Cilia

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Cilia and Nervous System Development and Function

Author : Kerry L. Tucker
Publisher : Springer Science & Business Media
ISBN 13 : 9400758081
Total Pages : 286 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cilia and Nervous System Development and Function by : Kerry L. Tucker

Download or read book Cilia and Nervous System Development and Function written by Kerry L. Tucker and published by Springer Science & Business Media. This book was released on 2013-01-19 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.

Primary Cilia

Author :
Publisher : Academic Press
ISBN 13 : 9780080962825
Total Pages : 408 pages
Book Rating : 4.9/5 (628 download)

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Book Synopsis Primary Cilia by :

Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. *Covers protocols for primary cilia across several systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians and scientists working in a wide range of fields

Cilia

Author : Wallace F. Marshall
Publisher :
ISBN 13 : 9781621821410
Total Pages : 0 pages
Book Rating : 4.8/5 (214 download)

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Book Synopsis Cilia by : Wallace F. Marshall

Download or read book Cilia written by Wallace F. Marshall and published by . This book was released on 2016-11-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly every cell in the human body has one or more protrusive structures called cilia or flagella. These power cell movement and fluid flow, sense the extracellular environment, coordinate cell signaling, and establish left-right asymmetry during development. Mutations in genes that encode cilia can lead to disorders known as ciliopathies. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines key aspects of ciliary biology-from the molecular to the organismal level-in normal physiology and disease. The contributors dissect the complex structures of motile and nonmotile (primary) cilia, discuss how the intraflagellar transport machinery moves cargo across the central axoneme, and review how the ciliary gate controls the composition of cilia and flagella. The roles of cilia in coordinating cellular responses to environmental stimuli via cell signaling pathways (e.g., Hedgehog) are also covered, as are physiological functions in processes such as fertilization, mucociliary clearance, and vision. The authors also survey the wide spectrum of ciliopathies, describing their genetic bases, pathogenic mechanisms, and clinical manifestations. This volume is therefore an indispensable reference for all cell and developmental biologists, as well as medical geneticists and clinical scientists wishing to understand and treat disorders involving ciliary dysfunction.

Artificial Cilia

Author : Jaap M. J. den Toonder
Publisher : Royal Society of Chemistry
ISBN 13 : 1849735972
Total Pages : 279 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Artificial Cilia by : Jaap M. J. den Toonder

Download or read book Artificial Cilia written by Jaap M. J. den Toonder and published by Royal Society of Chemistry. This book was released on 2013 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of the research field of artificial cilia, a novel technology for controlling and sensing fluid flow at microscopic scales. This field is inspired by nature, namely by naturally occurring cilia which are tiny hairs covering biological cells and that are used already for over a billion years by nature to generate and sense fluid flow. The research field started less than a decade ago and has grown fast in recent years, since it offers very interesting options for flow control in lab-on-a-chip devices.

The Ciliated Protozoa

Author : Denis Lynn
Publisher : Springer Science & Business Media
ISBN 13 : 1402082398
Total Pages : 627 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Ciliated Protozoa by : Denis Lynn

Download or read book The Ciliated Protozoa written by Denis Lynn and published by Springer Science & Business Media. This book was released on 2008-06-24 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: distances between groups of ciliates were as vast as significant hurdles to obtain copyright permissions the genetic distances between plants and animals for the over 1,000 required illustrations, and I put – THE major eukaryotic kingdoms at that time! the publication schedule ahead of this element. I continued to collaborate with Mitch, and in There are a number of significant illustrated guides 1991 my first “molecular” Magisterial student, to genera and species that have recently been pub- Spencer Greenwood, published an article estab- lished. References are made to these throughout lishing 1990 or thereabouts as the beginning of the book as sources that readers can consult for this the “Age of Refinement” – the period when gene aspect of ciliate diversity. A future project that I am sequencing techniques would deepen our under- contemplating is an illustrated guide to all the valid standing of the major lines of evolution within ciliate genera.

The Biology of Cilia and Flagella

Author : M. A. Sleigh
Publisher : Elsevier
ISBN 13 : 1483222756
Total Pages : 297 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis The Biology of Cilia and Flagella by : M. A. Sleigh

Download or read book The Biology of Cilia and Flagella written by M. A. Sleigh and published by Elsevier. This book was released on 2016-01-11 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biology of Cilia and Flagella reviews advances in the study of cilia and flagella since 1928. This book focuses on four main topics—structure of cilia, factors that affect ciliary activity, movement of cilia and flagella, and coordination of beat of cilia. In these topics, this compilation specifically discusses the intracellular structures associated with ciliary bases; viscosity of the medium and ciliary activity, and energy relationships of cilia and flagella. The compounding of synchronously beating cilia, variations in shaft structure, and control of ciliary activity by the organism are also elaborated. This text likewise covers the determination of the rate of beat of cilia and root-fiber systems and coordination of ciliary beat. This publication is suitable for biologists and clinicians of other disciplines researching on the structure and physiology of cilia and flagella.

