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Charting Novel Aspects Of The Cardiac Sodium Channel
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Download or read book Ion Channel Diseases written by and published by Academic Press. This book was released on 2011-09-06 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.
Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Book Synopsis Recent advances in voltage-gated sodium channels, their pharmacology and related diseases by : Mohamed Chahine
Download or read book Recent advances in voltage-gated sodium channels, their pharmacology and related diseases written by Mohamed Chahine and published by Frontiers E-books. This book was released on with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is our pleasure to co-edit a Research Topic on voltage-gated sodium channels pharmacology and related diseases. We are in a process to inviting submissions of novel research article, state-of-the-art review papers and viewpoints on this topic. All the papers will follow a peer-review process according to the guidelines of Frontiers in Pharmacology. Voltage-gated sodium channel play a critical role in electrical signalling in many excitable cells such as neurons, skeletal muscle cells and cardiac myocytes. They are responsible for the initiation and the propagation of action potential, allowing integration of higher processes. They are formed by one alpha subunit that forms the pore of the channel and one or several regulatory subunits. Sodium channels are the target for local anaesthetics, antiarrhythmic drugs, and anticonvulsants. This class of ion channels is prime target to several toxins. Recently, a number of mutations in sodium channels that often results in alterations of rapid channel gating have been identified and linked to human diseases. Such channelopathies cause periodic paralysis, myotonia, long QT syndrome and other cardiac conductance disturbances, pain, hemiplegic migraine, and epilepsy. Sodium channels play also a negative role in malignant cellular proliferation, chronic pain, and other diseases. Considering these crucial physiological and pathological implications, it is not surprising that sodium channels have been and still are key targets for drug development. This Research Topic of Frontiers of Pharmacology of Ion Channels and Channelopathies will focus on this important class of ion channels how they operate, their pharmacology and their implication in diseases.
Book Synopsis Cardiac Electrophysiology: From Cell to Bedside E-Book by : Douglas P. Zipes
Download or read book Cardiac Electrophysiology: From Cell to Bedside E-Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2009-05-06 with total page 1183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Electrophysiology: From Cell to Bedside defines the entire state of current scientific and clinical knowledge in this subspecialty. In response to the many major recent developments in the field, Drs. Zipes and Jalife have completely updated this modern classic, making the 5th Edition the most significant revision yet. From our latest understanding of ion channels, molecular genetics, and cardiac electrical activity through newly recognized syndromes, unique needs of special patient populations, and new diagnostic and therapeutic options, you'll find all the state-of-the-art guidance you need to make informed, effective clinical decisions. What's more, a significantly restructured organization, a new full-color layout, and full-text online access make reference easier than ever. Integrates the latest scientific understanding of arrhythmias with the newest clinical applications, giving you an informed basis for choosing the right treatment and management options for each patient. Synthesizes the knowledge of preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world, giving you a well-rounded, expert grasp of every issue that affects your patient management. Contains 24 new chapters (listed below) as well as exhaustive updates throughout, to keep you current with new scientific knowledge, newly discovered arrhythmia syndromes, and new diagnostic and therapeutic techniques. Developmental Regulation of Cardiac Ion Channels Neural Mechanisms of Initiating and Maintaining Arrhythmias Single Nucleotide Polymorphisms and Acquired Cardiac Arrhythmias Inheritable Sodium Channel Diseases Inheritable Potassium Channel Diseases Inheritable Diseases of Intracellular Calcium Regulation Morphological Correlates of Atrial Arrhythmias Andersen-Tawil Syndrome Timothy Syndrome Progressive Cardiac Conduction Disease Sudden Infant Death Syndrome Arrhythmias in Patients with Neurologic Disorders Autonomic Testing Cardiac Resynchronization Therapy Energy Sources for Catheter Ablation Linear Lesions to Ablate Atrial Fibrillation Catheter Ablation of Ventricular Arrhythmias in Patients with Structural Heart Disease Catheter Ablation of Ventricular Arrhythmias in Patients without Structural Heart Disease Catheter Ablation in Patients with Congenital Heart Disease Features a completely new section on "Arrhythmias in Special Populations" that explores arrhythmias in athletes ... gender differences in arrhythmias ... arrhythmias in pediatric patients ... and sleep-disordered breathing and arrhythmias. Offers an attractive new full-color design featuring color photos, tables, flow charts, ECGs, and more, making clinically actionable information easy to find and absorb at a glance. Includes full-text online access via Expert Consult, making reference easier for busy practitioners.
