Company Profiles Karyopharm Therapeutics Inc

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Regulation of Corporate Disclosure, 4th Edition

Author : Brown
Publisher : Wolters Kluwer
ISBN 13 : 145488634X
Total Pages : 2350 pages
Book Rating : 4.4/5 (548 download)

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Book Synopsis Regulation of Corporate Disclosure, 4th Edition by : Brown

Download or read book Regulation of Corporate Disclosure, 4th Edition written by Brown and published by Wolters Kluwer. This book was released on 2016-12-15 with total page 2350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Regulation of Corporate Disclosure is a one-volume treatise on the disclosure regime in place under the Federal securities laws. The treatise addresses the formal disclosure process (periodic reports, MD&A, Regulation FD), the informal disclosure process (press releases, social media, discussions with analysts), and the application of the antifraud provisions to these communications. The treatise includes chapters on scienter and materiality, and also addresses communications with and disclosure obligations to shareholders. The Fourth Edition has been significantly revised and, among other topics, includes coverage of: The duties and responsibilities of corporate officials relating to the disclosure process The most recent cases addressing disclosure issues, including decisions by the Supreme Court on topics such as the application of the antifraud provisions to beliefs and opinions Pronouncements by the U.S. Securities and Exchange Commission on disclosure issues, including consideration of the SEC's efforts to improve disclosure effectiveness The developing need to consider disclosure of public interest matters, including the effects of climate change on a company's business The disclosure requirements applicable to the proxy process, including the system for uncovering the identity of street name owners State disclosure obligations of the board of directors under its fiduciary obligations to shareholders.

I-Bytes Healthcare industry

Author : IT-Shades
Publisher : EGBG Services LLC
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4./5 ( download)

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Book Synopsis I-Bytes Healthcare industry by : IT-Shades

Download or read book I-Bytes Healthcare industry written by IT-Shades and published by EGBG Services LLC. This book was released on 2020-07-16 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document brings together a set of latest data points and publicly available information relevant for Healthcare Industry. We are very excited to share this content and believe that readers will benefit from this periodic publication immensely.

Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases

Author : Jiabo Wang
Publisher : Frontiers Media SA
ISBN 13 : 2832547001
Total Pages : 130 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases by : Jiabo Wang

Download or read book Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases written by Jiabo Wang and published by Frontiers Media SA. This book was released on 2024-03-27 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pediatric Clinical Pharmacology

Author : Hannsjörg W. Seyberth
Publisher : Springer Science & Business Media
ISBN 13 : 3642201954
Total Pages : 385 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Pediatric Clinical Pharmacology by : Hannsjörg W. Seyberth

Download or read book Pediatric Clinical Pharmacology written by Hannsjörg W. Seyberth and published by Springer Science & Business Media. This book was released on 2011-09-01 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this volume is to give an overview of the present state of the art of pediatric clinical pharmacology including developmental physiology, pediatric-specific pathology, special tools and methods for development of drugs for children (assessment of efficacy, toxicity, long-term safety etc.) as well as regulatory and ethical knowledge and skills. In the future, structural and educational changes have to lead back to a closer cooperation and interaction of pediatrics with (clinical) pharmacology and pharmacy.

Clinical Toxicology Testing

Author : Barbarajean Magnani
Publisher :
ISBN 13 : 9781941096505
Total Pages : 375 pages
Book Rating : 4.0/5 (965 download)

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Book Synopsis Clinical Toxicology Testing by : Barbarajean Magnani

Download or read book Clinical Toxicology Testing written by Barbarajean Magnani and published by . This book was released on 2020 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A comprehensive overview of clinical laboratory toxicology services and analytes"--

Budget-Impact Analysis of Health Care Interventions

Author : Josephine Mauskopf
Publisher : Springer
ISBN 13 : 3319504827
Total Pages : 234 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Budget-Impact Analysis of Health Care Interventions by : Josephine Mauskopf

Download or read book Budget-Impact Analysis of Health Care Interventions written by Josephine Mauskopf and published by Springer. This book was released on 2017-08-04 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind for budget-impact analysis, this comprehensive guide provides clear and concise instructions for evaluating the impact that new pharmaceuticals will have on the budget for a specific jurisdiction. The book demonstrates how to create a budget-impact analysis using a simple six-step process that is consistent with current guidelines for these analyses. Examples and exercises for each chapter afford an opportunity to practice the six-step process in practical applications. The book progresses from a framework for budget impact analyses to an in-depth review of components and how to develop and present these in software applications and reports. Critical considerations such as uncertainty analysis and validation, and considerations for alternate interventions, such as vaccines and diagnostics, are also covered. This book is a “must have” for the builder and budget holder, with builders benefiting from instructions to identify and estimate all necessary variables and budget holders receiving a guide to what should be included in the analyses they assess.

