Characterizing Coenzyme Q6 Biosynthesis In Saccharomyces Cerevisiae And The Role Of Coq5 In The Efficient Methylation Of Q6 Intermediates

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Characterizing Coenzyme Q6 Biosynthesis in Saccharomyces Cerevisiae and the Role of Coq5 in the Efficient Methylation of Q6-intermediates

Author : Theresa Phuong Thao Nguyen
Publisher :
ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (894 download)

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Book Synopsis Characterizing Coenzyme Q6 Biosynthesis in Saccharomyces Cerevisiae and the Role of Coq5 in the Efficient Methylation of Q6-intermediates by : Theresa Phuong Thao Nguyen

Download or read book Characterizing Coenzyme Q6 Biosynthesis in Saccharomyces Cerevisiae and the Role of Coq5 in the Efficient Methylation of Q6-intermediates written by Theresa Phuong Thao Nguyen and published by . This book was released on 2014 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coenzyme Q (ubiquinone or Q) is a lipophilic redox active compound essential for respiration via the electron transport chain. Q is composed of a polyisoprenoid "tail" that anchors to the lipid membrane, and a benzoquinone "head" that confers the abilities to shuttle electrons from Complexes I and II to Complex III. In Saccharomyces cerevisiae, the biosynthesis of Q6 occurs in the mitochondria inner membrane via eleven nuclear-encoded genes (COQ1-9, ARH1, YAH1), six of which compose a multi-subunit complex termed the CoQ-synthome. The following chapters in this dissertation summarize the body of work completed on various Q6 projects: the partial rescue of yeast coq5 mutants by the human COQ5 homolog only when the CoQ-synthome is assembled (Chapter 2), and the resulting novel Q6-intermediate IDDMQ6 detected in these coq5 strains via LC/MS-MS (Chapter 3); the localization of Coq-GFP polypeptides in mitochondria but not in peroxisomes via fluorescent microcopy (Chapter 4); and the requirement of de novo folate biosynthesis in yeast from the Q6 head group precursor pABA (Chapter 5).

Coenzyme Q Biosynthesis in Saccharomyces Cerevisiae

Author : Christopher Michael Allan
Publisher :
ISBN 13 :
Total Pages : 161 pages
Book Rating : 4.:/5 (97 download)

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Book Synopsis Coenzyme Q Biosynthesis in Saccharomyces Cerevisiae by : Christopher Michael Allan

Download or read book Coenzyme Q Biosynthesis in Saccharomyces Cerevisiae written by Christopher Michael Allan and published by . This book was released on 2014 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coenzyme Q (Q or ubiquinone) is a redox-active lipid consisting of a fully substituted benzoquinone ring and a lipophilic polyisoprenoid moiety which serves to anchor Q in biological membranes. Q is essential to mitochondrial electron transport where it accepts electrons from NADH or succinate at complexes I and II respectively, and donates them to cytochrome c at complex III. In the yeast Saccharomyces cerevisiae Q is synthesized by the products of eleven nuclear-encoded genes: COQ1-COQ9, YAH1, and ARH1. The product of an additional gene, COQ10, is not required for the biosynthesis of Q but is necessary for its function in efficient electron transport and respiration. Chapter 2 investigates the role of Coq10p in both mitochondrial respiration and de novo Q synthesis through analysis of coq10 null mutants and the Coq10p prokaryotic homolog CC1736. Expression of CC1736 harboring a mitochondrial leader sequence in yeast coq10 mutants restored respiration and growth on a non-fermentable carbon source, and binding assays demonstrated that CC1736 is capable of binding different isoforms of Q and a late-stage Q biosynthetic intermediate. Lipid analysis of the coq10 null mutant revealed significantly decreased de novo Q synthesis when compared to wild type, especially at early-log phase, indicating Coq10p is required for efficient de novo biosynthesis of Q. Chapter 3 describes characterization of a mitochondrial multi-subunit Coq polypeptide complex required for Q biosynthesis. The complex was purified by tandem affinity purification of particular dual-tagged Coq proteins and Western blotting analysis of purified eluates showed that the biosynthetic complex includes Coq3p, Coq4p, Coq5p, Coq6p, Coq7p, and Coq9p. In addition, Coq8p was observed to co-purify with tagged Coq6p but not other tagged Coq proteins. The purified eluates were also subject to proteomic analysis to identify potentially novel binding partners, identifying two proteins, Ilv6p and YLR290C. Lipid analysis of the corresponding null mutants revealed that the ylr290c mutant has significantly reduced de novo Q synthesis, while the ilv6 mutant synthesizes wild-type levels of Q. Tandem affinity purification of tagged YLR290C demonstrated that it is associated with Coq4p, Coq5p, and Coq7p.

