Chiral Drugs

Download Chiral Drugs full books in PDF, epub, and Kindle. Read online Chiral Drugs ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Chiral Drugs

Author : Guo-Qiang Lin
Publisher : John Wiley & Sons
ISBN 13 : 1118075633
Total Pages : 469 pages
Book Rating : 4.1/5 (18 download)

DOWNLOAD NOW!

Book Synopsis Chiral Drugs by : Guo-Qiang Lin

Download or read book Chiral Drugs written by Guo-Qiang Lin and published by John Wiley & Sons. This book was released on 2011-08-08 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.

Chirality in Drug Design and Development

Author : Indra K. Reddy
Publisher : CRC Press
ISBN 13 : 0824751094
Total Pages : 406 pages
Book Rating : 4.8/5 (247 download)

DOWNLOAD NOW!

Book Synopsis Chirality in Drug Design and Development by : Indra K. Reddy

Download or read book Chirality in Drug Design and Development written by Indra K. Reddy and published by CRC Press. This book was released on 2004-03-15 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Chirality in Drug Research

Author : Eric Francotte
Publisher : John Wiley & Sons
ISBN 13 : 3527608710
Total Pages : 370 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!

Book Synopsis Chirality in Drug Research by : Eric Francotte

Download or read book Chirality in Drug Research written by Eric Francotte and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Axially Chiral Compounds

Author : Bin Tan
Publisher : John Wiley & Sons
ISBN 13 : 3527347127
Total Pages : 338 pages
Book Rating : 4.5/5 (273 download)

DOWNLOAD NOW!

Book Synopsis Axially Chiral Compounds by : Bin Tan

Download or read book Axially Chiral Compounds written by Bin Tan and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.

Chiral Liquid Chromatography

Author : w Lough
Publisher : Springer Science & Business Media
ISBN 13 : 940090861X
Total Pages : 278 pages
Book Rating : 4.4/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Chiral Liquid Chromatography by : w Lough

Download or read book Chiral Liquid Chromatography written by w Lough and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.

Drug Stereochemistry

Author : Irving Wainer
Publisher : CRC Press
ISBN 13 : 9780824788193
Total Pages : 450 pages
Book Rating : 4.7/5 (881 download)

DOWNLOAD NOW!

Book Synopsis Drug Stereochemistry by : Irving Wainer

Download or read book Drug Stereochemistry written by Irving Wainer and published by CRC Press. This book was released on 1993-02-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.

Chiral Separation Techniques

Author : G. Subramanian
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Chiral Separation Techniques by : G. Subramanian

Download or read book Chiral Separation Techniques written by G. Subramanian and published by Wiley-VCH. This book was released on 2001 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor. The scope has been extended to further chiral separation techniques like electrophoresis, membrane separations, or biological assays. More emphasis is put on preparative separation techniques. From reviews of the previous edition: 'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field' European Journal of Drug Metabolism 'The dense mass of information contained in this book will make it a valuable resource ...' Chemical Engineering Research '... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field' The Analyst

Novel Optical Resolution Technologies

Author : Kenichi Sakai
Publisher : Springer
ISBN 13 : 3540463208
Total Pages : 318 pages
Book Rating : 4.5/5 (44 download)

DOWNLOAD NOW!

Book Synopsis Novel Optical Resolution Technologies by : Kenichi Sakai

Download or read book Novel Optical Resolution Technologies written by Kenichi Sakai and published by Springer. This book was released on 2007-01-30 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Chiral Drugs

Author : Cynthia A Challener
Publisher : Routledge
ISBN 13 : 1351808052
Total Pages : 662 pages
Book Rating : 4.3/5 (518 download)

DOWNLOAD NOW!

Book Synopsis Chiral Drugs by : Cynthia A Challener

Download or read book Chiral Drugs written by Cynthia A Challener and published by Routledge. This book was released on 2017-10-23 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.

Signposts to Chiral Drugs

Author : Vitomir Sunjic
Publisher : Springer Science & Business Media
ISBN 13 : 3034801254
Total Pages : 249 pages
Book Rating : 4.0/5 (348 download)

DOWNLOAD NOW!

Book Synopsis Signposts to Chiral Drugs by : Vitomir Sunjic

Download or read book Signposts to Chiral Drugs written by Vitomir Sunjic and published by Springer Science & Business Media. This book was released on 2011-05-10 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry. The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section is followed by detailed discussions of synthetic approaches to the chiral target structure, highlighting creative ideas, the scaling-up of laboratory methods and their replacement by efficient modern technologies for large-scale production. Nearly 60 synthetic reactions, most of them stereoselective, catalytic or biocatalytic, as well as chiral separating methodologies are included in the book. Vitomir Sunjic and Michael J. Parnham provide an invaluable source of information for scientists in academia and the pharmaceutical industry who are actively engaged in the interdisciplinary development of new drugs, as well as for advanced students in chemistry and related fields.

“What you need to know about Chiral Drugs: Nomenclature, Pharmacology, Mechanisms, Metabolism, Toxicology etc. An Overview.’’

Author : DR. HAKIM SABOOWALA
Publisher : Dr.Hakim Saboowala
ISBN 13 :
Total Pages : 73 pages
Book Rating : 4./5 ( download)

DOWNLOAD NOW!

