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Cellular Retinoic Acid Binding Protein And Breast Cancer
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Book Synopsis Cellular Retinoic Acid Binding Protein and Breast Cancer by :
Download or read book Cellular Retinoic Acid Binding Protein and Breast Cancer written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand. The first aim is to determine the extent to which CRABP-II acts in activating different isotypes of RAR. The second aim is to dissect the mechanism by which RA-induced growth inhibition is mediated. This will then allow for closer inspection of particular target genes that are under such control. The third aim is to understand the basis for RA-resistance of mammary carcinoma cells and how CRABP-II functions to overcome this resistance.
Book Synopsis The Retinoic Acid Receptors and Cellular Retinoic Acid Binding Protein II by : Leslie Jo Willmert
Download or read book The Retinoic Acid Receptors and Cellular Retinoic Acid Binding Protein II written by Leslie Jo Willmert and published by . This book was released on 2006 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Relationship of Cellular Retinoid Metabolism to Cellular Growth Inhibition in Normal Human and Carcinogenic Mammary Cell Lines by : Leslie Jean Hayden-Malloy
Download or read book The Relationship of Cellular Retinoid Metabolism to Cellular Growth Inhibition in Normal Human and Carcinogenic Mammary Cell Lines written by Leslie Jean Hayden-Malloy and published by . This book was released on 2001 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Retinoic Acid-binding Protein 2 Cooperates with HuR to Stabilize RNA and Inhibit Tumor Growth by : Amanda C Vreeland
Download or read book Cellular Retinoic Acid-binding Protein 2 Cooperates with HuR to Stabilize RNA and Inhibit Tumor Growth written by Amanda C Vreeland and published by . This book was released on 2015 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular retinoic acid-binding protein 2 (CRABP2) enhances the transcriptional activation of the nuclear receptors termed retinoic acid receptors (RARs) by transporting retinoic acid (RA) from the cytosol to the nucleus and directly "channeling" it to RARs. One outcome of this cooperation is that CRABP2 enhances the RAR-mediated anti-carcinogenic activity of RA.Interestingly, it has been reported that CRABP2 also regulates the expression of some genes and displays pro-apoptotic activities in the absence of RA, using a mechanism that does not involve RAR. These observations suggest a novel function for the protein. The goal of this work was to determine the molecular mechanism by which apo-CRABP2 exerts its RA-independent activity and to examine whether it contributes to the tumor suppressive function of the protein. We found that apo-CRABP2 cooperates with the RNA-binding and stabilizing protein HuR to upregulate and stabilize mRNAs. CRABP2 directly interacts with HuR and enhances its affinity for target mRNAs. We found further that some transcripts that are co-regulated by CRABP2 and HuR include mRNAs for cancer-related proteins such as apoptotic peptidase activating factor-1, caspase 7, BRCA1, and BRCA2. Additional studies revealed that both functions of CRABP2 respectively mediated by RAR and by HuR contribute to the tumor suppressive activity of the protein.
Book Synopsis Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications by : Maria A. Livrea
Download or read book Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications written by Maria A. Livrea and published by Birkhäuser. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolic pathways during oncogenesis. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer. The book presents recent findings on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. It also offers a survey of the molecular and cell biochemistry of retinoids. Basic researchers in biochemistry, pharmacology and cell biology as well as clinicians will find this book very informative and up-to-date. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on clinical efficiency of retinoids in skin disorders and cancer. Basic researchers in biochemistry, pharmacology, cell biology, and clinicians will find this book very informative and up-to-date. The chapters, organized in six sections, are contributed by leading scientists who have been working in the retinoid field for decades. Their experience and competence is aknowledged worldwide.