Metabolic Engineering of Plant Secondary Metabolism

Author : R. Verpoorte
Publisher : Springer Science & Business Media
ISBN 13 : 9401594236
Total Pages : 288 pages
Book Rating : 4.4/5 (15 download)

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Book Synopsis Metabolic Engineering of Plant Secondary Metabolism by : R. Verpoorte

Download or read book Metabolic Engineering of Plant Secondary Metabolism written by R. Verpoorte and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant secondary metabolism is an economically important source of fine chemicals, such as drugs, insecticides, dyes, flavours, and fragrances. Moreover, important traits of plants such as taste, flavour, smell, colour, or resistance against pests and diseases are also related to secondary metabolites. The genetic modification of plants is feasible nowadays. What does the possibility of engineering plant secondary metabolite pathways mean? In this book, firstly a general introduction is given on plant secondary metabolism, followed by an overview of the possible approaches that could be used to alter secondary metabolite pathways. In a series of chapters from various authorities in the field, an overview is given of the state of the art for important groups of secondary metabolites. No books have been published on this topic so far. This book will thus be a unique source of information for all those involved with plants as chemical factories of fine chemicals and those involved with the quality of food and ornamental plants. It will be useful in teaching graduate courses in the field of metabolic engineering in plants.

Coenzyme Q in Aging

Author : Guillermo López Lluch
Publisher : Springer
ISBN 13 : 9783030456412
Total Pages : 0 pages
Book Rating : 4.4/5 (564 download)

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Book Synopsis Coenzyme Q in Aging by : Guillermo López Lluch

Download or read book Coenzyme Q in Aging written by Guillermo López Lluch and published by Springer. This book was released on 2020-08-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.

Protein Structure and Modeling

Author : Natalya Kurochkina
Publisher : Springer
ISBN 13 : 9811366012
Total Pages : 276 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Protein Structure and Modeling by : Natalya Kurochkina

Download or read book Protein Structure and Modeling written by Natalya Kurochkina and published by Springer. This book was released on 2019-06-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will consider principles of the organization of protein molecules, the relationships between primary, secondary, and tertiary structure, the determinants of protein conformation, and the applications of structure determination and structure modeling in biomedical research.

Bacterial Physiology and Metabolism

Author : Byung Hong Kim
Publisher : Cambridge University Press
ISBN 13 : 113946762X
Total Pages : 934 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Bacterial Physiology and Metabolism by : Byung Hong Kim

Download or read book Bacterial Physiology and Metabolism written by Byung Hong Kim and published by Cambridge University Press. This book was released on 2008-02-21 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent determination of genome sequences for a wide range of bacteria has made in-depth knowledge of prokaryotic metabolic function essential in order to give biochemical, physiological, and ecological meaning to the genomic information. Clearly describing the important metabolic processes that occur in prokaryotes under different conditions and in different environments, this advanced text provides an overview of the key cellular processes that determine bacterial roles in the environment, biotechnology, and human health. Prokaryotic structure is described as well as the means by which nutrients are transported into cells across membranes. Glucose metabolism through glycolysis and the TCA cycle are discussed, as well as other trophic variations found in prokaryotes, including the use of organic compounds, anaerobic fermentation, anaerobic respiratory processes, and photosynthesis. The regulation of metabolism through control of gene expression and control of the activity of enzymes is also covered, as well as survival mechanisms used under starvation conditions.