Book Synopsis “What you need to know about Chiral Drugs: Nomenclature, Pharmacology, Mechanisms, Metabolism, Toxicology etc. An Overview.’’ by : DR. HAKIM SABOOWALA

Download or read book “What you need to know about Chiral Drugs: Nomenclature, Pharmacology, Mechanisms, Metabolism, Toxicology etc. An Overview.’’ written by DR. HAKIM SABOOWALA and published by Dr.Hakim Saboowala. This book was released on 2019-08-14 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately more than half of the drugs recently/currently in use are chiral compounds and near 90% of the last ones are marketed as racemates consisting of an equimolar mixture of two enantiomers. Although they have the same chemical structure, most isomers of chiral drugs exhibit marked differences in biological activities such as: · Pharmacology, · Toxicology, · Pharmacokinetics, · Metabolism etc. Therefore, it is important to promote the chiral separation and analysis of racemic drugs in pharmaceutical industry as well as in clinic in order to eliminate the unwanted isomer from the preparation and to find an optimal treatment and a right therapeutic control for the patient. An attempt has been made to review the nomenclature, pharmacology, toxicology, pharmacokinetics, metabolism etc. of some usual chiral drugs as well as their mechanisms of these properties. Additionally, different techniques used for the chiral separation in pharmaceutical industry as well as in clinical analyses have also been considered. …….Dr.H.K.Saboowala.M.B.(Bom) M.R.S.H.(London)

Chiral Environmental Pollutants

Author : R. Kallenborn
Publisher : Springer Science & Business Media
ISBN 13 : 9783540664239
Total Pages : 232 pages
Book Rating : 4.6/5 (642 download)

DOWNLOAD NOW!

Book Synopsis Chiral Environmental Pollutants by : R. Kallenborn

Download or read book Chiral Environmental Pollutants written by R. Kallenborn and published by Springer Science & Business Media. This book was released on 2001-01-18 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph contains a survey on the role of chirality in ecotoxicological processes. The focus is on environmental trace analysis. Areas such as toxicology, ecotoxicology, synthetic chemistry, biology, and physics are also covered in detail in order to explain the different properties of enantiomers in environmental samples. This monograph delivers a comprehensive survey for environmental trace analysts, analytical chemists, ecotoxicologists, food scientists and experienced lab workers.

Drug Stereochemistry

Author : Krzysztof Jozwiak
Publisher : CRC Press
ISBN 13 : 1420092391
Total Pages : 324 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Drug Stereochemistry by : Krzysztof Jozwiak

Download or read book Drug Stereochemistry written by Krzysztof Jozwiak and published by CRC Press. This book was released on 2012-04-23 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition covers all aspects of chiral drugs from academic, governmental, industrial, and clinical perspectives, reflecting the many advances in techniques and methodology. Topics include:The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug disc

Toxicology in Transition

Author : Gisela H. Degen
Publisher : Springer
ISBN 13 : 9783642794537
Total Pages : 0 pages
Book Rating : 4.7/5 (945 download)

DOWNLOAD NOW!

Book Synopsis Toxicology in Transition by : Gisela H. Degen

Download or read book Toxicology in Transition written by Gisela H. Degen and published by Springer. This book was released on 2011-12-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume contains the main papers presented at the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. Toxicology has become a less descriptive science because more importance has been placed on the mechanisms underlying toxic effects. This is reflected in symposia and workshops devoted to species differences in organ toxicity, receptor-mediated toxicity and stereochemical effects of xenobiotics. Recent progress in the fields of immunotoxicology, ecotoxicology, and neurotoxicology is highlighted and documented together with the present discussion on harmonized regulatory guidelines.

OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 307: Aerobic and Anaerobic Transformation in Soil

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264070508
Total Pages : 17 pages
Book Rating : 4.2/5 (64 download)

DOWNLOAD NOW!

Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 307: Aerobic and Anaerobic Transformation in Soil by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 307: Aerobic and Anaerobic Transformation in Soil written by OECD and published by OECD Publishing. This book was released on 2002-04-24 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method described in this Test Guideline is designed for evaluating aerobic and anaerobic transformation of chemicals in soil. The experiments are performed to determine the rate of transformation of the test substance, and the nature and rates ...

Chemical Engineering in the Pharmaceutical Industry

Author : Mary T. am Ende
Publisher : John Wiley & Sons
ISBN 13 : 111928550X
Total Pages : 1435 pages
Book Rating : 4.1/5 (192 download)

DOWNLOAD NOW!

Book Synopsis Chemical Engineering in the Pharmaceutical Industry by : Mary T. am Ende

Download or read book Chemical Engineering in the Pharmaceutical Industry written by Mary T. am Ende and published by John Wiley & Sons. This book was released on 2019-04-08 with total page 1435 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

Chiral Reactions in Heterogeneous Catalysis

Author : V. Dubois
Publisher : Springer Science & Business Media
ISBN 13 : 1461519098
Total Pages : 304 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Chiral Reactions in Heterogeneous Catalysis by : V. Dubois

Download or read book Chiral Reactions in Heterogeneous Catalysis written by V. Dubois and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was a great honor for us to organize ChiCat, a symposium devoted to Chiral Reactions in Heterogeneous Catalysis and to be the hostsofmore than 120 scientists coming from everywhere in the industrialized world, to celebrate together one century of existence ofInstitut Meurice. This school was established in 1892when an industrial chemist, named Albert Meurice, decided to educate practical chemists according to the perceived needs ofthe industry ofthat time. This is exactly what we are still trying to do. It is the reason why, thirty years ago, we started a research activity in catalysis, and why we progressively devote this research to the applications of catalysis in the field of fine chemicals. In this respect, we are very close to another initiative of Albert Meurice, who started the first production of synthetic pharmaceuticals in Belgium during World War I. This business later on became a part ofthe Belgian corporation DCB, still very active in pharmaceuticals today. The school created by Albert Meurice merged in the fifties with another school that had been created to meet the same needs in the field of the food industries, mainly distilleries and breweries. This merger was done in the frame of the establishment of CERIA. For people in catalysis, ceria stands for cerium oxide, but for those who engineered the concept, CERIA stood for Center of Education and Research for the Food and Chemical Industries.