Clinically Competitive

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The Prevention and Treatment of Missing Data in Clinical Trials

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030918651X
Total Pages : 163 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Prevention and Treatment of Missing Data in Clinical Trials by : National Research Council

Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Small Clinical Trials

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309171148
Total Pages : 221 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Small Clinical Trials by : Institute of Medicine

Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Sharing Clinical Trial Data

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309316324
Total Pages : 236 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Sharing Clinical Trial Data by : Institute of Medicine

Download or read book Sharing Clinical Trial Data written by Institute of Medicine and published by National Academies Press. This book was released on 2015-04-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Medicare's Competitive Bidding Program for Durable Medical Equipment

Author : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Medicare's Competitive Bidding Program for Durable Medical Equipment by : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health

Download or read book Medicare's Competitive Bidding Program for Durable Medical Equipment written by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health and published by . This book was released on 2013 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Textbook of Biochemistry for Medical Students

Author : D M Vasudevan
Publisher : JP Medical Ltd
ISBN 13 : 9385999745
Total Pages : 736 pages
Book Rating : 4.3/5 (859 download)

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Book Synopsis Textbook of Biochemistry for Medical Students by : D M Vasudevan

Download or read book Textbook of Biochemistry for Medical Students written by D M Vasudevan and published by JP Medical Ltd. This book was released on 2016-06-02 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised, new edition presenting students with latest advances in field of biochemistry. Features clinical case studies, MCQs, short questions, essays and viva voce questions for revision.

Subcommittee Hearing on Competitive Bidding for Durable Medical Equipment

Author : United States. Congress. House. Committee on Small Business. Subcommittee on Investigations and Oversight
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Subcommittee Hearing on Competitive Bidding for Durable Medical Equipment by : United States. Congress. House. Committee on Small Business. Subcommittee on Investigations and Oversight

Download or read book Subcommittee Hearing on Competitive Bidding for Durable Medical Equipment written by United States. Congress. House. Committee on Small Business. Subcommittee on Investigations and Oversight and published by . This book was released on 2007 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Competitive Problems in the Drug Industry

Author : United States. Congress. Senate. Select Committee on Small Business. Subcommittee on Monopoly
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Competitive Problems in the Drug Industry by : United States. Congress. Senate. Select Committee on Small Business. Subcommittee on Monopoly

Download or read book Competitive Problems in the Drug Industry written by United States. Congress. Senate. Select Committee on Small Business. Subcommittee on Monopoly and published by . This book was released on 1967 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guide to Clinical Resource Management

Author : Mickey L. Parsons
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780834208490
Total Pages : 260 pages
Book Rating : 4.2/5 (84 download)

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Book Synopsis Guide to Clinical Resource Management by : Mickey L. Parsons

Download or read book Guide to Clinical Resource Management written by Mickey L. Parsons and published by Jones & Bartlett Learning. This book was released on 1997 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of BioPharma Industry Acronyms & Terms is a comprehensive reference listing all terms and abbreviations used in the development and marketing of drugs.

Modern Methods of Clinical Investigation

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309042860
Total Pages : 241 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Modern Methods of Clinical Investigation by : Institute of Medicine

Download or read book Modern Methods of Clinical Investigation written by Institute of Medicine and published by National Academies Press. This book was released on 1990-02-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The very rapid pace of advances in biomedical research promises us a wide range of new drugs, medical devices, and clinical procedures. The extent to which these discoveries will benefit the public, however, depends in large part on the methods we choose for developing and testing them. Modern Methods of Clinical Investigation focuses on strategies for clinical evaluation and their role in uncovering the actual benefits and risks of medical innovation. Essays explore differences in our current systems for evaluating drugs, medical devices, and clinical procedures; health insurance databases as a tool for assessing treatment outcomes; the role of the medical profession, the Food and Drug Administration, and industry in stimulating the use of evaluative methods; and more. This book will be of special interest to policymakers, regulators, executives in the medical industry, clinical researchers, and physicians.