Linking Emotional Intelligence and Performance at Work

Author : Vanessa Urch Druskat
Publisher : Psychology Press
ISBN 13 : 1134998694
Total Pages : 341 pages
Book Rating : 4.1/5 (349 download)

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Book Synopsis Linking Emotional Intelligence and Performance at Work by : Vanessa Urch Druskat

Download or read book Linking Emotional Intelligence and Performance at Work written by Vanessa Urch Druskat and published by Psychology Press. This book was released on 2013-04-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this edited volume, leading edge researchers discuss the link between Emotional Intelligence (EI) and workplace performance. Contributors from many areas such as social science, management (including organizational practitioners), and psychologists have come together to develop a better understanding of how EI can influence work performance, and whether research supports it. A unique feature of this book is that it integrates the work of social scientists and organizational practitioners. Their mutual interests in EI provide a unique opportunity for basic and applied research and practices to learn from one another in order to continually refine and advance knowledge on EI. The primary audience for this book is researchers, teachers, and students of psychology, management, and organizational behavior. Due to its clear practical applications to the workplace, it will also be of interest to organizational consultants and human resource practitioners.

Brain Tumor Imaging

Author : Elke Hattingen
Publisher : Springer
ISBN 13 : 3642450407
Total Pages : 166 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Brain Tumor Imaging by : Elke Hattingen

Download or read book Brain Tumor Imaging written by Elke Hattingen and published by Springer. This book was released on 2015-09-02 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.

Bioengineering Research of Chronic Wounds

Author : Amit Gefen
Publisher : Springer Science & Business Media
ISBN 13 : 3642005349
Total Pages : 449 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Bioengineering Research of Chronic Wounds by : Amit Gefen

Download or read book Bioengineering Research of Chronic Wounds written by Amit Gefen and published by Springer Science & Business Media. This book was released on 2009-11-18 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.

Highlights of Progress in Research on Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Highlights of Progress in Research on Cancer by :

Download or read book Highlights of Progress in Research on Cancer written by and published by . This book was released on 1957 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Health Technologies

Author : Collectif
Publisher : OECD
ISBN 13 : 9264266445
Total Pages : 239 pages
Book Rating : 4.2/5 (642 download)

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Book Synopsis New Health Technologies by : Collectif

Download or read book New Health Technologies written by Collectif and published by OECD. This book was released on 2017-02-03 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report discusses the need for an integrated and cyclical approach to managing health technology in order to mitigate clinical and financial risks, and ensure acceptable value for money. The analysis considers how health systems and policy makers should adapt in terms of development, assessment and uptake of health technologies. The first chapter provides an examination of adoption and impact of medical technology in the past and how health systems are preparing for continuation of such trends in the future. Subsequent chapters examine the need to balance innovation, value, and access for pharmaceuticals and medical devices, respectively, followed by a consideration of their combined promise in the area of precision medicine. The final chapter examines how health systems can make better use of health data and digital technologies. The report focuses on opportunities linked to new and emerging technologies as well as current challenges faced by policy makers, and suggests a new governance framework to address these challenges.

Sarcomas

Author : Jonathan C. Trent, MD, PhD
Publisher : Springer Publishing Company
ISBN 13 : 0826148530
Total Pages : 444 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Sarcomas by : Jonathan C. Trent, MD, PhD

