Neural Circuit Development and Function in the Healthy and Diseased Brain

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Publisher :
ISBN 13 : 9780123972675
Total Pages : 834 pages
Book Rating : 4.9/5 (726 download)

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Book Synopsis Neural Circuit Development and Function in the Healthy and Diseased Brain by : John Rubenstein

Download or read book Neural Circuit Development and Function in the Healthy and Diseased Brain written by John Rubenstein and published by . This book was released on 2013 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development

Brain Theory From A Circuits And Systems Perspective

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Publisher : Springer Science & Business Media
ISBN 13 : 1461464129
Total Pages : 240 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Brain Theory From A Circuits And Systems Perspective by : John Robert Burger

Download or read book Brain Theory From A Circuits And Systems Perspective written by John Robert Burger and published by Springer Science & Business Media. This book was released on 2013-05-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book models an idealized neuron as being driven by basic electrical elements, the goal being to systematically characterize the logical properties of neural pulses. In order to constitute a system, neurons as pulsating devices may be represented using novel circuit elements as delineated in this book. A plausible brain system is implied by the delineated elements and logically follows from known and likely properties of a neuron. New to electrical science are novel pulse-related circuit elements involving recursive neurons. A recursive neuron, when properly excited, produces a self-sustaining pulse train that when sampled, provides a true output with a specified probability, and a false output with complementary probability. Because of its similarity to the qubits of quantum mechanics, the recursive pulsating neuron is termed a simulated qubit. Recursive neurons easily function as controlled toggle devices and so are capable of massively parallel calculations, this being a new dimension in brain functioning as described in this book. Simulated qubits and their possibilities are compared to the qubits of quantum physics. Included in the book are suggested neural circuits for associative memory search via a randomized process of cue selection, and neural circuits for priority calculations. These serve to select returns from long term memory, which in turn determines one's next conscious thought or action based on past memorized experiences. The book reports on proposals involving electron tunneling between synapses, and quantum computations within neurons. Although not a textbook, there are easy exercises at the ends of chapters, and in the appendix there are twelve simulation experiments concerning neurons. ​

Handbook of Brain Microcircuits

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Publisher : Oxford University Press
ISBN 13 : 0190636114
Total Pages : 625 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Handbook of Brain Microcircuits by : Gordon M. Shepherd

Download or read book Handbook of Brain Microcircuits written by Gordon M. Shepherd and published by Oxford University Press. This book was released on 2018 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to focus on principles, each chapter in this work is brief, organized around 1-3 wiring diagrams of the key circuits, with several pages of text that distil the functional significance of each microcircuit

Brain Circuits and Functions of the Mind

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Publisher : Cambridge University Press
ISBN 13 : 9780521378741
Total Pages : 456 pages
Book Rating : 4.3/5 (787 download)

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Book Synopsis Brain Circuits and Functions of the Mind by : Roger Sperry

Download or read book Brain Circuits and Functions of the Mind written by Roger Sperry and published by Cambridge University Press. This book was released on 1990-01-26 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Roger Sperry has made outstanding contributions to neuroscience. Here, he and over twenty of his contemporaries, review 50 years of both his work and their own in the context of Sperry's contribution to their fields. Sperry's challenging theories are still much alive in brain science, cognitive psychology and the philosophy of the mind.

Circuits of the Mind

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Publisher : Oxford University Press, USA
ISBN 13 : 9780195126686
Total Pages : 260 pages
Book Rating : 4.1/5 (266 download)

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Book Synopsis Circuits of the Mind by : Leslie G. Valiant

Download or read book Circuits of the Mind written by Leslie G. Valiant and published by Oxford University Press, USA. This book was released on 2000 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: While embracing the now classical theories of McCulloch and Pitts, the neuroidal model also accommodates state information in the neurons, more flexible timing mechanisms, a variety of assumptions about interconnectivity, and the possibility that different brain areas perform specialized functions. Programmable so that a wide range of algorithmic theories can be described and evaluated, the model provides a concrete computational language and a unified framework in which diverse cognitive phenomena - such as memory, learning, and reasoning - can be systematically and concurrently analyzed. Requiring no specialized knowledge, Circuits of the Mind masterfully offers an exciting new approach to brain science for students and researchers in computer science, neurobiology, neuroscience, artificial intelligence, and cognitive science.