Cilia and Flagella

Author :
Publisher : Academic Press
ISBN 13 : 9780080859453
Total Pages : 603 pages
Book Rating : 4.8/5 (594 download)

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Book Synopsis Cilia and Flagella by :

Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features * A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher * Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Integrated Nano-Biomechanics

Author : Takami Yamaguchi
Publisher : William Andrew
ISBN 13 : 0323389597
Total Pages : 314 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Integrated Nano-Biomechanics by : Takami Yamaguchi

Download or read book Integrated Nano-Biomechanics written by Takami Yamaguchi and published by William Andrew. This book was released on 2018-06-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases. Provides knowledge of integrated biomechanics, focusing on nano-scale, in this rapidly growing research field Explains how the different technologies can be integrated and applied in a variety of biomedical application fields, as well as for alternative energy sources Uses a collaborative, multidisciplinary approach to provide a comprehensive coverage of nano-biomechanics

Cilia

Author : Paraskevi Goggolidou
Publisher : CRC Press
ISBN 13 : 1351645692
Total Pages : 269 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Cilia by : Paraskevi Goggolidou

Download or read book Cilia written by Paraskevi Goggolidou and published by CRC Press. This book was released on 2018-02-28 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.

The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains

Author : Helena Soares
Publisher : Frontiers Media SA
ISBN 13 : 288971862X
Total Pages : 257 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains by : Helena Soares

Download or read book The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains written by Helena Soares and published by Frontiers Media SA. This book was released on 2021-12-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0128094273
Total Pages : 430 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Molecular Mechanisms of Cilia Related Diseases

Author : Joao Goncalves
Publisher : Frontiers Media SA
ISBN 13 : 2832549829
Total Pages : 175 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Molecular Mechanisms of Cilia Related Diseases by : Joao Goncalves

Download or read book Molecular Mechanisms of Cilia Related Diseases written by Joao Goncalves and published by Frontiers Media SA. This book was released on 2024-05-29 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic cilia are evolutionarily conserved microtubule-based structures that protrude from the cell surface. In vertebrates, multiple motile and primary (immotile) cilia fulfill sensory and motility functions that are critical for embryonic development and the homeostasis of adult tissues. Cilia malfunction has been shown to cause a growing number of diseases presenting phenotypes such as brain and skeletal developmental problems, intellectual disability, blindness, infertility, obesity, and kidney cysts. Despite their clinical relevance, we are still far from fully understanding the basic biology of these multiple cilia types. For example, we do not know the molecular compositions of all types of cilia nor how cilia structural and functional diversity is generated. Also, we are still identifying the genetic causes of ciliopathies and the impact of mutations on ciliary protein function, cilia biogenesis/maintenance, ciliary functions, and disease development. Understanding all these aspects concerning vertebrate cilia will greatly contribute to the design of innovative therapeutic approaches for cilia-related disorders. Understanding the basic biology of vertebrate cilia is critical for the understanding of cilia-related disorders. However, there are still many open questions about these organelles. For example, we do not know the proteomes and protein-protein interaction networks specific of each cilium type. Also, the function of ciliary proteins is often studied mostly in vitro and in the context of primary cilia. This limits our possibility to answer questions like “why does a certain disease mutation affect only certain types of cilia in specific tissues?”. Therefore, this Research Topic aims to address these issues and focus on the latest findings on the basic biology of vertebrate cilia such as their molecular composition and biogenesis pathways, and also on advances on our understanding of the molecular mechanisms of ciliopathies. The goal of this Research Topic is to cover novel research focused on furthering our understanding on the molecular mechanisms underlying the development of cilia-associated diseases. Areas to be covered in this Research Topic may include, but are not limited to: - Identification of novel cilia-related diseases - Genetic causes of ciliopathies - Molecular mechanisms of disease and development of therapeutic approaches - Molecular composition of vertebrate cilia - Molecular mechanisms of vertebrate cilia biogenesis and multiple functions Original research articles as well as review articles are welcomed.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Atlas of Cilia Bioengineering and Biocomputing

Author : Richard Mayne
Publisher : CRC Press
ISBN 13 : 1000792870
Total Pages : 217 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Atlas of Cilia Bioengineering and Biocomputing by : Richard Mayne

