Concepts In Vaccine Development

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Practical Aspects of Vaccine Development

Author : Parag Kolhe
Publisher : Elsevier
ISBN 13 : 0128143576
Total Pages : 386 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Practical Aspects of Vaccine Development by : Parag Kolhe

Download or read book Practical Aspects of Vaccine Development written by Parag Kolhe and published by Elsevier. This book was released on 2021-09-08 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Vaccine Development: From Concept to Clinic

Author : A. Krishna Prasad
Publisher : Royal Society of Chemistry
ISBN 13 : 178801877X
Total Pages : 323 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Vaccine Development: From Concept to Clinic by : A. Krishna Prasad

Download or read book Vaccine Development: From Concept to Clinic written by A. Krishna Prasad and published by Royal Society of Chemistry. This book was released on 2022-11-09 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Utilising successful case studies Vaccine Development will provide insight to the issues scientists face when producing a vaccine, the steps involved and will serve as an ideal reference tool regarding state-of-the-art vaccine development.

Concepts in Vaccine Development

Author : Stefan H. E. Kaufmann
Publisher : Walter de Gruyter
ISBN 13 : 311090666X
Total Pages : 608 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Concepts in Vaccine Development by : Stefan H. E. Kaufmann

Download or read book Concepts in Vaccine Development written by Stefan H. E. Kaufmann and published by Walter de Gruyter. This book was released on 2012-05-24 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Vaccines for the 21st Century

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309174988
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Vaccines for the 21st Century by : Institute of Medicine

Download or read book Vaccines for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2001-02-21 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

History of Vaccine Development

Author : Stanley A. Plotkin
Publisher : Springer Science & Business Media
ISBN 13 : 1441913394
Total Pages : 352 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis History of Vaccine Development by : Stanley A. Plotkin

Download or read book History of Vaccine Development written by Stanley A. Plotkin and published by Springer Science & Business Media. This book was released on 2011-05-11 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccinology, the concept of a science ranging from the study of immunology to the development and distribution of vaccines, was a word invented by Jonas Salk. This book covers the history of the methodological progress in vaccine development and to the social and ethical issues raised by vaccination. Chapters include "Jenner and the Vaccination against Smallpox," "Viral Vaccines," and "Ethical and Social Aspects of vaccines." Contributing authors include pioneers in the field, such as Samuel L. Katz and Hilary Koprowski. This history of vaccines is relatively short and many of its protagonists are still alive. This book was written by some of the chief actors in the drama whose subject matter is the conquest of epidemic disease.

Opportunities in Biotechnology for Future Army Applications

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309075556
Total Pages : 118 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Opportunities in Biotechnology for Future Army Applications by : National Research Council

Download or read book Opportunities in Biotechnology for Future Army Applications written by National Research Council and published by National Academies Press. This book was released on 2001-07-11 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.

The Vaccine Book

Author : Barry R. Bloom
Publisher : Academic Press
ISBN 13 : 012805400X
Total Pages : 666 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Vaccine Book by : Barry R. Bloom

Download or read book The Vaccine Book written by Barry R. Bloom and published by Academic Press. This book was released on 2016-06-23 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk. Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines Gives new ideas about future vaccines and concepts Introduces new vaccines and concepts Gives ideas about challenges facing public and private industrial investors in the vaccine area Discusses the problem of declining immunization rates and vaccine hesitancy

Vaccine Analysis: Strategies, Principles, and Control

Author : Brian K. Nunnally
Publisher : Springer
ISBN 13 : 3662450240
Total Pages : 669 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Vaccine Analysis: Strategies, Principles, and Control by : Brian K. Nunnally

Download or read book Vaccine Analysis: Strategies, Principles, and Control written by Brian K. Nunnally and published by Springer. This book was released on 2014-11-27 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities. Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.

Vaccine Development and Manufacturing

Author : Emily P. Wen
Publisher : John Wiley & Sons
ISBN 13 : 0470261943
Total Pages : 452 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Vaccine Development and Manufacturing by : Emily P. Wen

Download or read book Vaccine Development and Manufacturing written by Emily P. Wen and published by John Wiley & Sons. This book was released on 2014-11-17 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

Vaccinology

Author : W. John W. Morrow
Publisher : John Wiley & Sons
ISBN 13 : 1118345347
Total Pages : 552 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Vaccinology by : W. John W. Morrow

Download or read book Vaccinology written by W. John W. Morrow and published by John Wiley & Sons. This book was released on 2012-06-12 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Vaccine Design

