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Author : J.R. Vane
Publisher : Science Press Incorporated
ISBN 13 : 9781858739625
Total Pages : 72 pages
Book Rating : 4.7/5 (396 download)
Download or read book Clinician's Manual on Cox-2 Inhibition and Arthritis written by J.R. Vane and published by Science Press Incorporated. This book was released on 2002-01-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9781858733470
Total Pages : 58 pages
Book Rating : 4.7/5 (334 download)
Download or read book Clinician's Manual on COX-2 Inhibition written by and published by . This book was released on 1999 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John R. Vane
Publisher :
ISBN 13 : 9781858733821
Total Pages : 75 pages
Book Rating : 4.7/5 (338 download)
Download or read book Clinician's Manual on COX-2 Inhibition written by John R. Vane and published by . This book was released on 2002 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James B. LaValle
Publisher : Inner Traditions / Bear & Co
ISBN 13 : 9780892819843
Total Pages : 178 pages
Book Rating : 4.8/5 (198 download)
Download or read book The Cox-2 Connection written by James B. LaValle and published by Inner Traditions / Bear & Co. This book was released on 2001-09 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this innovative text, James LaValle clearly explains what can cause joint and muscle inflammation, then sets forward mutliple treatments, with step-by-step instructions on how to use these treatments most effectively. Futhermore, he writes about exciting new studies that indicate the possible effectiveness of Cox-2 inhibitors in treating diseases such as cancer and Alzheimer's.
Author : Michel Pairet
Publisher : Birkhäuser
ISBN 13 : 3034878796
Total Pages : 255 pages
Book Rating : 4.0/5 (348 download)
Download or read book COX-2 Inhibitors written by Michel Pairet and published by Birkhäuser. This book was released on 2012-12-06 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.
Author : Raphael J. Leo
Publisher : American Psychiatric Pub
ISBN 13 : 1585622753
Total Pages : 286 pages
Book Rating : 4.5/5 (856 download)
Download or read book Clinical Manual of Pain Management in Psychiatry written by Raphael J. Leo and published by American Psychiatric Pub. This book was released on 2007 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Clinical Manual of Pain Management in Psychiatry focuses on the role of mental health practitioners in evaluation and assessment, pharmacological management, psychotherapeutic interventions, and comprehensive treatment planning for pain. It balances theoretical foundations of pain pathophysiology with applied clinical information, all the while viewing the patient from biological, psychological, and social perspectives in order to tailor treatment to the whole person. This handy portable guide includes numerous tables and illustrations and expands on the author's previous Concise Guide to Pain Management for Psychiatrists to reflect significant advances in the field of pain medicine. It features particularly extensive revisions regarding the use of psychiatric and other adjunctive medications in pain management; includes updated coverage of common psychiatric comorbidities such as depression, anxiety, and personality disorders; and addresses common pain disorders ranging from headache and back pain to pain related to cancer and HIV. The manual includes an extensively revised chapter on pharmacology, fully discusses psychotherapeutic approaches, and covers special techniques such as acupuncture and regional neural blockade. It also offers updated advice on emerging forensic issues, from disability claims to controlled substance diversion.
Author : Maynard J. Howardell
Publisher : Nova Publishers
ISBN 13 : 9781600212222
Total Pages : 184 pages
Book Rating : 4.2/5 (122 download)
Download or read book Trends in COX-2 Inhibitor Research written by Maynard J. Howardell and published by Nova Publishers. This book was released on 2006 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cox-2 Inhibitors are newly developed drugs for inflammation that selectively block the Cox-2 enzyme. Blocking this enzyme impedes the production of the chemical messengers (prostaglandins) that cause the pain and swelling of arthritis inflammation. Cox-2 inhibitors are a new class of non-steroidal anti-inflammatory drugs (NSAIDS). Because they selectively block the Cox-2 enzyme and not the Cox-1 enzyme, these drugs are uniquely different from traditional NSAIDS. This book explores new research in the field.
Author : Joachim Sieper
Publisher : Springer Science & Business Media
ISBN 13 : 190767330X
Total Pages : 86 pages
Book Rating : 4.9/5 (76 download)
Download or read book Clinician's Manual on Ankylosing Spondylitis written by Joachim Sieper and published by Springer Science & Business Media. This book was released on 2011-10-24 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of diagnosis and current management of ankylosing spondylitis. Presented in a clear, concise format High quality clinical photos and figures to enhance descriptions and aid diagnosis Written by well-known authors in the field
Author : Sir John R. Vane
Publisher : Springer Science & Business Media
ISBN 13 : 9401148724
Total Pages : 153 pages
Book Rating : 4.4/5 (11 download)
Download or read book Selective COX-2 Inhibitors written by Sir John R. Vane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are two distinct isoforms of COX, a constitutive enzyme (COX-I) responsible for the production of prostanoids necessary for platelet aggregation and protection of the gastric mucosa and kidney; and an inducible enzyme (COX-2) that is newly synthesized at sites of tissue damage and produces prostaglandins that manifest pathological effects. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. ' The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result ing from inhibition of the constitutive enzyme.