The Physics of the Mind and Brain Disorders

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Publisher : Springer
ISBN 13 : 3319296744
Total Pages : 782 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis The Physics of the Mind and Brain Disorders by : Ioan Opris

Download or read book The Physics of the Mind and Brain Disorders written by Ioan Opris and published by Springer. This book was released on 2017-12-01 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent advances in the understanding of brain structure, function and disorders based on the fundamental principles of physics. It covers a broad range of physical phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the mind. It provides novel insights into the devastating brain disorders of the mind such as schizophrenia, dementia, autism, aging or addictions, as well as into the new devices for brain repair. The book is aimed at basic researchers in the fields of neuroscience, physics, biophysics and clinicians in the fields of neurology, neurosurgery, psychology, psychiatry.

Neural Circuit and Cognitive Development

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Publisher : Academic Press
ISBN 13 : 0128144122
Total Pages : 670 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neural Circuit and Cognitive Development by : Bin Chen

Download or read book Neural Circuit and Cognitive Development written by Bin Chen and published by Academic Press. This book was released on 2020-06-10 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Circuit and Cognitive Development, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume is devoted mainly to anatomical and functional development of neural circuits and neural systems and cognitive development. Understanding the critical role these changes play in neurodevelopment provides the ability to explore and elucidate the underlying causes of neurodevelopmental disorders and their effect on cognition. This series is designed to fill the knowledge gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms that control the assembly of neural circuits in specific regions of the nervous system and multiple aspects of cognitive development

Brain Circuitry and Signaling in Psychiatry

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Publisher : American Psychiatric Pub
ISBN 13 : 1585627712
Total Pages : 281 pages
Book Rating : 4.5/5 (856 download)

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Book Synopsis Brain Circuitry and Signaling in Psychiatry by : Gary B. Kaplan

Download or read book Brain Circuitry and Signaling in Psychiatry written by Gary B. Kaplan and published by American Psychiatric Pub. This book was released on 2008-08-13 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1990s, appropriately termed "the decade of the brain," witnessed unprecedented advances in our knowledge of psychiatric neuroscience. Yet with every advance, we realized afresh that we were still in the beginning stages of a much longer journey. This text chronicles the next step of that journey. Structured around a proven teaching methodology that uniquely integrates the clinical aspects of psychiatric disorders with their neurobiology, this volume begins with two introductory chapters on functional neural circuitry and neural signaling pathways. The remaining six chapters present current knowledge on the neuroanatomic and neurochemical mechanisms underlying schizophrenia, addiction, anxiety, depression, bipolar disorder, and dementia/Alzheimer's disease. For clarity and consistency, each chapter features the same four divisions -- clinical presentation, neural circuitry, signaling pathways, and psychopharmacology -- as they relate to Schizophrenia, which reviews studies of the neural basis of schizophrenia and describes how the cortex, the thalamus, the basal ganglia, and the medial temporal lobe work together during normal brain function and then how each is perturbed in psychosis. Addiction, which focuses on the consequences of psychoactive substance use, including compulsive practices (e.g., eating, sex, Internet browsing) that might also involve the same brain circuits and signaling pathways. Of exceptional value are two unique illustrations that capture -- for the first time -- much of what we know about the anatomy and neurochemistry underlying the behavioral symptoms of addiction. Anxiety, which presents current hypotheses regarding neurocircuitry and signaling pathways for the three best-studied (from a neurobiologic perspective) anxiety disorders: panic disorder, posttraumatic stress disorder, and obsessive-compulsive disorder. Depression, which offers evidence for the involvement of highly interconnected cortical and limbic structures such as the prefrontal cortex, medial thalamus, amygdala, ventral striatum, hippocampus, and the hypothalamic-pituitary-adrenal axis in unipolar major depression, and suggests target areas (such as the cAMP pathway) for study in the development of new antidepressants. Bipolar disorder, which shows that specific abnormalities in signal transduction pathways, including protein kinase activity, G protein levels, and gene expression, are unique to bipolar patients, concluding that the actions of lithium and anticonvulsants on intracellular signaling pathways provide a new paradigm for novel pharmacological interventions. Dementia and Alzheimer's disease, which details current findings on neurofibrillary degeneration, relevant genes and proteins, pathogenesis (metabolic decline, defective cell repair, and Aß toxicity), and treatment strategies (neurotransmitter replacement, and neuroprotective and regenerative approaches). Discusses frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease, and vascular dementia. Meticulously researched and clearly written by 15 contributors -- all recognized experts from leading research and teaching institutions in the United States -- this compact and extensively illustrated volume stands out in the literature because it combines readability and practicality with the breadth and depth typically found only in far lengthier works. Psychiatric practitioners, residents, and students alike will welcome this informative, easy-to-read text, which will also be of special interest to mental health and pharmaceutical industry professionals, and of general interest to anyone who wants to know more about the biology of psychiatric illness.