Medical Sciences

Author : Denise Syndercombe Court
Publisher : Elsevier Health Sciences
ISBN 13 : 0702082406
Total Pages : 936 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Medical Sciences by : Denise Syndercombe Court

Download or read book Medical Sciences written by Denise Syndercombe Court and published by Elsevier Health Sciences. This book was released on 2024-05-30 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Sciences is the leading integrated medical sciences textbook for medical students, and will become your go-to resource for understanding the basic science behind medicine.Packed with information across a wide range of topics, the book provides an excellent introduction to basic medical science as well as areas you will cover throughout medical school, including cell science, biochemistry and human physiological systems.This book is well loved and used by thousands of undergraduates and provides a thorough overview for revision, with enough detail to support you through your pre-clinical years. - Clear, integrated approach that shows the relevance of the medical sciences to good clinical practice - Provides easy to access physiological information – enhances general knowledge - Highly illustrated to help you grasp key concepts - Accessible and readable to support understanding - Interactive MCQs help with revision - Suitable for final exam preparation - Revised and updated, with additional new figures - Expanded examples on key clinical topics including metabolic diseases and psychiatric illness - Updated genetics chapter to include newer molecular technologies in this fast-moving area - New material throughout the book on the SARS-CoV2 virus and its effects on the human body through the disease, COVID-19. - New material on disease surveillance and health inequalities

Medical Pharmacology at a Glance

Author : Michael J. Neal
Publisher : John Wiley & Sons
ISBN 13 : 1118902416
Total Pages : 117 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Medical Pharmacology at a Glance by : Michael J. Neal

Download or read book Medical Pharmacology at a Glance written by Michael J. Neal and published by John Wiley & Sons. This book was released on 2015-10-07 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Pharmacology at a Glance is recognised as an excellent starting point for pharmacology study. This international best-seller is the perfect companion for all medical and health students, providing an accessible, visual overview of pharmacology. This 8th edition has been extensively updated, especially in the areas of anaesthetics, drugs used in AIDs, cardiovascular drugs, drugs used in anxiety, depression and schizophrenia, urological drugs, drug metabolism, as well as practical concerns such as drug indications and side effects. Ideal for USMLE and pharmacology exam revision, Medical Pharmacology at a Glance features: • The basic principles of drug action, interaction, absorption and excretion • Chapters based on diseases or syndrome, for efficient clinical learning • An emphasis on drug mechanisms • References to the pathophysiology of disease, to aid understanding of drug choice and action • Case studies with questions and full explanation of answers • A companion website at www.ataglanceseries.com/pharmacology featuring online cases and flashcards

A National Cancer Clinical Trials System for the 21st Century

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309157870
Total Pages : 317 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A National Cancer Clinical Trials System for the 21st Century by : Institute of Medicine

Download or read book A National Cancer Clinical Trials System for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2010-07-08 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.

Textbook of Medical Biochemistry

Author : MN Chatterjea
Publisher : Wife Goes On
ISBN 13 : 9789350254844
Total Pages : 902 pages
Book Rating : 4.2/5 (548 download)

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Book Synopsis Textbook of Medical Biochemistry by : MN Chatterjea

Download or read book Textbook of Medical Biochemistry written by MN Chatterjea and published by Wife Goes On. This book was released on 2011-10 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eighth edition of Textbook of Medical Biochemistry provides a concise, comprehensive overview of biochemistry, with a clinical approach to understand disease processes. Beginning with an introduction to cell biology, the book continues with an analysis of biomolecule chemistry, molecular biology and metabolism, as well as chapters on diet and nutrition, biochemistry of cancer and AIDS, and environmental biochemistry. Each chapter includes numerous images, multiple choice and essay-style questions, as well as highlighted text to help students remember the key points.

Textbook of Neural Repair and Rehabilitation: Neural repair and plasticity

Author : Michael E. Selzer
Publisher : Cambridge University Press
ISBN 13 : 9780521856416
Total Pages : 744 pages
Book Rating : 4.8/5 (564 download)

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Book Synopsis Textbook of Neural Repair and Rehabilitation: Neural repair and plasticity by : Michael E. Selzer

Download or read book Textbook of Neural Repair and Rehabilitation: Neural repair and plasticity written by Michael E. Selzer and published by Cambridge University Press. This book was released on 2006 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the basic sciences relevant to recovery of function following injury to the nervous system.

