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Cellular And Molecular Biology Of Myelination
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Book Synopsis Cellular and Molecular Biology of Myelination by : Gunnar Jeserich
Download or read book Cellular and Molecular Biology of Myelination written by Gunnar Jeserich and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Research Workshop on Cellular and Molecular Biology of Myelination, held at Monastery Ohrbeck near Osnabrück, FRG, August 28-September 2 1989
Download or read book Myelin written by Russell E. Martenson and published by Taylor & Francis. This book was released on 2023-02-06 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelin: Biology and Chemistry provides in-depth reviews and discussions regarding recent findings in the biology and chemistry of myelin. Topics are interdisciplinary and carry readers from the cellular level to that of the gene. Research in demyelinating diseases (naturally occurring and experimentally produced) is described and emphasizes autoimmune and virally induced mechanisms. Advances in molecular biology, such as those that provide details of the structures of the major myelin proteins, demonstrate the control of their synthesis, and explore the mutations within their genes that disrupt the process of myelination, are discussed in depth. Myelin: Biology and Chemistry will be an important addition to the libraries of molecular biologists, biochemists, cell biologists, physical chemists, immunologists, virologists, and pathologists involved in the study of myelin.
Author :Bernhard H.J. Juurlink Publisher :Springer Science & Business Media ISBN 13 :1461559499 Total Pages :392 pages Book Rating :4.4/5 (615 download)
Book Synopsis Cell Biology and Pathology of Myelin by : Bernhard H.J. Juurlink
Download or read book Cell Biology and Pathology of Myelin written by Bernhard H.J. Juurlink and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Fourth International Altschul Symposium held at Saskatoon, Saskatchewan, Canada, June 27-29, 1996
Download or read book Myelin written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelin: Biology and Chemistry provides in-depth reviews and discussions regarding recent findings in the biology and chemistry of myelin. Topics are interdisciplinary and carry readers from the cellular level to that of the gene. Research in demyelinating diseases (naturally occurring and experimentally produced) is described and emphasizes autoimmune and virally induced mechanisms. Advances in molecular biology, such as those that provide details of the structures of the major myelin proteins, demonstrate the control of their synthesis, and explore the mutations within their genes that disrupt the process of myelination, are discussed in depth. Myelin: Biology and Chemistry will be an important addition to the libraries of molecular biologists, biochemists, cell biologists, physical chemists, immunologists, virologists, and pathologists involved in the study of myelin.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Signaling and Regulation in Glial Cells by : Gunnar Jeserich
Download or read book Molecular Signaling and Regulation in Glial Cells written by Gunnar Jeserich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: An excellent survey of the most recent advances in the area of cellular and molecular biology of glial cells and their involvement in remyelination and functional repair in the CNS. A major part of this book deals with signaling paths within and among neural cells. Glial cells (astrocytes, oligodentrocytes, microglial cells) themselves release substantial amounts of cytokines, growth factors and other signaling molecules, which play an important role during injury and regeneration. Another signaling route between neurons and glial cells follows ion channels and neurotransmitter receptors. In addition to animal models, human oligodentrocytes in cell culture and in the human MS brain are characterized with respect to their immunocytochemistry and function.
Download or read book Myelin written by Ashwin Woodhoo and published by Humana. This book was released on 2019-07-28 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects research methodologies for both basic and translational studies of myelin authored by experts in the field. Chapters in this book are divided into three parts: Part One focuses on visualizing myelin and studying it on a biochemical level; Part Two looks at cell culture systems used to uncover key mechanisms that regulate formation and maintenance of myelin; and Part Three discusses modeling disorders of myelin in both CNS and PNS, and therapeutic strategies for targeting these disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Myelin: Methods and Protocols is a valuable resource for physiologists, molecular biologists, anatomists, cell and developmental biologists, and physician-scientists working in the field of myelin biology and the disorders associated with it.
