Cardiac Electrophysiology Methods and Models

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Publisher : Springer Science & Business Media
ISBN 13 : 1441966587
Total Pages : 490 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Cardiac Electrophysiology Methods and Models by : Daniel C. Sigg

Download or read book Cardiac Electrophysiology Methods and Models written by Daniel C. Sigg and published by Springer Science & Business Media. This book was released on 2010-09-11 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.

Computational Methods in Cardiac Electrophysiology

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832529259
Total Pages : 229 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Computational Methods in Cardiac Electrophysiology by : Matthijs Cluitmans

Download or read book Computational Methods in Cardiac Electrophysiology written by Matthijs Cluitmans and published by Frontiers Media SA. This book was released on 2023-07-06 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mathematical Cardiac Electrophysiology

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Author :
Publisher : Springer
ISBN 13 : 3319048015
Total Pages : 410 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Mathematical Cardiac Electrophysiology by : Piero Colli Franzone

Download or read book Mathematical Cardiac Electrophysiology written by Piero Colli Franzone and published by Springer. This book was released on 2014-10-30 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.

Computational Cardiology

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Publisher : Springer
ISBN 13 : 3540259260
Total Pages : 364 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Computational Cardiology by : Frank B. Sachse

Download or read book Computational Cardiology written by Frank B. Sachse and published by Springer. This book was released on 2005-01-12 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to computer-based modeling in cardiology, by taking an educational point of view, and by summarizing knowledge from several, commonly considered delimited areas of cardiac research in a consistent way. First, the foundations and numerical techniques from mathematics are provided, with a particular focus on the finite element and finite differences methods. Then, the theory of electric fields and continuum mechanics is introduced with respect to numerical calculations in anisotropic biological media. In addition to the presentation of digital image processing techniques, the following chapters deal with particular aspects of cardiac modeling: cardiac anatomy, cardiac electro physiology, cardiac mechanics, modeling of cardiac electro mechanics. This book was written for researchers in modeling and cardiology, for clinical cardiologists, and for advanced students.

Computational And Mathematical Methods In Cardiovascular Physiology

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Author :
Publisher : World Scientific
ISBN 13 : 9813270659
Total Pages : 458 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Computational And Mathematical Methods In Cardiovascular Physiology by : Liang Zhong

Download or read book Computational And Mathematical Methods In Cardiovascular Physiology written by Liang Zhong and published by World Scientific. This book was released on 2019-04-26 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular diseases (CVD) including heart diseases, peripheral vascular disease and heart failure, account for one-third of deaths throughout the world. CVD risk factors include systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and diabetic status. Clinical trials have demonstrated that when modifiable risk factors are treated and corrected, the chances of CVD occurring can be reduced. This illustrates the importance of this book's elaborate coverage of cardiovascular physiology by the application of mathematical and computational methods.This book has literally transformed Cardiovascular Physiology into a STEM discipline, involving (i) quantitative formulations of heart anatomy and physiology, (ii) technologies for imaging the heart and blood vessels, (iii) coronary stenosis hemodynamics measure by means of fractional flow reserve and intervention by grafting and stenting, (iv) fluid mechanics and computational analysis of blood flow in the heart, aorta and coronary arteries, and (v) design of heart valves, percutaneous valve stents, and ventricular assist devices.So how is this mathematically and computationally configured landscape going to impact cardiology and even cardiac surgery? We are now entering a new era of mathematical formulations of anatomy and physiology, leading to technological formulations of medical and surgical procedures towards more precise medicine and surgery. This will entail reformatting of (i) the medical MD curriculum and courses, so as to educate and train a new generation of physicians who are conversant with medical technologies for applying into clinical care, as well as (ii) structuring of MD-PhD (Computational Medicine and Surgery) Program, to train competent medical and surgical specialists in precision medical care and patient-specific surgical care.This book provides a gateway for this new emerging scenario of (i) science and engineering based medical educational curriculum, and (ii) technologically oriented medical and surgical procedures. As such, this book can be usefully employed as a textbook for courses in (i) cardiovascular physiology in both the schools of engineering and medicine of universities, as well as (ii) cardiovascular engineering in biomedical engineering departments worldwide.

