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Cell Mediated Immune Responses To Bovine Respiratory Syncytial Virus
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Book Synopsis Cell Mediated Immune Responses to Bovine Respiratory Syncytial Virus by : Robert Rankin
Download or read book Cell Mediated Immune Responses to Bovine Respiratory Syncytial Virus written by Robert Rankin and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Evaluation of the Cell-mediated Immune Response to Bovine Respiratory Syncytial Virus Infection in Cattle by : Emery Waine Field
Download or read book Evaluation of the Cell-mediated Immune Response to Bovine Respiratory Syncytial Virus Infection in Cattle written by Emery Waine Field and published by . This book was released on 1979 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Cell Mediated Immune Response to Bovine Respiratory Syncytial Virus in Calves by : Robert Rankin
Download or read book The Cell Mediated Immune Response to Bovine Respiratory Syncytial Virus in Calves written by Robert Rankin and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis T Cell Responses in Calves Vaccinated with Formalin-inactivated Bovine Respiratory Syncytial Virus (BRSV) Prior to BRSV Challenge by : Amelia Raye Woolums
Download or read book T Cell Responses in Calves Vaccinated with Formalin-inactivated Bovine Respiratory Syncytial Virus (BRSV) Prior to BRSV Challenge written by Amelia Raye Woolums and published by . This book was released on 1998 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell-mediated Immune Responses in Cattle by : Carlos Reggiardo
Download or read book Cell-mediated Immune Responses in Cattle written by Carlos Reggiardo and published by . This book was released on 1978 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bovine T Cell Responses to Bovine Respiratory Syncytial Virus and a Vaccine Vector Candidate by : Matthew Robert Sandbulte
Download or read book Bovine T Cell Responses to Bovine Respiratory Syncytial Virus and a Vaccine Vector Candidate written by Matthew Robert Sandbulte and published by . This book was released on 2003 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine respiratory syncytial virus (BRSV) causes mild to severe respiratory disease in calves. The literature review section of this dissertation summarizes current knowledge of BRSV, immunity to BRSV, bovine T cell biology, and methods for analyzing cell-mediated immunity (CMI) in domestic animals. Previous work indicates that CMI responses to BRSV are critical to protective immunity. Studies described here were designed to characterize BRSV-specific responses by the different T cell subsets, particularly following vaccination. In vitro assays for BRSV-specific T cell activation were performed in parallel with conventional serum virus neutralizing antibody assays. In one study, BRSV-responsive CD4, CD8+, and [gamma][delta] T cells were identified in calves lacking detectable antibody to the virus. It was demonstrated that these individuals had immunological memory for BRSV, as they mounted anamnestic-like antibody responses to a vaccine. The practical implications are that seronegative calves are not necessarily immunologically naïve and seroconversion may not be a necessary correlate for protective immunity after vaccinating calves that have maternal antibody. In two other studies, T cell priming was monitored following immunization with commercial modified-live virus (MLV) or inactivated, adjuvanted BRSV vaccines. In the first of these experiments, calves were initially seronegative and T cell negative to BRSV. The inactivated vaccine induced higher, more sustained CD4+ and [gamma][delta] T cell responses than MLV. Inactivated vaccine also induced CD8+ T cell responses as high as those induced by MLV. In the second of these experiments, comparable vaccines from other commercial sources were administered to calves with pre-existing antibody (presumably maternal), but no detectable T cell memory. Again, greater antigen-specific T cell responses were observed in calves receiving inactivated virus with adjuvant than those receiving MLV. These results seem to support the use of inactivated BRSV vaccines, which does not conform to usual expectations of live and inactivated vaccines. Another study examined interactions between bovine T cells and modified vaccinia virus Ankara (MVA), a potential vector for BRSV gene expression in vaccines or in vitro studies. [gamma][delta] T cells from normal cattle tended to respond to MVA in vitro, in a manner consistent with an innate response or antigen cross-reactivity.
