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Author : Heinz P. Bloch
Publisher : John Wiley & Sons
ISBN 13 : 0471929522
Total Pages : 592 pages
Book Rating : 4.4/5 (719 download)
Download or read book A Practical Guide to Compressor Technology written by Heinz P. Bloch and published by John Wiley & Sons. This book was released on 2006-09-18 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Complete overview of theory, selection, design, operation, and maintenance This text offers a thorough overview of the operating characteristics, efficiencies, design features, troubleshooting, and maintenance of dynamic and positive displacement process gas compressors. The author examines a wide spectrum of compressors used in heavy process industries, with an emphasis on improving reliability and avoiding failure. Readers learn both the theory underlying compressors as well as the myriad day-to-day practical issues and challenges that chemical engineers and plant operation personnel must address. The text features: Latest design and manufacturing details of dynamic and positive displacement process gas compressors Examination of the full range of machines available for the heavy process industries Thorough presentation of the arrangements, material composition, and basic laws governing the design of all important process gas compressors Guidance on selecting optimum compressor configurations, controls, components, and auxiliaries to maximize reliability Monitoring and performance analysis for optimal machinery condition Systematic methods to avoid failure through the application of field-tested reliability enhancement concepts Fluid instability and externally pressurized bearings Reliability-driven asset management strategies for compressors Upstream separator and filter issues The text's structure is carefully designed to build knowledge and skills by starting with key principles and then moving to more advanced material. Hundreds of photos depicting various types of compressors, components, and processes are provided throughout. Compressors often represent a multi-million dollar investment for such applications as petrochemical processing and refining, refrigeration, pipeline transport, and turbochargers and superchargers for internal combustion engines. This text enables the broad range of engineers and plant managers who work with these compressors to make the most of the investment by leading them to the best decisions for selecting, operating, upgrading, maintaining, and troubleshooting.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309302072
Total Pages : 95 pages
Book Rating : 4.3/5 (93 download)
Download or read book Drug Repurposing and Repositioning written by Institute of Medicine and published by National Academies Press. This book was released on 2014-08-08 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development can be time-consuming and expensive. Recent estimates suggest that, on average, it takes 10 years and at least $1 billion to bring a drug to market. Given the time and expense of developing drugs de novo, pharmaceutical companies have become increasingly interested in finding new uses for existing drugs - a process referred to as drug repurposing or repositioning. Historically, drug repurposing has been largely an unintentional, serendipitous process that took place when a drug was found to have an offtarget effect or a previously unrecognized on-target effect that could be used for identifying a new indication. Perhaps the most recognizable example of such a successful repositioning effort is sildenafil. Originally developed as an anti-hypertensive, sildenafil, marketed as Viagra and under other trade names, has been repurposed for the treatment of erectile dysfunction and pulmonary arterial hypertension. Viagra generated more than $2 billion worldwide in 2012 and has recently been studied for the treatment of heart failure. Given the widespread interest in drug repurposing, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine hosted a workshop on June 24, 2013, in Washington, DC, to assess the current landscape of drug repurposing activities in industry, academia, and government. Stakeholders, including government officials, pharmaceutical company representatives, academic researchers, regulators, funders, and patients, were invited to present their perspectives and to participate in workshop discussions. Drug Repurposing and Repositioning is the summary of that workshop. This report examines enabling tools and technology for drug repurposing; evaluates the business models and economic incentives for pursuing a repurposing approach; and discusses how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.
Author : Michael J. Barratt
Publisher : John Wiley & Sons
ISBN 13 : 0470878274
Total Pages : 499 pages
Book Rating : 4.4/5 (78 download)
Download or read book Drug Repositioning written by Michael J. Barratt and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Author : Arjan Singh
Publisher : Oxford University Press, USA
ISBN 13 : 9780195647983
Total Pages : 244 pages
Book Rating : 4.6/5 (479 download)
Download or read book Tiger Haven written by Arjan Singh and published by Oxford University Press, USA. This book was released on 1998 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tiger Haven is the story of the author's attempts to protect Indian wildlife in one small area of Uttar Pradesh, of his observations of the wildlife in his sanctuary, and of his own metamorphosis from sportsman and farmer to photographer and conservationist.
Author : Fr archpriest Evgeny I. Legach
Publisher : Springer
ISBN 13 : 9789811626074
Total Pages : 0 pages
Book Rating : 4.6/5 (26 download)
Download or read book SARS-CoV-2 and Coronacrisis written by Fr archpriest Evgeny I. Legach and published by Springer. This book was released on 2022-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is useful for administrators of different levels involved in counteracting COVID-19, surveillance professionals, clinicians, researchers specializing in epidemiology, microbiology, and infectious diseases, and politicians / legislators engaged in public health sector. We use an innovative approach of combining both epidemiological and sociological analyses, as the very problem is mainly an issue of correct governance. A team of authors from Europe, Russia and China summarizes their experience and knowledge useful for containing SARS-CoV-2 and overcoming social and managerial consequences of the pandemic. The editors are sure that sharing our different experience would help to elaborate necessary strategies, protocols, and principles that may be effectively applied in the future to avoid dramatic consequences of not only COVID-19 but also any possible epidemiological hazards for people and medicine.
Author : Isabelle Nickel
Publisher :
ISBN 13 : 9781682863275
Total Pages : 0 pages
Book Rating : 4.8/5 (632 download)
Download or read book Plant Genomics and Biotechnology written by Isabelle Nickel and published by . This book was released on 2016-05-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a revolution in the field of agriculture in the last few decades which has evolved the field of plant genomics and related techniques and processes of biotechnology as well. This book comprises advanced research in this field. Most of the topics introduced in this book cover new concepts, techniques and the applications of plant genomics such as DNA recombination, genetically modified crops, genetic sequencing and mapping, genomic structures, etc. The various sub-fields of plant genomics along with technological progress that have future implications are glanced at in this book. The book is appropriate for students seeking detailed information in this area as well as for experts.
Author : Parag Kulkarni
Publisher : Springer
ISBN 13 : 3319553127
Total Pages : 150 pages
Book Rating : 4.3/5 (195 download)
Download or read book Reverse Hypothesis Machine Learning written by Parag Kulkarni and published by Springer. This book was released on 2017-03-30 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces a paradigm of reverse hypothesis machines (RHM), focusing on knowledge innovation and machine learning. Knowledge- acquisition -based learning is constrained by large volumes of data and is time consuming. Hence Knowledge innovation based learning is the need of time. Since under-learning results in cognitive inabilities and over-learning compromises freedom, there is need for optimal machine learning. All existing learning techniques rely on mapping input and output and establishing mathematical relationships between them. Though methods change the paradigm remains the same—the forward hypothesis machine paradigm, which tries to minimize uncertainty. The RHM, on the other hand, makes use of uncertainty for creative learning. The approach uses limited data to help identify new and surprising solutions. It focuses on improving learnability, unlike traditional approaches, which focus on accuracy. The book is useful as a reference book for machine learning researchers and professionals as well as machine intelligence enthusiasts. It can also used by practitioners to develop new machine learning applications to solve problems that require creativity.
