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Author : Kyungmin Benjamin Hahm
Publisher :
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.:/5 ( download)
Download or read book Characterization of Transcription Factor LyF-1/Ikaros written by Kyungmin Benjamin Hahm and published by . This book was released on 1997 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Harinder Singh
Publisher : Springer Science & Business Media
ISBN 13 : 3540263632
Total Pages : 261 pages
Book Rating : 4.5/5 (42 download)
Download or read book Molecular Analysis of B Lymphocyte Development and Activation written by Harinder Singh and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Author : David Latchman
Publisher : OUP Oxford
ISBN 13 : 0191565792
Total Pages : 326 pages
Book Rating : 4.1/5 (915 download)
Download or read book Transcription Factors written by David Latchman and published by OUP Oxford. This book was released on 1999-04-08 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition five years ago, a wide range of new methodologies have been developed to facilitate studies on both isolated parts of the genome and the genome as a whole. This new edition has been updated and expanded so that it provides a comprehensive guide to the methods currently available to characterize the function and activity of an individual transcription factor. All the original chapters have been fully updated or rewritten and additional chapters cover the use of in vitro transcription assays, analysis of chromatin structure, use of the genomic binding site assay and analysis of transcription factor modifications. As with the previous edition, the book starts with a series of chapters concerned with characterizing the proteins binding to a specific DNA sequence and then a chapter on more detailed characterization of the protein itself. The next two chapters describe the isolation of cDNA clones encoding a transcription factor using oligonucleotides predicted from protein sequence and screening of a cDNA expression library. Chapter 6 deals with identification of transcription factors based on sequence homology analysis by both experimental screening and database searches. Chapter 7 is a new chapter that describes methods of identifying the target genes of a previously uncharacterized factor. The next chapters deal with analysis of transcription factor function. Chapter 8 deals with general techniques, and then the following chapters cover the specialized techniques of in vitro transcription assays using transcriptionally active nuclear extracts derived from rat brain, and analysis of the effect of transcription factors on chromatin structure. The final chapter describes methods for detecting the phosphorylation and glycosylation state of transcription factors.
Author : James John Achilles Contos
Publisher :
ISBN 13 :
Total Pages : 534 pages
Book Rating : 4.:/5 (318 download)
Download or read book Genomic and Functional Characterization of Lysophospholipid Receptor Genes written by James John Achilles Contos and published by . This book was released on 1999 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rupa Sridharan
Publisher :
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.:/5 ( download)
Download or read book Analysis of the Ikaros Family of Proteins in Thymocyte Development written by Rupa Sridharan and published by . This book was released on 2006 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joseph M. Bosilevac
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (414 download)
Download or read book Activating Transcription Factor 1 and Cyclic AMP Response Element Binding Protein written by Joseph M. Bosilevac and published by . This book was released on 1998 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roger Louis Ferrini
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 ( download)
Download or read book Ikaros written by Roger Louis Ferrini and published by . This book was released on 2005 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin J. Tymms
Publisher : Springer Science & Business Media
ISBN 13 : 159259686X
Total Pages : 304 pages
Book Rating : 4.5/5 (925 download)
Download or read book Transcription Factor Protocols written by Martin J. Tymms and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal promoter elements, and distal enhancer elements. General initiation factors are involved in positioning RNA polymerase II on the core promoter, but the complex - teraction of these proteins and transcriptional activators binding to DNA e- ments outside the core promoter regulate the rate of transcriptional initiation. This initiation process appears to be a crucial step in the modulation of mRNA levels in response to developmental and environmental signals. Transcription Factor Protocols provides step-by-step procedures for key techniques that have been developed to study DNA sequences and the protein factors that regulate the transcription of protein encoding genes. This volume is aimed at providing researchers in the field with the well-detailed protocols that have been the hallmark of previous volumes of the Methods in Molecular TM Biology series.
Author :
Publisher :
ISBN 13 :
Total Pages : 830 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1997 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Katya Ravid
Publisher : John Wiley & Sons
ISBN 13 : 0471461067
Total Pages : 640 pages
Book Rating : 4.4/5 (714 download)
Download or read book Transcription Factors written by Katya Ravid and published by John Wiley & Sons. This book was released on 2003-11-04 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Author : Nguyen-Hai-Ha
Publisher :
ISBN 13 :
Total Pages : 210 pages
Book Rating : 4.:/5 (18 download)
Download or read book Characterization of an Interaction Partner of the Transcription Factor PDX-1 written by Nguyen-Hai-Ha and published by . This book was released on 2006 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joseph Thomas Bruder
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.:/5 (25 download)
Download or read book Identification and Characterization of Transcription Factor EF-1A written by Joseph Thomas Bruder and published by . This book was released on 1990 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kerry F. Pedley
Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.3/5 (129 download)
Download or read book Characterization of a Transcription Factor Unique to Race 1 Isolates of Cochliobolus Carbonum written by Kerry F. Pedley and published by . This book was released on 2001 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John G. Monroe
Publisher : Springer Science & Business Media
ISBN 13 : 147572778X
Total Pages : 582 pages
Book Rating : 4.4/5 (757 download)
Download or read book Molecular Biology of B-Cell and T-Cell Development written by John G. Monroe and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
Author : Apostol Apostolov
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (866 download)
Download or read book Studying the Posttranslational Modifications of Transcription Factor Ikaros and Their Role in Its Function written by Apostol Apostolov and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main topic of my PhD studies was to investigate the role of sumoylation in the function of Ikaros transcription factor, that regulates the lymphocyte differentiation and function. Sumoylation is a posttranslational modification that can change the properties and regulate the function of a given protein. Up to now, one study addressed the question of how sumoylationmodulates Ikaros function. It shows that Ikaros is sumoylated in total primary thymocytes, and that this dynamic event modulates Ikaros' repressive function. It also describes two consensus sumoylation sites on Ikaros (K58 and K240), the sumoylation of which leads to loss of Ikaros repressive function in ectopic reporter gene assays. The final conclusion of the study is that sumoylation does not alter the nuclear localization of Ikaros but acts as a mechanism disrupting its participation in both histone deacetylase (HDAC) dependent and independent repression. My work shows the presence of additional sumoylation site on Ikaros and demonstrates that sumoylation does not significantly alter its interaction with the nucleosome remodelling and histone deacetylase (NURD) complex in T-cell lines. The functional analysis of sumo-deficientmutants indicates a complex role of this modification in regulating Ikaros' transcriptional properties. The identification of this new sumoylation site contributes to a better understanding of Ikaros' dual repressive - activating function and suggests the existence of conditional Ikaros' interacting partners. Moreover, the different Ikaros splicing isoforms would have differentsumoylation profiles, which would complete the knowledge of their functional diversity.
Author : Chung-Yih Wang
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.3/5 (91 download)
Download or read book Characterization of a Novel Ets Transcription Factor, Elf-1 written by Chung-Yih Wang and published by . This book was released on 1993 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Uschi Lindert
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (837 download)
Download or read book Comparisation and Functional Characterization of the Metalresponsive Transcription Factor 1 (MTF-1) from Rodents and Human written by Uschi Lindert and published by . This book was released on 2009 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
