Chemometric Tools For Automated Method Development And Data Interpretation In Liquid Chromatography

Download Chemometric Tools For Automated Method Development And Data Interpretation In Liquid Chromatography full books in PDF, epub, and Kindle. Read online Chemometric Tools For Automated Method Development And Data Interpretation In Liquid Chromatography ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Chemometric Tools for Automated Method-development and Data Interpretation in Liquid Chromatography

Author :
Publisher :
ISBN 13 : 9789464835250
Total Pages : 0 pages
Book Rating : 4.8/5 (352 download)

DOWNLOAD NOW!

Book Synopsis Chemometric Tools for Automated Method-development and Data Interpretation in Liquid Chromatography by :

Download or read book Chemometric Tools for Automated Method-development and Data Interpretation in Liquid Chromatography written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thesis explores the challenges and advancements in the field of liquid chromatography (LC), particularly focusing on complex sample analysis using high-resolution mass spectrometry (MS) and two-dimensional (2D) LC techniques. The research addresses the need for efficient optimization and data-handling strategies in modern LC practice. The thesis is divided into several chapters, each addressing specific aspects of LC and polymer analysis.Chapter 2 provides an overview of the need for chemometric tools in LC practice, discussing methods for processing and analyzing data from 1D and 2D-LC systems and how chemometrics can be utilized for method development and optimization.Chapter 3 introduces a novel approach for interpreting the molecular-weight distribution and intrinsic viscosity of polymers, allowing quantitative analysis of polymer properties without prior knowledge of their interactions. This method correlates the curvature parameter of the Mark-Houwink plot with the polymer's structural and chemical properties.Chapters 4 and 5 focus on the analysis of cellulose ethers (CEs), essential in various industrial applications. A new method is presented for mapping the substitution degree and composition of CE samples, providing detailed compositional distributions. Another method involves a comprehensive 2D LC-MS/MS approach for analyzing hydroxypropyl methyl cellulose (HPMC) monomers, revealing subtle differences in composition between industrial HPMC samples.Chapter 6 introduces AutoLC, an algorithm for automated and interpretive development of 1D-LC separations. It uses retention modeling and Bayesian optimization to achieve optimal separation within a few iterations, significantly improving the efficiency of gradient LC separations.Chapter 7 focuses on the development of an open-source algorithm for automated method development in 2D-LC-MS systems. This algorithm improves separation performance by refining gradient profiles and accurately predicting peak widths, enhancing the reliability of complex gradient LC separations.Chapter 8 addresses the challenge of gradient deformation in LC instruments. An algorithm based on the stable function corrects instrument-specific gradient deformations, enabling accurate determination of analyte retention parameters and improving data comparability between different sources.Chapter 9 introduces a novel approach using capacitively-coupled-contactless-conductivity detection (C4D) to measure gradient profiles without adding tracer components. This method enhances inter-system transferability of retention models for polymers, overcoming the limitations of UV-absorbance detectable tracer components.Chapter 10 discusses practical choices and challenges faced in the thesis chapters, highlighting the need for well-defined standard samples in industrial polymer analysis and emphasizing the importance of generalized problem-solving approaches.The thesis identifies future research directions, emphasizing the importance of computational-assisted methods for polymer analysis, the utilization of online reaction modulation techniques, and exploring continuous distributions obtained through size-exclusion chromatography (SEC) in conjunction with triple detection. Chemometric tools are recognized as essential for gaining deeper insights into polymer chemistry and improving data interpretation in the field of LC.

Liquid Chromatography

Author : Salvatore Fanali
Publisher : Elsevier
ISBN 13 : 0128093447
Total Pages : 840 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Liquid Chromatography by : Salvatore Fanali

Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2017-06-23 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. - Emphasizes the integration of chromatographic methods and sample preparation - Explains how liquid chromatography is used in different industrial sectors - Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) - Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making

Chemometrics in Chromatography

Author : Łukasz Komsta
Publisher : CRC Press
ISBN 13 : 1498772544
Total Pages : 506 pages
Book Rating : 4.4/5 (987 download)

DOWNLOAD NOW!

