Chemosensitivity

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Chemosensitivity

Author : Rosalyn D. Blumenthal
Publisher : Springer Science & Business Media
ISBN 13 : 1592598692
Total Pages : 234 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Chemosensitivity by : Rosalyn D. Blumenthal

Download or read book Chemosensitivity written by Rosalyn D. Blumenthal and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients.

Chemosensitivity Testing in Oncology

Author : Uwe Reinhold
Publisher : Springer Science & Business Media
ISBN 13 : 3642190227
Total Pages : 262 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Chemosensitivity Testing in Oncology by : Uwe Reinhold

Download or read book Chemosensitivity Testing in Oncology written by Uwe Reinhold and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

Breast Cancer Chemosensitivity

Author : Dihua Yu
Publisher : Springer Science & Business Media
ISBN 13 : 0387740392
Total Pages : 175 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Breast Cancer Chemosensitivity by : Dihua Yu

Download or read book Breast Cancer Chemosensitivity written by Dihua Yu and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

Augmentation of Peripheral Chemosensitivity During Hypermetabolism

Author : Ismaeel Bin-Jaliah
Publisher : Universal-Publishers
ISBN 13 : 1581123272
Total Pages : 361 pages
Book Rating : 4.5/5 (811 download)

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Book Synopsis Augmentation of Peripheral Chemosensitivity During Hypermetabolism by : Ismaeel Bin-Jaliah

Download or read book Augmentation of Peripheral Chemosensitivity During Hypermetabolism written by Ismaeel Bin-Jaliah and published by Universal-Publishers. This book was released on 2006 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The carotid body initiates reflexes aimed principally at the homeostatic maintenance of blood gas tensions. This thesis tested the hypothesis that the carotid body is also a physiological glucosensor, with a role in mediating exercise hyperpnoea. In anaesthetised rats, insulin-induced hypoglycaemia (from ca. 6.5 to 2.8 mmol L-1) caused an ca. two-fold increase of oxygen consumption that was associated with a significant, carotid body-dependent increase in ventilation (from ca. 420 to 640 ml min-1 kg-1) without change in blood gas tensions. This hypoglycaemic hyperpnoea was associated with hypokalaemia and no alterations of ventilation or metabolism were observed in euglycaemic, control studies, thus excluding any role for [K+] or insulin. During hypermetabolism, a proportional augmentation of peripheral CO2 gain, measured from the phrenic electroneurogram during artificial ventilation, was shown to maintain the arterial blood gas status. In vitro, measurements of single-fibre chemoafferent discharge showed that low [glucose], over a physiological range and during normoxia, increased neither the carotid baseline discharge nor the CO2 sensitivity. Taken together, these results demonstrate that the carotid body is not a physiological sensor of glucose but augmentation of the carotid body chemosensitivity via an undetermined yet, hypermetabolism-related factor(s) is most likely to be involved in exercise hyperpnoea.

Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer

Author : Ossi R. Köchli
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.4/5 (194 download)

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Book Synopsis Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer by : Ossi R. Köchli

Download or read book Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer written by Ossi R. Köchli and published by S. Karger AG (Switzerland). This book was released on 1994 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'It will form an important addition to a scientific library and a useful addition to the (contributions series) which should be part of any obstetrics and gynaecology library.' New Zealand Journal of Obstetrics and Gynaecology

Journal of the National Cancer Institute

Author :
Publisher :
ISBN 13 :
Total Pages : 696 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2000 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:

PH and Brain Function

Author : Kai Kaila
Publisher : John Wiley & Sons
ISBN 13 : 9780471118381
Total Pages : 694 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis PH and Brain Function by : Kai Kaila

Download or read book PH and Brain Function written by Kai Kaila and published by John Wiley & Sons. This book was released on 1998-09-15 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: "PH and Brain Function offers thorough coverage of this increasingly important area of research, beginning with the fundamental concepts, which include methodological and theoretical issues such as the measurement of pH and the concept of pH in neurobiology. It explores aspects of regulation and modulation of intracellular pH in brain cells, surveys the changes in pH that occur with neural activity and how these changes affect neural activity, and discusses the role of pH in the pathophysiology of neurological diseases." "pH and Brain Function is an important resource for researchers in all areas of neuroscience as well as cell biology and physiology." --Book Jacket.

Recent Advances in Diseases of the Esophagus

Author : Kin-ichi Nabeya
Publisher : Springer Science & Business Media
ISBN 13 : 4431682465
Total Pages : 1097 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Recent Advances in Diseases of the Esophagus by : Kin-ichi Nabeya

Download or read book Recent Advances in Diseases of the Esophagus written by Kin-ichi Nabeya and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1097 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth World Congress of the International Society for Diseases of the Esophagus was held in the historic city of Kyoto, Japan, from August 5 through 8, 1992. Approximately 40 countries throughout the world participated and roughly 500 presentations were made. Excellent authors were selected and they were requested to send in their manuscripts for publication of this book. It is our ardent hope that this book will prove to be beneficial to the doctor interested in the esophagus and that it will provide the reader with first-hand information from leading scientists and clinicians in this field. The incidence of esophageal diseases vary greatly from country to country and in recent years, worldwide interest in these diseases has resulted in various international studies. The International Society for Diseases of the Esophagus was inaugurated by Professor Komei Nakayama in 1979 and since that time it has actively contributed to the exchange of information regarding these diseases and has made endeavors in bringing about advancement in the struggle against diseases of the esophagus in every way possible.

