Chimeric Antigen Receptor T Cell Therapies For Cancer E Book

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Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book

Author : Daniel W. Lee
Publisher : Elsevier Health Sciences
ISBN 13 : 0323755976
Total Pages : 246 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book by : Daniel W. Lee

Download or read book Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book written by Daniel W. Lee and published by Elsevier Health Sciences. This book was released on 2019-11-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Chimeric Antigen Receptor T-Cell Therapies for Cancer

Author : Daniel W. Lee
Publisher : Elsevier Health Sciences
ISBN 13 : 9780323661812
Total Pages : 0 pages
Book Rating : 4.6/5 (618 download)

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Book Synopsis Chimeric Antigen Receptor T-Cell Therapies for Cancer by : Daniel W. Lee

Download or read book Chimeric Antigen Receptor T-Cell Therapies for Cancer written by Daniel W. Lee and published by Elsevier Health Sciences. This book was released on 2019-12-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy

Author : Mumtaz Y. Balkhi
Publisher : Academic Press
ISBN 13 : 0128197471
Total Pages : 92 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Basics of Chimeric Antigen Receptor (CAR) Immunotherapy by : Mumtaz Y. Balkhi

Download or read book Basics of Chimeric Antigen Receptor (CAR) Immunotherapy written by Mumtaz Y. Balkhi and published by Academic Press. This book was released on 2019-07-31 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

Chimeric Antigen Receptor T Cells

Author : Kamilla Swiech
Publisher :
ISBN 13 : 9781071601464
Total Pages : pages
Book Rating : 4.6/5 (14 download)

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Book Synopsis Chimeric Antigen Receptor T Cells by : Kamilla Swiech

Download or read book Chimeric Antigen Receptor T Cells written by Kamilla Swiech and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The EBMT/EHA CAR-T Cell Handbook

Author : Nicolaus Kröger
Publisher : Springer Nature
ISBN 13 : 3030943534
Total Pages : 221 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis The EBMT/EHA CAR-T Cell Handbook by : Nicolaus Kröger

Download or read book The EBMT/EHA CAR-T Cell Handbook written by Nicolaus Kröger and published by Springer Nature. This book was released on 2022-02-07 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.

Gene and Cellular Immunotherapy for Cancer

Author : Armin Ghobadi
Publisher : Springer Nature
ISBN 13 : 303087849X
Total Pages : 371 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Gene and Cellular Immunotherapy for Cancer by : Armin Ghobadi

Download or read book Gene and Cellular Immunotherapy for Cancer written by Armin Ghobadi and published by Springer Nature. This book was released on 2022-01-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches

Author : Robert E Hawkins
Publisher : World Scientific
ISBN 13 : 9814618535
Total Pages : 212 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches by : Robert E Hawkins

Download or read book Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches written by Robert E Hawkins and published by World Scientific. This book was released on 2014-05-05 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.

Cellular Therapies in Cancer

Author : Katy Rezvani
Publisher : Frontiers Media SA
ISBN 13 : 2889633780
Total Pages : 182 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Cellular Therapies in Cancer by : Katy Rezvani

Download or read book Cellular Therapies in Cancer written by Katy Rezvani and published by Frontiers Media SA. This book was released on 2020-01-16 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fast Facts: CAR T-Cell Therapy

Author : Richard J. Buka
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318067415
Total Pages : 71 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Fast Facts: CAR T-Cell Therapy by : Richard J. Buka

Download or read book Fast Facts: CAR T-Cell Therapy written by Richard J. Buka and published by Karger Medical and Scientific Publishers. This book was released on 2021-02-28 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells are and how they were developed, discusses the results of clinical trials and the management of toxicities, and outlines future improvements and applications. It is ideal reading for any healthcare professional wanting to know more about this exciting therapeutic field. Table of Contents: • CAR T cells • Clinical application • Practical aspects • Future directions

Protein Engineering

Author : Huimin Zhao
Publisher : John Wiley & Sons
ISBN 13 : 3527344705
Total Pages : 41 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Protein Engineering by : Huimin Zhao

Download or read book Protein Engineering written by Huimin Zhao and published by John Wiley & Sons. This book was released on 2021-08-23 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the adaptation and implementation of the strategies for new applications. The book contains information on the directed evolution, rational design, and semi-rational design of proteins and offers a review of the most recent applications in industrial and medical biotechnology. This important book: Covers technologies and methodologies used in protein engineering Includes the strategies behind the approaches, designed to help with the adaptation and implementation of these strategies for new applications Offers a comprehensive and thorough treatment of protein engineering from primary strategies to applications in industrial and medical biotechnology Presents cutting edge advances in the continuously evolving field of protein engineering Written for students and professionals of bioengineering, biotechnology, biochemistry, Protein Engineering: Tools and Applications offers an essential resource to the design strategies in protein engineering and reviews recent applications.

CAR T-Cell, An Issue of Hematology/Oncology Clinics of North America, E-Book

Author : Caron A Jacobson
Publisher : Elsevier Health Sciences
ISBN 13 : 0443183015
Total Pages : 193 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis CAR T-Cell, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Caron A Jacobson

Download or read book CAR T-Cell, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Caron A Jacobson and published by Elsevier Health Sciences. This book was released on 2023-10-12 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editors Drs. Caron A. Jacobson and Parth S. Shah bring their considerable expertise to the topic of CAR T-Cell Therapy. Top experts in the field discuss the multiple ways CAR T-cell therapy can be used to help fight a variety of cancers, such as diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, mantle cell lymphoma, multiple myeloma, and B-cell acute lymphoblastic leukemia (ALL). Contains 12 practice-oriented topics including CAR T-cells in aggressive B-cell lymphomas; CAR T-cells in multiple myeloma; CAR T-cells in AML; mechanisms of resistance of CAR T-cell therapy; the role of CAR T-cell therapy in the era of bispecific antibodies; and more. Provides in-depth clinical reviews on CAR T-cell therapy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Current Perspectives, Challenges and Advances in Cell Based Therapies

