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Cloning And Characterization Of A Specific Associated Protein Ara70 For Androgen Receptor And The Promoter Study Of Androgen Receptor
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Book Synopsis Cloning and Characterization of a Specific Associated Protein, ARA70, for Androgen Receptor and the Promoter Study of Androgen Receptor by : Shuyuan Yeh
Download or read book Cloning and Characterization of a Specific Associated Protein, ARA70, for Androgen Receptor and the Promoter Study of Androgen Receptor written by Shuyuan Yeh and published by . This book was released on 1996 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structural Characterization and Ligand Specific Protein Interactions of Androgen Receptor by : Stacy Baker
Download or read book Structural Characterization and Ligand Specific Protein Interactions of Androgen Receptor written by Stacy Baker and published by . This book was released on 2008 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Background: Androgen receptor (AR) is a protein in the human body that binds various steroidal androgens such as testosterone and causes specific anabolic and androgenic activities. Current methods of androgen therapy are limited in use because of their inability to target anabolic versus androgenic activities. Selective androgen receptor modulators (SARMs) are nonsteroidal AR ligands that hold clinical promise in that they have the ability to selectively target anabolic versus androgenic activities, because they have the ability to act as agonists and antagonists in various tissues. Despite all that is known about SARM pharmacology, there is limited information about their structure, stability, and protein-protein interactions. Study Design and Methods: The question arises of whether or not two known SARMs (007 and 014) differ in their biochemical properties when bound to AR. To explore the question of which complex is the most stable, AR-ligand complexes (i.e., AR-007 and AR-014) were formed with the SARMs and they were exposed to heat to determine if the two had different degradation rates. To determine differences in three-dimensional conformation, the complexes were degraded by typsin to explore if they yielded different patterns of degradation. Finally, to determine whether or not the two complexes have different protein-protein interactions, heat shock protein 70 (hsp70) was measured via a Western blot technique to determine if the two complexes have different levels of association with hsp70. Results: AR-007 degraded more quickly than AR-014 when exposed to heat. AR-007 and AR-014 were broken down by trypsin in a similar fashion. AR-007 and AR-014 seem to have a tighter and more coiled conformation than AR-DHT (dihydrotestosterone), which was used as a positive control, because AR-DHT was broken down more readily by trypsin than the AR-SARM complexes. The AR-007 complex also had a stronger association with hsp70 than the AR-014 complex. Conclusion: The faster degradation of AR-007 when exposed to heat and its stronger association with hsp70 indicates that it is the least stable out of the two SARM complexes with AR. We conclude that SARM-induced conformational changes in the AR contribute to their differing pharmacology from steroidal androgens. These conformational changes are ligand-specific and affect the stability of the AR and its interactions with other intracellular proteins.
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1996 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1997 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microarrays written by Jang B. Rampal and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 927 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second part in the two-volume work Microarrays details applications and data analysis. It includes insight into non-mammalian vertebrate systems, processes and protocols for high quality glass-based microarrays. Coverage includes applications in DNA, peptide, antibody and carbohydrate microarraying, oligonucleotide microarrays generated from hydrolysis PCR probe sequences, microarray platforms in clinical practice, and screening of cDNA libraries on glass slide microarrays. Authors in this volume also discuss protocols for predicting DNA duplex stability on oligonucleotide arrays and integrated analysis of microarray results.