Techniques in Genetic Engineering

Author : Isil Aksan Kurnaz
Publisher : CRC Press
ISBN 13 : 1482260905
Total Pages : 334 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Techniques in Genetic Engineering by : Isil Aksan Kurnaz

Download or read book Techniques in Genetic Engineering written by Isil Aksan Kurnaz and published by CRC Press. This book was released on 2015-05-08 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although designed for undergraduates with an interest in molecular biology, biotechnology, and bioengineering, this book-Techniques in Genetic Engineering-IS NOT: a laboratory manual; nor is it a textbook on molecular biology or biochemistry. There is some basic information in the appendices about core concepts such as DNA, RNA, protein, genes, and

Coenzyme Q

Author : Giorgio Lenaz
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Coenzyme Q by : Giorgio Lenaz

Download or read book Coenzyme Q written by Giorgio Lenaz and published by John Wiley & Sons. This book was released on 1985 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is becoming increasingly apparent that Coenzyme Q (Ubiquinone) is a major component of the electron transfer chains within aerobic micro-oganisms, photo-synthetic micro-organisms and mitochondria of eukaryotes. In particular, the proposal by Nobel laureate, Peter Mitchell, that Coenzyme Q possibly acts as a proton translocator within a proton motive Q-cycle, thus establishing an electrochemical membrane potential which in turn drives ATP synthesis, has received wide attention. This exhaustive, inter-disciplinary study discusses Ubiquinone's chemical and physical properties, metabolism, and function in different organisms.

Secondary Metabolites of Plant Growth Promoting Rhizomicroorganisms

Author : Harikesh Bahadur Singh
Publisher : Springer
ISBN 13 : 9811358621
Total Pages : 404 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Secondary Metabolites of Plant Growth Promoting Rhizomicroorganisms by : Harikesh Bahadur Singh

Download or read book Secondary Metabolites of Plant Growth Promoting Rhizomicroorganisms written by Harikesh Bahadur Singh and published by Springer. This book was released on 2019-04-15 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent changes in the pattern of agricultural practices from use of hazardous pesticides to natural (organic) cultivation has brought into focus the use of agriculturally important microorganisms for carrying out analogous functions. The reputation of plant growth promoting rhizomicroorganisms (PGPRs) is due to their antagonistic mechanisms against most of the fungal and bacterial phytopathogens. The biocontrol potential of agriculturally important microorganisms is mostly attributed to their bioactive secondary metabolites. However, low shelf life of many potential agriculturally important microorganisms impairs their use in agriculture and adoption by farmers. The focal theme of this book is to highlight the potential of employing biosynthesized secondary metabolites (SMs) from agriculturally important microorganisms for management of notorious phytopathogens, as a substitute of the currently available whole organism formulations and also as alternatives to hazardous synthetic pesticides. Accordingly, we have incorporated a comprehensive rundown of sections which particularly examine the SMs synthesized, secreted and induced by various agriculturally important microorganisms and their applications in agriculture. Section 1 includes discussion on biosynthesized antimicrobial secondary metabolites from fungal biocontrol agents. This section will cover the various issues such as development of formulation of secondary metabolites, genomic basis of metabolic diversity, metabolomic profiling of fungal biocontrol agents, novel classes of antimicrobial peptides. The section 1 will also cover the role of these secondary metabolites in antagonist-host interaction and application of biosynthesized antimicrobial secondary metabolites for management of plant diseases. Section 2 will discuss the biosynthesized secondary metabolites from bacterial PGPRs, strain dependent effects on plant metabolome profile, bio-prospecting various isolates of bacterial PGPRs for potential secondary metabolites and non-target effects of PGPR on microbial community structure and functions. Section 3 encompasses synthesis of antimicrobial secondary metabolites from beneficial endophytes, bio-prospecting medicinal and aromatic hosts and effect of endophytic SMs on plants under biotic and biotic stress conditions.

