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Chemical And Molecular Approach To Tumor Metastases
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Book Synopsis Chemical and Molecular Approach to Tumor Metastases by : Gianni Sava
Download or read book Chemical and Molecular Approach to Tumor Metastases written by Gianni Sava and published by MDPI. This book was released on 2018-07-05 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Chemical and Molecular Approach to Tumor Metastases" that was published in IJMS
Book Synopsis Chemical and Molecular Approach to Tumor Metastases by : Alberta Bergamo
Download or read book Chemical and Molecular Approach to Tumor Metastases written by Alberta Bergamo and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical and Molecular Approach to Tumor Metastases.
Book Synopsis Chemical and Molecular Approach to Tumor Metastases by : Gianni Sava (Ed.)
Download or read book Chemical and Molecular Approach to Tumor Metastases written by Gianni Sava (Ed.) and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Approach to Cancer Management by : Gajanan V. Sherbet
Download or read book Molecular Approach to Cancer Management written by Gajanan V. Sherbet and published by Academic Press. This book was released on 2017-06-15 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach
Book Synopsis The Molecular Biology of Cancer by : Harris Busch
Download or read book The Molecular Biology of Cancer written by Harris Busch and published by Academic Press. This book was released on 2013-10-22 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard to its biosynthesis, inhibition of synthesis, and development of resistance to inhibitors. The book further tackles the biochemical mechanisms of chemical carcinogenesis; the oncogenic viruses; and the molecular correlation concept. The text also demonstrates phenotypic variability as a manifestation of translational control; and plasmacytomas. Molecular biologists, virologists, pathologists, cell biologists, oncologists, pharmacologists, and students taking related courses will find the book useful.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Extracellular Targeting of Cell Signaling in Cancer by : James W. Janetka
Download or read book Extracellular Targeting of Cell Signaling in Cancer written by James W. Janetka and published by John Wiley & Sons. This book was released on 2018-07-23 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.
Book Synopsis Introduction to Cancer Metastasis by : Aamir Ahmad
Download or read book Introduction to Cancer Metastasis written by Aamir Ahmad and published by Academic Press. This book was released on 2016-11-14 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe
Book Synopsis Prostaglandins in Cancer Research by : Enrico Garaci
Download or read book Prostaglandins in Cancer Research written by Enrico Garaci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol ume is based on papers presented at the 1986 International Confer ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as pects of the complex phenomenon "cancer". Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos sible use of some of these compounds as antineoplastic agents.
Book Synopsis Homeostasis - Tumor - Metastasis by : Gaspar Banfalvi
Download or read book Homeostasis - Tumor - Metastasis written by Gaspar Banfalvi and published by Springer Science & Business Media. This book was released on 2013-10-16 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis. The health of an organism is influenced by external and internal changes that may lead to the loss of homeostasis. Under healthy conditions organisms compensate these changes. If compensation fails disease ensues. Attention will be paid to lifestyle, environmental changes, genetic makeup and health system. It will be answered how lifestyle, environment, genetic makeup and social conditions help to maintain or upset the biological balance and lead to cancer. Tumor formation. To understand this process the transfer of intracellular and the pathways of extracellular information (signal transduction) will be reviewed briefly. Loss of cellular balance may lead to cell death (.e.g. apoptosis) or to rapid cell growth of cells leading to tumor formation. Metastasis. Animal tumor models serve to understand the spread of the primary tumor cells to distant locations of the organism. Different types of tumors and metastases will be reviewed.
Book Synopsis Molecular Chemistry and Biomolecular Engineering by : Lionello Pogliani
Download or read book Molecular Chemistry and Biomolecular Engineering written by Lionello Pogliani and published by CRC Press. This book was released on 2019-09-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume is devoted to molecular chemistry and its applications to the fields of biology. It looks at the integration of molecular chemistry with biomolecular engineering, with the goal of creating new biological or physical properties to address scientific or societal challenges. It takes a both multidisciplinary and interdisciplinary perspective on the interface between molecular biology, biophysical chemistry, and chemical engineering. Molecular Chemistry and Biomolecular Engineering: Integrating Theory and Research with Practice provides effective support for the development of the laboratory and data analysis skills that researchers will draw on time and again for the practical aspects and also gives a solid grounding in the broader transferable skills.
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Book Synopsis Metastasis Research Protocols by : Miriam Dwek
Download or read book Metastasis Research Protocols written by Miriam Dwek and published by Humana. This book was released on 2016-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diverse molecular, cellular, and environmental events must all come together to allow the successful formation of secondary cancers, metastases. The second edition of Metastasis Research Protocols, brings together updated versions of the seminal technique that were presented in the first edition and also includes new techniques that have recently been shown to be important in illuminating the processes underlying this important area of biology. Volume 2 presents techniques applicable at the level of living cells and tissues, and presents methodologies applicable to cell behaviour in vitro, in animal models and in mathematical constructs. The aim is the study of the interaction between cancer cells and their host/environment. The focus throughout is on the tools that have been shown to be helpful in unravelling the processes important in cancer metastasis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Metastasis Research Protocols, Second Edition seeks to aid scientists in the further study of new methods in the area of metastasis research.
Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Biology by : Raymond W. Ruddon
Download or read book Cancer Biology written by Raymond W. Ruddon and published by Oxford University Press, USA. This book was released on 1987 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Substantially expanded in its second edition, Cancer Biology incorporates the important recent advances in research on the cellular and molecular biology of cancer and provides a comprehensive discussion of the mechanisms of carcinogenesis. The text describes the malignant transformation of cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of diseased cells into the host organism. In addition to a new chapter on the biology of tumor metastasis, there are three new chapters on cancer causation, dealing with the chemical and physical carcinogens; viruses and oncogenes; and chromosomal abnormalities and gene depression. Updated material on growth factors and their receptors, differentiation, and the cell matrix is also presented, and the pathophysiology of cancer as a clinical disease is discussed. Praise for the first edition: "Highly recommended for readers who wish to spend several hours with a well-written, well-selected, effectively illustrated, and well-integrated overview of the sciences that join to make up the field of tumor biology."-- The New England Journal of Medicine. "I can think of no better introduction for a graduate student to contemporary cancer research, especially at the cellular level."--G.A. Currie in The Times Higher Education Supplement. "Ruddon provides a status report in a rapidly moving field. The material is will presented and current, and includes excellent essays on differentiation, phenotype expression, genetic mutation, and tumor growth.... A welcome contrast to multiauthor oncologic behemoths that are too heavy to carry and too expensive to acquire."--Journal of the American Medical Association
Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