Book Synopsis Handbook of Cell Signaling, Three-Volume Set by : Ralph A. Bradshaw
Download or read book Handbook of Cell Signaling, Three-Volume Set written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2003-12-02 with total page 2560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field):* Initiation: Extracellular and Membrane Events* Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation* Events in Intracellular Compartments* Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field.Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field!* Contains approximately 470 articles* Provides well-organized sections on each essential area in signaling* Includes discussion on everything from ligand/receptor interactions to organ/organism responses* Extremely user-friendly
Book Synopsis Nuclear Receptors and Genetic Disease by : Thomas P. Burris
Download or read book Nuclear Receptors and Genetic Disease written by Thomas P. Burris and published by Academic Press. This book was released on 2000-09-06 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors and Genetic Disease provides the first compilation of the role of nuclear hormones in health and disease and incorporates the latest breakthroughs in the field. It provides comprehensive reviews of the major receptors prepared by the acknowledged experts in each area. Each chapter provides information on the history, physiology, structure, mechanism of action, genetics, pathophysiology, disease diagnosis, and disease treatment for a particular nuclear receptor. Each chapter also includes a table showing all the known mutations of the respective nuclear receptor with the corresponding clinical disorder.Receptors included in this book are: - The Nuclear Receptor Superfamily - Thyroid Hormone Receptors - Estrogen and Progesterone Receptors - The Androgen Receptor - DAX-1 and Related Orphan Receptors - The Vitamin D Receptor - Retinoid Receptors - Mineralocorticoid and Glucocorticoid Receptors - Hepatocyte Nuclear Factor 4 a - Peroxisome Proliferator Activated Receptors - Coactivators and Corepressors
Book Synopsis The Fish Oocyte by : Patrick J. Babin
Download or read book The Fish Oocyte written by Patrick J. Babin and published by Springer Science & Business Media. This book was released on 2007-08-17 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview on egg production in fish, from the standpoint of the oocyte. It covers oocyte development, maturation, hydration and fertilization. The book places special emphasis on using state-of-the-art tools for discerning the ultra-structure of the follicle and genomic/proteomic tools to fully understand biological basis of fish reproduction.
Book Synopsis Program & Abstracts, 10th International Congress of Endocrinology (ICE 96) by :
Download or read book Program & Abstracts, 10th International Congress of Endocrinology (ICE 96) written by and published by . This book was released on 1996 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of Prostate Cancer by : Manfred Wirth
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nuclear Hormone Receptors by : Malcolm G. Parker
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Book Synopsis Gene Regulation and Therapeutics for Cancer by : Surinder K. Batra
Download or read book Gene Regulation and Therapeutics for Cancer written by Surinder K. Batra and published by CRC Press. This book was released on 2021-03-22 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.
Download or read book Bisphenol A written by Pinar Erkekoglu and published by BoD – Books on Demand. This book was released on 2017-06-07 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bisphenol A (BPA) is a synthetic compound for hardening and clearing polycarbonate plastics. BPA is mainly classified as an estrogen-like endocrine-disrupting chemical. In the last decade, attention has arisen in scientific communities that it is not safe to use this chemical in mainly polycarbonate plastics. Exposure to BPA starts in prenatal period, which is the critical period for its toxic effects on different organs. Throughout this book, the readers will obtain information on the effects of BPA on different systems. They will also get information on the prenatal and postnatal effects of BPA. We believe that readers will get qualified scientific knowledge and a general overview of the toxic effects of BPA exposure and its consequences from this book.
Download or read book Cancer Research written by and published by . This book was released on 2008 with total page 886 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1812 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Androgen Action by : Fahri Saatcioglu
Download or read book Androgen Action written by Fahri Saatcioglu and published by Humana Press. This book was released on 2011-08-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.
Book Synopsis Gaseous Molecular Ions by : Eugen Illenberger
Download or read book Gaseous Molecular Ions written by Eugen Illenberger and published by Springer Science & Business Media. This book was released on 1992-05-26 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the matter in our solar system, and, probably, within the whole universe, exists in the form of ionized particles. On the other hand, in our natural environ ment, gaseous matter generally consists of neutral atoms and molecules. Only under certain conditions, such as within the path oflightning or in several technical devices (e. g. gas discharges, rocket engines, etc. ) will some of the atoms and molecules be ionized. It is also believed that the chemistry of the earth's troposphere predomi nantly proceeds via reactions between neutral particles. (The complex system of atmospheric chemistry will be treated in one of the forthcoming volumes to this series. ) Why, then, are ions considered so important that hundreds oflaboratories all over the world (including some of the most prestigious) are involved in research pro grams on ions, covering many different facets, from biochemistry to physics? One may obtain as many different answers as there are research groups busy in this field. There is, however, one simple, common feature which makes it attractive to work with ions: since they carry one or more net elementary charges, they can easily be gui ded, focused or separated by appropriate electric and magnetic fields, and, last but not least, they can easily be detected. Apart from these advantages, which are welcome and appreciated by the researcher, the study of molecular ions can provide insight into very fundamental aspects of the general behavior of molecules.
