book Invitation to Protein Sequence Analysis Through Probability and Information written by Daniel J. Graham and published by CRC Press. This book was released on 2019-02-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the remarkable information correspondences and probability structures of proteins. Correspondences are pervasive in biochemistry and bioinformatics: proteins share homologies, folding patterns, and mechanisms. Probability structures are just as paramount: folded state graphics reflect Angstrom-scale maps of electron density. The author explores protein sequences (primary structures), both individually and in sets (systems) with the help of probability and information tools. This perspective will enhance the reader’s knowledge of how an important class of molecules is designed and put to task in natural systems, and how we can approach class members in hands-on ways.

Alternate Conformational Analysis of Protein Crystal Structures

Author : Erdahl Tahsin Teber
Publisher :
ISBN 13 :
Total Pages : 486 pages
Book Rating : 4.:/5 (32 download)

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Book Synopsis Alternate Conformational Analysis of Protein Crystal Structures by : Erdahl Tahsin Teber

Download or read book Alternate Conformational Analysis of Protein Crystal Structures written by Erdahl Tahsin Teber and published by . This book was released on 2008 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Textbook Of Structural Biology (Second Edition)

Author : Anders Liljas
Publisher : World Scientific
ISBN 13 : 9813142499
Total Pages : 610 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Textbook Of Structural Biology (Second Edition) by : Anders Liljas

Download or read book Textbook Of Structural Biology (Second Edition) written by Anders Liljas and published by World Scientific. This book was released on 2016-09-27 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.

Analytical Characterization of Biotherapeutics

Author : Jennie R. Lill
Publisher : John Wiley & Sons
ISBN 13 : 1119053102
Total Pages : 378 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Analytical Characterization of Biotherapeutics by : Jennie R. Lill

Download or read book Analytical Characterization of Biotherapeutics written by Jennie R. Lill and published by John Wiley & Sons. This book was released on 2017-08-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.