Book Synopsis Chemometrics in Chromatography by : Łukasz Komsta

Download or read book Chemometrics in Chromatography written by Łukasz Komsta and published by CRC Press. This book was released on 2018-02-02 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemometrics uses advanced mathematical and statistical algorithms to provide maximum chemical information by analyzing chemical data, and obtain knowledge of chemical systems. Chemometrics significantly extends the possibilities of chromatography and with the technological advances of the personal computer and continuous development of open-source software, many laboratories are interested in incorporating chemometrics into their chromatographic methods. This book is an up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.

Comprehensive Two Dimensional Gas Chromatography

Author : Lourdes Ramos
Publisher : Elsevier
ISBN 13 : 008093269X
Total Pages : 324 pages
Book Rating : 4.0/5 (89 download)

DOWNLOAD NOW!

Book Synopsis Comprehensive Two Dimensional Gas Chromatography by : Lourdes Ramos

Download or read book Comprehensive Two Dimensional Gas Chromatography written by Lourdes Ramos and published by Elsevier. This book was released on 2009-07-22 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book reviews the basic concepts and highlights the most relevant advances and developments that have taken place in the field of comprehensive two dimensional gas chromatography (GC x GC) since its introduction in 1991. The several instrumental and technical approaches assayed and developed during these seventeen years and that have contributed to the development of this powerful separation technique and to its increasing application in many areas is explained and comprehensively illustrated through a number of chapters devoted these specific topics. More specialized aspects of the technique, including theoretical aspects, modelization of the chromatographic process, software developments, and alternative couplings is also covered. Finally, special attention is paid to data treatment, for both qualitative and quantitative analysis. This book will be a practical resource that will explain from basic to specialized concepts of GC x GC and will show the current state-of-the-art and discuss future trends of this technique. - Outlines basic concepts and principles of GCxGC technique for non-specialists to apply the technique to their research - Provides detailed descriptions of recent technical advances and serves as an instructional guide in latest applications in GCxGC - Sets the scene for possible future development and alternative new applications of technique

Comprehensive Foodomics

Author :
Publisher : Elsevier
ISBN 13 : 0128163968
Total Pages : 2444 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Comprehensive Foodomics by :

Download or read book Comprehensive Foodomics written by and published by Elsevier. This book was released on 2020-11-12 with total page 2444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Foodomics, Three Volume Set offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics and related technologies, including the latest advances and applications. By bringing all this information together in an easily navigable reference, food scientists and nutritionists in both academia and industry will find it the perfect, modern day compendium for frequent reference. List of sections and Section Editors: Genomics - Olivia McAuliffe, Dept of Food Biosciences, Moorepark, Fermoy, Co. Cork, Ireland Epigenetics & Noncoding RNA - Juan Cui, Department of Computer Science & Engineering, University of Nebraska-Lincoln, Lincoln, NE Transcriptomics - Robert Henry, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Australia Proteomics - Jens Brockmeyer, Institute of Biochemistry and Technical Biochemistry, University Stuttgart, Germany Metabolomics - Philippe Schmitt-Kopplin, Research Unit Analytical BioGeoChemistry, Neuherberg, Germany Omics data treatment, System Biology and Foodomics - Carlos Leon Canseco, Visiting Professor, Biomedical Engineering, Universidad Carlos III de Madrid Green Foodomics - Elena Ibanez, Foodomics Lab, CIAL, CSIC, Madrid, Spain Food safety and Foodomics - Djuro Josic, Professor Medicine (Research) Warren Alpert Medical School, Brown University, Providence, RI, USA & Sandra Kraljevic Pavelic, University of Rijeka, Department of Biotechnology, Rijeka, Croatia Food Quality, Traceability and Foodomics - Daniel Cozzolino, Centre for Nutrition and Food Sciences, The University of Queensland, Queensland, Australia Food Bioactivity, Health and Foodomics - Miguel Herrero, Department of Bioactivity and Food Analysis, Foodomics Lab, CIAL, CSIC, Madrid, Spain Brings all relevant foodomics information together in one place, offering readers a ‘one-stop,’ comprehensive resource for access to a wealth of information Includes articles written by academics and practitioners from various fields and regions Provides an ideal resource for students, researchers and professionals who need to find relevant information quickly and easily Includes content from high quality authors from across the globe

Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring

Author : Melissa N. Dunkle
Publisher : John Wiley & Sons
ISBN 13 : 1119523303
Total Pages : 464 pages
Book Rating : 4.1/5 (195 download)

DOWNLOAD NOW!

