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Characterisation Of Hair Follicle Stem Cell Function In Epidermal Regeneration And Tumourigenesis
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Book Synopsis Characterisation of Hair Follicle Stem Cell Function in Epidermal Regeneration and Tumourigenesis by : Monika Petersson
Download or read book Characterisation of Hair Follicle Stem Cell Function in Epidermal Regeneration and Tumourigenesis written by Monika Petersson and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Dual Role of Stem Cell-specific Bcl-2 Function for Epidermal Regeneration and Cancer by : Giada Mantellato
Download or read book The Dual Role of Stem Cell-specific Bcl-2 Function for Epidermal Regeneration and Cancer written by Giada Mantellato and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-renewing tissues like the mammalian epidermis and its appendages go through cycles of proliferation, terminal differentiation and apoptosis. To maintain tissue integrity and stem cell (SC) function, these diverse processes need to sustain constant environmental assaults, including UV radiation. In the mammalian epidermis, multiple SC compartments have been identified, including SCs in the basal layer of the interfollicular epidermis and the hair follicle bulge. Bulge SCs are the primary cellular source for hair follicle renewal. Previous work has shown that bulge SCs are equipped with specific surveillance mechanisms protecting them against accumulation of DNA damage and unwanted cell loss to maintain tissue integrity and HF regeneration throughout lifetime. Importantly, protection of hair follicle SCs against DNA damage-induced apoptosis was shown to correlate with high levels of the anti-apoptotic protein Bcl-2 in bulge SCs. Here we show that suprabasal bulge SCs (CD34+/Itguf0616Low), located between the old and the new hair follicle, are particularly dependent on Bcl-2 mediated protection. Thus, revealing heterogeneity in the control of bulge SC survival which is required to maintain hair follicle regeneration. Our data suggest that loss of cell-matrix adhesion in suprabasal bulge SCs correlates with an increased pro-apoptotic signature, rendering suprabasal bulge SCs more prone to apoptosis and therefore more dependent on Bcl-2 mediated protection. Bcl-2 is also known as a potent proto-oncogene associated with different types of cancer. Using our previously established mutant Lef1 mouse model for oncogenic stress and SC-driven tumorigenesis we could show that Bcl-2 expression is reduced in the SC compartment but highly expressed in the tumors. Moreover, overexpression of Bcl-2 in mutant Lef1 mice resulted in an increase of tumor incidence and frequency, suggesting survival and selection of Bcl-2 expressing SCs as cells of origin for tumor formation. In summary our data reveal a dual role for Bcl-2 for epidermal regeneration and cancer. During HF regeneration, Bcl-2 is selectively protecting suprabasal bulge SCs from apoptosis while upon oncogenic stress, Bcl-2 is preventing cell death of potential tumor-inducing SCs, thereby promoting tumor formation.
Book Synopsis Neural Crest Stem Cells by : Maya Sieber-Blum
Download or read book Neural Crest Stem Cells written by Maya Sieber-Blum and published by World Scientific. This book was released on 2012 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.
Download or read book Nevogenesis written by Ashfaq A. Marghoob and published by Springer Science & Business Media. This book was released on 2012-10-13 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
Book Synopsis Stem Cells by : Mariusz Z. Ratajczak
Download or read book Stem Cells written by Mariusz Z. Ratajczak and published by Springer Nature. This book was released on 2020-01-02 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.
Book Synopsis Handbook of hair in health and disease by : Victor R. Preedy
Download or read book Handbook of hair in health and disease written by Victor R. Preedy and published by Springer. This book was released on 2012-05-23 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hair is a major component of the body's tissue system that contributes to the individual's make up and confers a large degree of personal identity. Apart from its visible façade, hair also has a functional role. It has an unique structure and complex molecular development. The very nature of hair makes it a suitable marker for the prognosis of disease. Hair can also be used to screen for toxins and changes in the diet. However, there are currently no suitable publications available that describe hair in a rational scientific context. This handbook provides an academic approach to hair in health and disease. Divided into five sections the Handbook of Hair in Health and Disease provides an insight into hair growth and loss, molecular and cellular biology of hair, dietary toxicity and pathological history, diseases and treatments of hair, as well as shampoos and conditioners. Unique features of each chapter in this volume include relevant and useful 'Key facts' which highlight interesting or important findings of the specific subjects and 'Summary points' that will give a clear overview of the subjects treated in each chapter. The Handbook of Hair in Health and Disease will be essential to a variety of users, such as trichologists, doctors and nurses and all those interested or working within the area of hair health. This includes nutritionists and dieticians, scientific beauticians, health workers and practitioners, college and university lecturers and undergraduate and graduate students.
