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Author : Environmental Mutagen Information Center (U.S.)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (429 download)
Download or read book Chemical Mutagenesis in Laboratory Mammals written by Environmental Mutagen Information Center (U.S.) and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 164 pages
Book Rating : 4.E/5 ( download)
Download or read book Chemical Mutagenesis in Laboratory Mammals written by and published by . This book was released on 1973 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 350 references to books and journal articles published during 1928-1973. Also covers foreign-language literature. Arranged under citation index, Agent index, Chemical abstracts registry number index, Organism index, KWIC index, Author index, First author index, and Addendum. Entries in Citation index and First author index provide essential bibliographical information.
Author : Environmental Mutagen Information Center (U.S.)
Publisher :
ISBN 13 :
Total Pages : 105 pages
Book Rating : 4.:/5 (427 download)
Download or read book Chemical Mutagenesis in Laboratory Mammals written by Environmental Mutagen Information Center (U.S.) and published by . This book was released on 1976 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 650 references; mostly journal articles dating from the 1960's to 1975. Also includes foreign-language literature. Arranged under Citation index, Agent index, Chemical abstracts service registry number index, Taxonomic index, Test object index, Mammalian germ cell assay systems index, Author index, and KWIC index. Entry in Citation index gives bibliographical information.
Author : W. L. Russell
Publisher :
ISBN 13 :
Total Pages : 13 pages
Book Rating : 4.:/5 (19 download)
Download or read book The Role of Mammals in the Future of Chemical Mutagenesis Research written by W. L. Russell and published by . This book was released on 1977 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F Vogel (Ed)
Publisher :
ISBN 13 :
Total Pages : 556 pages
Book Rating : 4.:/5 (42 download)
Download or read book Chemical Mutagenesis in Mammals and Man written by F Vogel (Ed) and published by . This book was released on 1970 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G.E. Paget
Publisher : Springer Science & Business Media
ISBN 13 : 9401166390
Total Pages : 234 pages
Book Rating : 4.4/5 (11 download)
Download or read book Mutagenesis in Sub-Mammalian Systems written by G.E. Paget and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in Toxicology Toxicology is a science that stands at the intersection of several interests and disciplines. These intersecting forces are by no means all scientific since some are legal and some are commercial. All have valid things to say about the conduct and interpretation of toxicity experiments. The practising toxicologist must bear all these sometimes conflicting forces in mind as he carries out his duties. This is especially true, of course, of the toxicologist in industry. Toxicology is also a field in which contract research particularly flourishes and a number of major contract research companies have established over the years a reputation for contributing usefully to the practice of this skill. These contract research organisations are particu larly favoured to develop an appreciation of the problems of the industrial toxicologist, since it is very common for such a company to service the toxicological needs of companies in several sectors of industry producing new chemical compounds, and the contract research company, therefore, is aware of a wider diversity of problems than probably affects a single toxicologist in one industry.
Author : Frederick De Serres
Publisher : Springer Science & Business Media
ISBN 13 : 1461334098
Total Pages : 1113 pages
Book Rating : 4.4/5 (613 download)
Download or read book Comparative Chemical Mutagenesis written by Frederick De Serres and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 1113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari sons. To restate the first comparison: is the chemical under ques tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms.
Author : Monica Justice
Publisher : Springer Science & Business Media
ISBN 13 : 1402050577
Total Pages : 98 pages
Book Rating : 4.4/5 (2 download)
Download or read book Mutagenesis of the Mouse Genome written by Monica Justice and published by Springer Science & Business Media. This book was released on 2007-11-12 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.
Author : Alexander Hollaender
Publisher : Springer Science & Business Media
ISBN 13 : 146158972X
Total Pages : 256 pages
Book Rating : 4.4/5 (615 download)
Download or read book Chemical Mutagens written by Alexander Hollaender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ready acceptance and wide demand for copies of the first two volumes of Chemical Mutagens: Principles and Methods Jar Their Detection have demon strated the need for wider dissemination of information on this timely and urgent subject. Therefore, it was imperative that a third volume be prepared to include more detailed discussions on techniques of some of the methods that were presented from a theoretical point of view in the first two volumes, and to update this rapidly expanding field with current findings and the new developments that have taken place in the past three years. Also included is a special chapter by Dr. Charlotte Auerbach giving the historical background of the discovery of chemical mutagenesis. Methods for recognizing mutagenic compounds in vitro are a necessary preliminary step toward arriving at satisfactory solutions for recognizing significant mutation rates in man, which must be done before our test tube methods of detection can be considered reliable. Two chapters in this volume make important contributions to this problem. Due to the increasing activity in efforts to perfect techniques for detecting chemical mutagens and their effects on man, it is planned to continue this series of volumes as necessary to keep abreast of current findings.
