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Chemokines In Disease
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Book Synopsis Chemokines, Chemokine Receptors and Disease by : Lisa M. Schwiebert
Download or read book Chemokines, Chemokine Receptors and Disease written by Lisa M. Schwiebert and published by Gulf Professional Publishing. This book was released on 2005-09-02 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research
Book Synopsis Chemokine Biology - Basic Research and Clinical Application by : Kuldeep Neote
Download or read book Chemokine Biology - Basic Research and Clinical Application written by Kuldeep Neote and published by Springer Science & Business Media. This book was released on 2007-08-08 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Book Synopsis Cytokines and Chemokines in Autoimmune Disease by : Pere Santamaria
Download or read book Cytokines and Chemokines in Autoimmune Disease written by Pere Santamaria and published by Springer. This book was released on 2003-01-31 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book attempts to capture recent knowledge on the role of cytokines and chemokines in autoimmunity by focusing on some of the most prevalent organ-specific or systemic autoimmune disorders. After beginning chapters on the function and structure of cytokines and chemokines, sections cover their genetics and mechanisms of action in the context of autoimmunity, and the role of different cytokines and chemokines in various autoimmune disorders. Santamaria teaches in the Department of Microbiology and Infectious Diseases at the University of Calgary, Canada.
Book Synopsis Chemokines in Disease by : Caroline A. Hébert
Download or read book Chemokines in Disease written by Caroline A. Hébert and published by Springer Science & Business Media. This book was released on 1999-06-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caroline Hébert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases.
Book Synopsis Fundamentals of Inflammation by : Charles N. Serhan
Download or read book Fundamentals of Inflammation written by Charles N. Serhan and published by Cambridge University Press. This book was released on 2010-04-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
Book Synopsis Chemokines in Disease by : Alisa E. Koch
Download or read book Chemokines in Disease written by Alisa E. Koch and published by R. G. Landes. This book was released on 1996 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemokine Roles in Immunoregulation and Disease by : Philip M. Murphy
Download or read book Chemokine Roles in Immunoregulation and Disease written by Philip M. Murphy and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ernst Schering Workshop on Chemokine Roles in Immunoregulation and Disease, with contributions by leading experts in the field, succinctly summarizes cutting-edge research in immunology, protein chemistry, and disease. This book gives an up-to-date overview of important developments in immunology with a concise, state-of-the-art review of chemokines. It is a time-saving reference for both researchers and students, providing fast and easy access to the latest information in this important area of research.
Book Synopsis Chemokine Biology - Basic Research and Clinical Application by : Bernhard Moser
Download or read book Chemokine Biology - Basic Research and Clinical Application written by Bernhard Moser and published by Springer Science & Business Media. This book was released on 2006-03-16 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two-volume set discusses the immunobiology of chemokines. It is divided into two parts: a) cellular targets in innate and adaptive immunity, and b) effector cell traffic-unrelated functions. Together with volume 2, which discusses the pathophysiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Author :Surendran Mahalingam Publisher :Springer Science & Business Media ISBN 13 :9780306482342 Total Pages :140 pages Book Rating :4.4/5 (823 download)
Book Synopsis Chemokines in Viral Infections by : Surendran Mahalingam
Download or read book Chemokines in Viral Infections written by Surendran Mahalingam and published by Springer Science & Business Media. This book was released on 2004-10-14 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past five years, a large number of new chemokines and chemokine receptors have been identified. Alarming progress in the areas of bioinformatics and expressed sequence tag (EST) databases attributed to this development. Recent discoveries provide compelling evidences supporting the roles of these messengers and their receptors in the control of viral infection as well as in aiding virus survival. Chemokines in Viral Infections is the first to provide a comprehensive write up on the various evidences available to date on the interactions between host chemokine system and viral chemokines. This book intends to unravel the chemokine constellation in the context of viral infections, a versatility that was not fully understood five years ago. This book is excellent reading material and will be of interest to research scientists, clinicians and postgraduate students.
Book Synopsis Cytokines and Chemokines in Infectious Diseases Handbook by : Malak Kotb
Download or read book Cytokines and Chemokines in Infectious Diseases Handbook written by Malak Kotb and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.
Book Synopsis Universes in Delicate Balance: Chemokines and the Nervous System by : R.M. Ransohoff
Download or read book Universes in Delicate Balance: Chemokines and the Nervous System written by R.M. Ransohoff and published by Elsevier. This book was released on 2002-04-29 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development. Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue. This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts. The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis. Understanding human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.
Book Synopsis Chemokine Receptors in Health and Disease by :
Download or read book Chemokine Receptors in Health and Disease written by and published by Elsevier. This book was released on 2024-09-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells’ surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer. Chemokine receptors in the era of single cell gene and protein analysis Chemokine receptor’s role in COVID-19 Update in the role of chemokine receptors in health and disease
Book Synopsis Chemokine Receptors in Cancer by : Amy M. Fulton
Download or read book Chemokine Receptors in Cancer written by Amy M. Fulton and published by Springer Science & Business Media. This book was released on 2009-06-12 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.
Download or read book Chemokines and Skin written by Kownatzki and published by Springer. This book was released on 2012-12-06 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume summarizes the state of information on chemokines focussing on skin diseases. The first three chapters deal with the structure and molecular biology of chemokines and their receptors. The following three review information on the interaction of chemokines with lymphocytes, mast cells and eosinophilic granulocytes. One chapter deals with the expression of chemokines in several inflammatory skin diseases. The final chapter reports on in vitro evidence for a growth-promoting activity of chemokines in skin-derived tumor cells. The volume is of use for the basic scientist interested in practical aspects and for the physician in search for basic mechanisms of skin diseases.
Book Synopsis Chemokine Receptors and AIDS by : Thomas R. O'Brien
Download or read book Chemokine Receptors and AIDS written by Thomas R. O'Brien and published by CRC Press. This book was released on 2019-04-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative reference presents the latest research on the role of chemokines, chemokine receptors, and genetic variability in the susceptibility, prevention, and treatment of HIV-1-exploring new therapeutic strategies for improved treatment of HIV-1 infected patients by blocking chemokine receptor expression. With contributions from s
Book Synopsis Chemokine Research Trends by : Leah R. Grinwald
Download or read book Chemokine Research Trends written by Leah R. Grinwald and published by Nova Publishers. This book was released on 2007 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines are the cytokines that may activate or chemoattract leukocytes. Each chemokine contains 65-120 amino acids, with molecular weight of 8-10 kD. Their receptors belong to G-protein-coupled receptors. Inflammatory chemokines are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. They function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or damage. They can be released by many different cell types and serve to guide cells involved in innate immunity and also the lymphocytes of the adaptive immune system. The cells that are attracted by chemokines follow a signal of increasing chemokine concentration to the site of infection or tissue injury. Some chemokines also have roles in the development of lymphocytes, migration and angiogenesis (the growth of new blood vessels).Since the entry of HIV into host cells requires chemokine receptors, their antagonists are being developed to treat AIDS.
Book Synopsis Chemokine Receptors as Drug Targets by : Martine J. Smit
Download or read book Chemokine Receptors as Drug Targets written by Martine J. Smit and published by John Wiley & Sons. This book was released on 2010-12-07 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.
