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Author : Yi-Ju Li
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (363 download)
Download or read book Characterizing the Structure of Genetic Population written by Yi-Ju Li and published by . This book was released on 1996 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chen, Xi
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (166 download)
Download or read book Characterizing the Genetic Structure of Populations written by Chen, Xi and published by . This book was released on 2006 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: population structure, Fst estimation.
Download or read book Characterizing the Genetic Structure of Populations written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to characterize the genetic structure of populations continues to be central to all aspects of population and quantitative genetics, and measures based on correlations of pairs of alleles continue to be as relevant now as they were when discussed by Wright in 1951. The need to develop methodology for the characterization of the genetic structure of natural populations, especially of humans, has increased with recent large-scale disease association studies. We have proposed various estimators for population structure measure Fst, such as the moment estimator, the Kappa type estimator and the likelihood estimator. The likelihood estimates based on assumed normality of allele frequencies over populations have proven difficult to obtain in practice. Maximum likelihood estimates based on the Dirichlet distribution will provide a more robust framework, in spite of the implicit assumptions for that distribution not applying to microsatellite markers. The behavior of moment and MLE estimates in different scenarios were explored. Another population specific Fst estimator was proposed using GEE2 method. The proposed method yielded consistent results which are demonstrated via simulations.
Download or read book A Statistical Characterization of the Genetic Structure of Populations written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Suvajit Samanta
Publisher :
ISBN 13 :
Total Pages : 151 pages
Book Rating : 4.:/5 (183 download)
Download or read book A Statistical Characterization of the Genetic Structure of Populations written by Suvajit Samanta and published by . This book was released on 2006 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: generalized linear model, parametirc bootstrap, method of moments, population genetics, F-statistics, coancestry coefficient.
Author : P.P. Majumder
Publisher : Springer Science & Business Media
ISBN 13 : 1461529700
Total Pages : 558 pages
Book Rating : 4.4/5 (615 download)
Download or read book Human Population Genetics written by P.P. Majumder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: J. B. S. Haldane, R. A. Fisher and Sewall Wright simultaneously, and largely independently, laid the foundations of population genetics and the mathematical theory of evolution. Hal dane was born on November 5, 1892. Although he primarily worked at the University College London (UCL), in 1957 he resigned from the UCL and joined the Indian Statistical Institute, Calcutta (India) as a Research Professor. In celebration of his birth centenary, the Indian Statistical Institute organized an International Conference on Human Genetics from 15 to 19 December, 1992. The prime motive in holding this Conference was to bring together a group of scientists - geneticists, anthropologists, clinicians and statisticians - to evaluate the impact of Haldane's contributions to various areas of human genetics, and also to review recent developments in the subject. Session and lecture themes were so chosen that they covered areas theoretical and applied, classical and emerging. Speakers were then identified and invited to deliver lectures on these themes. Manuscripts of all invited presentations and a selected number of contributed presentations were considered for inclusion in this Proceed ings Volume. Each manuscript was reviewed by at least one Conference participant, which resulted in revision of several manuscripts and rejection of some. This volume is a collection of the manuscripts which have been 'accepted' after the review-process. The Conference began with the "J. B. S. Haldane Centenary Lecture" delivered by C. R. Rao.
Author : C. Cannings
Publisher : Cambridge University Press
ISBN 13 : 9780521239462
Total Pages : 172 pages
Book Rating : 4.2/5 (394 download)
Download or read book Genealogical Genetic Structure written by C. Cannings and published by Cambridge University Press. This book was released on 1981-11-26 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the long-term processes of evolution are selection and mutation, the infrastructure of a population is a no less important force in determining the distributions of genetic characteristics observable within populations. In small populations, and in particular in human populations, complex patterns of genealogical relationship between individuals can be an important factor in the maintenance of genetic variability. The aim of this book is to develop the quantitative theory of the interrelationship between the genealogical and the genetic structures of a population. Aspects of other structural features, such as migration patterns, are also discussed, but are not central to the development. There are three major aspects; each comprises two chapters of the text. First, genealogical relationships are characterized in a way which can illuminate their genetic consequences. Second, the evolutionary aspects of genealogical structure are developed. Finally, the last two chapters present methods of characterizing the complete structure of a genealogy, and of computing relevant parameters of genealogical structure; these topics are of relevance to genetic epidemiology as well as to population genetics.