Brewing Microbiology

Author : F. G. Priest
Publisher : Springer Science & Business Media
ISBN 13 : 146840038X
Total Pages : 312 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Brewing Microbiology by : F. G. Priest

Download or read book Brewing Microbiology written by F. G. Priest and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the latter part of the last century and the early years of this century, the microbiology of beer and the brewing process played a central role in the development of modern microbiology. An important advance was Hansen's development of pure culture yeasts for brewery fermentations and the recognition of different species of brewing and wild yeasts. The discovery by Winge of the life cycles of yeasts and the possibilities of hybridization were among the first steps in yeast genetics with subsequent far-reaching consequences. Over the same period the contaminant bacteria of the fermentation industries were also studied, largely influenced by Shimwell's pioneering research and resulting in the improvement of beer quality. Towards the end of the century, the influence of brewing microbiology within the discipline as a whole is far less important, but it retains an essential role in quality assurance in the brewing industry. Brewing microbiology has gained from advances in other aspects of microbiology and has adopted many of the techniques of biotechnology. Of particular relevance are the developments in yeast genetics and strain improvement by recombinant DNA techniques which are rapidly altering the way brewers view the most important microbiological components of the process: yeast and fermentation.

Handbook of Veterinary Pharmacology

Author : Walter H. Hsu
Publisher : John Wiley & Sons
ISBN 13 : 1118714164
Total Pages : 564 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Handbook of Veterinary Pharmacology by : Walter H. Hsu

Download or read book Handbook of Veterinary Pharmacology written by Walter H. Hsu and published by John Wiley & Sons. This book was released on 2013-04-25 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Veterinary Pharmacology is a clear and concise guide to pharmacology concepts and commonly used veterinary drugs. Providing a succinct overview of veterinary pharmacology, this book presents information in a user-friendly outline format to allow quick access to practical drug information. With chapters covering the basic principles, specific drugs, interactions, and legal considerations, Handbook of Veterinary Pharmacology offers up-to-date information on basic and clinical veterinary pharmacology. As an aid to student comprehension, simple line drawings depict the mechanisms of action and study questions with explanations are included at the end of each chapter. Appendices on withdrawal times for drugs in production animals and drug dosages in domestic species are a valuable tool, allowing quick decisions on drug therapy. Handbook of Veterinary Pharmacology is an indispensable text for veterinary students and practitioners.

Microbial Respiration

Author : Walter P. Hempfling
Publisher : Hutchinson Ross Publishing Company
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Microbial Respiration by : Walter P. Hempfling

Download or read book Microbial Respiration written by Walter P. Hempfling and published by Hutchinson Ross Publishing Company. This book was released on 1979 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacotherapeutics for Advanced Practice

Author : Virginia Poole Arcangelo
Publisher : LWW
ISBN 13 : 9781496319968
Total Pages : 0 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Pharmacotherapeutics for Advanced Practice by : Virginia Poole Arcangelo