Book Synopsis The Biology of Oligodendrocytes by : Patricia Armati
Download or read book The Biology of Oligodendrocytes written by Patricia Armati and published by Cambridge University Press. This book was released on 2010-10-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
Book Synopsis Myelin Biology and Disorders, Two-Volume Set by :
Download or read book Myelin Biology and Disorders, Two-Volume Set written by and published by Academic Press. This book was released on 2004-01-02 with total page 1600 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist. * Critically reviews and evaluates all the important genetic and molecular and cellular biological data on the individual myelin genes/proteins * Details the structural and functional biology of myelin, including a look at the relationship between neuronal damage and myelin damage as seen in multiple sclerosis * Includes forward-looking section on potential therapeutic interventions in myelin diseases
Book Synopsis Myelin Biology and Disorders by : Robert A. Lazzarini
Download or read book Myelin Biology and Disorders written by Robert A. Lazzarini and published by Academic Press. This book was released on 2004-01-01 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. This book brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. It represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.
Book Synopsis Myelination and Demyelination by : Seung U. Kim
Download or read book Myelination and Demyelination written by Seung U. Kim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: In June 1987, neurobiologists, immunologists, molecular biologists, virologists and neurologists from several countries met in Vancouver to discuss recent advances of relevance to multiple sclerosis. The symposium was a part of the 22nd Canadian Congress of Neurological Sciences meeting and was sponsored by funds from the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada. The presentations covered five major topics: basic neurobiology, molecular biology, the role of viruses in demyelination, immune function and dysfunction in multiple sclerosis, and clinical magnetic resonance imaging studies. It was heartening to note that scientists from several different disciplines were working towards a common end-point: the understanding and treatment of multiple sclerosis. In this book, speakers at the symposium have each presented a chapter of their findings and discussions. In addition, some non-participants at the symposium have been invited to submit chapters in order to give this volume a more complete scope. It is hoped that the reader will find this book a useful reference for several subjects of interest to multiple sclerosis. In closing, I would like to thank the following for their help and support: the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada for their financial support; the contributors of this book for their manuscripts; Dr. A. Eisen, Mrs. K. Eisen, Mrs. P. Bodnarchuk and Mrs. M. Kim for their efforts in planning and organizing the symposium; and Ms. Catherine Schikowski for her secretarial assistance. Seung U. Kim, M.D. Ph.D.
Book Synopsis Peripheral Nerve Disorders by : Grahame J. Kidd
Download or read book Peripheral Nerve Disorders written by Grahame J. Kidd and published by Elsevier Inc. Chapters. This book was released on 2013-08-17 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental roles of Schwann cells during peripheral nerve formation and regeneration have been recognized for more than 100 years, but the cellular and molecular mechanisms that integrate Schwann cell and axonal functions continue to be elucidated. Derived from the embryonic neural crest, Schwann cells differentiate into myelinating cells or bundle multiple unmyelinated axons into Remak fibers. Axons dictate which differentiation path Schwann cells follow, and recent studies have established that axonal neuregulin1 signaling via ErbB2/B3 receptors on Schwann cells is essential for Schwann cell myelination. Extracellular matrix production and interactions mediated by specific integrin and dystroglycan complexes are also critical requisites for Schwann cell–axon interactions. Myelination entails expansion and specialization of the Schwann cell plasma membrane over millimeter distances. Many of the myelin-specific proteins have been identified, and transgenic manipulation of myelin genes have provided novel insights into myelin protein function, including maintenance of axonal integrity and survival. Cellular events that facilitate myelination, including microtubule-based protein and mRNA targeting, and actin based locomotion, have also begun to be understood. Arguably, the most remarkable facet of Schwann cell biology, however, is their vigorous response to axonal damage. Degradation of myelin, dedifferentiation, division, production of axonotrophic factors, and remyelination all underpin the substantial regenerative capacity of the Schwann cells and peripheral nerves. Many of these properties are not shared by CNS fibers, which are myelinated by oligodendrocytes. Dissecting the molecular mechanisms responsible for the complex biology of Schwann cells continues to have practical benefits in identifying novel therapeutic targets not only for Schwann cell-specific diseases but other disorders in which axons degenerate.