Author : Michel Tibayrenc
Publisher : Elsevier
ISBN 13 : 0123848903
Total Pages : 773 pages
Book Rating : 4.1/5 (238 download)
Download or read book Genetics and Evolution of Infectious Diseases written by Michel Tibayrenc and published by Elsevier. This book was released on 2010-12-17 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field
Author : Girdhar K. Pandey
Publisher : John Wiley & Sons
ISBN 13 : 1118888928
Total Pages : 1114 pages
Book Rating : 4.1/5 (188 download)
Download or read book Mechanism of Plant Hormone Signaling under Stress, 2 Volume Set written by Girdhar K. Pandey and published by John Wiley & Sons. This book was released on 2017-04-24 with total page 1114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant hormone signaling plays an important role in many physiological and developmental processes including stress response. With the advent of new post-genomic molecular techniques, the potential for increasing our understanding of the impact of hormone signaling on gene expression and adaptive processes has never been higher. Unlocking the molecular underpinnings of these processes shows great promise for the development of new plant biotechnologies and improved crop varieties. The topics included in this book emphasize on genomics and functional genomics aspects, to understand the global and whole genome level changes upon particular stress conditions. With the functional genomics tools, the mechanism of phytohormone signaling and their target genes can be defined in a more systematic manner. The integrated analysis of phytohormone signaling under single or multiple stress conditions may prove exceptional to design stress tolerant crop plants in the field conditions. Bringing together the latest advances, as well as the work being done to apply these findings to plant and crop science, Mechanism of Plant Hormone Signaling Under Stress will prove extremely useful to plant and stress biologists, plant biotechnology researchers, as well as students and teachers.
Author : Amanda Tonia Joan Xuereb
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (825 download)
Download or read book Characterizing Population Genetic Structure and Inferring the Influence of Landscape Features on Gene Flow in a Temperate Snake Species written by Amanda Tonia Joan Xuereb and published by . This book was released on 2012 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patterns of genetic diversity in natural systems are influenced by landscape heterogeneity over spatial and temporal scales. Certain natural or anthropogenic landscape features may facilitate or impede organism dispersal and subsequent gene flow. Characterizing the geographical distribution of genetic diversity and identifying the factors contributing to population genetic structure is imperative for maintaining functional connectivity between isolated populations across a fragmented landscape. In this study, I combined genetic data and high-resolution land cover information to investigate patterns of population genetic structure in the threatened eastern hog-nosed snake (Heterodon platirhinos) at its northern range limit in Ontario, Canada. First, using putatively neutral microsatellite markers, I found evidence of genetic differentiation between two geographically disjunct regional populations: in the Carolinian region of southwestern Ontario, and along the eastern shoreline of Georgian Bay. Spatial and non-spatial Bayesian clustering algorithms also detected population genetic structure within each regional population. I found evidence of weak structure within Georgian Bay, roughly corresponding to regions north and south of Parry Sound. A genetic cluster at Wasaga Beach, located at the southern terminus of Georgian Bay, was highly differentiated from other populations, despite its geographic proximity to Georgian Bay. Excess homozygosity and reduced allelic diversity in Wasaga Beach compared to other sampled populations imply a population bottleneck event. Secondly, I inferred the role of landscape features on eastern hog-nosed snake dispersal and subsequent gene flow in the Georgian Bay regional population. Using techniques derived from electrical circuit theory, I estimated pairwise resistance distances between individuals by assigning costs to landscape features that are predicted to impede hog-nosed snake movement: open water, wetland, settlement and agriculture, and roads. Landscape features did not influence genetic structure within Wasaga Beach. However, I found weak evidence for an effect of landscape features, particularly open water and roads, on gene flow in eastern Georgian Bay. This study is the first to examine potential factors driving population genetic structure of eastern hog-nosed snakes and provides an empirical foundation for future tests of demographic models and spatially explicit simulations of gene flow.