Author : Larry F. Chu
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451153996
Total Pages : 1613 pages
Book Rating : 4.4/5 (511 download)
Download or read book Manual of Clinical Anesthesiology written by Larry F. Chu and published by Lippincott Williams & Wilkins. This book was released on 2012-02-20 with total page 1613 pages. Available in PDF, EPUB and Kindle. Book excerpt: This portable manual provides a highly visual, rapid-reference resource that presents anesthesia in a practical and clinically-focused manner. Manual of Clinical Anesthesiology guides anesthesiologists in rapid and focused clinical decision making with its practical, clinically-focused chapters on anesthesia management. This highly formatted manual includes chapter summaries to highlight key points discussed within each chapter, color-coded sections to quickly identify information, and icons calling out pearls and pitfalls. Chapters are short and easy to read. The book includes four atlases for rapid reference: Atlas of Transesophageal Echocardiography, Atlas of Regional Anesthesia, Atlas of Anesthesia Procedures, and Crisis Management Cognitive Aids. There is also a Drug Dosing pull-out card for rapid reference. A section covering Anesthesia Phrases in Foreign Languages will enhance communication with non-English speaking patients in situations where an interpreter may not be available.
Author : N. Bazan
Publisher : Springer Science & Business Media
ISBN 13 : 9401153868
Total Pages : 155 pages
Book Rating : 4.4/5 (11 download)
Download or read book New Targets in Inflammation written by N. Bazan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past 100 years the mainstay of therapy for rheumatoid arthritis (RA) has been aspirin or other drugs of the non-steroid anti-inflammatory group. In 1971 Vane pro posed that both the beneficial and toxic actions of these drugs was through inhibition of prostaglandin synthesis. The recent discovery that prostaglandins responsible for pain and other symptoms at inflammatory foci are synthesized by an inducible cyclooxygenase (COX-2) that is encoded by a gene distinct from that of the consti tutive enzyme (COX-I) provided a new target for therapy of RA. A drug that would selectively inhibit COX-2 would hopefully produce the symptomatic benefit provided by existing NSAIDs without the gastrointestinal and renal toxicity due to the inhibition of COX-I. Drugs selective for COX-2 are now available. Experimental studies have shown them to be effective with minimal toxicity, and in clinical trials gastric and renal toxicities are less. Highly selective COX-2 inhibitors, perhaps designed with knowledge of the crystal structures of COX-I and COX-2, are also available. Other experimental studies, including those in animals lacking effective genes for COX-lor COX-2 and in experimental carcinomas, suggest there is still much to be learned of the pathophysiological functions of these enzymes. The inflammatory response is a complex reaction involving many mediators that derive from white blood cells, endothelial cells and other tissues. Preliminary data have revealed that inhibitors of the cytokines and adhesion molecules that play a crucial role in the migration of white cells to inflammatory sites may be useful in RA.
Author : Randall E. Harris
Publisher : Springer Science & Business Media
ISBN 13 : 1402056885
Total Pages : 323 pages
Book Rating : 4.4/5 (2 download)
Download or read book Inflammation in the Pathogenesis of Chronic Diseases written by Randall E. Harris and published by Springer Science & Business Media. This book was released on 2007-05-09 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
Author : Maynard J. Howardell
Publisher : Nova Publishers
ISBN 13 : 9781594549946
Total Pages : 274 pages
Book Rating : 4.5/5 (499 download)
Download or read book COX-2 Inhibitor Research written by Maynard J. Howardell and published by Nova Publishers. This book was released on 2006 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: COX-2 Inhibitors are newly developed drugs for inflammation that selectively block the COX-2 enzyme. Blocking this enzyme impedes the production of the chemical messengers (prostaglandins) that cause the pain and swelling of arthritis inflammation. Cox-2 inhibitors are a new class of nonsteroidal anti-inflammatory drugs (NSAIDS). Because they selectively block the Cox-2 enzyme and not the Cox-1 enzyme, these drugs are uniquely different from traditional NSAIDS. This book explores new research in this field.
