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Author : Tadhg P. Begley
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Cofactor Biosynthesis written by Tadhg P. Begley and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 9780080544533
Total Pages : 361 pages
Book Rating : 4.5/5 (445 download)
Download or read book Cofactor Biosynthesis: A Mechanistic Perspective written by and published by Academic Press. This book was released on 2001-01-02 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The longest running serial published by Academic Press continues its well-respected run with Volume 61, a special volume in which a guest editor has come on board and has assembled some well-known contributors who are international authorities in the field. Together they tackle some of the latest topics in the field such as riboflavin and folate biosynthesis, biotin and lipoic acid biosynthesis, nicotinamide adenine dinucleotide biosynthesis, biosynthesis of vitamin B6 and structurally related derivatives, pantothenic acid and coenzyme A biosynthesis, mechanistic biosynthesis of protein-derived redox cofactors, ascorbic acid biosynthesis, biosynthesis of menaquinone and ubiquinone - Vitamin B12 biosynthesis, biosynthesis of the methanogenic cofactors, and thiamin biosynthesis.
Author : F.J. Leeper
Publisher : Springer Science & Business Media
ISBN 13 : 3540695427
Total Pages : 214 pages
Book Rating : 4.5/5 (46 download)
Download or read book Biosynthesis written by F.J. Leeper and published by Springer Science & Business Media. This book was released on 2003-09-05 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concerned with discovering the chemical pathways of biosynthesis, this book devotes four chapters to the use of isotopes in biosynthetic research and the biosynthesis of enzyme cofactors and vitamin B12 and of reduced polyketides such as erythromycin. The topics covered demonstrate the revolution that has occurred in biosynthetic studies with the advent of gene cloning and overexpression. Yet the book also shows that the more classical approach to biosynthetic studies must go hand in hand with these new techniques.
Author :
Publisher : Academic Press
ISBN 13 : 9780128127940
Total Pages : 0 pages
Book Rating : 4.1/5 (279 download)
Download or read book Radical SAM Enzymes written by and published by Academic Press. This book was released on 2018-08-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.
Author :
Publisher : Elsevier
ISBN 13 : 0081026919
Total Pages : 4266 pages
Book Rating : 4.0/5 (81 download)
Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience
Author : Rajan Mariappan
Publisher : Academic Press
ISBN 13 : 0128244844
Total Pages : 330 pages
Book Rating : 4.1/5 (282 download)
Download or read book A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy written by Rajan Mariappan and published by Academic Press. This book was released on 2021-03-15 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy examines drug carrier development for controlled, targeted, pH and stimuli responsive drug releases for tuberculosis. The book provides in-depth information about mycobacterium tuberculosis, tuberculosis formation, and synthetic procedures for carrier synthesis, characterizations and mechanistic approaches. Key topics include the properties and functions of nanomedicines and how they might be applied for clinical diagnosis and treatment. Emphasis is placed on the basic fundamentals, biomaterial formulations, design principles, fabrication techniques, and transitioning bench-to-bed clinical applications. This book is useful for new researchers who focus on nanomedicine, stem cell therapy and bone tissue engineering. In addition, it introduces experienced researchers and clinicians to key trends, thus increasing their knowledge in drug discovery for tuberculosis and nanomedicine. Features the most notable uses of drug for tuberculosis treatment, including novel advances in materials Assesses new agents and chemical compounds against tuberculosis Examines the interaction of new technologies to discover ways to treat tuberculosis more effectively and efficiently
Author : Finian J. Leeper
Publisher : Springer
ISBN 13 : 354048146X
Total Pages : 255 pages
Book Rating : 4.5/5 (44 download)
Download or read book Biosynthesis written by Finian J. Leeper and published by Springer. This book was released on 2003-07-01 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). The first volume covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.