Book Synopsis Cell Biology of the Axon by : Edward Koenig
Download or read book Cell Biology of the Axon written by Edward Koenig and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGF’s role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation; (Va) injury-induced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injury-induced activation of specific genes governing regeneration. Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axon’s intrinsic makeup and capacities.
Book Synopsis Molecular Biology of Multiple Sclerosis by : W. C. Russell
Download or read book Molecular Biology of Multiple Sclerosis written by W. C. Russell and published by . This book was released on 1997 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is a devastating demyelinating disease with complex aetiology which defies simple molecular description. Molecular Biology of Multiple Sclerosis provides a compendium of information on the molecular aspects of the disease. It embraces contributions on the biology and pathology of the cells of the central nervous system as well as recent advances in our understanding of the relevant biochemistry, immunology, genetics and virology. With this enhanced knowledge the prospects for transplantation and repair of the damaged myelin as well as approaches to rational therapy are considered. Studies in MS embrace a wide spectrum of disciplines and this volume will be indispensible to neurologist, molecular biologists, biochemists, microbiologists, geneticists and immunologists with an interest in MS.
Book Synopsis Magnetic Resonance of Myelin, Myelination, and Myelin Disorders by : Marjo S. van der Knaap
Download or read book Magnetic Resonance of Myelin, Myelination, and Myelin Disorders written by Marjo S. van der Knaap and published by . This book was released on 1995 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second, completely rewritten edition of the widely acclaimed book on MR of myelin, myelination and myelin disorders (1989). In the last five years many new data became available with regard to genetics, molecular biology, the role of cellular substructures on one side and on the other side regarding the growing experience with MR patterns of less common myelin disorders. Not only, therefore, the text has been updated, but many new chapters have been added on disorders of which previously the white matter involvement was less clear. The acquired myelin disorders were reorganized and their backgrounds were more extensively elucidated, to place the MR examinations in the clinical context where they belong.
Book Synopsis A Multidisciplinary Approach to Myelin Diseases II by : S. Salvati
Download or read book A Multidisciplinary Approach to Myelin Diseases II written by S. Salvati and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diseases that fall under the generalized group of demyelinating diseases -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the focus of worldwide concern. This volume contains papers presented by leading scientists who attended the NATO Advanced Research Workshop held at the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This book is an update of the previous one published in 1987 of the research discussed at a similar meeting held in 1986. It was decided to hold this 2nd meeting since there has been great progress in the advances in understanding the myelinogenesis process in the last five years. The workshop gathered together scientists from many fields such as cellular and molecular biology, immunology, pathology, virology and of course clinical neurology. Stimulating ideas were exchanged in the hope that more knowledge of demyelinating diseases can lead to new theraupetic approaches. Although the workshop was on the whole similar to the previous one, this time there was more emphasis on experimental models and clinical aspects. In the former the use of animal and cellular models as tools for understanding the pathological mechanisms linked to human disease were discussed; in the latter the clinicians described the filtering down of basic research to clinical treatment The publication of this interdisciplinary exchange is to make known the results of the most recent research among the investigators from allover the world involved in these studies.
Book Synopsis Oligodendrocytes by : David A. Lyons
Download or read book Oligodendrocytes written by David A. Lyons and published by Humana Press. This book was released on 2019-03-01 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume looks at the study of oligodendrocytes through in vitro and in vivo techniques, multiple model organisms, using approaches that bridge scales from molecular through system. Chapters in this book cover topics such as fundamental molecular analyses of oligodendrocytes and myelin; in vitro, ex vivo, and in vivo molecular-cellular-electrophysiology-based techniques; oligodendrocyte formation, homeostasis, and disruption in zebrafish and Xenopus; and parallel system-level imaging of animal and human models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Oligodendrocytes: Methods and Protocols is a valuable reference guide that highlights the expansive and fast-paced nature of research into oligodendrocyte biology underlying health and function.