Book Synopsis Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring by : Melissa N. Dunkle

Download or read book Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring written by Melissa N. Dunkle and published by John Wiley & Sons. This book was released on 2020-09-01 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough introduction to environmental monitoring in the oil and gas industry Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring examines the analytical side of the oil and gas industry as it also provides an overall introduction to the industry. You’ll discover how oil and natural gas are sourced, refined, and processed. You can learn about what’s produced from oil and natural gas, and why evaluating these sourced resources is important. The book discusses the conventional analyses for oil and natural gas feeds, along with their limitations. It offers detailed descriptions of advanced analytical techniques that are commercially available, plus explanations of gas and oil industry equipment and instrumentation. You’ll find technique descriptions supplemented with a list of references as well as with real-life application examples. With this book as a reference, you can prepare to apply specific analytical methods in your organization’s lab environment. Analytical Techniques can also serve as your comprehensive resource on key techniques in the characterization of oil and gas samples, within both refinery and environmental contexts. Understand of the scope of oil and gas industry techniques available Consider the benefits and limitations of each available process Prepare for applying analytical techniques in your lab See real examples and a list of references for each technique Read descriptions of off-line analytics, as well as on-line and process applications As a chemist, engineer, instructor, or student, this book will also expand your awareness of the role these techniques have in environmental monitoring and environmental impact assessments.

Chemometrics

Author : Matthias Otto
Publisher : John Wiley & Sons
ISBN 13 : 3527699384
Total Pages : 400 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!

Book Synopsis Chemometrics by : Matthias Otto

Download or read book Chemometrics written by Matthias Otto and published by John Wiley & Sons. This book was released on 2016-09-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of this long-selling introductory textbook and ready reference covers all pertinent topics, from basic statistics via modeling and databases right up to the latest regulatory issues. The experienced and internationally recognized author, Matthias Otto, introduces the statistical-mathematical evaluation of chemical measurements, especially analytical ones, going on to provide a modern approach to signal processing, designing and optimizing experiments, pattern recognition and classification, as well as modeling simple and nonlinear relationships. Analytical databases are equally covered as are applications of multiway analysis, artificial intelligence, fuzzy theory, neural networks, and genetic algorithms. The new edition has 10% new content to cover such recent developments as orthogonal signal correction and new data exchange formats, tree based classification and regression, independent component analysis, ensemble methods and neuro-fuzzy systems. It still retains, however, the proven features from previous editions: worked examples, questions and problems, additional information and brief explanations in the margin.

Laboratory Automation in the Chemical Indus

Author : David G. Cork
Publisher : CRC Press
ISBN 13 : 9780203908945
Total Pages : 392 pages
Book Rating : 4.9/5 (89 download)

DOWNLOAD NOW!

Book Synopsis Laboratory Automation in the Chemical Indus by : David G. Cork

Download or read book Laboratory Automation in the Chemical Indus written by David G. Cork and published by CRC Press. This book was released on 2002-04-02 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring extensive calculations and examples, this reference discusses theoretical and practical aspects of short-circuit currents in ac and dc systems, load flow, and harmonic analyses to provide a sound knowledge base for modern computer-based studies that can be utilized in real-world applications. Presenting more than 2300 figures, tables, and equations, the author explores matrix methods for network solutions and includes load flow and optimization techniques. He discusses ac and dc short-circuit systems calculations in accordance with standards set by the American National Standards Institute (ANSI) and the International Electrotechnical Commission (IEC).

1987 Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 954 pages
Book Rating : 4.:/5 (42 download)

DOWNLOAD NOW!

Book Synopsis 1987 Abstracts by :

Download or read book 1987 Abstracts written by and published by . This book was released on 1987 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Applied Chemoinformatics

Author : Thomas Engel
Publisher : John Wiley & Sons
ISBN 13 : 352734201X
Total Pages : 660 pages
Book Rating : 4.5/5 (273 download)

DOWNLOAD NOW!