Author :
Publisher :
ISBN 13 :
Total Pages : 399 pages
Book Rating : 4.:/5 (915 download)
Download or read book Population Biology of Plant Pathogens written by and published by . This book was released on 2015 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author : Tandy Warnow
Publisher : Springer
ISBN 13 : 3030108376
Total Pages : 410 pages
Book Rating : 4.0/5 (31 download)
Download or read book Bioinformatics and Phylogenetics written by Tandy Warnow and published by Springer. This book was released on 2019-04-08 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a compelling collection of state-of-the-art work in algorithmic computational biology, honoring the legacy of Professor Bernard M.E. Moret in this field. Reflecting the wide-ranging influences of Prof. Moret’s research, the coverage encompasses such areas as phylogenetic tree and network estimation, genome rearrangements, cancer phylogeny, species trees, divide-and-conquer strategies, and integer linear programming. Each self-contained chapter provides an introduction to a cutting-edge problem of particular computational and mathematical interest. Topics and features: addresses the challenges in developing accurate and efficient software for the NP-hard maximum likelihood phylogeny estimation problem; describes the inference of species trees, covering strategies to scale phylogeny estimation methods to large datasets, and the construction of taxonomic supertrees; discusses the inference of ultrametric distances from additive distance matrices, and the inference of ancestral genomes under genome rearrangement events; reviews different techniques for inferring evolutionary histories in cancer, from the use of chromosomal rearrangements to tumor phylogenetics approaches; examines problems in phylogenetic networks, including questions relating to discrete mathematics, and issues of statistical estimation; highlights how evolution can provide a framework within which to understand comparative and functional genomics; provides an introduction to Integer Linear Programming and its use in computational biology, including its use for solving the Traveling Salesman Problem. Offering an invaluable source of insights for computer scientists, applied mathematicians, and statisticians, this illuminating volume will also prove useful for graduate courses on computational biology and bioinformatics.
Author : Kostas Kampourakis
Publisher : Cambridge University Press
ISBN 13 : 1107034914
Total Pages : 275 pages
Book Rating : 4.1/5 (7 download)
Download or read book Understanding Evolution written by Kostas Kampourakis and published by Cambridge University Press. This book was released on 2014-04-03 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together conceptual obstacles and core concepts of evolutionary theory, this book presents evolution as straightforward and intuitive.
Author : Samantha Fowler
Publisher :
ISBN 13 : 9781680922400
Total Pages : 622 pages
Book Rating : 4.9/5 (224 download)
Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2017-12-30 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: The images in this textbook are in color. There is a less-expensive non-color version available - search for ISBN 9781680922202. Concepts of Biology is designed for the introductory biology course for nonmajors taught at most two- and four-year colleges. The scope, sequence, and level of the program are designed to match typical course syllabi in the market. Concepts of Biology includes interesting applications, features a rich art program, and conveys the major themes of biology.
Author : Kelly McCulloh
Publisher :
ISBN 13 : 9781339824741
Total Pages : pages
Book Rating : 4.8/5 (247 download)
Download or read book The Genetic Structure of Native Americans in North America Based on the Globalfiler® STRs written by Kelly McCulloh and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Current forensic STR databases, such as CODIS, lack sufficient population genetic data on Native American populations; these populations are likely to have greater genetic differentiation than populations residing in the US. Given the limited population genetic data for Native American populations, it is necessary to generate information for a genetically and geographically diverse array of tribes to provide better statistical estimates of the strength of associations with DNA evidence in forensic investigations as well as to characterize Native American population structure. This study used the Globalfiler® STR markers to characterize the genetic structure of ten Native American tribal populations from seven geographically distinct regions in North America, including tribes that are presently not represented in forensic STR databases. Samples from the seven locations which include the Arctic region, Baja California, California/Great Basin, the Southeast, Mexico, the Midwest and the Southwest were analyzed for allele frequencies, observed and expected heterozygosities, and F-statistics using the Globalfiler® PCR Amplification kit's 24 loci. Population specific private alleles observed in this study may assist direct or indirect comparisons to identify the source of forensic evidence or infer tribal or ethnic origin. Geographic isolation and distance, as well as past migration events, have shaped and structured the population genetics of current day Native Americans in North America. The tribal samples exhibited an F[subscript]ST or [theta] value above the conservative 0.03 estimate recommended by the National Research Council (NRC) for calculating random match probabilities among Native Americans. This finding, together with lower levels of heterozygosity, implies the locations from which these samples were derived were both geographically isolated and also genetically subdivided. The greater differentiation among tribal populations, F[subscript]ST = 0.04, than had been previously estimated warrants the inclusion of additional regional Native American samples into STR databases, such as CODIS.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309184746
Total Pages : 101 pages
Book Rating : 4.3/5 (91 download)
Download or read book Evaluating Human Genetic Diversity written by National Research Council and published by National Academies Press. This book was released on 1998-01-19 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.