Book Synopsis Stem Cells in Aesthetic Procedures by : Melvin A. Shiffman
Download or read book Stem Cells in Aesthetic Procedures written by Melvin A. Shiffman and published by Springer. This book was released on 2014-07-21 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.
Book Synopsis Nanoscience in Dermatology by : Michael R. Hamblin
Download or read book Nanoscience in Dermatology written by Michael R. Hamblin and published by Academic Press. This book was released on 2016-08-13 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine. Provides knowledge of current and future applications of nanoscience and nanotechnology in dermatology Outlines the fundamentals, methods, toxicity aspects, and other relevant aspects for nanotechnology based applications in dermatology Coherently structured book written by experts working in the fields covered
Book Synopsis Cancer Stem Cells: New Horizons in Cancer Therapies by : Surajit Pathak
Download or read book Cancer Stem Cells: New Horizons in Cancer Therapies written by Surajit Pathak and published by Springer Nature. This book was released on 2020-10-17 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.
Download or read book Muse Cells written by Mari Dezawa and published by Springer. This book was released on 2018-11-27 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.
Book Synopsis Cell Biology of the Ovary by : Hidetaka Katabuchi
Download or read book Cell Biology of the Ovary written by Hidetaka Katabuchi and published by Springer. This book was released on 2018-05-11 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique compilation focuses on a very curious organ, the ovary. There are still many unknown facts about the origins of ovarian tissue and ovarian cancer, and each chapter describes in detail the latest insights into the ovary from basic to clinical aspects. Expert authors reveal the most recent findings on ovariogenesis and ovarian carcinogenesis by shedding light on stem cell biology for the ovarian surface epithelial cells or primordial germ cells. Readers will greatly increase their understanding of the relevance of the cells that constitute the ovary, which is of vast significance in comprehending the occurrence mechanism of ovarian tissue and ovarian cancer. In this way the book covers a wide range of fields concerned with the ovary. This work benefits not only gynecologists and obstetricians, but also basic researchers in the field of stem cell biology and all clinicians who are involved in the management of fertility preservation or ovarian cancer.
Download or read book Stem Cells written by C. Potten and published by Elsevier. This book was released on 1996-10-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells are relatively undifferentiated cells which are the permanent lineage ancestor cells of tissues. Newly developed molecular biological techniques and probes have made possible dramatic advances in our ability to study the lineage development of stem cells. A major impetus to develop these techniques has been to identify specific stem cells for gene therapy purposes. The role that stem cells play in the development of cancer is also an important area. This book provides up-to-date reviews on a wide variety of stem cell systems by world experts. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest. It will also be usefule to radiobiologist, biotechnologists, and gene therapists. Provides reviews of stem cell systems by world experts Covers stem cell biology in plants, invertebrates, and mammals Presents clinical implications of stem cell differentiation
Book Synopsis Stem Cell Biology by : Daniel R. Marshak
Download or read book Stem Cell Biology written by Daniel R. Marshak and published by CSHL Press. This book was released on 2001 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells are the focus of intense interest from a growing, multidisciplinary community of investigators with new tools for isolating and characterizing these elusive cell types. This volume, which features contributions from many of the world's leading laboratories, provides a uniquely broad and authoritative basis for understanding the biology of stem cells and the current excitement about their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their collaborators in the emerging field of regenerative medicine.
Book Synopsis Cytoskeletal-membrane Interactions and Signal Transduction by : Pam Cowin
Download or read book Cytoskeletal-membrane Interactions and Signal Transduction written by Pam Cowin and published by Landes Bioscience. This book was released on 1997 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hair and Scalp Disorders by : Zekayi Kutlubay
Download or read book Hair and Scalp Disorders written by Zekayi Kutlubay and published by BoD – Books on Demand. This book was released on 2017-05-03 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook contains the latest advances and scientific knowledge from the leading experts in hair biology, hair disorders, and clinical trichology. The book consists of ten sections in which hair biology, hair genetics, hair diagnostics, hair loss types, pathogenesis, treatment options, and restoration techniques are discussed. This book also emphasizes on various genetic and nongenetic alopecia types, differential diagnosis, and the measurement of hair loss. One chapter of the book is devoted to natural products for hair care and treatment. We believe that this textbook will serve as a comprehensive guide to many physicians dealing with hair disorders in their clinical practice.
Book Synopsis Stem Cells & Regenerative Medicine by : Krishnarao Appasani
Download or read book Stem Cells & Regenerative Medicine written by Krishnarao Appasani and published by Springer Science & Business Media. This book was released on 2010-11-01 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.
Download or read book Prognostic Epigenetics written by and published by Academic Press. This book was released on 2019-11-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive information on how mapping an individual's epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook.