Cortical Circuits

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Publisher : Springer Science & Business Media
ISBN 13 : 1468487213
Total Pages : 299 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Cortical Circuits by : WHITE

Download or read book Cortical Circuits written by WHITE and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This elegant book presents current evidence on the organization of the mammalian cerebral cortex. The focus on synapses and their function provides the basis for understanding how this critical part of the brain could work. Dr. White and his colleague Dr. Keller have collated an impressive mass of material. This makes the crucial information accessible and coherent. Dr. White pioneered an area of investigation that to most others, and occasionally to himself, seemed a bottomless pit of painstaking at tention to detail for the identification and enumeration of cortical syn apses. I do not recall that he or anyone else suspected, when he began to publish his now classic papers, that the work would be central to an accelerating convergence of information and ideas from neurobiology and computer science, especially artificial intelligence (AI) (Rumelhart and McClelland, 1986). The brain is the principal organ responsible for the adaptive capacities of animals. What has impressed students of biology, of medicine, and, to an extent, of philosophy is the correlation between the prominence of the cerebral cortex and the adaptive "complexity" of a particular spe cies. Most agree that the cortex is what sets Homo sapiens apart from other species quantitatively and qualitatively (Rakic, 1988). This is summarized in the first chapter.

Local Cortical Circuits

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Publisher : Springer Science & Business Media
ISBN 13 : 3642817084
Total Pages : 105 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Local Cortical Circuits by : Moshe Abeles

Download or read book Local Cortical Circuits written by Moshe Abeles and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurophysiologists are often accused by colleagues in the physical sci ences of designing experiments without any underlying hypothesis. This impression is attributable to the ease of getting lost in the ever-increasing sea of professional publications which do not state explicitly the ultimate goal of the research. On the other hand, many of the explicit models for brain function in the past were so far removed from experimental reality that they had very little impact on further research. It seems that one needs much intimate experience with the real nerv-. ous system before a reasonable model can be suggested. It would have been impossible for Copernicus to suggest his model of the solar system without the detailed observations and tabulations of star and planet motion accu mulated by the preceeding generations. This need for intimate experience with the nervous system before daring to put forward some hypothesis about its mechanism of action is especially apparent when theorizing about cerebral cortex function. There is widespread agreement that processing of information in the cor tex is associated with complex spatio-temporal patterns of activity. Yet the vast majority of experimental work is based on single neuron recordings or on recordings made with gross electrodes to which tens of thousands of neurons contribute in an unknown fashion. Although these experiments have taught us a great deal about the organization and function of the cor tex, they have not enabled us to examine the spatio-temporal organization of neuronal activity in any detail.

Neuroscience for Clinicians

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Publisher : Oxford University Press
ISBN 13 : 0190948892
Total Pages : 833 pages
Book Rating : 4.1/5 (99 download)

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Book Synopsis Neuroscience for Clinicians by : Eduardo E. Benarroch

Download or read book Neuroscience for Clinicians written by Eduardo E. Benarroch and published by Oxford University Press. This book was released on 2021 with total page 833 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The aim of this book is to provide the clinician with a comprehensive and clinical relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms, at the molecular, cellular and system levels. The content of is based on the review of information obtained from recent advances in genetic, molecular and cell biology techniques, electrophysiological recordings, brain mapping, and mouse models, emphasizing the clinical and possible therapeutic implications. Many chapters of this book contain information that will be relevant not only clinical neurologists but also to psychiatrists and physical therapists. The scope includes the mechanisms and abnormalities of DNA/RNA metabolism, proteostasis, vesicular biogenesis, and axonal transport and mechanisms of neurodegeneration; the role of the mitochondria in cell function and death mechanisms; ion channels, neurotransmission and mechanisms of channelopathies and synaptopathies; the functions of astrocytes, oligodendrocytes and microglia and their involvement in disease; the local circuits and synaptic interactions at the level of the cerebral cortex, thalamus, basal ganglia, cerebellum, brainstem and spinal cord transmission regulating sensory processing, behavioral state and motor functions; the peripheral and central mechanisms of pain and homeostasis; and networks involved in emotion, memory, language, and executive function"--

