Computational Methods For Solving Next Generation Sequencing Challenges

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Computational Methods for Next Generation Sequencing Data Analysis

Author : Ion Mandoiu
Publisher : John Wiley & Sons
ISBN 13 : 1119272165
Total Pages : 462 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Computational Methods for Next Generation Sequencing Data Analysis by : Ion Mandoiu

Download or read book Computational Methods for Next Generation Sequencing Data Analysis written by Ion Mandoiu and published by John Wiley & Sons. This book was released on 2016-09-12 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applications This book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational challenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest work in leading labs actively contributing to the fast-growing field of NGS. The book is divided into four parts: Part I focuses on computing and experimental infrastructure for NGS analysis, including chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling strategies for massive viral sequencing, and high-fidelity sequencing protocols. Part II concentrates on analysis of DNA sequencing data, covering the classic scaffolding problem, detection of genomic variants, including insertions and deletions, and analysis of DNA methylation sequencing data. Part III is devoted to analysis of RNA-seq data. This part discusses algorithms and compares software tools for transcriptome assembly along with methods for detection of alternative splicing and tools for transcriptome quantification and differential expression analysis. Part IV explores computational tools for NGS applications in microbiomics, including a discussion on error correction of NGS reads from viral populations, methods for viral quasispecies reconstruction, and a survey of state-of-the-art methods and future trends in microbiome analysis. Computational Methods for Next Generation Sequencing Data Analysis: Reviews computational techniques such as new combinatorial optimization methods, data structures, high performance computing, machine learning, and inference algorithms Discusses the mathematical and computational challenges in NGS technologies Covers NGS error correction, de novo genome transcriptome assembly, variant detection from NGS reads, and more This text is a reference for biomedical professionals interested in expanding their knowledge of computational techniques for NGS data analysis. The book is also useful for graduate and post-graduate students in bioinformatics.

Computational Exome and Genome Analysis

Author : Peter N. Robinson
Publisher : CRC Press
ISBN 13 : 1351650815
Total Pages : 444 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Computational Exome and Genome Analysis by : Peter N. Robinson

Download or read book Computational Exome and Genome Analysis written by Peter N. Robinson and published by CRC Press. This book was released on 2017-09-13 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.

Bioinformatics in Agriculture

Author : Pradeep Sharma
Publisher : Academic Press
ISBN 13 : 0323885993
Total Pages : 707 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Bioinformatics in Agriculture by : Pradeep Sharma

Download or read book Bioinformatics in Agriculture written by Pradeep Sharma and published by Academic Press. This book was released on 2022-04-28 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics in Agriculture: Next Generation Sequencing Era is a comprehensive volume presenting an integrated research and development approach to the practical application of genomics to improve agricultural crops. Exploring both the theoretical and applied aspects of computational biology, and focusing on the innovation processes, the book highlights the increased productivity of a translational approach. Presented in four sections and including insights from experts from around the world, the book includes: Section I: Bioinformatics and Next Generation Sequencing Technologies; Section II: Omics Application; Section III: Data mining and Markers Discovery; Section IV: Artificial Intelligence and Agribots. Bioinformatics in Agriculture: Next Generation Sequencing Era explores deep sequencing, NGS, genomic, transcriptome analysis and multiplexing, highlighting practices forreducing time, cost, and effort for the analysis of gene as they are pooled, and sequenced. Readers will gain real-world information on computational biology, genomics, applied data mining, machine learning, and artificial intelligence. This book serves as a complete package for advanced undergraduate students, researchers, and scientists with an interest in bioinformatics. - Discusses integral aspects of molecular biology and pivotal tool sfor molecular breeding - Enables breeders to design cost-effective and efficient breeding strategies - Provides examples ofinnovative genome-wide marker (SSR, SNP) discovery - Explores both the theoretical and practical aspects of computational biology with focus on innovation processes - Covers recent trends of bioinformatics and different tools and techniques

Next Generation Sequencing

Author : Jerzy Kulski
Publisher : BoD – Books on Demand
ISBN 13 : 9535122401
Total Pages : 466 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Next Generation Sequencing by : Jerzy Kulski

Download or read book Next Generation Sequencing written by Jerzy Kulski and published by BoD – Books on Demand. This book was released on 2016-01-14 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.