Modeling and Simulating Cardiac Electrical Activity

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Publisher :
ISBN 13 : 9780750320641
Total Pages : 0 pages
Book Rating : 4.3/5 (26 download)

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Book Synopsis Modeling and Simulating Cardiac Electrical Activity by : David J. Christini

Download or read book Modeling and Simulating Cardiac Electrical Activity written by David J. Christini and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.

Exploring Mechanisms of Cardiac Rhythm Disturbances Using Novel Computational Methods: Prediction, Classification, and Therapy

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832517587
Total Pages : 232 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Exploring Mechanisms of Cardiac Rhythm Disturbances Using Novel Computational Methods: Prediction, Classification, and Therapy by : Xin Li

Download or read book Exploring Mechanisms of Cardiac Rhythm Disturbances Using Novel Computational Methods: Prediction, Classification, and Therapy written by Xin Li and published by Frontiers Media SA. This book was released on 2023-03-16 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Numerical Solution of Partial Differential Equations on Parallel Computers

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Publisher : Springer Science & Business Media
ISBN 13 : 3540316191
Total Pages : 491 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Numerical Solution of Partial Differential Equations on Parallel Computers by : Are Magnus Bruaset

Download or read book Numerical Solution of Partial Differential Equations on Parallel Computers written by Are Magnus Bruaset and published by Springer Science & Business Media. This book was released on 2006-03-05 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of computing, the quest for a better understanding of Nature has been a driving force for technological development. Groundbreaking achievements by great scientists have paved the way from the abacus to the supercomputing power of today. When trying to replicate Nature in the computer’s silicon test tube, there is need for precise and computable process descriptions. The scienti?c ?elds of Ma- ematics and Physics provide a powerful vehicle for such descriptions in terms of Partial Differential Equations (PDEs). Formulated as such equations, physical laws can become subject to computational and analytical studies. In the computational setting, the equations can be discreti ed for ef?cient solution on a computer, leading to valuable tools for simulation of natural and man-made processes. Numerical so- tion of PDE-based mathematical models has been an important research topic over centuries, and will remain so for centuries to come. In the context of computer-based simulations, the quality of the computed results is directly connected to the model’s complexity and the number of data points used for the computations. Therefore, computational scientists tend to ?ll even the largest and most powerful computers they can get access to, either by increasing the si e of the data sets, or by introducing new model terms that make the simulations more realistic, or a combination of both. Today, many important simulation problems can not be solved by one single computer, but calls for parallel computing.

Artificial Intelligence for Computational Modeling of the Heart

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Publisher : Academic Press
ISBN 13 : 012817594X
Total Pages : 274 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Artificial Intelligence for Computational Modeling of the Heart by : Tommaso Mansi

Download or read book Artificial Intelligence for Computational Modeling of the Heart written by Tommaso Mansi and published by Academic Press. This book was released on 2019-11-28 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient's heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications.

Applications of Machine Learning

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Publisher : Springer Nature
ISBN 13 : 9811533571
Total Pages : 404 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Applications of Machine Learning by : Prashant Johri

Download or read book Applications of Machine Learning written by Prashant Johri and published by Springer Nature. This book was released on 2020-05-04 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers applications of machine learning in artificial intelligence. The specific topics covered include human language, heterogeneous and streaming data, unmanned systems, neural information processing, marketing and the social sciences, bioinformatics and robotics, etc. It also provides a broad range of techniques that can be successfully applied and adopted in different areas. Accordingly, the book offers an interesting and insightful read for scholars in the areas of computer vision, speech recognition, healthcare, business, marketing, and bioinformatics.

