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Author : R. Alan B. Ezekowitz
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.F/5 ( download)
Download or read book Collectins and Innate Immunity written by R. Alan B. Ezekowitz and published by . This book was released on 1996 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Uffe Laurits Holmskov
Publisher :
ISBN 13 : 9788716164230
Total Pages : 59 pages
Book Rating : 4.1/5 (642 download)
Download or read book Collectins and Collectin Receptors in Innate Immunity written by Uffe Laurits Holmskov and published by . This book was released on 2000 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Uday Kishore
Publisher : Springer Science & Business Media
ISBN 13 : 144190901X
Total Pages : 220 pages
Book Rating : 4.4/5 (419 download)
Download or read book Target Pattern Recognition in Innate Immunity written by Uday Kishore and published by Springer Science & Business Media. This book was released on 2010-01-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events. The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target pattern recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Pattern recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipids—and the subsequent interaction of the bound CR P with C1q—to give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganisms—to give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted pattern recognition receptors, it is accepted that all these pattern recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells. In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune system—and to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms.
Author : Uday Kishore
Publisher : Springer Nature
ISBN 13 : 3030670481
Total Pages : 249 pages
Book Rating : 4.0/5 (36 download)
Download or read book The Collectin Protein Family and Its Multiple Biological Activities written by Uday Kishore and published by Springer Nature. This book was released on 2021-03-12 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as: · Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. · Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. · The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. · Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health.
Author : Irving C. Allen
Publisher : Humana
ISBN 13 : 9781493960361
Total Pages : 0 pages
Book Rating : 4.9/5 (63 download)
Download or read book Mouse Models of Innate Immunity written by Irving C. Allen and published by Humana. This book was released on 2016-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
Author : Bali Pulendran
Publisher : Springer Science & Business Media
ISBN 13 : 3540326367
Total Pages : 189 pages
Book Rating : 4.5/5 (43 download)
Download or read book From Innate Immunity to Immunological Memory written by Bali Pulendran and published by Springer Science & Business Media. This book was released on 2006-10-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to remember an antigenic encounter for several decades, even for a life time, is one of the fundamental properties of the immune system. This book assembles a collection of essays from leading experts that span the entire spectrum of immunological research, from understanding the molecular mechanisms of innate immune recognition, to dendritic cell function, to the generation and maintenance of antigen-specific B and T-cell responses.
Author : Peter D. Katsikis
Publisher : Springer Science & Business Media
ISBN 13 : 1461462177
Total Pages : 144 pages
Book Rating : 4.4/5 (614 download)
Download or read book Crossroads Between Innate and Adaptive Immunity IV written by Peter D. Katsikis and published by Springer Science & Business Media. This book was released on 2013-03-01 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference “Crossroads between Innate and Adaptive Immunity” brought together leading international scientists and experts to address critical areas of Innate and Adaptive immunity something necessary for the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive immunity. The conference had limited participation and a scientific and social program that maximized scientific interchange through lecture presentations, poster sessions and informal discussions.
Author : Stephen P. Schoenberger
Publisher : Springer
ISBN 13 : 3319157744
Total Pages : 158 pages
Book Rating : 4.3/5 (191 download)
Download or read book Crossroads Between Innate and Adaptive Immunity V written by Stephen P. Schoenberger and published by Springer. This book was released on 2015-08-31 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a collection of reviews derived from work presented at the Aegean Conference: “5th Crossroads Between Innate and Adaptive Immunity”. This meeting was the fifth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference “Crossroads between Innate and Adaptive Immunity” brought together leading international scientists and experts to address critical areas of Innate and Adaptive Immunity, a necessary step in the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive Immunity, and maximized scientific interchange through lecture presentations, poster sessions and informal discussions.