Neural Plasticity and Memory

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Publisher : CRC Press
ISBN 13 : 1420008412
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neural Plasticity and Memory by : Federico Bermudez-Rattoni

Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Fast Oscillations in Cortical Circuits

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Publisher : MIT Press
ISBN 13 : 9780262201186
Total Pages : 364 pages
Book Rating : 4.2/5 (11 download)

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Book Synopsis Fast Oscillations in Cortical Circuits by : Roger D. Traub

Download or read book Fast Oscillations in Cortical Circuits written by Roger D. Traub and published by MIT Press. This book was released on 1999 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Fast Oscillations in Cortical Circuits, the authors use a combination of electrophysiological and computer modeling techniques to analyze how large networks of neurons can produce both epileptic seizures and functionally relevant synchronized oscillations.

Neural Circuits of Innate Behaviors

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Publisher : Springer Nature
ISBN 13 : 9811570868
Total Pages : 112 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Neural Circuits of Innate Behaviors by : Hao Wang

Download or read book Neural Circuits of Innate Behaviors written by Hao Wang and published by Springer Nature. This book was released on 2020-08-27 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest research findings in the neurocircuitry of innate behaviors, covering major topics such as innate fear, aggression, feeding, reward, social interaction, parental care, spatial navigation, and sleep-wake regulation. For decades, humans have been fascinated by wild animals’ instincts, like the annual two-thousand-mile migration of the monarch butterfly in North American, and the “imprint” behavior of newborn birds. Since these instincts are always displayed in stereotypical patterns in most individuals of a given species, the neural circuits processing such behaviors must be genetically hard-wired in the brain. Recently, with the development of modern techniques, including optogenetics, retrograde and anterograde virus tracing, and in vivo calcium imaging, researchers have been able to determine and dissect the specific neural circuits for many innate behaviors by selectively manipulating well-defined cell types in the brain. This book discusses recent advances in the investigation of the neural-circuit mechanisms underlying innate behaviors.

Corticonics

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Publisher : Cambridge University Press
ISBN 13 : 9780521376174
Total Pages : 298 pages
Book Rating : 4.3/5 (761 download)

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Book Synopsis Corticonics by : M. Abeles

Download or read book Corticonics written by M. Abeles and published by Cambridge University Press. This book was released on 1991-02-22 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how the brain works is probably the greatest scientific and intellectual challenge of our generation. The cerebral cortex is the instrument by which we carry the most complex mental functions. Fortunately, there exists an immense body of knowledge concerning both cortical structure and the properties of single neurons in the cortex. With the advent of the supercomputer, there has been increased interest in neural network modeling. What is needed is a new approach to an understanding of the mammalian cerebral cortex that will provide a link between the physiological description and the computer model. This book meets that need by combining anatomy, physiology, and modeling to achieve a quantitative description of cortical function. The material is presented didactically, starting with descriptive anatomy and comprehensively examining all aspects of modeling. The book gradually leads the reader from the macroscopic cortical anatomy and standard electrophysiological properties of single neurons to neural network models and synfire chains. The most modern trends in neural network modeling are explored.

Frontal-subcortical Circuits in Psychiatric and Neurological Disorders

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Author :
Publisher : Guilford Press
ISBN 13 : 9781572306233
Total Pages : 474 pages
Book Rating : 4.3/5 (62 download)

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Book Synopsis Frontal-subcortical Circuits in Psychiatric and Neurological Disorders by : David G. Lichter

Download or read book Frontal-subcortical Circuits in Psychiatric and Neurological Disorders written by David G. Lichter and published by Guilford Press. This book was released on 2001-01-01 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors review knowledge on the anatomy of the frontal-subcortical circuits, their connections to other brain regions, and their influences on motor, cognitive, affective, and behavioral functioning. Specific clinical problems are addressed, including Parkinson's disease, obsessive/compulsive disorder, ADHD, and more. of full-color illustrations.

Visual Attention and Cortical Circuits

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Publisher : MIT Press
ISBN 13 : 9780262024938
Total Pages : 358 pages
Book Rating : 4.0/5 (249 download)

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Book Synopsis Visual Attention and Cortical Circuits by : Jochen Braun

Download or read book Visual Attention and Cortical Circuits written by Jochen Braun and published by MIT Press. This book was released on 2001 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: An attempt to derive a comprehensive theory of attention from both neurobiological and psychological data.