Cephalosporins And Penicillins Chemistry And Biology

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Cephalosporins and Penicillins

Author : Edwin H. Flynn
Publisher : Elsevier
ISBN 13 : 1483270173
Total Pages : 769 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Cephalosporins and Penicillins by : Edwin H. Flynn

Download or read book Cephalosporins and Penicillins written by Edwin H. Flynn and published by Elsevier. This book was released on 2013-10-22 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cephalosporins and Penicillins: Chemistry and Biology describes the studies made on cephalosporin in relation to the scientific and medicinal benefits that can be derived from cephalosporin C. This collection discusses how cephalosporin C is produced through modern isolation methods. One paper discusses its structure through chemical means, its degradation products, its derivative and other metabolic products such as penicillin N and cephalosporin P. Another paper explains the preparation method for 7-aminocephalosporanic acid and 6-aminopenicillanic acid through biological or chemical means. Another paper explains the alteration of the dihydrothiazine ring of the cephalosporins as the functionalities of these rings are chemically difficult to obtain. One paper also explains the rearrangements of cephalosporins and penicillins; cephalosporin can be synthesized from penicillin through an intermediacy of penicillin sulfoxide. Other papers discuss the pharmacology and toxicology of cephalosporins, as well as the practical tests and methods of assay that can be used in most cephalosporins, and in some cases, in penicillins. This book can prove useful for pharmacologists, microchemists, research workers, and technologists dealing with toxicology.

Chemistry of Penicillin

Author : Hans T. Clarke
Publisher : Princeton University Press
ISBN 13 : 1400874912
Total Pages : 1116 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Chemistry of Penicillin by : Hans T. Clarke

Download or read book Chemistry of Penicillin written by Hans T. Clarke and published by Princeton University Press. This book was released on 2015-12-08 with total page 1116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book makes available, for interested scientists to procure, absorb, and evaluate, the vast body of information on the research and results of the work on the chemistry of penicillin done in England and the United States during the war. The National Academy of Sciences arranged for the preparation of this summary, Dr. H. T. Clarke and Dr. J. R. Johnson representing the United States on the editorial board, and Sir Robert Robinson representing Britain. The body of the work was prepared by more than 60 outstanding biochemists and biophysicists, who describe the phases of research to which they contributed the most. The work of 23 academic, medical, industrial, and government laboratories is reported. Originally published in 1949. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Recent Progress in the Chemical Synthesis of Antibiotics

Author : Gabor Lukacs
Publisher : Springer Science & Business Media
ISBN 13 : 3642756174
Total Pages : 808 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Recent Progress in the Chemical Synthesis of Antibiotics by : Gabor Lukacs

Download or read book Recent Progress in the Chemical Synthesis of Antibiotics written by Gabor Lukacs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antibiotics in the treatment by antibacterial and antifungal chemo therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.

Penicillins and Cephalosporins

Author : Robert B. Morin
Publisher : Academic Press
ISBN 13 : 1483277194
Total Pages : 594 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Penicillins and Cephalosporins by : Robert B. Morin

Download or read book Penicillins and Cephalosporins written by Robert B. Morin and published by Academic Press. This book was released on 2014-05-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

Synthesis of β-Lactam Antibiotics

Author : Alle Bruggink
Publisher : Springer Science & Business Media
ISBN 13 : 9401008507
Total Pages : 328 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Synthesis of β-Lactam Antibiotics by : Alle Bruggink

Download or read book Synthesis of β-Lactam Antibiotics written by Alle Bruggink and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.

Synthesis of Best-Seller Drugs

Author : Ruben Vardanyan
Publisher : Academic Press
ISBN 13 : 0124115241
Total Pages : 870 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan

Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Green Chemistry and Engineering

Author : Mukesh Doble
Publisher : Academic Press
ISBN 13 : 008052477X
Total Pages : 343 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Green Chemistry and Engineering by : Mukesh Doble

Download or read book Green Chemistry and Engineering written by Mukesh Doble and published by Academic Press. This book was released on 2010-07-27 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical processes provide a diverse array of valuable products and materials used in applications ranging from health care to transportation and food processing. Yet these same chemical processes that provide products and materials essential to modern economies, also generate substantial quantities of wastes and emissions. Green Chemistry is the utilization of a set of principles that reduces or eliminate the use or generation of hazardous substances in design. Due to extravagant costs needed to managing these wastes, tens of billions of dollars a year, there is a need to propose a way to create less waste. Emission and treatment standards continue to become more stringent, which causes these costs to continue to escalate. Green Chemistry and Engineering describes both the science (theory) and engineering (application) principles of Green Chemistry that lead to the generation of less waste. It explores the use of milder manufacturing conditions resulting from the use of smarter organic synthetic techniques and the maintenance of atom efficiency that can temper the effects of chemical processes. By implementing these techniques means less waste, which will save industry millions of dollars over time. - Chemical processes that provide products and materials essential to modern economies generate substantial quantities of wastes and emissions, this new book describes both the science (theory) and engineering (application) principles of Green Chemistry that lead to the generation of less waste - This book contains expert advise from scientists around the world, encompassing developments in the field since 2000 - Aids manufacturers, scientists, managers, and engineers on how to implement ongoing changes in a vast developing field that is important to the environment and our lives

Evolution of Metabolic Pathways

Author : R. Ibrahim
Publisher : Elsevier
ISBN 13 : 0080531326
Total Pages : 481 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Evolution of Metabolic Pathways by : R. Ibrahim

Download or read book Evolution of Metabolic Pathways written by R. Ibrahim and published by Elsevier. This book was released on 2000-09-15 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has seen major advances in the cloning of genes encoding enzymes of plant secondary metabolism. This has been further enhanced by the recent project on the sequencing of the Arabidopsis genome. These developments provide the molecular genetic basis to address the question of the Evolution of Metabolic Pathways. This volume provides in-depth reviews of our current knowledge on the evolutionary origin of plant secondary metabolites and the enzymes involved in their biosynthesis. The chapters cover five major topics: 1. Role of secondary metabolites in evolution; 2. Evolutionary origins of polyketides and terpenes; 3. Roles of oxidative reactions in the evolution of secondary metabolism; 4. Evolutionary origin of substitution reactions: acylation, glycosylation and methylation; and 5. Biochemistry and molecular biology of brassinosteroids.

Antimicrobial Resistance in Agriculture

Author : Indranil Samanta
Publisher : Academic Press
ISBN 13 : 0128165235
Total Pages : 394 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Antimicrobial Resistance in Agriculture by : Indranil Samanta

Download or read book Antimicrobial Resistance in Agriculture written by Indranil Samanta and published by Academic Press. This book was released on 2019-09-25 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation is a valuable industrial resource that addresses complex, multi-factorial topics regarding farm, wild, companion animals, fish, and how the environment plays an important role in amplification and transmission of resistant bugs into the human food chain. Information of phenotypical and genotypical properties of each bacterial genus associated with antimicrobial resistance, transmission dynamics from different reservoirs (food animals, poultry, fishes) and control measures with alternative therapy, such as phytobiotics and nanomaterials are provided. Researchers, scientists and practitioners will find this an essential resource on the judicial use of antibiotics in animals and humans. - Explores all the genera of livestock and fish originated pathogenic bacteria associated with antimicrobial resistance - Presents cutting-edge research on epigenetics, nanotechnology and intervention technologies - Discusses transmission dynamics of resistance gene pools from different reservoirs, including food animals, poultry, fishes and the environment

Synthesis of Essential Drugs

Author : Ruben Vardanyan
Publisher : Elsevier
ISBN 13 : 008046212X
Total Pages : 635 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Synthesis of Essential Drugs by : Ruben Vardanyan

Download or read book Synthesis of Essential Drugs written by Ruben Vardanyan and published by Elsevier. This book was released on 2006-03-10 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references

Oxford Handbook of Infectious Diseases and Microbiology

Author : Estée Török
Publisher : Oxford University Press
ISBN 13 : 019105920X
Total Pages : 914 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Oxford Handbook of Infectious Diseases and Microbiology by : Estée Török

Download or read book Oxford Handbook of Infectious Diseases and Microbiology written by Estée Török and published by Oxford University Press. This book was released on 2016-12-06 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully reviewed and revised for its second edition, the Oxford Handbook of Infectious Diseases and Microbiology maintains its position as the must-have guide to all aspects of infectious diseases and microbiology. Reflecting the current approach to joint postgraduate training programmes, the handbook takes an integrated approach to both subjects. It covers the basic principles of bacteriology and virology, along with specific guidance on individual diseases and conditions, all in the accessible Oxford Handbook style. Now including new topics on important subjects such as microbiology specimen collection, commonly used media, molecular diagnostics, and antimicrobials in pregnancy, as well as incorporating new guidelines from WHO, NICE, and BASHH among others, this handbook ensures that the informaiton you need is accessible, clear, and easy-to-understand. Practical and comprehensive, this handbook includes coverage of National Frameworks and current legislation, together with information on topical issues such as bioterrorism and preventative medicine. Fully reviewed by specialist senior readers, and with useful links to up-to-date clinical information and online resources, this is an important addition to the Oxford Handbook Series.

Antibiotic Discovery and Development

Author : Thomas J. Dougherty
Publisher : Springer Science & Business Media
ISBN 13 : 1461414008
Total Pages : 1119 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Antibiotic Discovery and Development by : Thomas J. Dougherty

Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Antibiotics

Author : Claudio O. Gualerzi
Publisher : John Wiley & Sons
ISBN 13 : 3527659706
Total Pages : 549 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Antibiotics by : Claudio O. Gualerzi

Download or read book Antibiotics written by Claudio O. Gualerzi and published by John Wiley & Sons. This book was released on 2013-09-05 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Antimicrobial Chemotherapy

Author : Roger Finch
Publisher : OUP Oxford
ISBN 13 : 0191628654
Total Pages : 409 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Antimicrobial Chemotherapy by : Roger Finch

Download or read book Antimicrobial Chemotherapy written by Roger Finch and published by OUP Oxford. This book was released on 2012-01-05 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.

The Chemistry and Biology of Beta-Lactams

Author : Zerong Wang
Publisher : CRC Press
ISBN 13 : 1000755169
Total Pages : 468 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis The Chemistry and Biology of Beta-Lactams by : Zerong Wang

Download or read book The Chemistry and Biology of Beta-Lactams written by Zerong Wang and published by CRC Press. This book was released on 2023-05-12 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume provides the most updated information about beta-lactams relating to both the pharmaceutical industry and synthetic chemistry. It provides the antibiotic activities as well as chemical reactivities of beta-lactams, which are important because they are commonly applied as antibiotics in the treatment of bacterial infections. The volume provides comprehensive coverage of most of the known beta-lactam antibiotics with both structural and biological information, antibiotic mechanisms, self-defense mechanisms of bacteria, nearly all known synthetic methods for the preparation of beta-lactams, and possible reactions in which beta-lactams can participate. Key features: Provides the most comprehensive collection of beta-lactam antibiotics (up to 269 molecules) with chemical structures, CAS number, IUPAC names and associated biological activities attached Offers a comprehensive and detailed collection of beta-lactamase databases Explains the self-defense mechanisms of bacteria for surviving, including the formation of biofilm and conversion into L-form and secretion of beta-lactamase to deactivate the beta-lactam antibiotics Provides a comprehensive survey on the synthetic methods to make beta-lactams Gives all of the possible reactions involving beta-lactams as the starting materials Surveys over 1000 research works and includes all available DOI information The volume is a valuable resource on the antibiotic activities as well as chemical reactivities of beta-lactams for researchers and scientists, faculty, and advanced students, as well as for industry professionals working in medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, proteins and peptides.

Penicillium and Acremonium

Author : John F. Peberdy
Publisher : Springer Science & Business Media
ISBN 13 : 1489919864
Total Pages : 305 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Penicillium and Acremonium by : John F. Peberdy

Download or read book Penicillium and Acremonium written by John F. Peberdy and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology is a word that was originally coined to describe the new processes which could be derived from our ability to manipulate, in vitro, the genetic material common to all organisms. I t has now become a generic term encompassing all "applications" of living systems, including the more traditional fermentation and agricultural industries. Recombinant DNA technology has opened up new opportunities for the exploitation of microorganisms and animal and plant cells as producers or modifiers of chemical and biological products. This series of handbooks deals exclusively with microorganisms which are at the forefront of the new technologies and brings together in each of its volumes the background information necessary to appreciate the historical development of the organisms making up a particular genus, the degree to which molecular biology has opened up new opportunities, and the place they occupy in today's biotechnology industry. Our aim was to make this primarily a practical approach, with emphasis on methodology, combining for the first time information which has largely been spread across a wide literature base or only touched upon briefly in review articles. Each handbook should provide the reader with a source text, from which the importance of the genus to his or her work can be identified, and a practical guide to the handling and exploitation of the organisms included.

Prodrugs

Author : Valentino Stella
Publisher : Springer Science & Business Media
ISBN 13 : 038749782X
Total Pages : 1447 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Prodrugs by : Valentino Stella

Download or read book Prodrugs written by Valentino Stella and published by Springer Science & Business Media. This book was released on 2007-03-12 with total page 1447 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.