Author : Bali Pulendran
Publisher : Springer Science & Business Media
ISBN 13 : 1441956328
Total Pages : 179 pages
Book Rating : 4.4/5 (419 download)
Download or read book Crossroads between Innate and Adaptive Immunity III written by Bali Pulendran and published by Springer Science & Business Media. This book was released on 2011-08-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a collection of reviews derived from work presented at the Aegean Conference: “3rd Crossroads between innate and adaptive immunity” which occurred during September 27 - October 2, 2009 at the Minoa Palace Conference Center in Chania, Crete, Greece. This meeting was the third in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The various facets of the innate response, including dendritic cells, T cells, B cells, NK cells, NK-T cells and the complement cascade during the host response to pathogens and tumors is only now starting to be elucidated. The respective fields that focus on these immune cells and molecules have tended to be relatively compartmentalized, and yet emerging evidence points to the interconnectedness of these facets in coordinating the innate response, and its subsequent impact on the adaptive response. The goal of this conference was to initiate cross-talk between these diverse immunological fields, and promote and facilitate discussion on the interactions between the innate immune response and the adaptive immune response and ultimately facilitate collaboration between these areas of study. Following on the footsteps of the outstanding success of its precursors, the “3rd Crossroads between Innate and Adaptive Immunity” Aegean Conference was highly successful in bringing together and connecting scientists and experts from around the world to address critical areas of Innate and Adaptive immunity.
Author : Yona Keisari
Publisher : Springer Science & Business Media
ISBN 13 : 030646831X
Total Pages : 324 pages
Book Rating : 4.3/5 (64 download)
Download or read book The Biology and Pathology of Innate Immunity Mechanisms written by Yona Keisari and published by Springer Science & Business Media. This book was released on 2006-07-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.
Author : R. Alan B. Ezekowitz
Publisher : Springer Science & Business Media
ISBN 13 : 1592593208
Total Pages : 404 pages
Book Rating : 4.5/5 (925 download)
Download or read book Innate Immunity written by R. Alan B. Ezekowitz and published by Springer Science & Business Media. This book was released on 2002-12-06 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to playa key role in stimulating the subsequent clonal response of adaptive immunity. Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic principles of first line host defense that are conserved in mammalian systems. The next frontier in the field is to understand the dynamic adaptive changes that occur as a result of the inter play between host defenses and infectious agents. One emerging theme is that microorganisms are constantly seeking ways to co-opt host defenses. On the other hand, host defense to infection is mediated by the coordinate action of pattern recognition molecules and receptors that, in mammals, are important and probably necessary antecedents to the development of an adaptive immune response. Innate Immunity aims to explore the intersection between host pathogen interactions across an evolutionary spectrum that will inform our understanding of the dynamic interplay between infectious agents and host defense in man.
Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470035382
Total Pages : 238 pages
Book Rating : 4.4/5 (7 download)
Download or read book Innate Immunity to Pulmonary Infection written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung. Innate Immunity to Pulmonary Infection: Provides a comprehensive overview of pulmonary infectious diseases, including basic pathology, current and potential therapies, and detailed consideration of the innate biological resistance mechanisms in the lung Thoroughly examines the major topic of innate immunity in immunology, which is now seen as key to the pathogenesis of and vaccination strategies for infectious diseases Describes the genetic and environmental factors which determine the outcome of infection, such as latency of Tuberculosis, blood stream invasion from local infection, and local target tissue damage Covers the roles of cells such as neutrophils, macrophages and dendritic cells and of molecular components such as Toll-like receptors Discusses the clinical applications of the new knowledge regarding innate immunity and how this can be used in both treatment and prevention (vaccination) strategies Includes contributions from an international and interdisciplinary group of experts Innate Immunity to Pulmonary Infection is an essential resource for researchers in both industry and academia. It is of interest for all those interested in the disciplines of immunology, virology, biology, biotechnology and genetics.
Author : Arne Egesten
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805585489
Total Pages : 221 pages
Book Rating : 4.8/5 (55 download)
Download or read book Trends in Innate Immunity written by Arne Egesten and published by Karger Medical and Scientific Publishers. This book was released on 2008 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decade has witnessed the delineation of innate immunity - a new area which has revolutionized our understanding of host-parasite interactions and their impact on defense mechanisms in infectious and noninfectious diseases. This volume of the book series 'Contributions to Microbiology' provides an update of the current knowledge of this expanding field of research and highlights some of its most important aspects. In eleven state-of-the-art articles, eminent international experts in the field address topics such as the innate immune system in mammals and insects, microbial protein ligands, antimicrobial peptides, complement, antibacterial chemokines, the role of neutrophils and monocytes, oxidative innate immune defenses and the effect of aging on innate immunity. The book will be a valuable resource for microbiologists, immunologists, students, scientists of other related disciplines, and clinicians with an interest in infectious or immunological diseases.