Biological Sequence Analysis

Author : Richard Durbin
Publisher : Cambridge University Press
ISBN 13 : 113945739X
Total Pages : 372 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Biological Sequence Analysis by : Richard Durbin

Download or read book Biological Sequence Analysis written by Richard Durbin and published by Cambridge University Press. This book was released on 1998-04-23 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Computational Methods for Understanding Bacterial and Archaeal Genomes

Author : Ying Xu
Publisher : World Scientific
ISBN 13 : 1860949827
Total Pages : 494 pages
Book Rating : 4.8/5 (69 download)

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Book Synopsis Computational Methods for Understanding Bacterial and Archaeal Genomes by : Ying Xu

Download or read book Computational Methods for Understanding Bacterial and Archaeal Genomes written by Ying Xu and published by World Scientific. This book was released on 2008 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.

Next-generation DNA Sequencing Informatics

Author : Stuart M. Brown
Publisher :
ISBN 13 : 9781621821236
Total Pages : 0 pages
Book Rating : 4.8/5 (212 download)

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Book Synopsis Next-generation DNA Sequencing Informatics by : Stuart M. Brown

Download or read book Next-generation DNA Sequencing Informatics written by Stuart M. Brown and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data"

Next-Generation Genome Sequencing

Author : Michal Janitz
Publisher : John Wiley & Sons
ISBN 13 : 3527644733
Total Pages : 281 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Next-Generation Genome Sequencing by : Michal Janitz

Download or read book Next-Generation Genome Sequencing written by Michal Janitz and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.

Tropical Diseases: An Overview of Major Diseases Occurring in the Americas

Author : Milena de Paiva Cavalcanti
Publisher : Bentham Science Publishers
ISBN 13 : 1681085879
Total Pages : 531 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Tropical Diseases: An Overview of Major Diseases Occurring in the Americas by : Milena de Paiva Cavalcanti

Download or read book Tropical Diseases: An Overview of Major Diseases Occurring in the Americas written by Milena de Paiva Cavalcanti and published by Bentham Science Publishers. This book was released on 2017-12-26 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tropical Diseases: An Overview of Major Diseases Occurring in the Americas offers an overview of neglected tropical diseases found in the Americas. Information in the book addresses the understanding of challenges faced in controlling these diseases and brings new insight on many important aspects of these diseases. Chapters of this volume explore many related topics, including epidemiological data, immune response and pathogenesis, and the current methods for diagnosis and treatment, thus providing a useful resource for readers (undergraduate, graduate and Ph.D. students as well as biologists and medical researchers).

PlantOmics: The Omics of Plant Science

Author : Debmalya Barh
Publisher : Springer
ISBN 13 : 8132221729
Total Pages : 839 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis PlantOmics: The Omics of Plant Science by : Debmalya Barh

Download or read book PlantOmics: The Omics of Plant Science written by Debmalya Barh and published by Springer. This book was released on 2015-03-18 with total page 839 pages. Available in PDF, EPUB and Kindle. Book excerpt: PlantOmics: The Omics of Plant Science provides a comprehensive account of the latest trends and developments of omics technologies or approaches and their applications in plant science. Thirty chapters written by 90 experts from 15 countries are included in this state-of-the-art book. Each chapter describes one topic/omics such as: omics in model plants, spectroscopy for plants, next generation sequencing, functional genomics, cyto-metagenomics, epigenomics, miRNAomics, proteomics, metabolomics, glycomics, lipidomics, secretomics, phenomics, cytomics, physiomics, signalomics, thiolomics, organelle omics, micro morphomics, microbiomics, cryobionomics, nanotechnology, pharmacogenomics, and computational systems biology for plants. It provides up to date information, technologies, and their applications that can be adopted and applied easily for deeper understanding plant biology and therefore will be helpful in developing the strategy for generating cost-effective superior plants for various purposes. In the last chapter, the editors have proposed several new areas in plant omics that may be explored in order to develop an integrated meta-omics strategy to ensure the world and earth’s health and related issues. This book will be a valuable resource to students and researchers in the field of cutting-edge plant omics.

New Computational Methods in Power System Reliability

Author : David Elmakias
Publisher : Springer
ISBN 13 : 3540778128
Total Pages : 416 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis New Computational Methods in Power System Reliability by : David Elmakias

Download or read book New Computational Methods in Power System Reliability written by David Elmakias and published by Springer. This book was released on 2008-05-22 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Power system reliability is the focus of intensive study due to its critical role in providing energy supply to modern society. This comprehensive book describes application of some new specific techniques: universal generating function method and its combination with Monte Carlo simulation and with random processes methods, Semi-Markov and Markov reward models and genetic algorithm. The book can be considered as complementary to power system reliability textbooks.