Author : Philip M. Weintraub
Publisher : Gulf Professional Publishing
ISBN 13 : 9780120408290
Total Pages : 428 pages
Book Rating : 4.4/5 (82 download)
Download or read book Annual Reports in Organic Synthesis 1999 written by Philip M. Weintraub and published by Gulf Professional Publishing. This book was released on 1999-08-23 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the more difficult problems facing chemists today is that of "keeping up with the literature." Thus, an organized annual review of synthetically useful information would prove beneficial to nearly all organic chemists, both specialists and non-specialists in synthesis. Weintraub et al. are very successful in creating such an original review. Key Features * Provides clearly illustrated structures of compounds in every feasible synthetic pathway * Presents a general review of structure/activity information for each synthetic compound * Includes extensive reference information on additional publications available for each reaction discussed * Yields a current awareness of the literature, ideas for research, and questions for cumulative exams * Highlights papers dealing with asymmetric syntheses * Remains the most comprehensive, reasonably priced compilation of its type
Author : Herbert Waldmann
Publisher : Springer
ISBN 13 : 3540450351
Total Pages : 235 pages
Book Rating : 4.5/5 (44 download)
Download or read book Bioorganic Chemistry of Biological Signal Transduction written by Herbert Waldmann and published by Springer. This book was released on 2003-07-01 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transduction of signals from the extracellular space across the plasma membrane into the interior of cells and ultimately to the nucleus, where in - sponse to such external signals the transcription of the genetic code is inf- enced, belongs to the most fundamental and important events in the regulation of the life cycle of cells. During recent years several signal transduction cascades have been elucidated which regulate, for instance, the growth and the prolife- tion of organisms as diverse as mammals, flies, worms and yeast. The general picture which emerged from these investigations is that nature employs a c- bination of non-covalent ligand/protein and protein/protein interactions together with a set of covalent protein modifications to generate the signals and transduce them to their destinations. The ligands which are recognized may be low molecular weight compounds like lipids, inositol derivatives, steroids or microbial products like cyclosporin. They may be proteins like, for instance, growth factors or intracellular adaptor proteins which carry SH2 or SH3 domains, and they may be specific DNA stretches which are selectively rec- nized by transcription factors. These and other aspects of biological signal transduction provide an open and rewarding field for investigations by scientists from various different dis- plines of biology, medical research and chemistry working in academic research institutions or in industry.
Author : Franz P. Schmidtchen
Publisher : Springer
ISBN 13 : 3540489908
Total Pages : 141 pages
Book Rating : 4.5/5 (44 download)
Download or read book Implementation and Redesign of Catalytic Function in Biopolymers written by Franz P. Schmidtchen and published by Springer. This book was released on 2003-07-03 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improvement of the catalytic properties of biological catalysts is equally important in the optimization of industrial processes as in the fundamental understanding of the catalytic machinery at the molecular level. The approaches taken are diverse and span from purely result-oriented, but nevertheless methodologically subtle, making and screening of combinatorial libraries to highly sophisticated tailoring of the environment of active sites. This volume illustrates four different concepts for modifying a given biocatalyst framework or create novel functions using Nature's basic building blocks. Summing up the state-of-the-art biocatalyst engineering it, serves as an orientational landmark and a platform for the specialist and non-expert alike to keep abreast of developments in this rapidly evolving field.
Author : Fritz Vögtle
Publisher : Springer
ISBN 13 : 3540697799
Total Pages : 248 pages
Book Rating : 4.5/5 (46 download)
Download or read book Dendrimers written by Fritz Vögtle and published by Springer. This book was released on 2003-09-05 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendrimers are a class of highly branched molecules that combine the properties of polymers and small discrete molecules. One classified among the exotic molecules of chemistry, dendrimers have attracted considerable attention in recent years, as their unique host/guest properties and their capability of being functionalized in the periphery as well in the core have led to new materials with a great potential for applications. This volume presents the state of art in this blossoming area, written by pioneers in the fields. Covering the synthetic, supramolecular, stereochemical, host/guest and polymer chemistry of dendritic and hyperbranched molecules, this volume explains both theoretical and practical aspects, including chirality reactivity, mechanism, material properties and biological relevance.