Electrocardiographic Imaging

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Publisher : Frontiers Media SA
ISBN 13 : 2889636712
Total Pages : 178 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Electrocardiographic Imaging by : Maria S. Guillem

Download or read book Electrocardiographic Imaging written by Maria S. Guillem and published by Frontiers Media SA. This book was released on 2020-04-17 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrical activity in the myocardium coordinates the contraction of the heart, and its knowledge could lead to a better understanding, diagnosis, and treatment of cardiac diseases. This electrical activity generates an electromagnetic field that propagates outside the heart and reaches the human torso surface, where it can be easily measured. Classical electrocardiography aims to interpret the 12-lead electrocardiogram (ECG) to determine cardiac activity and support the diagnosis of cardiac pathologies such as arrhythmias, altered activations, and ischemia. More recently, a higher number of leads is used to reconstruct a more detailed quantitative description of the electrical activity in the heart by solving the so-called inverse problem of electrocardiography. This technique is known as ECG imaging. Today, clinical applications of ECG imaging are showing promising results in guiding a variety of electrophysiological interventions such as catheter ablation of atrial fibrillation and ventricular tachycardia. However, in order to promote the adoption of ECG imaging in the routine clinical practice, further research is required regarding more accurate mathematical methods, further scientific validation under different preclinical scenarios and a more extensive clinical validation

Computational Methods in Systems Biology

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Publisher : Springer Nature
ISBN 13 : 3031426975
Total Pages : 287 pages
Book Rating : 4.0/5 (314 download)

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Book Synopsis Computational Methods in Systems Biology by : Jun Pang

Download or read book Computational Methods in Systems Biology written by Jun Pang and published by Springer Nature. This book was released on with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mathematically Modelling The Electrical Activity Of The Heart: From Cell To Body Surface And Back Again

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Publisher : World Scientific Publishing Company
ISBN 13 : 9813106565
Total Pages : 442 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Mathematically Modelling The Electrical Activity Of The Heart: From Cell To Body Surface And Back Again by : Andrew Pullan

Download or read book Mathematically Modelling The Electrical Activity Of The Heart: From Cell To Body Surface And Back Again written by Andrew Pullan and published by World Scientific Publishing Company. This book was released on 2005-09-07 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book on modelling the electrical activity of the heart is an attempt to describe continuum based modelling of cardiac electrical activity from the cell level to the body surface (the forward problem), and back again (the inverse problem). Background anatomy and physiology is covered briefly to provide a suitable context for understanding the detailed modelling that is presented herein. The questions of what is mathematical modelling and why one would want to use mathematical modelling are addressed to give some perspective to the philosophy behind our approach. Our view of mathematical modelling is broad — it is not simply about obtaining a solution to a set of mathematical equations, but includes some material on aspects such as experimental and clinical validation.

Computational Models in Biomedical Engineering

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Publisher : Academic Press
ISBN 13 : 0323906699
Total Pages : 402 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Computational Models in Biomedical Engineering by : Milos Kojic

Download or read book Computational Models in Biomedical Engineering written by Milos Kojic and published by Academic Press. This book was released on 2022-09-11 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells. - Provides a methodology based on the smeared concept within the finite element method which is simple, straightforward and easy to use - Enables the modeling of complex physical field problems and the mechanics of biological systems - Includes features that are illustrated in chapters devoted to applications surrounding tissue, heart and lung - Includes a methodology that can serve as a basis for further enhancements by including additional phenomena which can be described by relevant relationships, derived theoretically or experimentally observed in laboratories and clinics

Systems Medicine

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Publisher : Academic Press
ISBN 13 : 0128160780
Total Pages : 1571 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Systems Medicine by :

Download or read book Systems Medicine written by and published by Academic Press. This book was released on 2020-08-24 with total page 1571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

Functional Imaging and Modeling of the Heart

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Publisher : Springer
ISBN 13 : 364238899X
Total Pages : 510 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Functional Imaging and Modeling of the Heart by : Sebastien Ourselin

Download or read book Functional Imaging and Modeling of the Heart written by Sebastien Ourselin and published by Springer. This book was released on 2013-06-21 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 7th International Conference on Functional Imaging and Modeling of the Heart, held in London, UK, in June 2013. The 58 revised full papers were carefully reviewed and selected from numerous initial submissions. The focus of the papers is on following topics: image driven modeling, biophysical modeling, image analysis, biophysical modeling, cardiac imaging, parameter estimation, modeling methods, and biomedical engineering.

Computational Science – ICCS 2008

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Publisher : Springer Science & Business Media
ISBN 13 : 3540693831
Total Pages : 1070 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Computational Science – ICCS 2008 by :

Download or read book Computational Science – ICCS 2008 written by and published by Springer Science & Business Media. This book was released on 2008 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: