Chapter 35 The Importance Of Geographic Differences In Pediatric Clinical Trials

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Chapter 35: The Importance of Geographic Differences in Pediatric Clinical Trials

Author : Andrew E. Mulberg
Publisher : Wiley-Blackwell
ISBN 13 : 9780470582398
Total Pages : 683 pages
Book Rating : 4.5/5 (823 download)

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Book Synopsis Chapter 35: The Importance of Geographic Differences in Pediatric Clinical Trials by : Andrew E. Mulberg

Download or read book Chapter 35: The Importance of Geographic Differences in Pediatric Clinical Trials written by Andrew E. Mulberg and published by Wiley-Blackwell. This book was released on 2009-08-13 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive treatmentof this vital topicFor decades, the specific needs of infants, children, and adolescents have been largely ignored in the drug development process, and healthcare providers have most often had to make do with pediatric dosing of drugs that were developed and intended for adults. Now, an awareness of the differences between the pediatric patient and the adult patient have begun to be realized and addressed by the pharmaceutical and wider healthcare industries, as well as the governmental and regulatory bodies that sanction the development and testing of drugs for children.This is the first book to provide a comprehensive treatment of pediatric drug development. Written by a team of experts, it provides industry, academia, and governmental agencies with an understanding of how to properly develop drugs for children without compromising business objectives. The authors address the scientific differences between the pediatric and adult subject in the development of pharmaceutical products. They discuss and consider: ethics--from product concept to production; specific medical needs of children; business rationale for the proper development of drugs for children; and the technical feasibility of studies and processes that are necessary for a proper pediatric drug development program.The book clearly explains the challenges and opportunities facing the entire healthcare community as it strives to improve the health of children worldwide. It demonstrates how these approaches will benefit all stakeholders and, ultimately, provide better and safer drugs for the pediatric population at large.This timely new work is essential reading for academic researchers, pharmaceutical managers and executives, healthcare clinicians, policymakers, regulators, and lobbyists with an interest in pediatric drug development. It also serves as an important textbook for students in pharmacy, science, and medicine courses.

Pediatric Drug Development

Author : Andrew E. Mulberg
Publisher : John Wiley & Sons
ISBN 13 : 1118210433
Total Pages : 843 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Pediatric Drug Development by : Andrew E. Mulberg

Download or read book Pediatric Drug Development written by Andrew E. Mulberg and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 843 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Drug Development: Concepts and Applications is designed as a reference and textbook and is meant to address the science of differences between the pediatric and adult subject in the development of pharmaceutical products. Considered are the ethics and medical needs of proper understanding the pediatric and adult differences, the business case for proper development of drugs for children, as well as the technical feasibility studies and processes that are necessary for a proper pediatric drug development program. The applications of these approaches will benefit all stakeholders and ultimately not only educate but also provide better and safer drugs for pediatric patients.

Understanding Information Retrieval Systems

Author : Marcia J. Bates
Publisher : CRC Press
ISBN 13 : 1439891990
Total Pages : 752 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Understanding Information Retrieval Systems by : Marcia J. Bates

Download or read book Understanding Information Retrieval Systems written by Marcia J. Bates and published by CRC Press. This book was released on 2011-12-20 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to be effective for their users, information retrieval (IR) systems should be adapted to the specific needs of particular environments. The huge and growing array of types of information retrieval systems in use today is on display in Understanding Information Retrieval Systems: Management, Types, and Standards, which addresses over 20 typ

Retina

Author : David R. Hinton
Publisher : Elsevier Health Sciences
ISBN 13 : 0323025986
Total Pages : 2744 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Retina by : David R. Hinton

Download or read book Retina written by David R. Hinton and published by Elsevier Health Sciences. This book was released on 2005-09-21 with total page 2744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praised by JAMA as "The most complete description of the development, structure, function, pathophysiology, and treatment of the retina and its diseases to be found anywhere," this monumental three-volume work puts all of today's scientific and clinical knowledge of the retina at readers' fingertips. The New Edition has been comprehensively updated and reorganized to reflect all of the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques. The result is an indispensable reference and diagnostic tool for generalists and specialists alike. Delivers the editorial expertise of four highly respected authorities, as well as contributions from internationally recognized leaders in visual science, ophthalmology, and vitreoretinal studies. Presents more than 3,400 superb illustrations (2,200 in full color) that capture all forms of retinal disease from every perspective. Offers the very latest information on the genetic basis of retinal disease, diagnostic retinal imaging, photodynamic therapy, and age-related macular degeneration. Examines the most recent advances in diagnostic indocyanine green angiography � optical coherence tomography (OCT) and quantitative fluoroscein angiography � macular translocation with 360� peripheral retinectomy � surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy � artificial vision � and much more. Features a completely restructured section on age-related macular degeneration that includes epidemiology and risk factors � prophylaxis and prevention knowledge gained from large clinical trials like AREDS � proven and experimental treatments for AMD � and pharmacotherapy. Incorporates a multitude of new full-color images, 2200 in all.

Pharmacoepidemiology

Author : Brian L. Strom
Publisher : John Wiley & Sons
ISBN 13 : 0470866837
Total Pages : 912 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Pharmacoepidemiology by : Brian L. Strom

Download or read book Pharmacoepidemiology written by Brian L. Strom and published by John Wiley & Sons. This book was released on 2006-01-04 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of Pharmacoepidemiology is an outstandingand fully comprehensive textbook, which will be an essentialresource for all interested in the field—in academia, inregulatory agencies, in industry and in the law. BrianStrom’s classic textbook continues both to reflect theincreased maturation of pharmacoepedemiology and to help shapeit’s direction. Reviews of previous editions of his celebrated textbookinclude: "The book is essential reading for anyone interested inpharmacoepidemiology." INTERNATIONAL JOURNAL OF EPIDEMIOLOGY “…an excellent textbook and a comprehensivereference which belongs in the library of everypharmaceutical manufacturer and regulator." EUROPEAN JOURNAL OF PUBLIC HEALTH

Hunter's Tropical Medicine and Emerging Infectious Diseases E-Book

Author : Edward T Ryan
Publisher : Elsevier Health Sciences
ISBN 13 : 0323625509
Total Pages : 1264 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Hunter's Tropical Medicine and Emerging Infectious Diseases E-Book by : Edward T Ryan

Download or read book Hunter's Tropical Medicine and Emerging Infectious Diseases E-Book written by Edward T Ryan and published by Elsevier Health Sciences. This book was released on 2019-03-25 with total page 1264 pages. Available in PDF, EPUB and Kindle. Book excerpt: New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter’s Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You’ll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. Provides new vaccine schedules and information on implementation. Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more.

Transforming the Workforce for Children Birth Through Age 8

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309324882
Total Pages : 706 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Transforming the Workforce for Children Birth Through Age 8 by : National Research Council

Download or read book Transforming the Workforce for Children Birth Through Age 8 written by National Research Council and published by National Academies Press. This book was released on 2015-07-23 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Children are already learning at birth, and they develop and learn at a rapid pace in their early years. This provides a critical foundation for lifelong progress, and the adults who provide for the care and the education of young children bear a great responsibility for their health, development, and learning. Despite the fact that they share the same objective - to nurture young children and secure their future success - the various practitioners who contribute to the care and the education of children from birth through age 8 are not acknowledged as a workforce unified by the common knowledge and competencies needed to do their jobs well. Transforming the Workforce for Children Birth Through Age 8 explores the science of child development, particularly looking at implications for the professionals who work with children. This report examines the current capacities and practices of the workforce, the settings in which they work, the policies and infrastructure that set qualifications and provide professional learning, and the government agencies and other funders who support and oversee these systems. This book then makes recommendations to improve the quality of professional practice and the practice environment for care and education professionals. These detailed recommendations create a blueprint for action that builds on a unifying foundation of child development and early learning, shared knowledge and competencies for care and education professionals, and principles for effective professional learning. Young children thrive and learn best when they have secure, positive relationships with adults who are knowledgeable about how to support their development and learning and are responsive to their individual progress. Transforming the Workforce for Children Birth Through Age 8 offers guidance on system changes to improve the quality of professional practice, specific actions to improve professional learning systems and workforce development, and research to continue to build the knowledge base in ways that will directly advance and inform future actions. The recommendations of this book provide an opportunity to improve the quality of the care and the education that children receive, and ultimately improve outcomes for children.

Pediatric Respiratory Medicine E-Book

Author : Lynn M. Taussig
Publisher : Elsevier Health Sciences
ISBN 13 : 0323070728
Total Pages : 1400 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Pediatric Respiratory Medicine E-Book by : Lynn M. Taussig

Download or read book Pediatric Respiratory Medicine E-Book written by Lynn M. Taussig and published by Elsevier Health Sciences. This book was released on 2008-04-09 with total page 1400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring the work of recognized worldwide experts, this user-friendly text presents the most current scientific information, diagnostic approaches, and management strategies for the care of children with acute and chronic respiratory diseases. A consistent chapter format enables you to rapidly and effortlessly locate the most current protocols on manifestations, etiologies, triggers, approaches to treatment, complications, and preventative strategies. And, a bonus website—new to this edition—features all of the book’s illustrations and extensive reference lists for each chapter in electronic format for your personal use. Includes guidance on differential diagnosis to help you determine which disease or condition your patient may have. Uses extensive color-coded algorithms to facilitate quick diagnosis, management, and treatment decisions. Organizes material to parallel your clinical decision making process. Provides expert guidance on what diagnostic tests to order for each patient—and how to interpret the results. Presents important “take home concepts within each chapter to help you recall clinical pearls. Includes the most need-to-know basic science, focusing on providing clear implications for patient care. Includes a separate website with all of the images from the text and extensive reference lists—downloadable for your personal use. Provides the latest scientific information and diagnostic and management strategies for the care of children with respiratory illnesses. Features a new, functional four-color design to help you identify important information quickly and differentiate between essential and extraneous material. Presents cutting-edge coverage with new information on the biology of, and the influences on, the respiratory system during childhood, as well as the diagnosis and management of both common (ie, wheezing infant, cystic fibrosis, tuberculosis) and less common (ie, SARS, chest tumors, collagen vascular diseases, Familial Mediterranean Fever) conditions.

Model Rules of Professional Conduct

Author : American Bar Association. House of Delegates
Publisher : American Bar Association
ISBN 13 : 9781590318737
Total Pages : 216 pages
Book Rating : 4.3/5 (187 download)

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Book Synopsis Model Rules of Professional Conduct by : American Bar Association. House of Delegates

Download or read book Model Rules of Professional Conduct written by American Bar Association. House of Delegates and published by American Bar Association. This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.

Hypertension Primer

Author : Joseph L. Izzo
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781782050
Total Pages : 644 pages
Book Rating : 4.7/5 (82 download)

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Book Synopsis Hypertension Primer by : Joseph L. Izzo

Download or read book Hypertension Primer written by Joseph L. Izzo and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its thoroughly updated Fourth Edition, the Hypertension Primer is a comprehensive, readable source of state-of-the-art scientific and clinical information on hypertension. The book contains 171 short chapters by distinguished experts that cover every aspect of hypertension and its pathogenesis, epidemiology, impact, and management. Highlights of this edition include updated JNC 7 findings regarding special population therapy and clinical management. Chapters are grouped into three well-organized sections—basic science, population science, and clinical management—and each chapter is cross-referenced to other relevant chapters. Each chapter is easily digestible and begins with a bulleted list of key points.

Pediatric Hematology

Author : Robert Wynn
Publisher : Cambridge University Press
ISBN 13 : 1107439361
Total Pages : 299 pages
Book Rating : 4.1/5 (74 download)

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Book Synopsis Pediatric Hematology by : Robert Wynn

Download or read book Pediatric Hematology written by Robert Wynn and published by Cambridge University Press. This book was released on 2017-02-16 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: A succinct summary of the key principles and facts that guide the everyday practice of modern, clinical paediatric hematology. Covering all the information necessary for examinations in the topic, this book is ideal for postgraduates studying paediatric hematology, as well as for junior doctors in training.

Burns' Pediatric Primary Care - E-Book

Author : Dawn Lee Garzon
Publisher : Elsevier Health Sciences
ISBN 13 : 0443110425
Total Pages : 1026 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Burns' Pediatric Primary Care - E-Book by : Dawn Lee Garzon

Download or read book Burns' Pediatric Primary Care - E-Book written by Dawn Lee Garzon and published by Elsevier Health Sciences. This book was released on 2023-11-27 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: Build a comprehensive foundation in children’s primary care. Burns' Pediatric Primary Care, 8th Edition, covers the full spectrum of health conditions seen in primary care pediatrics, emphasizing both prevention and management. This in-depth, evidence-based textbook is the only one on the market written from the unique perspective of the Nurse Practitioner. It guides you through assessing, managing, and preventing health problems in children from infancy through adolescence. Key topics include developmental theory, issues of daily living, the health status of children today, and diversity and cultural considerations. Updated content throughout reflects the latest research evidence, national and international protocols, and standardized guidelines. Additionally, this edition includes three new chapters on topics such as palliative care; inclusivity, equity, diversity, and justice; and child maltreatment. Comprehensive content provides a complete foundation in the primary care of children from the unique perspective of the Nurse Practitioner and covers the full spectrum of health conditions seen in the primary care of children, emphasizing both prevention and management. In-depth guidance covers assessing and managing pediatric health problems in patients from infancy through adolescence. Highlights indicate situations that require urgent action, consultation, or referral for additional treatment outside the primary care setting. Coverage of activities related to every child’s daily living, such as nutrition and toilet training, explores issues that could lead to health problems unless appropriate education and guidance are given. Algorithms throughout the book provide a concise overview of the evaluation and management of common disorders. Resources for providers and families are included throughout the text for further information. Expert editor team is well-versed in the scope of practice and knowledge base of Pediatric Nurse Practitioners (PNPs) and Family Nurse Practitioners (FNPs).