Book Synopsis Bovine Respiratory Syncytial Virus Modulation of NF-κB P65 Mediated Innate Immune Responses by : Fatoumatta Jobe
Download or read book Bovine Respiratory Syncytial Virus Modulation of NF-κB P65 Mediated Innate Immune Responses written by Fatoumatta Jobe and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression of BRSV Nucleoprotein in a Prokaryotic System by : Heather Ann van Hoosear McEligot
Download or read book Expression of BRSV Nucleoprotein in a Prokaryotic System written by Heather Ann van Hoosear McEligot and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine respiratory syncytial virus (BRSV) and respiratory syncytial virus (RSV) cause severe respiratory disease in calves and young children, respectively. Commercial vaccines against BRSV have been available for nearly two decades; however, none have proven to provide satisfactory protection. Currently, there are no commercially available vaccines against RSV. It is therefore important to evaluate various vaccine strategies for development of an effective vaccine against BRSV and RSV. BRSV infected calves develop similar clinical disease and lung lesion pathology as children do to RSV infections, making the development of an effective vaccine against BRSV also beneficial in developing an effective vaccine against RSV. Data from previous studies have demonstrated that eliciting a strong initial cell mediated immune response is essential in developing a successful vaccine against BRSV and RSV. The administration of a vaccine based on the nucleocapsid protein (NP) has been previously shown to stimulate a robust cell mediated immune response without elicitation of an IgE response in calves; undesirable IgE responses have occurred in calves vaccinated with formalin killed BRSV vaccines. In this study, the expression of the nucleocapsid gene of BRSV using a prokaryotic expression system was investigated to determine if sufficient quantities of soluble NP could be produced to use in a subunit vaccine. The nucleocapsid gene was first cloned into the GEX-4T-1 plasmid and expression of NP was induced in E. coli DH5 alpha; cells. However, expression of NP was only detected in the insoluble fraction of the DH5 alpha; cells, making the use of another prokaryotic expression system necessary. The nucleocapsid gene was then cloned into the pET100/D-TOPO plasmid and expression of NP was induced in E. coli BL21 cells. NP was preferentially expressed in the insoluble fraction of E. coli BL21 cell lysates and a detectable amount of soluble NP was expressed. However, purification of the soluble fraction of pEt100-NP transformed E. coli BL21 cells did not yield sufficient quantities of NP to be used in a subunit vaccine for BRSV to merit further use of this expression system.
Book Synopsis Studies on the Cellular Immune Responses of Lambs to Bovine Respiratory Syncytial Virus by : Alok Kumar Sharma
Download or read book Studies on the Cellular Immune Responses of Lambs to Bovine Respiratory Syncytial Virus written by Alok Kumar Sharma and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus by :
Download or read book Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interferon Production and Cell Mediated Immunity in Cattle Persistently Infected with Bovine Viral Diarrhea Virus by : Joseph Ntsefo Brewoo
Download or read book Interferon Production and Cell Mediated Immunity in Cattle Persistently Infected with Bovine Viral Diarrhea Virus written by Joseph Ntsefo Brewoo and published by . This book was released on 2006 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell Mediated Immune Response of Calves to Bovine Parainfluenza-3 Virus by : Arshad Hussain
Download or read book Cell Mediated Immune Response of Calves to Bovine Parainfluenza-3 Virus written by Arshad Hussain and published by . This book was released on 1982 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on cell-mediated immune response of cattle to parainfluenza-3 virus by : J. Moreno-López
Download or read book Studies on cell-mediated immune response of cattle to parainfluenza-3 virus written by J. Moreno-López and published by . This book was released on 1977 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Rebhun's Diseases of Dairy Cattle E-Book by : Thomas J. Divers