Book Synopsis Applied Chemoinformatics by : Thomas Engel

Download or read book Applied Chemoinformatics written by Thomas Engel and published by John Wiley & Sons. This book was released on 2018-06-05 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of the properties of chemicals, the development of new cosmetics products, quality control in food, the design of new materials with improved properties, toxicity modeling, assessment of the risk of chemicals, and the control of chemical processes. The book is aimed at advanced students as well as lectures but also at scientists that want to learn how chemoinformatics could assist them in solving their daily scientific tasks. Together with the corresponding textbook Chemoinformatics - Basic Concepts and Methods (ISBN 9783527331093) on the fundamentals of chemoinformatics readers will have a comprehensive overview of the field.

Hayes' Principles and Methods of Toxicology

Author : A. Wallace Hayes
Publisher : CRC Press
ISBN 13 : 1842145371
Total Pages : 2141 pages
Book Rating : 4.8/5 (421 download)

DOWNLOAD NOW!

Book Synopsis Hayes' Principles and Methods of Toxicology by : A. Wallace Hayes

Download or read book Hayes' Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap

Statistics for Analytical Chemistry

Author : Jane C. Miller
Publisher : Ellis Horwood Limited
ISBN 13 : 9780138454210
Total Pages : 227 pages
Book Rating : 4.4/5 (542 download)

DOWNLOAD NOW!

Book Synopsis Statistics for Analytical Chemistry by : Jane C. Miller

Download or read book Statistics for Analytical Chemistry written by Jane C. Miller and published by Ellis Horwood Limited. This book was released on 1992 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Handbook of Metabonomics and Metabolomics

Author : John C. Lindon
Publisher : Elsevier
ISBN 13 : 0080468004
Total Pages : 573 pages
Book Rating : 4.0/5 (84 download)

DOWNLOAD NOW!

Book Synopsis The Handbook of Metabonomics and Metabolomics by : John C. Lindon

Download or read book The Handbook of Metabonomics and Metabolomics written by John C. Lindon and published by Elsevier. This book was released on 2011-08-11 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.* comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies* aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification* covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Journal of Chromatography

Author :
Publisher :
ISBN 13 :
Total Pages : 604 pages
Book Rating : 4.6/5 (156 download)

DOWNLOAD NOW!

Book Synopsis Journal of Chromatography by :

Download or read book Journal of Chromatography written by and published by . This book was released on 2002 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques

Author : Paul H. Gamache
Publisher : John Wiley & Sons
ISBN 13 : 0470937785
Total Pages : 548 pages
Book Rating : 4.4/5 (79 download)

DOWNLOAD NOW!

Book Synopsis Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques by : Paul H. Gamache

Download or read book Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques written by Paul H. Gamache and published by John Wiley & Sons. This book was released on 2017-05-30 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors’ professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection Includes contributions from experts from various fields of applications who explore CAD’s advantages over traditional HPLC techniques, as well its limitations Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.

HPLC for Pharmaceutical Scientists

Author : Yuri V. Kazakevich
Publisher : John Wiley & Sons
ISBN 13 : 0470087943
Total Pages : 1136 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis HPLC for Pharmaceutical Scientists by : Yuri V. Kazakevich

Download or read book HPLC for Pharmaceutical Scientists written by Yuri V. Kazakevich and published by John Wiley & Sons. This book was released on 2007-02-16 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

Practical Guide To Chemometrics

Author : Paul Gemperline
Publisher : CRC Press
ISBN 13 : 1420018302
Total Pages : 555 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Practical Guide To Chemometrics by : Paul Gemperline

Download or read book Practical Guide To Chemometrics written by Paul Gemperline and published by CRC Press. This book was released on 2006-04-16 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The limited coverage of data analysis and statistics offered in most undergraduate and graduate analytical chemistry courses is usually focused on practical aspects of univariate methods. Drawing in real-world examples, Practical Guide to Chemometrics, Second Edition offers an accessible introduction to application-oriented multivariate meth