Dopamine Handbook

Author : Leslie L. Iversen
Publisher :
ISBN 13 : 0195373030
Total Pages : 632 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Dopamine Handbook by : Leslie L. Iversen

Download or read book Dopamine Handbook written by Leslie L. Iversen and published by . This book was released on 2010 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.

Medical Conditions in the Physically Active

Author : Katie Walsh Flanagan
Publisher : Human Kinetics
ISBN 13 : 171821541X
Total Pages : 554 pages
Book Rating : 4.7/5 (182 download)

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Book Synopsis Medical Conditions in the Physically Active by : Katie Walsh Flanagan

Download or read book Medical Conditions in the Physically Active written by Katie Walsh Flanagan and published by Human Kinetics. This book was released on 2024-04-02 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Conditions in the Physically Active, Fourth Edition With HKPropel Access, assists athletic trainers and other allied health care providers in recognizing and identifying medical conditions in athletes and active individuals. The book addresses medical conditions by body system, their mechanism of acquisition, signs, symptoms, differential diagnoses, referral, treatment, return-to-participation criteria, and potential comorbidities. Previously titled Medical Conditions in the Athlete, this fourth edition uses current research to offer assessment and treatment information for medical conditions that affect both athletes and active populations. The highly esteemed authors, Katie Walsh Flanagan and Micki Cuppett, have combined their professional skills and educational expertise to create a valuable athletic training resource with updated content that aligns with Board of Certification (BOC) and Commission on Accreditation of Athletic Training Education (CAATE) standards. The fourth edition offers the following updates: A new section on acute respiratory illnesses, including COVID-19 and SARS A new section on gastrointestinal disorders A new chapter on endocrine disorders Expanded content on concussion detection, treatment, and management, including return to play guidance New photos presenting medical conditions on diverse skin colors to help students learn identification skills Three case studies per chapter, delivered through HKPropel, to provide students with real-world examples; the case studies include multiple-choice questions that are assignable and automatically graded The book is organized into three sections—Introduction to Medical Conditions, Pharmacology and Interventions, and Medical Conditions by System—and there are 18 comprehensive chapters. Throughout the text, more than 350 full-color illustrations and photographs visually enhance readers’ comprehension of anatomy, physiology, and pathophysiology. Pharmacological tables organize drugs by categories that include generic and trade names, therapeutic uses, adult dosage information, and possible adverse effects. Important terminology is highlighted throughout the chapters, and a glossary appears at the end of the text. Chapter objectives and chapter summaries assist students in finding key information. Chapter quizzes, which are automatically graded, may also be assigned to test comprehension of critical concepts. At the beginning of the text, a Condition Finder serves as a quick reference so students or clinicians can easily flip to the information they need on specific conditions. Throughout the book, Red Flags for Urgent Intervention offer warning signs that health care providers should look for when working with patients; Clinical Tips discuss information that is critically important to professionals; and Condition Highlights cover specific medical conditions common to athletes and the physically active that require special attention or medical care. Medical Conditions in the Physically Active, Fourth Edition With HKPropel Access, provides comprehensive medical information to help readers build a framework for decision making that will help them choose effective courses of treatment. Note: A code for accessing HKPropel is not included with this ebook but may be purchased separately.

Clinical Pharmacology and Practical Prescribing on the Move

Author : James Turnbull
Publisher : CRC Press
ISBN 13 : 1444176048
Total Pages : 356 pages
Book Rating : 4.4/5 (441 download)

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Book Synopsis Clinical Pharmacology and Practical Prescribing on the Move by : James Turnbull

Download or read book Clinical Pharmacology and Practical Prescribing on the Move written by James Turnbull and published by CRC Press. This book was released on 2016-03-30 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Medicine on the Move series provides fully-flexible access to subjects across the curriculum, in this case clinical pharmacology and prescribing practice, in a combination of print and mobile formats. The books are ideal for the busy medical student and junior doctor, irrespective of individual learning style and whether they are studying a sub