Author : Prashant Trikha
Publisher : Frontiers Media SA
ISBN 13 : 2889635643
Total Pages : 192 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Current Perspectives, Challenges and Advances in Cell Based Therapies by : Prashant Trikha

Download or read book Current Perspectives, Challenges and Advances in Cell Based Therapies written by Prashant Trikha and published by Frontiers Media SA. This book was released on 2020-03-24 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Stem Cell Transplantation and Cellular Therapy Management

Author : Edwin P. Alyea, III, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826139949
Total Pages : 353 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Handbook of Stem Cell Transplantation and Cellular Therapy Management by : Edwin P. Alyea, III, MD

Download or read book Handbook of Stem Cell Transplantation and Cellular Therapy Management written by Edwin P. Alyea, III, MD and published by Springer Publishing Company. This book was released on 2020-09-29 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma and allogenic transplantation for leukemia, lymphoma, and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, and more clinical issues. Concluding chapters address new CAR T-cell therapies, including their mechanisms of action, indications, and unique associated toxicities, in addition to a chapter dedicated to biostatistics and clinical trials. Throughout the book, extensive tables, flow diagrams, and other figures highlight, simplify, and illustrate key concepts. Written by experienced clinicians at the world-renowned Dana Farber Cancer Center and Harvard Medical School in Boston as well as leading experts at other institutions, this stem cell transplantation handbook combines the clinical knowledge, expertise and practical application of these potential life-saving cell therapies in one quick, point-of-care reference. With real-world clinical vignettes interwoven among the chapters, this handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies. Key Features: Provides latest insights and recommendations for managing challenging treatment complications and adverse events Consolidates key information such as diagnosis criteria, disease staging, common complications, and more using detailed tables and diagrams Shares real-world clinical vignette examples, which provide insight into clinical assessment, treatment, and management Emphasizes patient management and best practices Discusses short- and long-term risks for stem cell transplantation and cellular therapy

CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels

Author : Avery Dexter Posey, Jr.
Publisher : Frontiers Media SA
ISBN 13 : 2889636879
Total Pages : 164 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels by : Avery Dexter Posey, Jr.

Download or read book CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels written by Avery Dexter Posey, Jr. and published by Frontiers Media SA. This book was released on 2020-04-24 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T cells for the treatment of solid malignancies have thus far been few and far between. Furthermore, several instances of severe and lethal toxicities have arisen due to on-target, off-tumor recognition of antigen by T cell products. Recent advances in phase I trials for solid tumors, as well as in pre-clinical models, have revealed several variables that will be important to consider for the successful use of CAR-T cells in treating solid tumors. These variables include (i) regional versus systemic delivery; (ii) scFv versus ligand interactions; (iii) antigen loss versus escape; (iv) epitope spreading and (v) checkpoint expression on immune cells or tumor cells. Also, there remains outstanding mechanistic questions related to why differences exist in the persistence and tonic signaling of second-generation CD28 versus 4-1BB co-stimulated CAR-T cells. In addition, we are now learning the roles of lympho-depleting regimens (and associated toxicities) in modifying the persistence of engineered T cell therapies. A more comprehensive view of CAR-T cell strategies and important advances, both of pre-clinical and clinical evaluations, in solid tumors is necessary to drive these therapies forward.

Cancer Immunology and Immunotherapy

Author : Mansoor M. Amiji
Publisher : Academic Press
ISBN 13 : 012823637X
Total Pages : 550 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cancer Immunology and Immunotherapy by : Mansoor M. Amiji

Download or read book Cancer Immunology and Immunotherapy written by Mansoor M. Amiji and published by Academic Press. This book was released on 2021-08-18 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Immunotherapy of Hepatocellular Carcinoma

Author : Tim F. Greten
Publisher : Springer
ISBN 13 : 3319649582
Total Pages : 167 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Immunotherapy of Hepatocellular Carcinoma by : Tim F. Greten

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2017-10-04 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Emerging Learnings in Cell Therapy: Novel Binding Domains, Universal CAR-T Cells, and More

Author : Anand Rotte
Publisher : Frontiers Media SA
ISBN 13 : 2832548326
Total Pages : 129 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Emerging Learnings in Cell Therapy: Novel Binding Domains, Universal CAR-T Cells, and More by : Anand Rotte

Download or read book Emerging Learnings in Cell Therapy: Novel Binding Domains, Universal CAR-T Cells, and More written by Anand Rotte and published by Frontiers Media SA. This book was released on 2024-04-22 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Past decade has seen significant advances in cancer immunotherapy with the development of multiple strategies including monoclonal antibodies targeting checkpoint blockers, oncolytic viruses, fusion proteins and cell therapies such as tumor-specific chimeric antigen receptor (CAR-) T cell therapy, NK cell therapy and γδ-T-cell therapy. Multiple cell therapies including sipuleucel-T (Provange), axicabtagene ciloleucel (Yescarta), brexucabtagene autoleucel (Tecartus), tisagenlecleucel (Kymriah), lisocabtagene maraleucel (Breyanzi), idecabtagene vicleucel (Abecma) and ciltacabtagene autoleucel (Carvykti) have been approved by the US FDA for different hematological cancers and hormone-refractory prostate cancer (Provange). Impressive results were noted with CAR-T cell therapy with objective response rates (ORR) as high as 100% in certain hematological cancers and with responses durable over 10 years in some patients.