Download or read book Pharmacotherapeutics for Advanced Practice written by Virginia Poole Arcangelo and published by LWW. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Be ready to prescribe and administer drugs safely and effectively--and grasp all the vitals of pharmacology--with the fully updated Pharmacotherapeutics for Advanced Practice, 4th edition. Written by pharmacology nursing experts, this easy-to-read text offers proven frameworks for treating more than 50 common diseases and disorders. Learn how to identify disorders, review possible therapies, then prescribe and monitor drug treatment, accurately. Based on current evidence and real-life patient scenarios, this is the perfect pharmacology learning guide and on-the-spot clinical resource. Absorb the key principles and practical methods for accurate prescribing and monitoring, with . . . NEW chapter on Parkinson's disease, osteoarthritis, and rheumatoid arthritis NEWand updated therapies, and updated and additional case studies, with sample questions NEW content on the impacts of the Affordable Care Act Updated chapters on complementary and alternative medicine (CAM) and pharmacogenomics Updated evidence-basedalgorithms and drugtables - Listing uses, mechanisms, adverse effects, drug interactions, contraindications, and monitoring parameters, organized by drug class; quick access to generic and trade names and dosages Quick-scan format organizes information by body system Chapter features include: Brief overview - Pathophysiology of each disorder, and relevant classes of drugs Monitoring Patient Response section - What to monitor, and when Patient Education section - Includes information on CAM for each disorder Drug Overview tables - Usual dose, contraindications and side effects, and special considerations Algorithms - Visual cues on how to approach treatment Updated Recommended Order of Treatment tables - First-, second- and third-line drug therapies for each disorder Answers to Case Study Questions for each disorder - Strengthens critical thinking skills Selecting the Most Appropriate Agentsection - The thought process for choosing an initial drug therapy Principles of Therapeuticsunit - Avoiding medication errors; pharmacokinetics and pharmacodynamics; impact of drug interactions and adverse events; principles of pharmacotherapy for pediatrics, pregnancy/lactation, and geriatrics Disorders units - Pharmacotherapy for disorders in various body systems Pharmacotherapy in Health Promotion unit - Smoking cessation, immunizations, weight management Women's Health unit - Including contraception, menopause, and osteoporosis Integrative Approach to Patient Care unit - Issues to consider when presented with more than one diagnosis Standard pharmacotherapeutics text for nurse practitioners, students, and physician assistants Ancillaries - Case Study answers, multiple choice questions and answers for every chapter, PowerPoints, Acronyms List

Mitochondrial Diseases

Author : Placido Navas
Publisher :
ISBN 13 : 9783030701482
Total Pages : 0 pages
Book Rating : 4.7/5 (14 download)

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Book Synopsis Mitochondrial Diseases by : Placido Navas

Download or read book Mitochondrial Diseases written by Placido Navas and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach. This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options. Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research. This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.

Essential Cell Biology

Author : Bruce Alberts
Publisher : Garland Science
ISBN 13 : 1317806271
Total Pages : 863 pages
Book Rating : 4.3/5 (178 download)

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Book Synopsis Essential Cell Biology by : Bruce Alberts

Download or read book Essential Cell Biology written by Bruce Alberts and published by Garland Science. This book was released on 2015-01-01 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. The Fourth Edition has been thoroughly revised, and covers the latest developments in this fast-moving field, yet retains the academic level and length of the previous edition. The book is accompanied by a rich package of online student and instructor resources, including over 130 narrated movies, an expanded and updated Question Bank. Essential Cell Biology, Fourth Edition is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students’ needs precisely and efficiently. For more information and sample material, visit http://garlandscience.rocketmix.com/.

The Pearson Guide To GPAT and other Entrance Examination in Pharmacy

Author : Umang H Shah
Publisher : Pearson Education India
ISBN 13 : 933258785X
Total Pages : 852 pages
Book Rating : 4.3/5 (325 download)

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Book Synopsis The Pearson Guide To GPAT and other Entrance Examination in Pharmacy by : Umang H Shah

Download or read book The Pearson Guide To GPAT and other Entrance Examination in Pharmacy written by Umang H Shah and published by Pearson Education India. This book was released on 2017 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pearson Guide to GPAT and Other Competitive Examinations in Pharmacy• The entire book is divided into six modules as per GPAT syllabus which also covers thesyllabus of all other entrance examinations like NIPER, MAHCET and GUJCET and MANIPAL

Introductory Review on Sirtuins in Biology, Aging, and Disease

Author : Leonard Guarente
Publisher : Academic Press
ISBN 13 : 012813500X
Total Pages : 222 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Introductory Review on Sirtuins in Biology, Aging, and Disease by : Leonard Guarente

Download or read book Introductory Review on Sirtuins in Biology, Aging, and Disease written by Leonard Guarente and published by Academic Press. This book was released on 2018-04-20 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses