Changing Paradigms in Breast Cancer Diagnosis and Treatment, An Issue of Surgical Oncology Clinics of North America, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 032356660X
Total Pages : pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Changing Paradigms in Breast Cancer Diagnosis and Treatment, An Issue of Surgical Oncology Clinics of North America, E-Book by : Kelly K. Hunt

Download or read book Changing Paradigms in Breast Cancer Diagnosis and Treatment, An Issue of Surgical Oncology Clinics of North America, E-Book written by Kelly K. Hunt and published by Elsevier Health Sciences. This book was released on 2017-11-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Kelly Hunt, is devoted to Changing Paradigms in Breast Cancer Diagnosis and Treatment. Dr. Hunt has assembled expert authors to review the following topics: Tomosynthesis in breast cancer imaging: how does it fit into preoperative evaluation and surveillance?; Lobular breast cancer: different disease, different algorithms?; Hypofractionated radiation therapy in breast conserving therapy; Oncoplastic breast reconstruction: should all patients be considered?; Neoadjuvant endocrine therapy: who benefits most?; Breast cancer disparities: how can we leverage genomics to improve outcomes?; Anatomy and breast cancer staging: is it still relevant?; When does atypical ductal hyperplasia require surgical intervention?; Surgical intervention for lymphedema; Are there alternative strategies in the local management of DCIS?; Genetic testing and genetic counseling: what is standard of care?; Molecular subtypes and local-regional control of breast cancer; Intraoperative margin assessment in breast cancer management; Triple negative breast cancer: who should receive neoadjuvant chemotherapy?; and more!

Changing Paradigms in Breast Cancer Diagnosis and Treatment, an Issue of Surgical Oncology Clinics of North America

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Publisher : Elsevier
ISBN 13 : 9780323566599
Total Pages : pages
Book Rating : 4.5/5 (665 download)

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Book Synopsis Changing Paradigms in Breast Cancer Diagnosis and Treatment, an Issue of Surgical Oncology Clinics of North America by : Kelly K. Hunt

Download or read book Changing Paradigms in Breast Cancer Diagnosis and Treatment, an Issue of Surgical Oncology Clinics of North America written by Kelly K. Hunt and published by Elsevier. This book was released on 2017-12-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Kelly Hunt, is devoted to Changing Paradigms in Breast Cancer Diagnosis and Treatment. Dr. Hunt has assembled expert authors to review the following topics: Tomosynthesis in breast cancer imaging: how does it fit into preoperative evaluation and surveillance?; Lobular breast cancer: different disease, different algorithms?; Hypofractionated radiation therapy in breast conserving therapy; Oncoplastic breast reconstruction: should all patients be considered?; Neoadjuvant endocrine therapy: who benefits most?; Breast cancer disparities: how can we leverage genomics to improve outcomes?; Anatomy and breast cancer staging: is it still relevant?; When does atypical ductal hyperplasia require surgical intervention?; Surgical intervention for lymphedema; Are there alternative strategies in the local management of DCIS?; Genetic testing and genetic counseling: what is standard of care?; Molecular subtypes and local-regional control of breast cancer; Intraoperative margin assessment in breast cancer management; Triple negative breast cancer: who should receive neoadjuvant chemotherapy?; and more!

Changing Paradigms in the Management of Breast Cancer

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Author :
Publisher : Springer
ISBN 13 : 3319603361
Total Pages : 243 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Changing Paradigms in the Management of Breast Cancer by : Marissa Howard-McNatt

Download or read book Changing Paradigms in the Management of Breast Cancer written by Marissa Howard-McNatt and published by Springer. This book was released on 2017-09-12 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is designed to present a comprehensive and state-of the-art approach to the management of breast cancer within the fields of surgery, medical oncology, and radiation oncology. Sections address changes in these fields. These areas include breast imaging, management of the axilla, atypical breast lesions, surgical margins, new techniques in breast reconstruction, and nipple sparing and contralateral mastectomies. Subsequent chapters focus on issues in medical oncology including, triple negative breast cancer and metastatic breast disease. New paradigms in radiation oncology are examined. Breast cancer treatment in the elderly and in young women, and genetic risk in breast cancer management is also be discussed. Written by experts in their field, each of these sections addresses advances and changes in the field. A brief review of the existing literature addressing the particular topic follows in each section. The text concludes with chapters on pathological issues and advances in radiation oncology. As access to a comprehensive multidisciplinary resource such as this is currently limited in the literature, Changing Paradigms in the Management of Breast Cancer represents the first single source to provide information on advances and outcomes for the physician caring for breast cancer patients in a multidisciplinary setting.

Breast Cancer, An Issue of Surgical Oncology Clinics of North America,

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 032331192X
Total Pages : 241 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Breast Cancer, An Issue of Surgical Oncology Clinics of North America, by : Lisa Newman

Download or read book Breast Cancer, An Issue of Surgical Oncology Clinics of North America, written by Lisa Newman and published by Elsevier Health Sciences. This book was released on 2014-09-08 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Oncology Clinics of North America is devoted to "Breast Cancer" and is edited by Lisa Newman, MD, of the University of Michigan. Expert authors in this issue review this topic in articles such as: Applications for Breast MRI; Lobular Neoplasia; Epidemiology of Breast Cancer; Percutaneous Ablation of Breast Tumors; Triple Negative Breast Cancer and the Basal Breast Cancer Subtype; Molecular Profiling of Breast Cancer; Surgical Leadership and Standardization of Multidisciplinary Breast Cancer Care; Neoadjuvant/Primary Systemic Therapy for Breast Cancer; Management of the Clinically Node-Negative Axilla in Patients with Primary and Locally-Recurrent Breast Cancer; Management of the Axilla in Patients with Node-Positive Breast Cancer; Prophylactic Bilateral Mastectomy and Contralateral Prophylactic Mastectomy; Advances in Reconstruction of Mastectomy and Lumpectomy Defects; Nipple-Sparing Mastectomy; and Breast Cancer Disparities.

Personalizing Breast Cancer Care, an Issue of Surgical Oncology Clinics of North America: Volume 32-4

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Publisher : Clinics: Surgery
ISBN 13 : 9780443181757
Total Pages : 0 pages
Book Rating : 4.1/5 (817 download)

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Book Synopsis Personalizing Breast Cancer Care, an Issue of Surgical Oncology Clinics of North America: Volume 32-4 by : Melissa Pilewskie

Download or read book Personalizing Breast Cancer Care, an Issue of Surgical Oncology Clinics of North America: Volume 32-4 written by Melissa Pilewskie and published by Clinics: Surgery. This book was released on 2023-10-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Management of Breast Cancer, An Issue of Surgical Clinics, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323613527
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Management of Breast Cancer, An Issue of Surgical Clinics, E-Book by : Catherine C. Parker

Download or read book Management of Breast Cancer, An Issue of Surgical Clinics, E-Book written by Catherine C. Parker and published by Elsevier Health Sciences. This book was released on 2018-07-20 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Clinics of North America focuses on Management of Breast Cancer, and is edited by Dr. Catherine C. Parker. Articles will include: Screening mammography: recommendations and controversies; High risk breast cancer patients: genetics and indications for prophylactic mastectomy; Incorporation of biologic factors into breast cancer staging; Impact of advancing technology on diagnosis and treatment of breast cancer; Ductal Carcinoma In Situ; Management of the axilla in the patient with breast cancer; Definition and management of positive margins for invasive breast cancer; Neoadjuvant chemotherapy for HER2-positive and triple negative breast cancer; Inflammatory breast cancer; Role of radiation in breast cancer; Breast cancer in the elderly; Evolution of operative technique for mastectomy; Breast reconstruction; Role of operative management in Stage IV breast cancer; Sarcomas of the breast; and more!

Breast Disease

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Publisher : Springer
ISBN 13 : 1493911457
Total Pages : 588 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Breast Disease by : Adam I. Riker

Download or read book Breast Disease written by Adam I. Riker and published by Springer. This book was released on 2014-11-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast Disease: Comprehensive Management provides a clear, concise source of information in order to make real-life, evidence-based decisions for all aspects of breast disease, both benign and malignant. The volume provides the latest breakthroughs in breast cancer research, ranging from paradigm shifts in the surgical management of the axilla, the changing role of adjuvant and neoadjuvant chemotherapy, the impact of molecular medicine in decision-making and the controversial role of prophylactic mastectomy in our era. Within select chapters, “How I do it” clinical scenarios are supplied and described in very practical terms. Also included at the end of each chapter are synoptic questions with detailed answers, akin to the self-assessment (SESAP) format questions and answers. These questions provide a basis for continuous medical education (CME) for the practicing physician and surgeon, further in surgical oncology and breast surgery, medical oncologists, radiation oncologists, and breast radiologists enhancing a focused approach to the management of breast disease in preparation for the American Board of Surgery certification and re-certification for the general surgeon. Breast Disease: Comprehensive Management is of great value to general surgeons, breast surgeons, surgical oncologists, general surgery residents, and fellows.

Breast Cancer, an Issue of Surgical Oncology Clinics

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Author :
Publisher : Saunders
ISBN 13 : 9781416027867
Total Pages : 240 pages
Book Rating : 4.0/5 (278 download)

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Book Synopsis Breast Cancer, an Issue of Surgical Oncology Clinics by : Stephen B. Edge

Download or read book Breast Cancer, an Issue of Surgical Oncology Clinics written by Stephen B. Edge and published by Saunders. This book was released on 2005-04 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue moves away from the standard treatise on diagnosis and treatment of breast cancer, and instead will address the some of the issues facing breast cancer medicine as we move into the future. Articles will address new technologies (immunotherapy, non-surgical ablation, biomarkers, and molecular predictors) and health care disparities (treatment in older women, and the quality of early-stage treatment, and underserved populations).

Mammography Screening

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Publisher : CRC Press
ISBN 13 : 1000477096
Total Pages : 271 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Mammography Screening by : Peter Gotzsche

Download or read book Mammography Screening written by Peter Gotzsche and published by CRC Press. This book was released on 2021-06-29 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'This book gives plenty of examples of ad hominem attacks, intimidation, slander, threats of litigation, deception, dishonesty, lies and other violations of good scientific practice. For some years I kept a folder labeled Dishonesty in breast cancer screening on top of my filing cabinet, storing articles and letters to the editor that contained statements I knew were dishonest. Eventually I gave up on the idea of writing a paper about this collection, as the number of examples quickly exceeded what could be contained in a single article.' From the Introduction The most effective way to decrease women's risk of becoming a breast cancer patient is to avoid attending screening. Mammography screening is one of the greatest controversies in healthcare, and the extent to which some scientists have sacrificed sound scientific principles in order to arrive at politically acceptable results in their research is extraordinary. In contrast, neutral observers increasingly find that the benefit has been much oversold and that the harms are much greater than previously believed. This groundbreaking book takes an evidence-based, critical look at the scientific disputes and the information provided to women by governments and cancer charities. It also explains why mammography screening is unlikely to be effective today. All health professionals and members of the public will find these revelations disturbingly illuminating. It will radically transform the way healthcare policy makers view mammography screening in the future. 'If Peter Gotzsche did not exist, there would be a need to invent him ...It may still take time for the limitations and harms of screening to be properly acknowledged and for women to be enabled to make adequately informed decisions. When this happens, it will be almost entirely due to the intellectual rigour and determination of Peter Gotzsche.' From the Foreword by Iona Heath, President, RCGP 'If you care about breast cancer, and we all should, you must read this book. Breast cancer is complex and we cannot afford to rely on the popular media, or on information from marketing campaigns from those who are invested in screening. We need to question and to understand. The story that Peter tells matters very much.' From the Foreword by Fran Visco, President, National Breast Cancer Coalition

Breast Cancer Metastasis and Drug Resistance

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Publisher : Springer Nature
ISBN 13 : 3030203018
Total Pages : 427 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Breast Cancer Metastasis and Drug Resistance by : Aamir Ahmad

Download or read book Breast Cancer Metastasis and Drug Resistance written by Aamir Ahmad and published by Springer Nature. This book was released on 2019-08-27 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Diagnosing and Treating Adult Cancers and Associated Impairments

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Publisher : National Academies Press
ISBN 13 : 9780309684002
Total Pages : pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Diagnosing and Treating Adult Cancers and Associated Impairments by : National Academies Of Sciences Engineeri

Download or read book Diagnosing and Treating Adult Cancers and Associated Impairments written by National Academies Of Sciences Engineeri and published by National Academies Press. This book was released on 2021-11-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the second leading cause of death among adults in the United States after heart disease. However, improvements in cancer treatment and earlier detection are leading to growing numbers of cancer survivors. As the number of cancer survivors grows, there is increased interest in how cancer and its treatments may affect a person's ability to work, whether the person has maintained employment throughout the treatment or is returning to work at a previous, current, or new place of employment. Cancer-related impairments and resulting functional limitations may or may not lead to disability as defined by the U.S. Social Security Administration (SSA), however, adults surviving cancer who are unable to work because of cancer-related impairments and functional limitations may apply for disability benefits from SSA. At the request of SSA, Diagnosing and Treating Adult Cancers and Associated Impairments provides background information on breast cancer, lung cancer, and selected other cancers to assist SSA in its review of the listing of impairments for disability assessments. This report addresses several specific topics, including determining the latest standards of care as well as new technologies for understanding disease processes, treatment modalities, and the effect of cancer on a person's health and functioning, in order to inform SSA's evaluation of disability claims for adults with cancer.

The Drug Development Paradigm in Oncology

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Publisher : National Academies Press
ISBN 13 : 0309457971
Total Pages : 145 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Drug Development Paradigm in Oncology by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.

Clinical Gynecology

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Publisher : Cambridge University Press
ISBN 13 : 1107040396
Total Pages : 1127 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Clinical Gynecology by : Eric J. Bieber

Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Concerning the Origin of Malignant Tumours

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Publisher :
ISBN 13 :
Total Pages : 108 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Concerning the Origin of Malignant Tumours by : Theodor Boveri

Download or read book Concerning the Origin of Malignant Tumours written by Theodor Boveri and published by . This book was released on 2008 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: An English translation of Boveri's famous monograph which was first published in Germany in 1914. Written almost a hundred years ago, Theodor Boveri's Zur Frage der Entstehung maligner Tumoren has had a momentous impact on cancer research. In it he argues that malignancy arises as a consequence of chromosomal abnormalities and that multiplication is an inherent property of cells. With astonishing prescience, Boveri predicts in this monograph the existence of tumor suppressor mechanisms and is perhaps the first to suggest that hereditary factors (genes) are linearly arranged along chromosomes. This new translation by Sir Henry Harris, Regius Professor of Medicine Emeritus at Oxford University and former Editor-in-Chief of Journal of Cell Science, includes extensive annotations in which he discusses the relevance of Boveri's views today. It is essential reading for all cancer researchers, as well as those interested in the history of cytogenetics and cell biology.

Selected Health Conditions and Likelihood of Improvement with Treatment

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Publisher : National Academies Press
ISBN 13 : 0309670950
Total Pages : 319 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Selected Health Conditions and Likelihood of Improvement with Treatment by : National Academies of Sciences, Engineering, and Medicine

Download or read book Selected Health Conditions and Likelihood of Improvement with Treatment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-12 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.

AJCC Cancer Staging Manual

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Publisher : Springer Science & Business Media
ISBN 13 : 1475736568
Total Pages : 386 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis AJCC Cancer Staging Manual by : Frederick L, Greene

Download or read book AJCC Cancer Staging Manual written by Frederick L, Greene and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.

Adjuvant Therapy of Breast Cancer

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Author :
Publisher : Springer
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Adjuvant Therapy of Breast Cancer by : I. Craig Henderson

Download or read book Adjuvant Therapy of Breast Cancer written by I. Craig Henderson and published by Springer. This book was released on 1992-08-31 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that we have made no progress in the treatment of cancer. Many of the tumors that we have been most successful in curing with chemotherapy and other newer forms of treatment are relatively uncommon. In contrast, breast cancer continues to be the single most common malignancy among women in the western world, is increasingly a cause of death throughout Asia and Third-World countries, and remains one of the most substantial causes of cancer mortality world wide. The use of mammography as a means of early detection has been shown to reduce breast cancer mortality by 25-35% among those popu lations in which it is utilized. The use of adjuvant systemic treatment in appropriate patients provides a similar (and additional) reduction in breast cancer mortality. Few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value to adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations ofsurgery and radiotherapy.