Combinatorial Library

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Combinatorial Library

Author : Lisa B. English
Publisher : Springer Science & Business Media
ISBN 13 : 1592592856
Total Pages : 380 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Combinatorial Library by : Lisa B. English

Download or read book Combinatorial Library written by Lisa B. English and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.

Combinatorial Synthesis of Natural Product-Based Libraries

Author : Armen M. Boldi
Publisher : CRC Press
ISBN 13 : 1420009273
Total Pages : 363 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Combinatorial Synthesis of Natural Product-Based Libraries by : Armen M. Boldi

Download or read book Combinatorial Synthesis of Natural Product-Based Libraries written by Armen M. Boldi and published by CRC Press. This book was released on 2006-05-16 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Combinatorial Peptide Library Protocols

Author : Shmuel Cabilly
Publisher : Springer Science & Business Media
ISBN 13 : 1592595715
Total Pages : 320 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Combinatorial Peptide Library Protocols by : Shmuel Cabilly

Download or read book Combinatorial Peptide Library Protocols written by Shmuel Cabilly and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the course of evolution, an imbalance was created between the rate of vertebrate genetic adaptation and that of the lower forms of living organisms, such as bacteria and viruses. This imbalance has given the latter the advantage of generating, relatively quickly, molecules with unexpected structures and features that carry a threat to vertebrates. To compensate for their weakness, vertebrates have accelerated their own evolutionary processes, not at the level of whole organism, but in specialized cells containing the genes that code for antibody molecules or for T-cell receptors. That is, when an immediate requirement for molecules capable of specific interactions arose, nature has preferred to speed up the mode of Darwinian evolution in pref- ence to any other approach (such as the use of X-ray diffraction studies and computergraphic analysis). Recently, Darwinian rules have been adapted for test tube research, and the concept of selecting molecules having particular characteristics from r- dom pools has been realized in the form of various chemical and biological combinatorial libraries. While working with these libraries, we noticed the interesting fact that when combinatorial libraries of oligopeptides were allowed to interact with different selector proteins, only the actual binding sites of these proteins showed binding properties, whereas the rest of the p- tein surface seemed "inert. " This seemingly common feature of protein- having no extra potential binding sites--was probably selected during evolution in order to minimize nonspecific interactions with the surrounding milieu.

Solid-Phase Synthesis and Combinatorial Technologies

Author : Pierfausto Seneci
Publisher : John Wiley & Sons
ISBN 13 : 0471460737
Total Pages : 653 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Solid-Phase Synthesis and Combinatorial Technologies by : Pierfausto Seneci

Download or read book Solid-Phase Synthesis and Combinatorial Technologies written by Pierfausto Seneci and published by John Wiley & Sons. This book was released on 2003-05-28 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, Solid-Phase Synthesis and Combinatorial Technologies: * Surveys the most recent developments in SPS and combinatorial chemistry * Explains the entire process, from determining the need for a library to the details necessary for synthesis of the library * Discusses choice of format, size, and the rationale behind the design of each synthetic step * Surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries * Employs a large number of examples to illustrate important concepts * Includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis * Describes the quality control and activity screening of combinatorial libraries for various applications * Features a detailed bibliography of more than 1,700 relevant sources

Combinatorial Chemistry

Author : Günther Jung
Publisher : John Wiley & Sons
ISBN 13 : 352761351X
Total Pages : 634 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Combinatorial Chemistry by : Günther Jung

Download or read book Combinatorial Chemistry written by Günther Jung and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.

Combinatorial Chemistry

Author : Stephen R. Wilson
Publisher : John Wiley & Sons
ISBN 13 : 9780471126874
Total Pages : 288 pages
Book Rating : 4.1/5 (268 download)

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Book Synopsis Combinatorial Chemistry by : Stephen R. Wilson

Download or read book Combinatorial Chemistry written by Stephen R. Wilson and published by John Wiley & Sons. This book was released on 1997-03-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Combinatorial Peptide and Nonpeptide Libraries

Author : Günther Jung
Publisher : John Wiley & Sons
ISBN 13 : 3527614907
Total Pages : 571 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Combinatorial Peptide and Nonpeptide Libraries by : Günther Jung

Download or read book Combinatorial Peptide and Nonpeptide Libraries written by Günther Jung and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research. Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively. This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.

Handbook of Combinatorial Chemistry

Author : K. C. Nicolaou
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 652 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Handbook of Combinatorial Chemistry by : K. C. Nicolaou

Download or read book Handbook of Combinatorial Chemistry written by K. C. Nicolaou and published by Wiley-VCH. This book was released on 2002-04-29 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: In two volumes, this comprehensive handbook provides coverage of the whole area of combinatorial synthetic chemistry, including compound library design and synthesis.

Combinatorial Library Design and Evaluation

Author : Arup Ghose
Publisher : CRC Press
ISBN 13 : 1482270765
Total Pages : 655 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Combinatorial Library Design and Evaluation by : Arup Ghose

Download or read book Combinatorial Library Design and Evaluation written by Arup Ghose and published by CRC Press. This book was released on 2001-06-26 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text traces developments in rational drug discovery and combinatorial library design with contributions from 50 leading scientists in academia and industry who offer coverage of basic principles, design strategies, methodologies, software tools and algorithms, and applications. It outlines the fundamentals of pharmacophore modelling and 3D Qua

Combinatorial Chemistry and Technologies

Author : Stanislav Miertus
Publisher : CRC Press
ISBN 13 : 1420027840
Total Pages : 597 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Combinatorial Chemistry and Technologies by : Stanislav Miertus