Author : Sunil Thomas
Publisher :
ISBN 13 : 9781493933877
Total Pages : 873 pages
Book Rating : 4.9/5 (338 download)

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Book Synopsis Vaccine Design by : Sunil Thomas

Download or read book Vaccine Design written by Sunil Thomas and published by . This book was released on 2016 with total page 873 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunopotentiators in Modern Vaccines

Author : Virgil Schijns
Publisher : Elsevier
ISBN 13 : 0080457215
Total Pages : 396 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Immunopotentiators in Modern Vaccines by : Virgil Schijns

Download or read book Immunopotentiators in Modern Vaccines written by Virgil Schijns and published by Elsevier. This book was released on 2005-12-19 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. Contributions from leading international authorities in the field Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator

Mucosal Vaccines

Author : Hiroshi Kiyono
Publisher : Academic Press
ISBN 13 :
Total Pages : 528 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Mucosal Vaccines by : Hiroshi Kiyono

Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Academic Press. This book was released on 1996-10-14 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all facets of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which with basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Key Features Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization

Biological Threats and Terrorism

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030916995X
Total Pages : 335 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biological Threats and Terrorism by : Institute of Medicine

Download or read book Biological Threats and Terrorism written by Institute of Medicine and published by National Academies Press. This book was released on 2002-03-07 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the wake of September 11th and recent anthrax events, our nation's bioterrorism response capability has become an imminent priority for policymakers, researchers, public health officials, academia, and the private sector. In a three-day workshop, convened by the Institute of Medicine's Forum on Emerging Infections, experts from each of these communities came together to identify, clarify, and prioritize the next steps that need to be taken in order to prepare and strengthen bioterrorism response capabilities. From the discussions, it became clear that of utmost urgency is the need to cast the issue of a response in an appropriate framework in order to attract the attention of Congress and the public in order to garner sufficient and sustainable support for such initiatives. No matter how the issue is cast, numerous workshop participants agreed that there are many gaps in the public health infrastructure and countermeasure capabilities that must be prioritized and addressed in order to assure a rapid and effective response to another bioterrorist attack.

Vaccine Protocols

Author : Andrew P. Robinson
Publisher : Springer Science & Business Media
ISBN 13 : 1592593992
Total Pages : 411 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Vaccine Protocols by : Andrew P. Robinson

Download or read book Vaccine Protocols written by Andrew P. Robinson and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccine research and development is advancing at an unprecedented pace, with an increasing emphasis on rational design based upon a fundamental und- standing of the underlying molecular mechanisms. The aim of this volume is to provide a selection of contemporary protocols that will be useful to both novice and advanced practitioner alike. The variety of procedures required to design, develop, produce, and assess a vaccine is immense and covers aspects of ch- istry, biochemistry, molecular biology, cell biology, and immunology. No single volume can hope to cover these topics exclusively. Rather, here we attempt to provide a methods sourcebook focusing on hands-on practical advice. Comp- mentary and background information may be found in other volumes in the Me- ods in Molecular Medicine series. Of particular interest are volumes on Dendritic Cell Protocols, Interleukin Protocols, Vaccine Adjuvants, and DNA Vaccines. Since the publication of the first edition of Vaccine Protocols there have been major advances, particularly in the areas of bacterial genomics, antig- specific T-cell quantification, genetic manipulation of vaccine vectors, the h- nessing of natural molecules concerned with the regulation of immune responses, and the burgeoning field of DNA vaccinology. Hence, the extensive revision of this edition with new chapters on live viral vaccine vectors, atte- ated bacterial vectors, immunomodulators, MHC-peptide tetrameric complexes, and the identification of vaccine candidates by genomic analysis. Additionally, chapters from the first edition have been updated to accommodate state-of-t- art methods in vaccinology.

The Science and Applications of Synthetic and Systems Biology

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309219396
Total Pages : 570 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine

Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Design and Analysis of Vaccine Studies

Author : M. Elizabeth Halloran
Publisher : Springer Science & Business Media
ISBN 13 : 0387686363
Total Pages : 390 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Design and Analysis of Vaccine Studies by : M. Elizabeth Halloran

Download or read book Design and Analysis of Vaccine Studies written by M. Elizabeth Halloran and published by Springer Science & Business Media. This book was released on 2009-10-27 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: As well as being a reference for the design, analysis, and interpretation of vaccine studies, the text covers all design and analysis stages, from vaccine development to post-licensure surveillance, presenting likelihood, frequentists, and Bayesian approaches.