Computer Literature Bibliography: 1964-1967

Author : W. W. Youden
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Computer Literature Bibliography: 1964-1967 by : W. W. Youden

Download or read book Computer Literature Bibliography: 1964-1967 written by W. W. Youden and published by . This book was released on 1965 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Translational Bioinformatics in Healthcare and Medicine

Author :
Publisher : Academic Press
ISBN 13 : 0323898904
Total Pages : 256 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Translational Bioinformatics in Healthcare and Medicine by :

Download or read book Translational Bioinformatics in Healthcare and Medicine written by and published by Academic Press. This book was released on 2021-05-13 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Bioinformatics in Healthcare and Medicine offers an overview of main principles of bioinformatics, biological databases, clinical informatics, health informatics, viroinformatics and real-case applications of translational bioinformatics in healthcare. Written by experts from both technology and clinical sides, the content brings together essential knowledge to make the best of recent advancements of the field. The book discusses topics such as next generation sequence analysis, genomics in clinical care, IoT applications, blockchain technology, patient centered interoperability of EHR, health data mining, and translational bioinformatics methods for drug discovery and drug repurposing. In addition, it discusses the role of bioinformatics in cancer research and viroinformatics approaches to counter viral diseases through informatics. This is a valuable resource for bioinformaticians, clinicians, healthcare professionals, graduate students and several members of biomedical field who are interested in learning more about how bioinformatics can impact in their research and practice. - Covers recent advancements in translational bioinformatics and its healthcare applications - Discusses integrative and multidisciplinary approaches to U-healthcare systems development and management - Bridges the gap among various knowledge domains in the field, integrating both technological and clinical knowledge into practical content

NBS Special Publication

Author :
Publisher :
ISBN 13 :
Total Pages : 398 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis NBS Special Publication by :

Download or read book NBS Special Publication written by and published by . This book was released on 1968 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Computational Methods for Microbiome Analysis

Author : Joao Carlos Setubal
Publisher : Frontiers Media SA
ISBN 13 : 2889664376
Total Pages : 170 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Computational Methods for Microbiome Analysis by : Joao Carlos Setubal

Download or read book Computational Methods for Microbiome Analysis written by Joao Carlos Setubal and published by Frontiers Media SA. This book was released on 2021-02-02 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cloud Computing

Author : Jaydip Sen
Publisher : BoD – Books on Demand
ISBN 13 : 9535132431
Total Pages : 142 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Cloud Computing by : Jaydip Sen

Download or read book Cloud Computing written by Jaydip Sen and published by BoD – Books on Demand. This book was released on 2017-06-14 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the era of Internet of Things and with the explosive worldwide growth of electronic data volume, and associated need of processing, analysis, and storage of such humongous volume of data, it has now become mandatory to exploit the power of massively parallel architecture for fast computation. Cloud computing provides a cheap source of such computing framework for large volume of data for real-time applications. It is, therefore, not surprising to see that cloud computing has become a buzzword in the computing fraternity over the last decade. This book presents some critical applications in cloud frameworks along with some innovation design of algorithms and architecture for deployment in cloud environment. It is a valuable source of knowledge for researchers, engineers, practitioners, and graduate and doctoral students working in the field of cloud computing. It will also be useful for faculty members of graduate schools and universities.

Algorithms for Next-Generation Sequencing

Author : Wing-Kin Sung
Publisher : CRC Press
ISBN 13 : 1498752985
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Algorithms for Next-Generation Sequencing by : Wing-Kin Sung

Download or read book Algorithms for Next-Generation Sequencing written by Wing-Kin Sung and published by CRC Press. This book was released on 2017-05-18 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in sequencing technology have allowed scientists to study the human genome in greater depth and on a larger scale than ever before – as many as hundreds of millions of short reads in the course of a few days. But what are the best ways to deal with this flood of data? Algorithms for Next-Generation Sequencing is an invaluable tool for students and researchers in bioinformatics and computational biology, biologists seeking to process and manage the data generated by next-generation sequencing, and as a textbook or a self-study resource. In addition to offering an in-depth description of the algorithms for processing sequencing data, it also presents useful case studies describing the applications of this technology.