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1422 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiorespiratory and Motor Coordination

Author : Hans-Peter Koepchen
Publisher : Springer Science & Business Media
ISBN 13 : 3642755070
Total Pages : 346 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Cardiorespiratory and Motor Coordination by : Hans-Peter Koepchen

Download or read book Cardiorespiratory and Motor Coordination written by Hans-Peter Koepchen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the contributions to a Satellite Symposium of the XXXI In ternational Congress of Physiological Sciences in Espoo, Helsinki, Finland, July 15-17,1989. The general purpose of this Symposium was to bring together specialists from different fields of physiology who work on systems that are closely linked function ally with regard to behavioral adaptation. In a certain sense it represents a contin uation of two former books on the Central Interaction Between Respiratory and Cardiovascular Control Systems 1 and on Neurovegetative Control Systems: Basic 2 Function, Integration and Disorders , but explicitly includes the relationship with motor control. Since the first book appeared, much has been achieved in the field of physiology of respiratory, cardiovascular, and somatomotor control. It is not intended that this book compete with other publications from more specialized meetings which deal with the most recent findings in a particular field of research, and rightly so.

Cancer Treatment Reports

Author :
Publisher :
ISBN 13 :
Total Pages : 734 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Cancer Treatment Reports by :

Download or read book Cancer Treatment Reports written by and published by . This book was released on 1984 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Apoptosis and Cancer Chemotherapy

Author : John A. Hickman
Publisher : Springer Science & Business Media
ISBN 13 : 1592597203
Total Pages : 347 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Apoptosis and Cancer Chemotherapy by : John A. Hickman

Download or read book Apoptosis and Cancer Chemotherapy written by John A. Hickman and published by Springer Science & Business Media. This book was released on 1999-04-08 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.

Biology of Sensory Systems

Author : C. U. M. Smith
Publisher : John Wiley & Sons
ISBN 13 : 0470694386
Total Pages : 534 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Biology of Sensory Systems by : C. U. M. Smith

Download or read book Biology of Sensory Systems written by C. U. M. Smith and published by John Wiley & Sons. This book was released on 2008-11-20 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the first edition, huge developments have taken place in sensory biology research and new insights have been provided in particular by molecular biology. These show the similarities in the molecular architecture and in the physiology of sensory cells across species and across sensory modality and often indicate a common ancestry dating back over half a billion years. Biology of Sensory Systems has thus been completely revised and takes a molecular, evolutionary and comparative approach, providing an overview of sensory systems in vertebrates, invertebrates and prokaryotes, with a strong focus on human senses. Written by a renowned author with extensive teaching experience, the book covers, in six parts, the general features of sensory systems, the mechanosenses, the chemosenses, the senses which detect electromagnetic radiation, other sensory systems including pain, thermosensitivity and some of the minority senses and, finally, provides an outline and discussion of philosophical implications. New in this edition: Greater emphasis on molecular biology and intracellular mechanisms New chapter on genomics and sensory systems Sections on TRP channels, synaptic transmission, evolution of nervous systems, arachnid mechanosensitive sensilla and photoreceptors, electroreception in the Monotremata, language and the FOXP2 gene, mirror neurons and the molecular biology of pain Updated passages on human olfaction and gustation. Over four hundred illustrations, boxes containing supplementary material and self-assessment questions and a full bibliography at the end of each part make Biology of Sensory Systems essential reading for undergraduate students of biology, zoology, animal physiology, neuroscience, anatomy and physiological psychology. The book is also suitable for postgraduate students in more specialised courses such as vision sciences, optometry, neurophysiology, neuropathology, developmental biology. Praise from the reviews of the first edition: "An excellent advanced undergraduate/postgraduate textbook." ASLIB BOOK GUIDE "The emphasis on comparative biology and evolution is one of the distinguishing features of this self-contained book. .... this is an informative and thought-provoking text..." TIMES HIGHER EDUCATIONAL SUPPLEMENT

The Tribute of Physiology for the Understanding of COVID-19 Disease

Author : Georges Leftheriotis
Publisher : Frontiers Media SA
ISBN 13 : 2889716546
Total Pages : 406 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The Tribute of Physiology for the Understanding of COVID-19 Disease by : Georges Leftheriotis

Download or read book The Tribute of Physiology for the Understanding of COVID-19 Disease written by Georges Leftheriotis and published by Frontiers Media SA. This book was released on 2021-11-23 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Interplay between Metabolism and Chromosomes in Tumorigenesis

Author : Jiayi Wang
Publisher : Frontiers Media SA
ISBN 13 : 2832500242
Total Pages : 199 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The Role of Interplay between Metabolism and Chromosomes in Tumorigenesis by : Jiayi Wang

Download or read book The Role of Interplay between Metabolism and Chromosomes in Tumorigenesis written by Jiayi Wang and published by Frontiers Media SA. This book was released on 2022-09-22 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Customized Cancer Treatment

Author : Ralph W. Moss
Publisher :
ISBN 13 : 9781881025016
Total Pages : 0 pages
Book Rating : 4.0/5 (25 download)

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Book Synopsis Customized Cancer Treatment by : Ralph W. Moss

Download or read book Customized Cancer Treatment written by Ralph W. Moss and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Customized Cancer Treatment is the first book for the layperson on chemosensitivity testing. This is a laboratory procedure by which patients and their doctors can discover which drugs are mostly like to work for them and which to avoid. Chemosensitivity testing is very effective at finding the best drugs for each individual. It is a form of personalized treatment. According to Dr. Robert Nagourney, No cancer patient should begin treatment without first reading this book.