Author : Shie-Liang Hsieh
Publisher : Springer Nature
ISBN 13 : 9811515808
Total Pages : 240 pages
Book Rating : 4.8/5 (115 download)
Download or read book Lectin in Host Defense Against Microbial Infections written by Shie-Liang Hsieh and published by Springer Nature. This book was released on 2020-03-09 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous ‘pathogen-associated molecular patterns’ or ‘damage-associated molecular patterns’. As such, microbes’ interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.
Author : Holger Heine
Publisher : Springer Science & Business Media
ISBN 13 : 3540739300
Total Pages : 248 pages
Book Rating : 4.5/5 (47 download)
Download or read book Innate Immunity of Plants, Animals and Humans written by Holger Heine and published by Springer Science & Business Media. This book was released on 2007-12-07 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.
Author : M.D. Cooper
Publisher : Springer Science & Business Media
ISBN 13 : 3662047004
Total Pages : 126 pages
Book Rating : 4.6/5 (62 download)
Download or read book The Interface Between Innate and Acquired Immunity written by M.D. Cooper and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobial peptides has been de fined. A variety of cell surface receptors that recognize common patterns displayed by infectious organisms have been identified along with the intracellular pathways that these receptors use to activate cellular defense functions. Cell surface receptors on natural killer (NK) cells have been shown to sense microbial invasion in neighboring cells, thereby setting into motion their elimination by cy totoxic mechanisms. Other receptors have been found to facilitate phagocytosis and intracellular killing of microbes by phagocytic cells. These and other natural defense mechanisms have traditionally been viewed as the first line of body defense in vertebrate species that also possess the capacity for acquired or adaptive immunity. Sharks and all of the other jawed vertebrates generate large repertoires of T and B lymphocyte clones that display different antigen specific receptors in the form ofT cell receptors (TCR) and immunoglobulins (Ig) that allow them to recognize and respond to antigens in collaboration with antigen-present ing cells. Memory T and B cells are then generated to allow faster and heightened cellular and humoral immune re sponses on secondary antigen encounter. In recent years it has also become obvious that innate immune responses can directly influence adaptive immune responses in ways that will enhance body defense.
Author : Narayan Changder
Publisher : CHANGDER OUTLINE
ISBN 13 :
Total Pages : 23 pages
Book Rating : 4./5 ( download)
Download or read book INNATE IMMUNITY written by Narayan Changder and published by CHANGDER OUTLINE. This book was released on 2024-03-29 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE INNATE IMMUNITY MCQ (MULTIPLE CHOICE QUESTIONS) SERVES AS A VALUABLE RESOURCE FOR INDIVIDUALS AIMING TO DEEPEN THEIR UNDERSTANDING OF VARIOUS COMPETITIVE EXAMS, CLASS TESTS, QUIZ COMPETITIONS, AND SIMILAR ASSESSMENTS. WITH ITS EXTENSIVE COLLECTION OF MCQS, THIS BOOK EMPOWERS YOU TO ASSESS YOUR GRASP OF THE SUBJECT MATTER AND YOUR PROFICIENCY LEVEL. BY ENGAGING WITH THESE MULTIPLE-CHOICE QUESTIONS, YOU CAN IMPROVE YOUR KNOWLEDGE OF THE SUBJECT, IDENTIFY AREAS FOR IMPROVEMENT, AND LAY A SOLID FOUNDATION. DIVE INTO THE INNATE IMMUNITY MCQ TO EXPAND YOUR INNATE IMMUNITY KNOWLEDGE AND EXCEL IN QUIZ COMPETITIONS, ACADEMIC STUDIES, OR PROFESSIONAL ENDEAVORS. THE ANSWERS TO THE QUESTIONS ARE PROVIDED AT THE END OF EACH PAGE, MAKING IT EASY FOR PARTICIPANTS TO VERIFY THEIR ANSWERS AND PREPARE EFFECTIVELY.