Maternal Child Nursing Care in Canada - E-Book

Author : Lisa Keenan-Lindsay
Publisher : Elsevier Health Sciences
ISBN 13 : 0323759203
Total Pages : 1620 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Maternal Child Nursing Care in Canada - E-Book by : Lisa Keenan-Lindsay

Download or read book Maternal Child Nursing Care in Canada - E-Book written by Lisa Keenan-Lindsay and published by Elsevier Health Sciences. This book was released on 2021-12-17 with total page 1620 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW! Consolidated, revised, and expanded mental health concerns chapter and consolidated pediatric health promotion chapter offer current and concise coverage of these key topics. NEW and UPDATED! Information on the latest guidelines includes SOGC guidelines, STI and CAPWHN perinatal nursing standards, Canadian Pediatrics Association Standards, Canadian Association of Midwives, and more. NEW! Coverage reflects the latest Health Canada Food Guide recommendations. UPDATED! Expanded coverage focuses on global health perspectives and health care in the LGBTQ2 community, Indigenous, immigrant, and other vulnerable populations. EXPANDED! Additional case studies and clinical reasoning/clinical judgement-focused practice questions in the printed text and on the Evolve companion website promote critical thinking and prepare you for exam licensure. NEW! Case studies on Evolve for the Next Generation NCLEX-RN® exam provide practice for the Next Generation NCLEX.

BOPOD - Wong's Nursing Care of Infants and Children

Author : Marilyn J. Hockenberry
Publisher : Elsevier Health Sciences
ISBN 13 : 0323293409
Total Pages : 1845 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis BOPOD - Wong's Nursing Care of Infants and Children by : Marilyn J. Hockenberry

Download or read book BOPOD - Wong's Nursing Care of Infants and Children written by Marilyn J. Hockenberry and published by Elsevier Health Sciences. This book was released on 2014-01-30 with total page 1845 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most trusted authority in pediatric nursing, Wong's Nursing Care of Infants and Children provides unmatched, comprehensive coverage of pediatric growth, development, and conditions. Its unique 'age and stage' approach covers child development and health promotion as well as specific health problems organized by age groups and body systems. Leading pediatric experts Dr. Marilyn Hockenberry and David Wilson provide an evidence-based, clinical perspective based on nearly 30 years of hands-on experience. Easy to read and extensively illustrated, this edition focuses on patient-centered outcomes and includes updates on topics such as the late preterm infant, immunizations, the H1N1 virus, and childhood obesity. A clear, straightforward writing style makes content easy to understand. Unique Evidence-Based Practice boxes help you apply both research and critical thought processes to support and guide the outcomes of nursing care. Unique Atraumatic Care boxes contain techniques for care that minimize pain, discomfort, or stress. Unique Critical Thinking exercises help you test and develop your own analytical skills. A unique focus on family content emphasizes the role and influence of the family in health and illness with a separate chapter, discussions throughout the text, and family-centered care boxes. Nursing Care Guidelines provide clear, step-by-step, detailed instructions on performing specific skills or procedures. Unique Emergency Treatment boxes serve as a quick reference for critical situations. Unique Cultural Awareness boxes highlight ways in which variations in beliefs and practices affect nursing care for children. A developmental approach identifies each stage of a child's growth. Health promotion chapters emphasize principles of wellness and injury prevention for each age group. Student-friendly features include chapter outlines, learning objectives, key points, references, and related topics and electronic resources to help you study and review important content. A community focus helps you care for children outside the clinical setting. Nursing Care Plans include models for planning patient care, with nursing diagnoses, patient/family goals, nursing interventions/rationales, expected outcomes, and NIC and NOC guidelines. Nursing Tips include helpful hints and practical, clinical information, and Nursing Alerts provide critical information that must be considered in providing care.