Book Synopsis Structure-function Studies of Cellular Retinoic Acid Binding Protein (CRABP) by : Jianhua Zhang
Download or read book Structure-function Studies of Cellular Retinoic Acid Binding Protein (CRABP) written by Jianhua Zhang and published by . This book was released on 1991 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Retinoic Acid Binding Protein: Cloning and Expression of the Gene by : Maria Josephina Vaessen
Download or read book Cellular Retinoic Acid Binding Protein: Cloning and Expression of the Gene written by Maria Josephina Vaessen and published by . This book was released on 1991 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retinoid Signaling Pathways written by and published by Academic Press. This book was released on 2020-04-29 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Book Synopsis Regulation of the Gene for Cellular Retinoic Acid Binding Protein Type 1 by : Dirk Adrianus Kleinjan
Download or read book Regulation of the Gene for Cellular Retinoic Acid Binding Protein Type 1 written by Dirk Adrianus Kleinjan and published by . This book was released on 1998 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Cellular Retinoic Acid-binding Protein in Retinoic Acid Mediation of Differentiation by : John Hastings Winston
Download or read book The Role of Cellular Retinoic Acid-binding Protein in Retinoic Acid Mediation of Differentiation written by John Hastings Winston and published by . This book was released on 1990 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression, Purification and Characterization of Cellular Retinoic Acid Binding Protein Types I and II. A Role in Vitamin A Metabolism by : Paul Douglas Fiorella
Download or read book Expression, Purification and Characterization of Cellular Retinoic Acid Binding Protein Types I and II. A Role in Vitamin A Metabolism written by Paul Douglas Fiorella and published by . This book was released on 1995 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Changes in Cellular Retinoic Acid Binding Proteins and Nuclear Retinoic Acid Receptors in Murine Melanoma Cell Lines Following Retinoic Acid Exposure by : Raburn M. Mallory
Download or read book Changes in Cellular Retinoic Acid Binding Proteins and Nuclear Retinoic Acid Receptors in Murine Melanoma Cell Lines Following Retinoic Acid Exposure written by Raburn M. Mallory and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Retinoic Acid on Importins [alpha] Expression Levels in Mammary Carcinoma Cells, and Electrophoretic Mobility and Stability of Cellular Retinoic Acid Binding Protein-II by : Noel Chan
Download or read book Effects of Retinoic Acid on Importins [alpha] Expression Levels in Mammary Carcinoma Cells, and Electrophoretic Mobility and Stability of Cellular Retinoic Acid Binding Protein-II written by Noel Chan and published by . This book was released on 2006 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Retinoic Acid Binding Protein, CRABP, MRNA Expression in Splotch Mutant Mouse Embryos by : Jennifer Roundell
Download or read book Cellular Retinoic Acid Binding Protein, CRABP, MRNA Expression in Splotch Mutant Mouse Embryos written by Jennifer Roundell and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Sensitivity of Primary Breast Cancer Cells to Retinoids Protein Clinical Implications by :
Download or read book Sensitivity of Primary Breast Cancer Cells to Retinoids Protein Clinical Implications written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our main goal in this study is to evaluate the sensitivity of primary breast cancer cells (PBCCs) grown both in vitro and in vivo (nude mice) to retinoids. Contrary to most previous studies on established breast cancer cell lines, in this study we assessed the effects of retinoids (all-trans retinoic acid (atRA), 9-cis retinoic acid (9cisRA) and 4-(hydroxyphenyl)retinamide (4-HPR) on PBCCs grown both, in vitro (first several passages) and in nude mice. Tissue samples from 16 breast carcinomas were cultured in vitro and in 10 of them (62.5%) satisfactory growth was found. We optimized the protocol for assessment ER, retinoic acid receptors (RAR-alpha, beta, 7), and retinoid X receptors (RAR-alpha, beta, gamma) in paraffin sections from breast tumors as well as in cells growing in vitro. We found that 7 from 16 tumors were ER negative, that RARalpha was expressed in 14, RARbeta in 10, RARgamma in 15, from 16 tumors respectively. In 60% of tumors RARbeta was expressed both in nucleus and cytoplasm. RXRalphaa and RXRgamma were also expressed both in 15 from 16 tumors. Cells from 5 tumors were implanted in nude mice and 4 indicated satisfactory growth. Tumor cells cultured in vitro, as well as growing in nude mice are currently under investigation for assessment the effects of various retinoids on cell proliferation and cell death-related markers.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2012 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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