Book Synopsis Anatomy and Physiology by : J. Gordon Betts
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Electrophysiological Disorders of the Heart E-Book by : Sanjeev Saksena
Download or read book Electrophysiological Disorders of the Heart E-Book written by Sanjeev Saksena and published by Elsevier Health Sciences. This book was released on 2011-12-12 with total page 1726 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient problems. Stay current with the latest molecular and technical advances as well as new treatment options implemented over the last few years. Use the latest technologies and devices to accurately diagnose and manage heart rhythm disorders. Consult new and expanded coverage of regenerative therapies, echo-guided procedures, cardiac pacing, and CRT, as well as a new section on pediatric electrophysiology and imaging. Enjoy improved visual guidance with many new full-color images. Log on to www.expertconsult.com to easily search the complete contents online and access a downloadable image library.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2098 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiac Repolarization by : Ihor Gussak
Download or read book Cardiac Repolarization written by Ihor Gussak and published by Springer Science & Business Media. This book was released on 2003-03-13 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.
Book Synopsis Inherited cardiac diseases predisposing to sudden death, An Issue of Cardiac Electrophysiology Clinics, E-Book by : Rafik Tadros
Download or read book Inherited cardiac diseases predisposing to sudden death, An Issue of Cardiac Electrophysiology Clinics, E-Book written by Rafik Tadros and published by Elsevier Health Sciences. This book was released on 2023-08-11 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Rafik Tadros, Julia Cadrin-Tourigny, and Jason D. Roberts bring their considerable expertise to the topic of Inherited Cardiac Diseases Predisposing to Sudden Death. Top experts in the field cover key topics such as genetic counseling and genetic testing in inherited heart disease; implantable devices in genetic heart disease; gene-based therapy in inherited arrythmias and cardiomyopathies; personalized care in long QT syndrome; and more. - Contains 16 relevant, practice-oriented topics including novelties in Brugada syndrome: complex genetics, risk stratification and catheter ablation; novel approaches to treatment of catecholaminergic polymorphic ventricular tachycardia; investigation of unexplained cardiac arrest: phenotyping and genetic testing; impact of imaging to arrhythmic risk stratification in non-ischemic cardiomyopathy; and more. - Provides in-depth clinical reviews on inherited cardiac diseases predisposing to sudden death, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiac Electrophysiology by : Douglas P. Zipes
Download or read book Cardiac Electrophysiology written by Douglas P. Zipes and published by Saunders. This book was released on 2009 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the many major recent developments in the field, the authors have completely updated this modern classic, making this edition the most significant revision yet. Practitioners will find all the state-of-the-art guidance they need to make informed, effective clinical decisions.
Book Synopsis Cardiovascular Disability by : Institute of Medicine
Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Book Synopsis Miller's Anesthesia by : Lars I. Eriksson
Download or read book Miller's Anesthesia written by Lars I. Eriksson and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 3221 pages. Available in PDF, EPUB and Kindle. Book excerpt: From fundamental principles to advanced subspecialty procedures, this text is the go-to reference on the technical, scientific, and clinical challenges professionals face. Features new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design.
Book Synopsis Biology of Brain Disorders by : Daniela Tropea
Download or read book Biology of Brain Disorders written by Daniela Tropea and published by Frontiers Media SA. This book was released on 2018-01-31 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future. In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.
Book Synopsis Natural Healing for Dogs and Cats by : Diane Stein
Download or read book Natural Healing for Dogs and Cats written by Diane Stein and published by Crossing Press. This book was released on 2011-03-23 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable resource tells how to use nutrition, minerals, massage, herbs, homeopathy, acupuncture, acupressure, flower essences, and psychic healing for optimal health. Meticulously researched. Fully illustrated. Comprehensive guide to holistic healing methods. Extensive resource directory. Effective ways to reduce veterinary costs.
Book Synopsis Electrical Diseases of the Heart by : Ihor Gussak
Download or read book Electrical Diseases of the Heart written by Ihor Gussak and published by Springer Science & Business Media. This book was released on 2008-09-08 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique contemporary and succinct distillation of the current status of recently delineated electrical diseases of the heart, emphasizing their common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. The book is divided into seven major parts. Each part consists of chapters (total of 64) dealing with related topics.