Download or read book Combinatorial Chemistry and Technologies written by Stanislav Miertus and published by CRC Press. This book was released on 2005-04-12 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the

Combinatorial Optimization

Author : Alexander Schrijver
Publisher : Springer Science & Business Media
ISBN 13 : 9783540443896
Total Pages : 2024 pages
Book Rating : 4.4/5 (438 download)

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Book Synopsis Combinatorial Optimization by : Alexander Schrijver

Download or read book Combinatorial Optimization written by Alexander Schrijver and published by Springer Science & Business Media. This book was released on 2003-02-12 with total page 2024 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the reviews: "About 30 years ago, when I was a student, the first book on combinatorial optimization came out referred to as "the Lawler" simply. I think that now, with this volume Springer has landed a coup: "The Schrijver". The box is offered for less than 90.- EURO, which to my opinion is one of the best deals after the introduction of this currency." OR-Spectrum

Structure-based Design of Combinatorial Libraries

Author : Allan Geoffrey Skillman
Publisher :
ISBN 13 :
Total Pages : 840 pages
Book Rating : 4.:/5 (82 download)

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Book Synopsis Structure-based Design of Combinatorial Libraries by : Allan Geoffrey Skillman

Download or read book Structure-based Design of Combinatorial Libraries written by Allan Geoffrey Skillman and published by . This book was released on 1999 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Combinatorial Chemistry and Technologies

Author : Stanislav Miertus
Publisher : CRC Press
ISBN 13 : 0824758374
Total Pages : 616 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Combinatorial Chemistry and Technologies by : Stanislav Miertus

Download or read book Combinatorial Chemistry and Technologies written by Stanislav Miertus and published by CRC Press. This book was released on 2005-04-12 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Combinatorial Chemistry and Technology

Author : Stanislav Miertus
Publisher : CRC Press
ISBN 13 : 9781420000566
Total Pages : 456 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Combinatorial Chemistry and Technology by : Stanislav Miertus

Download or read book Combinatorial Chemistry and Technology written by Stanislav Miertus and published by CRC Press. This book was released on 1999-07-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

LEDA

Author : Kurt Mehlhorn
Publisher : Cambridge University Press
ISBN 13 : 9780521563291
Total Pages : 1050 pages
Book Rating : 4.5/5 (632 download)

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Book Synopsis LEDA by : Kurt Mehlhorn

Download or read book LEDA written by Kurt Mehlhorn and published by Cambridge University Press. This book was released on 1999-11-11 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt: LEDA is a library of efficient data types and algorithms and a platform for combinatorial and geometric computing on which application programs can be built. In each of the core computer science areas of data structures, graph and network algorithms, and computational geometry, LEDA covers all (and more) that is found in the standard textbooks. LEDA is the first such library; it is written in C++ and is available on many types of machine. Whilst the software is freely available worldwide and is installed at hundreds of sites, this is the first book devoted to the library. Written by the main authors of LEDA, it is the definitive account, describing how the system is constructed and operates and how it can be used. The authors supply ample examples from a range of areas to show how the library can be used in practice, making the book essential for all workers in algorithms, data structures and computational geometry.

Dynamic Covalent Chemistry

Author : Wei Zhang
Publisher : John Wiley & Sons
ISBN 13 : 1119075726
Total Pages : 624 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Dynamic Covalent Chemistry by : Wei Zhang

Download or read book Dynamic Covalent Chemistry written by Wei Zhang and published by John Wiley & Sons. This book was released on 2017-09-07 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first and only exhaustive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems Dynamic Covalent Chemistry: Principles, Reactions, and Applications presents a comprehensive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems. It features contributions from a team of international scientists, grouped into three main sections covering the principles of dynamic covalent chemistry, types of dynamic covalent chemical reactions, and the latest applications of dynamic covalent chemistry (DCvC) across an array of fields. The past decade has seen tremendous progress in (DCvC) research and industrial applications. The great synthetic power and reversible nature of this chemistry has enabled the development of a variety of functional molecular systems and materials for a broad range of applications in organic synthesis, materials development, nanotechnology, drug discovery, and biotechnology. Yet, until now, there have been no authoritative references devoted exclusively to this powerful synthetic tool, its current applications, and the most promising directions for future development. Dynamic Covalent Chemistry: Principles, Reactions, and Applications fills the yawning gap in the world literature with comprehensive coverage of: The energy landscape, the importance of reversibility, enthalpy vs. entropy, and reaction kinetics Single-type, multi-type, and non-covalent reactions, with a focus on the advantages and disadvantages of each reaction type Dynamic covalent assembly of discrete molecular architectures, responsive polymer synthesis, and drug discovery Important emerging applications of dynamic covalent chemistry in nanotechnology, including both material- and bio-oriented directions Real-world examples describing a wide range of industrial applications for organic synthesis, functional materials development, nanotechnology, drug delivery and more Dynamic Covalent Chemistry: Principles, Reactions, and Applications is must-reading for researchers and chemists working in dynamic covalent chemistry and supramolecular chemistry. It will also be of value to academic researchers and advanced students interested in applying the principles of (DCvC) in organic synthesis, functional materials development, nanotechnology, drug discovery, and chemical biology.

The Combinatorial Index

Author : Barry A. Bunin
Publisher : Elsevier
ISBN 13 : 0080542409
Total Pages : 341 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Combinatorial Index by : Barry A. Bunin

Download or read book The Combinatorial Index written by Barry A. Bunin and published by Elsevier. This book was released on 1998-04-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods Serves as a laboratory manual for bench chemists Includes a chapter on linkers to assist in choice of linking strategy Discusses strengths and limitations of the various methods Contains a structural index showing functional group transformations in solid-phase synthesis