Download or read book Atlas of Cilia Bioengineering and Biocomputing written by Richard Mayne and published by CRC Press. This book was released on 2022-09-01 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are microscopic finger-like cell-surface organelles possessed by a great many eukaryotic organisms, including humans, whose purposes include generating local fluid movements via rhythmic whip-like beating and environmental sensing. Despite intense research efforts since their discovery by van Leeuwenhoek in the 1670's, several key questions regarding ciliary functions, experimental manipulation and in silico imitation remain unanswered. Major justifications for cilia research lie in their involvement in various forms of human disease (ciliopathies) and their ability to instantiate decentralised, asynchronous sensorial-actuation of adjacent matter through modulation of beating characteristics. Further elucidation of these characteristics, which is a problem requiring the combined expertise of mathematicians, computer scientists, engineers and life scientists, will lead to novel biomedical therapies, creation of `smart' actuating surfaces for microfluidics/lab-on-chip applications and a greater understanding of fluid mechanics in real-world scenarios. This lavishly-illustrated anthology presents recent advances in the fields of ciliary investigation, manipulation, emulation, mimesis and modelling from key researchers in their fields: its goal is to explain the state-of-the-art in cilia bioengineering and bio-computation in a uniquely creative, accessible manner, towards encouraging further transdisciplinary work in the field as well as educating a broad spectrum of scientists and lay people. The volume is split into three distinct but interwoven themes:Biology: Biological preliminaries for the study of cilia; the state-of-the-art in genetic engineering of ciliated cells for biomedical purposes; reprogramming of cilia dynamics in live cells.Engineering: Creation of macro cilia robots for object sorting applications; pneumatic cilia for the optimization of fluid motion; electrostatic, magnetic and MEMS cilia for microfluidic mixing; reviews in artificial cilia fabrication, actuation and flow induction methods.Numerical and computational modelling. Analyses of thin film cilia for `lab on chip' microfluidic mixing applications; modelling of gel-based artificial cilia towards simulating dynamic behaviors of responsive cilia layers in complex fluids across a wide range of potential applications.

Methods in Cilia and Flagella

Author :
Publisher : Academic Press
ISBN 13 : 0128026405
Total Pages : 616 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Methods in Cilia and Flagella by :

Download or read book Methods in Cilia and Flagella written by and published by Academic Press. This book was released on 2015-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to collect methods and protocols for studying cilia in a wide range of different cell types, so that researchers from many fields of biology can start exploring the role of cilia in their own system. Chapters are written by experts in the field Cutting-edge material

Comparative Protozoology

Author : Orvil Roger Anderson
Publisher : Springer Science & Business Media
ISBN 13 : 3662113406
Total Pages : 489 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Comparative Protozoology by : Orvil Roger Anderson

Download or read book Comparative Protozoology written by Orvil Roger Anderson and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The protozoa are an eclectic assemblage of organisms encompassing a wide range of single-celled and multiple-celled colonial organisms lacking tissue organiza tion, but exhibiting remarkably refined biological behavior. In some modern classifications, they are classified as a subkingdom among the Protista (eukary otic single-celled organisms). Although they are not considered a formal cate gory by some taxonomists and some biologists consider the name inappropriate (inferring that they are the first unicellular animals, although some photosynthe size), it is still convenient to consider this group of organisms as an informal collection under the heading of protozoa. Their cosmopolitan distribution, sig nificant ecological role in mineral recycling and enhancement of carbon flow through lower trophic levels of food webs, and remarkable cellular adaptations to enhance survival in diverse environments make them significant organisms for biological investigation. In some cases, biologists are introduced to this group in first level courses or in invertebrate zoology, but never develop a full appreciation for the diverse and biologically sophisticated characteristics of these organisms. This book is intended as a survey of broad concepts in protozoan biology with an emphasis on comparative data. The focus is on the zoological aspects of the group. Topics more closely related to plantlike characteristics, as presented in books on phycol ogy, are not considered in detail here. A sound background in modern biology and an introduction to cellular biology will be helpful in understanding Chapters 15 and 16, which include a substantial amount of information on biochemistry.

Cilia and Mucus

Author : Matthias Salathe
Publisher : CRC Press
ISBN 13 : 1482270587
Total Pages : 456 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Cilia and Mucus by : Matthias Salathe

Download or read book Cilia and Mucus written by Matthias Salathe and published by CRC Press. This book was released on 2001-07-27 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details advances in research regarding cilia, mucus, and mucociliary clearance, examining changes in mucus expression and goblet cell metaplasia, and assessing the ability of the mucociliary system to respond to abnormalities. Recognizes that cilia and dynein arms play pivotal roles in developing mammalian embryos! Examines the rol