Download or read book Rebhun's Diseases of Dairy Cattle E-Book written by Thomas J. Divers and published by Elsevier Health Sciences. This book was released on 2007-11-13 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: REBHUN'S DISEASES OF DAIRY CATTLE, 2nd Edition is your all-in-one guide to bovine disease management. With thorough, up-to-date coverage of differential diagnosis methods, surgical and therapeutic treatment options, and prevention strategies, it provides vital information for battling bovine diseases in both dairy and non-dairy cattle. The book is organized by body system for quick, convenient reference, and this new edition meets the growing need for management of both diseases of individual cows and problems affecting whole herds. Individual case presentations provide a valuable tool for differential diagnosis. Practical overviews for procedures such as blood transfusion, abdominal paracentesis, and ECG give you reliable support for some of the most common procedures in bovine care. Body systems organization makes diagnosis easier and more effective by isolating system-specific diseases and conditions. Full-color design and over 200 new photographs depict disease processes in realistic clarity and ensure the most accurate diagnosis and treatment. Emphasis on herd health addresses the dairy industry's increased concern over population medicine. Expanded coverage of lameness highlights key problem areas in bovine feet. Revised drug usage recommendations and legal considerations present the most current information in these critical areas to help you prevent dangerous or costly errors. Additional public health/safety considerations identify diseases that pose a substantial public threat and detail special measures for related care of dairy cattle. New, innovative DVD features real-time videos of neurologic case studies, ultrasound and endoscopy procedures, and imaging techniques that familiarize you with the latest technological equipment and protocols. Features coverage of the latest treatment innovations including antibiotic residue testing, care of individual metabolic disease, troubleshooting, and much more.
Book Synopsis Concepts in Viral Pathogenesis by : A. L. Notkins
Download or read book Concepts in Viral Pathogenesis written by A. L. Notkins and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.
Book Synopsis Cell-mediated Antiviral Immunity and Host Responses to CD8 T-cell Vaccines and Respiratory Virus Infection by :
Download or read book Cell-mediated Antiviral Immunity and Host Responses to CD8 T-cell Vaccines and Respiratory Virus Infection written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immunobiology of respiratory virus infection is complex, and immunity depends upon the successful integration of contributions from the innate, humoral, and cell-mediated branches of the immune system. This dissertation focuses on cell-mediated immunity to respiratory viruses, and was motivated by 3 main questions 1) how and under what circumstances can the novel vaccine adjuvant Adjuplex® generate CD8 T-cell responses to non-replicating antigens, 2) what are the key gaps in our knowledge of anti-viral CD4 T-cell memory, and 3) can a systems biology analysis be used to elucidate the complex biology of ferret host responses to pandemic influenza viruses. We found that the vaccine adjuvant Adjuplex® can elicit potent CD8+ T-cell responses to non-replicating antigens in mice, and can be administered by multiple routes. We also found that systemic and intranasal vaccinations with Adjuplex® generate similar CD8+ T-cell recall responses in the lung after influenza challenge. However, only intranasal vaccines are protective, and protection correlates with increased effector and resident memory populations in the lung. Importantly, intranasal vaccination also results in potent heterosubtypic immunity. Mechanistically, Adjuplex® functions through complex interactions with innate cells in vivo and in vitro, including alterations in recruitment and activation of antigen-presenting cells, as well as antigen up-take and processing. Next, we identified important functionally distinct subsets of CD4 T cells that differ in their phenotype, trafficking patterns, and intrinsic abilities to differentiate into memory cells, and proposed a new integrated model for understanding CD4 T-cell memory generation that accounts for phenotypic plasticity. Lastly, we characterized and validated a complex systems-biology approach to analyzing host immune responses to infection with influenza, and in doing so identified new associations between histologic lesions, virus subtypes, gene expression patterns, and changes in abundance of lipids, metabolites, and proteins during the course of infection. This research provides critical insights into the mechanisms by which vaccine adjuvants can be used to generate protective CD8 T-cell immunity to non-replicating antigens, outlines a new model for understanding CD4 T cell memory generation, and validates the use of systems biology approaches to gain critical insights into the complex host responses to influenza virus infection.
Book Synopsis Polymicrobial Diseases by : Kim A. Brogden
Download or read book Polymicrobial Diseases written by Kim A. Brogden and published by . This book was released on 2002 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.