Download or read book Sarcomas written by Jonathan C. Trent, MD, PhD and published by Springer Publishing Company. This book was released on 2020-09-23 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sarcomas: Evidence-Based Diagnosisand Management is the most comprehensive clinical reference on sarcomas available to oncologists and trainees. Presenting a compilation of the current knowledge of specific soft tissue and bone sarcomas, this accessible resource on diagnosis and management is the most practical in the market. Led by the world’s foremost sarcomas experts in medical oncology, surgical oncology, radiation oncology, gynecologic oncology, orthopedic surgery, radiology, and pathology, the book addresses the general principles of each major medical discipline, provides details on each major sarcoma subtype, and presents the evidence for standard frontline, adjuvant, and novel treatment approaches such as immunotherapy, cellular therapies, and more. The book begins with general principles of diagnosis and management for each discipline in the field, covering specialties from medical oncology to radiology. Following the chapters on general principles, are chapters characterizing the most prevalent subtypes of sarcoma including their estimated incidence, common presenting symptoms, diagnostic approach, radiographic features and essential imaging, key diagnostic features, molecular characteristics, approaches to treatment, recommended follow up, the metastatic potential as well as evidence-based therapeutic approaches. Each chapter ends with a summary of caveats, clinical pearls, pitfalls, and solutions as well as a case study from the clinician’s point of view. The book ends with chapters focusing on new approaches to treatment and the development of therapeutics to combat sarcoma using immunotherapy, cellular therapy, and interventional radiology. Numerous tables and disease-based images support the text and provide key information for quick reference. Presenting detailed evidence and authoritative clinical guidance throughout, Sarcomas is a “one-stop” guide for any clinician diagnosing, treating, or managing patients suffering from these heterogenous diseases. Key Features: Provides the standards of care and evidence base for treatment of each major sarcoma subtype Covers all new treatment paradigms and FDA approvals Includes numerous quick reference tables and high-quality color images Presents over 20 practical case studies from leading clinicians in the field

SITC’s Guide to Managing Immunotherapy Toxicity

Author : Marc S. Ernstoff, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826172156
Total Pages : 275 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis SITC’s Guide to Managing Immunotherapy Toxicity by : Marc S. Ernstoff, MD

Download or read book SITC’s Guide to Managing Immunotherapy Toxicity written by Marc S. Ernstoff, MD and published by Springer Publishing Company. This book was released on 2019-03-15 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer

Ovarian Cancers

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309380499
Total Pages : 397 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Ovarian Cancers by : National Academies of Sciences, Engineering, and Medicine

Download or read book Ovarian Cancers written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-04-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Official List of Section 13(f) Securities

Author :
Publisher :
ISBN 13 :
Total Pages : 182 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Official List of Section 13(f) Securities by :

Download or read book Official List of Section 13(f) Securities written by and published by . This book was released on 1981 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Scorched Earth

Author : Michael Savage
Publisher : Center Street
ISBN 13 : 1455568236
Total Pages : 205 pages
Book Rating : 4.4/5 (555 download)

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Book Synopsis Scorched Earth by : Michael Savage

Download or read book Scorched Earth written by Michael Savage and published by Center Street. This book was released on 2016-09-13 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Michael Savage predicted the chaos that is Obama's legacy. Now he tells us whether the destruction can be stopped! The prophetic author of the bestselling Government Zero, Dr. Michael Savage is back with his most urgent and powerful work. Listeners to Dr. Savage's top-rated radio talk show, The Savage Nation, know him to be an articulate and engaged spokesman for traditional American values of borders, language, and culture. Now, after eight divisive years of Barack Obama, Dr. Savage lays out an irrefutable case for how our nation has been undermined by terrorists from without, by anarchists from within, by a president and politicians with contempt for the Constitution and the law, and by a complicit liberal media. With words and topics that are as insightful as they are timely, he makes an ironclad case for the dangers we face from Hillary Clinton and her fellow travelers in the progressive movement. He also explains why Donald Trump may be one of the two best hopes for America's future as we try to regain control of our government, our country, and our national soul. The other hope? As Dr. Savage explains in some of his most heartfelt and passionate words, it is we, the people: the ordinary "Eddies," as he calls them-motivated, roused, and engaged. This book is about much more than an election. It is a veteran commentator and celebrated raconteur providing a blueprint for how to regain our cherished freedoms and our national identity . . . before they are lost forever.

The Evaluation of Surrogate Endpoints

Author : Geert Molenberghs
Publisher : Springer Science & Business Media
ISBN 13 : 9780387202778
Total Pages : 440 pages
Book Rating : 4.2/5 (27 download)

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Book Synopsis The Evaluation of Surrogate Endpoints by : Geert Molenberghs

Download or read book The Evaluation of Surrogate Endpoints written by Geert Molenberghs and published by Springer Science & Business Media. This book was released on 2005-02-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the latest research on a sensitive and controversial topic in a professional and well researched manner. Provides practical outlook as well as model guidelines and software tools that should be of interest to people who use the software tools described and those who do not. Related title by Co-author Geert Molenbergh has sold more than 3500 copies world wide. Provides dual viewpoints: from scientists in the industry as well as regulatory authorities.