Pediatric Critical Care E-Book

Author : Bradley P. Fuhrman
Publisher : Elsevier Health Sciences
ISBN 13 : 032341558X
Total Pages : 1960 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Pediatric Critical Care E-Book by : Bradley P. Fuhrman

Download or read book Pediatric Critical Care E-Book written by Bradley P. Fuhrman and published by Elsevier Health Sciences. This book was released on 2016-11-29 with total page 1960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Still the #1 resource for today’s pediatric ICU teams, Pediatric Critical Care, 5th Edition covers the entire field, from basic science to cutting-edge clinical applications. Drs. Bradley P. Fuhrman and Jerry J. Zimmerman, accompanied by an expert team of editors and contributors from around the world, bring you today’s best information on the current and future landscape of pediatric critical care so you can consistently deliver optimum care to your young patients. Boasts highly readable, concise chapters with hundreds of useful photos, diagrams, algorithms, and clinical pearls. Clear, logical, organ-system approach allows you to focus on the development, function, and treatment of a wide range of disease entities. Includes new content on the expanding use of ultrasound at the bedside and the increase in nursing responsibilities in the PICU. Eighteen new chapters cover topics such as delirium, metabolism, endocrinology, nutrition, nursing, and much more. Features expanded and updated information on critical communication, professionalism, long-term outcomes, palliative care, ultrasonography, PCCM in resource-limited settings, ventilator-induced lung injury, non-invasive ventilation, updated CNS pathophysiology, the ‘Erythron’, and immunity and infection.

Principles and Practice of Pediatric Infectious Diseases E-Book

Author : Marc Fischer
Publisher : Elsevier Health Sciences
ISBN 13 : 0323461328
Total Pages : 2253 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Principles and Practice of Pediatric Infectious Diseases E-Book by : Marc Fischer

Download or read book Principles and Practice of Pediatric Infectious Diseases E-Book written by Marc Fischer and published by Elsevier Health Sciences. This book was released on 2017-05-09 with total page 2253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 5th Edition, by Drs. Sarah Long, Charles Prober, and Marc Fischer, is your go-to resource for authoritative information on infectious diseases in children and adolescents. A veritable "who's who" of global authorities provides the practical knowledge you need to understand, diagnose, and manage almost any pediatric infectious disease you may encounter. Features a consistent, easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables. Allows quick look-up by clinical presentation, pathogen, or type of host. Includes coverage of the latest vaccine products, recommendations, and effectiveness as well as expanded diagnostics and therapies for autoinflammatory/periodic fever syndromes. Covers emerging viruses such as Zika, Ebola, and EV-D68, as well as infectious risks of immunomodulating drugs and expanding antimicrobial resistance patterns. Discusses expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Blood and Marrow Transplantation Long Term Management

Author : Bipin N. Savani
Publisher : John Wiley & Sons
ISBN 13 : 111961273X
Total Pages : 464 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Blood and Marrow Transplantation Long Term Management by : Bipin N. Savani

Download or read book Blood and Marrow Transplantation Long Term Management written by Bipin N. Savani and published by John Wiley & Sons. This book was released on 2021-03-16 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood and Marrow Transplantation Long Term Management Hematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances have been made in the field of HCT, to the point where HCT has become an integral part of treatment modality for a variety of hematologic malignancies and some nonmalignant diseases. HCT remains an important treatment option for a wide variety of hematologic and nonhematologic disorders, despite recent advances in the field of immunologic therapies. Factors driving this growth include expanded disease indications, greater donor options (expanding unrelated donor registries and haploidentical HCT), and accommodation of older and less fit recipients. The development of less toxic pretransplant conditioning regimens, more effective prophylaxis of graft-versus-host disease (GVHD), improved infection control, and other advances in transplant technology have resulted in a rapidly growing number of transplant recipients surviving long-term free of the disease for which they were transplanted. The changes over decades in the transplant recipient population and in the practice of HCT will have almost inevitably altered the composition of the long-term survivor population over time. Apart from an increasingly older transplant recipient cohort, the pattern of transplant indications has shifted from the 1990s when chronic myeloid leukemia made up a significant proportion of allo-HCT indications. Changes in cell source, donor types, conditioning regimens, GVHD prophylaxis, and supportive care have all occurred, with ongoing reductions in both relapse and non-relapse mortality (NRM) have been demonstrated. These patients have increased risks for a variety of late complications, which can cause morbidity and mortality. Most long-term survivors return to the care of their local hematologists/oncologists or primary care physicians, who may not be familiar with specialized monitoring and management of long complications after HCT for this patient population. As HCT survivorship increases, the focus of care has shifted to the identification and treatment of long-term complications that may affect quality of life and long-term morbidity and mortality. Preventive care as well as early detection and treatments are important aspects to reducing morbidity and mortality in long-term survivors after allo-HCT. This second edition, Blood and Marrow Transplantation Long Term Management: Survivorship after Transplant, provides up-to-date information about diagnosis, screening, treatment, and long-term surveillance of long-term survivors after HCT.