Author : Ashutosh Kumar
Publisher : Academic Press
ISBN 13 : 0128092602
Total Pages : 352 pages
Book Rating : 4.1/5 (28 download)
Download or read book Mutagenicity: Assays and Applications written by Ashutosh Kumar and published by Academic Press. This book was released on 2017-09-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
Author : National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology
Publisher : Routledge
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.1/5 (384 download)
Download or read book Biologic Markers in Reproductive Toxicology written by National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology and published by Routledge. This book was released on 1989 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F.J. De Serres
Publisher : Springer Science & Business Media
ISBN 13 : 1461337399
Total Pages : 343 pages
Book Rating : 4.4/5 (613 download)
Download or read book Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk written by F.J. De Serres and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never theless, the potential hazards of many chemicals have been identi fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.
Author : Martha M. Moore
Publisher : Cold Spring Harbor Laboratory Press
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.:/5 (44 download)
Download or read book Mammalian Cell Mutagenesis written by Martha M. Moore and published by Cold Spring Harbor Laboratory Press. This book was released on 1987 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309166152
Total Pages : 254 pages
Book Rating : 4.3/5 (91 download)
Download or read book Safety of Genetically Engineered Foods written by National Research Council and published by National Academies Press. This book was released on 2004-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171474
Total Pages : 167 pages
Book Rating : 4.3/5 (91 download)
Download or read book Microbial Status and Genetic Evaluation of Mice and Rats written by National Research Council and published by National Academies Press. This book was released on 2000-10-30 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.
Author : Alexander Hollaender
Publisher : Springer Science & Business Media
ISBN 13 : 1461321476
Total Pages : 316 pages
Book Rating : 4.4/5 (613 download)
Download or read book Chemical Mutagens written by Alexander Hollaender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 9 of Chemical Mutagens consists mainly of chapters discussing the development and validation of short-term assays to detect the mutagenic effects of environmental chemicals. These chapters include an assay with the grasshopper neuroblast, a comparison of mutagenic responses of human lung-derived and skin-derived diploid fibroblasts, a forward-mutation assay in Salmonella, a multigene sporulation test in Bacillus subtilis, a specific locus assay in mouse lymphoma cells, a study of the induction of bacteriophage lambda, and the granuloma pouch assay. In addition, there are two chapters on the identification of mutagens in cooked food and in human feces. Frederick 1. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 The Grasshopper Neuroblast Short-Term Assay for Evaluating the Effects of Environmental Chemicals on Chromosomes and Cell Kinetics 1 Mary Esther Gaulden, Jan C. Liang, and Martha J. Ferguson 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Embryo Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 1. Species. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 2. Origin of Colonies . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 3. Life Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 4. Colony Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 5. Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2. 6. Allergy to Grasshoppers . . . . . . . . . . . . . . . . . . . . . . 14 3. Grasshopper Egg, Embryo, and Cells . . . . . . . . . . . . . . . . . 14 3. 1. The Egg Shell and Membranes . . . . . . . . . . . . . . . . . 14 3. 2. Embryonic Development . . . . . . . . . . . . . . . . . . . . . . 17 3. 3. Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4. Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 1. Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 2. Preparation of Embryos for Cell Analysis . . . . . . . . . 34 4. 3. Analysis of Mutagen Effects. . . . . . . . . . . . . . . . . 40 . . . 5. Response of the Grasshopper Neuroblast to Mutagens . . . . 50 5. 1. Reproducibility of Data . . . . . . . . . . . . . . . . . . . . . . . 50 5. 2. Radiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 5. 3. Chemical Mutagens . . . . . . . . . . . . . . . . . . . . . . . . . .
Author : Abraham W. Hsie
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.3/5 (91 download)
Download or read book Mammalian Cell Mutagenesis written by Abraham W. Hsie and published by . This book was released on 1979 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