Author : Armin de Meijere
Publisher : Springer
ISBN 13 : 3540696911
Total Pages : 238 pages
Book Rating : 4.5/5 (46 download)
Download or read book Carbon Rich Compounds I written by Armin de Meijere and published by Springer. This book was released on 2003-09-05 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon Rich Compounds are defined here as carbon skeletons with a carbon to hydrogen ratio of 1:(=
Author : Andreas Hirsch
Publisher : Springer
ISBN 13 : 3540681175
Total Pages : 255 pages
Book Rating : 4.5/5 (46 download)
Download or read book Fullerenes and Related Structures written by Andreas Hirsch and published by Springer. This book was released on 2003-09-05 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aesthetically pleasing molecular architectures of fullerenes and nanotubes are appealing not only because of their beauty but also because they are responsible for the many unprecedented chemical and physical properties of this compound class. Although succession of exciting new discoveries continues unabated fullerene research has become a mature science. It is now possible to predict fullerene chemistry, to design new structure variations like open fullerene clusters, heterofullerenes and endohedral fullerenes, and to develop fullerene materials and modified nanotubes with high potential for technological applications. This volume represents the state-of-the-art of fullerene research, focussing on areas showing high potential for future growth and practical applications. The authors are leading scientists whose groups are making major contributions in the field.
Author : Edwin Weber
Publisher : Springer
ISBN 13 : 3540691782
Total Pages : 230 pages
Book Rating : 4.5/5 (46 download)
Download or read book Design of Organic Solids written by Edwin Weber and published by Springer. This book was released on 2003-09-05 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considering the high level of our knowledge concerning covalent bond formation in the organic chemistry of molecules, our understanding of the principles involved in organic solid design is almost in its infancy. While chemists today are able to synthesize organic molecules of very high complexity using sophisticated methods of preparation, they lack general approaches enabling them to reliably predict organic crystalline or solid structures from molecular descriptors - no matter how simple they are. On the other hand, nearly all the organic matter surrounding us is not in the single-molecule state but aggregated and condensed to form liquid or solid molecular assemblages and structural arrays giving rise to the appearances and properties of organic compounds we usually observe. Obviously, the electrical, optical or magnetic properties of solid organic materials that are important requirements for future technologies and high-tech applications, as well as the stability and solubility behavior of a medicament depend on the structure of the molecule and the intramolecular forces, but even more decisively on the intermolecular forces, i. e. the packing structure of the molecules to which a general approach is lacking. This situation concerned ]. Maddox some years ago to such a degree that he described it as "one of the continuing scandals in the physical sciences" [see (1998) Nature 335:201; see also Ball, P. (1996) Nature 381:648]. The problem of predicting organic solid and crystal structures is very dif- cult.
Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 032391053X
Total Pages : 883 pages
Book Rating : 4.3/5 (239 download)
Download or read book Human Biochemistry written by Gerald Litwack and published by Academic Press. This book was released on 2021-11-28 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers
Author :
Publisher : Elsevier
ISBN 13 : 0443152772
Total Pages : 572 pages
Book Rating : 4.4/5 (431 download)
Download or read book New Experimental Probes for Enzyme Specificity and Mechanism written by and published by Elsevier. This book was released on 2023-05-26 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more. Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on New Experimental Probes for Enzyme Specificity and Mechanism
Author : John McMurry
Publisher : Roberts and Company Publishers
ISBN 13 : 9780974707716
Total Pages : 524 pages
Book Rating : 4.7/5 (77 download)
Download or read book The Organic Chemistry of Biological Pathways written by John McMurry and published by Roberts and Company Publishers. This book was released on 2005 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for advanced undergraduates and graduate students in all areas of biochemistry, The Organic Chemistry of Biological Pathways provides an accurate treatment of the major biochemical pathways from the perspective of mechanistic organic chemistry.
