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Characterization Of Mechanisms Of Myocardial Remodeling In Genetic Models Of Cardiac Hypertrophy
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Book Synopsis Characterization of Mechanisms of Myocardial Remodeling in Genetic Models of Cardiac Hypertrophy by : Andrea A. Domenighetti
Download or read book Characterization of Mechanisms of Myocardial Remodeling in Genetic Models of Cardiac Hypertrophy written by Andrea A. Domenighetti and published by . This book was released on 2005 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanoresponsive Mechanisms In Hypertrophic Cardiac Remodeling by : Todd Haswell Kimball
Download or read book Mechanoresponsive Mechanisms In Hypertrophic Cardiac Remodeling written by Todd Haswell Kimball and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: All cells of the body are under some form of mechanical load and these forces are part of the factors defining cell type specificity. The mechanical environment influences cellular behavior and is the basis of mechanobiology. The forces acting on cells must be met with a cellular response, as the input signals are transduced to molecular mechanisms that drive gene regulation. In the heart, the distinct roles of cardiomyocytes and fibroblasts, as fibroblasts enforce tissue stiffness homeostasis through extracellular matrix maintenance and cardiomyocyte contraction-relaxation cycles work against this stiffness with every heartbeat, enable each to respond to cardiac stressors through differential gene expression, changing their cellular physical phenotype. At the cellular level, cardiac hypertrophy is a growth of the cardiomyocyte (without proliferation) and increased interstitial fibrosis, and these phenotypes are the result of changes to gene expression. While the gene expression program induced by cardiac hypertrophy is well documented, this dissertation unravels mechanosensitive mechanisms activated by changes to the myocardial environment and cellular forces driving dysfunctional gene regulation perpetuating cardiac disease. Gene translation ends in the nucleus; however, it does not always start there. We viewed gene expression as an end point, being influenced by a number of factors outside the nucleus, including metabolism, nucleoskeletal, cytoskeletal, sarcomere organization, sarcolemmal signal transduction pathways, and the tissue environment. In examining transcriptional influence outside the nucleus, we first summarize the bidirectional effect of metabolic and gene regulation dysfunction in heart disease, as metabolic substrates and intermediates impact cardiac epigenetics and chromatin stores information. We report our findings from our pressure overload induced cardiac hypertrophy studies, demonstrating cardiomyocyte cellular remodeling influences nucleoskeletal ultrastructure through the expression of the structural and chromatin binding protein Lamin A/C. We phenotypically characterize an [alpha]1-adrenergic model of cardiac hypertrophy and investigate cell specific mechanism driving tissue remodeling and cellular mechanosensitive pathways underlying pathological stress. Through these studies, we explore the cardiac stressors that remodel the heart tissue during hypertrophy and the cellular mechanisms altering the cellular phenotype through gene regulation.
Book Synopsis Cardiac Hypertrophy and Failure by : Bernard Swynghedauw
Download or read book Cardiac Hypertrophy and Failure written by Bernard Swynghedauw and published by . This book was released on 1990 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac insufficiency, a major cause of premature mortality, is a key focus of medical and pharmaceutical research. This book aims to bring clinicians and researchers up-to-date on recent biophysical, cellular physiological and molecular biological developments and their clinical applications.
Book Synopsis Dilated Cardiomyopathy by : Gianfranco Sinagra
Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Book Synopsis Cardiac Regeneration by : Masaki Ieda
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Book Synopsis Diagnosis and Management of Hypertrophic Cardiomyopathy by : Barry J. Maron
Download or read book Diagnosis and Management of Hypertrophic Cardiomyopathy written by Barry J. Maron and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis and Management of Hypertrophic Cardiomyopathy is aunique, multi-authored compendium of information regarding thecomplexities of clinical and genetic diagnosis, natural history,and management of hypertrophic cardiomyopathy (HCM)—the mostcommon and important of the genetic cardiovasculardiseases—as well as related issues impacting the health oftrained athletes. Edited by Dr. Barry J. Maron, a world authority on HCM, and withmajor contributions from all of the international experts in thisfield, this book provides a single comprehensive source ofinformation concerning HCM. Recent advances in the field arediscussed, including the importance of left ventricular outflowtract obstruction, the use of implantable defibrillators for theprevention of sudden death in young people, definition of thegenetic basis for HCM and its role in clinical diagnosis and riskstratification, the development of more precise strategies forassessing the level of risk for sudden death among all patientswith HCM, and the evolution of invasive interventions for heartfailure symptoms, such as surgical management and its alternatives(alcohol septal ablation and dual-chamber pacing). Key Features: Contributions from all experts in the field,representing diverse viewpoints regarding this heterogeneousdisease and related issues in athletes Information to dispel misunderstandings regarding issuesassociated with HCM and cardiovascular disease in athletes The only comprehensive source of information available on thetopic
Book Synopsis Heart Failure: A Companion to Braunwald's Heart Disease E-Book by : G. Michael Felker
Download or read book Heart Failure: A Companion to Braunwald's Heart Disease E-Book written by G. Michael Felker and published by Elsevier Health Sciences. This book was released on 2019-02-06 with total page 937 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).