Author : Sara Lister
Publisher : John Wiley & Sons
ISBN 13 : 1119532973
Total Pages : 1152 pages
Book Rating : 4.1/5 (195 download)
Download or read book The Royal Marsden Manual of Clinical Nursing Procedures, Student Edition written by Sara Lister and published by John Wiley & Sons. This book was released on 2021-04-13 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The student edition of The Royal Marsden Manual of Clinical Nursing Procedures has been the definitive, market-leading textbook of clinical nursing skills for fifteen years. This internationally best-selling title sets the gold standard for nursing care, providing the procedures, rationale, and guidance required by pre-registration students to deliver clinically effective, patient-focused care with expertise and confidence. With over two-hundred detailed procedures which reflect the skills required to meet The Standards of Proficiency for Registered Nurses (NMC 2019), this comprehensive manual presents the evidence and underlying theory alongside full-colour illustrations and a range of learning activities designed to support student nurses in clinical practice. Loved and trusted by millions, The Royal Marsden Manual of Clinical Nursing Procedures, Student Edition continues to be a truly indispensable textbook for students, and includes coverage of patient assessment and discharge planning, communication, infection prevention and control, perioperative care, wound management, nutrition, diagnostic testing, medicines management, and much more. Learning features in this revised tenth edition include: Learning outcomes – summarise the focus of the information in each chapter Learning in practice – asks you to consider issues within your practice environment Case studies – provide learning around a particular patient scenario Clinical applications – ask you to consider how you would apply your knowledge to a clinical situation Stretch activities – challenge you with more nuanced, advanced issues to reflect upon Many of the features in the book are relevant to trainee nursing associates, especially when used in conjunction with supervision from academic and clinical teachers. A companion website to this title is available at www.royalmarsdenmanual.com/student10e
Author : Aggarwal Praveen
Publisher : Elsevier Health Sciences
ISBN 13 : 8131255026
Total Pages : 1080 pages
Book Rating : 4.1/5 (312 download)
Download or read book Medicine: Prep Manual for Undergraduates E-book written by Aggarwal Praveen and published by Elsevier Health Sciences. This book was released on 2019-07-15 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: With ever-expanding knowledge and advances in medicine, the sixth edition of this book is significantly revised and presented in new full-colour format. Structured in question-answer format, this book is a must-have for all undergraduate medical students as it prepares them for both theory and viva-voce examinations. It is also useful for dentistry and nursing students. • Thorough revision of all the chapters without changing basic framework to keep up with the latest changes in the field of medicine. • Revision of topics especially respiratory system, immunological factors in disease, diseases of the cardiovascular system, diseases of the gastrointestinal system, acute poisoning and environmental emergencies, oncology, diseases of the kidneys and genitourinary system, diseases due to infections, endocrine and metabolic diseases. • Presentation of text pointwise with suitable boxes and tables, which helps the student in quick learning and revision. • Addition of newer innovations and treatments modalities. • Inclusion of clinical decision pathways for some of the commonly encountered critical and non-emergent disease conditions • Expansion of normal values of investigations and understanding the evolution of disease. • Management of acute medical emergencies like acute myocardial infarction, acute pulmonary oedema, acute anaphylactic and hypovolumic shock, status asthmaticus, tension pneumothorax, status epilepticus, haemoptysis, gastrointestinal bleeding, diabetic coma, snake bites, common poisoning, etc. • Emphasis has been laid on clinical presentation with description of the drugs. New to this Edition • Addition of many new line diagrams, tables, flowcharts to facilitate greater retention of knowledge. • Updates on Zika, Ebola, Nipah, sepsis, monoclonal antibodies, adult immunisation, paracetamol poisoning, acute radiation syndrome, myelodysplastic syndrome, lymphoid malignancies, influenza, tuberculosis, human immunodeficiency virus infection, hepatitis B and C, heart failure, rheumatic fever, pulmonary hypertension and hyperlipidaemia. Additional Feature • Complimentary access to full e-book
Author : Sir John R. Vane
Publisher : Springer Science & Business Media
ISBN 13 : 9401090297
Total Pages : 249 pages
Book Rating : 4.4/5 (1 download)
Download or read book Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors written by Sir John R. Vane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene from COX-I. COX-2 is induced by inflammatory stimuli and by cytokines in migratory and other cells. Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.
Author : Jeffrey C. Gershel
Publisher : Cambridge University Press
ISBN 13 : 131664863X
Total Pages : 857 pages
Book Rating : 4.3/5 (166 download)
Download or read book Clinical Manual of Emergency Pediatrics written by Jeffrey C. Gershel and published by Cambridge University Press. This book was released on 2018-06-14 with total page 857 pages. Available in PDF, EPUB and Kindle. Book excerpt: User-friendly handbook providing critical guidance at point of care; for practitioners and trainees caring for sick and injured children.