Book Synopsis Animal Models in Medicine and Biology by : Eva Tvrdá
Download or read book Animal Models in Medicine and Biology written by Eva Tvrdá and published by BoD – Books on Demand. This book was released on 2020-04-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to animal models, our knowledge of biology and medicine has increased enormously over the past decades, leading to significant breakthroughs that have had a direct impact on the prevention, management and treatment of a wide array of diseases.This book presents a comprehensive reference that reflects the latest scientific research being done in a variety of medical and biological fields utilizing animal models. Chapters on Drosophila, rat, pig, rabbit, and other animal models reflect frontier research in neurology, psychiatry, cardiology, musculoskeletal disorders, reproduction, chronic diseases, epidemiology, and pain and inflammation management. Animal Models in Medicine and Biology offers scientists, clinicians, researchers and students invaluable insights into a wide range of issues at the forefront of medical and biological progress.
Book Synopsis Mechanobiology by : Simon C. F. Rawlinson
Download or read book Mechanobiology written by Simon C. F. Rawlinson and published by John Wiley & Sons. This book was released on 2017-01-31 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.
Download or read book Cardiomyopathy written by Gustav Mattsson and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiomyopathies are diseases of the heart muscle with diverse etiologies ranging from myocarditis to gene mutations. They are classified according to morphology and function, and then further categorized based on whether they are familial or non-familial and based on specific etiologies. This book examines the various cardiomyopathies, including arrhythmogenic cardiomyopathy, hypertrophic cardiomyopathy, and dilated cardiomyopathy, as well as their genetic basis.
Book Synopsis Cardiac Receptors by : R. Hainsworth
Download or read book Cardiac Receptors written by R. Hainsworth and published by CUP Archive. This book was released on 1979-11-22 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fetal Cardiac Function by : E. Gratacós
Download or read book Fetal Cardiac Function written by E. Gratacós and published by S. Karger AG (Switzerland). This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fetal echocardiography was initially used to detect structural anomalies, but has more recently also been proposed to assess fetal cardiac function. Functional echocardiography has been demonstrated to select high-risk populations and has been seen to have an effect on the outcome of several fetal conditions. Because of the small size and high heart rate and the restricted access away from the transducer, cardiovascular parameters should be validated but used with caution in the fetus. This special issue on fetal cardiac function is a collection of review and original articles showing several potential clinical and research applications of functional echocardiography in intrauterine growth restriction, twin-to-twin transfusion syndrome, congenital heart disease and aneuploides. The insights provided show that fetal cardiac function assessment is a promising tool that may soon be incorporated into clinical practice to diagnose, monitor or predict outcome in some fetal conditions. Therefore, this special issue on 'fetal cardiac function' provides valuable reading for clinicians and researchers in fetal medicine and cardiology who are interested in the fetal heart.
Book Synopsis Heart Failure in the Child and Young Adult by : Joseph Rossano
Download or read book Heart Failure in the Child and Young Adult written by Joseph Rossano and published by Academic Press. This book was released on 2017-12-05 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine. - Provides coverage of the basic science of heart failure, its epidemiology and economic aspects, outpatient and inpatient management, and advanced therapies, including mechanical circulatory support and heart transplantation - Combines cutting-edge research with current guidelines from the field
Book Synopsis Mechanobiology in Health and Disease by : Stefaan Verbruggen
Download or read book Mechanobiology in Health and Disease written by Stefaan Verbruggen and published by Academic Press. This book was released on 2018-08-09 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science
Book Synopsis Genetic Cardiomyopathies by : Gianfranco Sinagra
Download or read book Genetic Cardiomyopathies written by Gianfranco Sinagra and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, genetics has been emerging as a primary issue in the diagnosis and management of cardiomyopathies. This book is intended to be a state-of-the-art monograph on these diseases, describing their genetic causes, defining the molecular basis and presenting extensive descriptions of genotype–phenotype correlations. Other chapters are focused on the role of clinical observation, on ECG and echocardiography. With its highlight on the most recent discoveries in the field of molecular genetics as well as on the correct clinical approach to patients with heart muscle disease, the book is aimed at physicians and clinical cardiologists with a particular interest in myocardial diseases and in their genetic causes.
Book Synopsis Inflammation in Heart Failure by : Matthijs Blankesteijn
Download or read book Inflammation in Heart Failure written by Matthijs Blankesteijn and published by Academic Press. This book was released on 2014-12-05 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure's breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. - Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment - Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure - Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure - Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases
Book Synopsis The Stressed Heart by : Marianne J. Legato
Download or read book The Stressed Heart written by Marianne J. Legato and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no matter what his or her field of expertise and interest. The title, although quite appropriate, does not adequately indicate the range of topics considered or the rational interrelationships among them. Indeed, perhaps the most important point to be learned from the book is that a serious consideration of the response of the heart to mechanical overload, ischemia, or excessive humoral stimuli must include evaluation of each of the topics in the table of contents. The heart responds to stress through alterations in both structure and function. How these changes are brought about is the subject of the initial chapters. These consider first the normal regulation of gene expression in the heart, the rapid response to mechanical overload that leads to both quantitative and qualitative changes in the contractile proteins, and our current understand ing of the signals that might be elicited by stress and alter gene expression. One chapter emphasizes the fact that, regardless of the nature of the stress, the common denominator is a discrepancy between energy requirements and expenditure. The central role of cellular acidosis in initiating the sequence of responses to stress and the possible roles of peptide regulators of transcription and protein regulators of translation are considered in detail.
