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Cell Based Microarrays
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Book Synopsis Cell-Based Microarrays by : Peter Ertl
Download or read book Cell-Based Microarrays written by Peter Ertl and published by Humana. This book was released on 2019-04-24 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive look at the current fabrication methods, materials, cell patterning techniques, and practical application of live-cell microarrays. The chapters in this book are categorized into six parts: introduction, biointerface engineering and live-cell microarrays, printing techniques for live-cell microarrays, live-cell microarray application, microfluidic live-cell arrays, and advanced materials suitable for live-cell microarrays. Some of the topics covered are artificial micro-niche array with spatially structured biochemical cues; inkjet printing for biomedical application; fabrication of multi-electrode arrays for neurobiology applications; rapid prototyping of thermoplastic microfluidic devices; and oxygen-generating photocrosslinkable hydrogel. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cell-Based Microarrays: Methods and Protocols is a valuable resource for anyone interested in expanding their knowledge and research of cell-based microarrays.
Book Synopsis Cell-Based Microarrays by : Ella Palmer
Download or read book Cell-Based Microarrays written by Ella Palmer and published by Springer Science & Business Media. This book was released on 2014-04-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a review on the evolution of cell-based microarrays and an update to the author's earlier book Methods in Molecular Biology: Cell-Based Microarrays. Since their development in 2001, cell-based microarrays have advanced significantly to include expression arrays, short interfering RNA arrays and antibody arrays. The surface used to coat the glass slides has also been significantly improved to allow non-adherent cells to bind to the arrays.
Book Synopsis Cell-based Biosensors by : Qingjun Liu
Download or read book Cell-based Biosensors written by Qingjun Liu and published by Artech House. This book was released on 2009-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
Book Synopsis High Throughput Screening of Stem Cell-surface Interactions Based on Cell Microarray Platforms by : Soraya Rasi Ghaemi
Download or read book High Throughput Screening of Stem Cell-surface Interactions Based on Cell Microarray Platforms written by Soraya Rasi Ghaemi and published by . This book was released on 2015 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell microarrays are a high throughput screening platform that allows the re - creation of a multitude of cell microenvironments on a single chip, using only minimal amounts of reagent. This thesis describes the fabrication of cell microarrays that retain pattern integrity throughout long periods of tissue culture required to investigate stem cell behaviour and differentiation.
Book Synopsis Genome-wide Analyses of Single Cell Phenotypes Using Cell Microarrays by : Rammohan Narayanaswamy
Download or read book Genome-wide Analyses of Single Cell Phenotypes Using Cell Microarrays written by Rammohan Narayanaswamy and published by . This book was released on 2008 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few decades have witnessed a revolution in recombinant DNA and nucleic acid sequencing technologies. Recently however, technologies capable of massively high-throughout, genome-wide data collection, combined with computational and statistical tools for data mining, integration and modeling have enabled the construction of predictive networks that capture cellular regulatory states, paving the way for 'Systems biology'. Consequently, protein interactions can be captured in the context of a cellular interaction network and emergent 'system' properties arrived at, that may not have been possible by conventional biology. The ability to generate data from multiple, non-redundant experimental sources is one of the important facets to systems biology. Towards this end, we have established a novel platform called 'spotted cell microarrays' for conducting image-based genetic screens. We have subsequently used spotted cell microarrays for studying multidimensional phenotypes in yeast under different regulatory states. In particular, we studied the response to mating pheromone using a cell microarray comprised of the yeast non-essential deletion library and analyzed morphology changes to identify novel genes that were involved in mating. An important aspect of the mating response pathway is large-scale spatiotemporal changes to the proteome, an aspect of proteomics, still largely obscure. In our next study, we used an imaging screen and a computational approach to predict and validate the complement of proteins that polarize and change localization towards the mating projection tip. By adopting such hybrid approaches, we have been able to, not only study proteins involved in specific pathways, but also their behavior in a systemic context, leading to a broader comprehension of cell function. Lastly, we have performed a novel metabolic starvation-based screen using the GFP-tagged collection to study proteome dynamics in response to nutrient limitation and are currently in the process of rationalizing our observations through follow-up experiments. We believe this study to have implications in evolutionarily conserved cellular mechanisms such as protein turnover, quiescence and aging. Our technique has therefore been applied towards addressing several interesting aspects of yeast cellular physiology and behavior and is now being extended to mammalian cells.
Book Synopsis Microarray Innovations by : Gary Hardiman
Download or read book Microarray Innovations written by Gary Hardiman and published by CRC Press. This book was released on 2009-04-02 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr
Download or read book Microarrays written by Kilian Dill and published by Springer Science & Business Media. This book was released on 2008-12-30 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial chemistry is used to find materials that form sensor microarrays. This book discusses the fundamentals, and then proceeds to the many applications of microarrays, from measuring gene expression (DNA microarrays) to protein-protein interactions, peptide chemistry, carbodhydrate chemistry, electrochemical detection, and microfluidics.
Book Synopsis Microarrays in Diagnostics and Biomarker Development by : Bertrand Jordan
Download or read book Microarrays in Diagnostics and Biomarker Development written by Bertrand Jordan and published by Springer Science & Business Media. This book was released on 2012-04-23 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.
Book Synopsis Microarray Technology in Practice by : Steve Russell
Download or read book Microarray Technology in Practice written by Steve Russell and published by Academic Press. This book was released on 2008-11-21 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using chips composed of thousands of spots, each with the capability of holding DNA molecules corresponding to a given gene, DNA microarray technology has enabled researchers to measure simultaneously gene expression across the genome. As with other large-scale genomics approaches, microarray technologies are broadly applicable across disciplines of life and biomedical sciences, but remain daunting to many researchers. This guide is designed to demystify the technology and inform more biologists about this critically important experimental technique. Cohesive overview of the technology and available platforms, followed by detailed discussion of experimental design and analysis of microarray experiments Up-to-date description of normalization methods and current methods for sample amplification and labeling Deep focus on oligonucleotide design, printing, labeling and hybridization, data acquisition, normalization, and meta-analysis Additional uses of microarray technology such as ChIP (chromatin immunoprecipitation) with hybridization to DNA arrays, microarray-based comparative genomic hybridization (CGH), and cell and tissue arrays
Book Synopsis Protein and Peptide-based Microarrays for Multiplex Detection by : Navid Rabiee
Download or read book Protein and Peptide-based Microarrays for Multiplex Detection written by Navid Rabiee and published by IOP Publishing Limited. This book was released on 2020-10-07 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein and Peptide-based Microarrays for Multiplex Detection looks at the aspects of protein and peptide-based microarrays for multiplex detection, based on Rabiee's Theory. A comprehensive guide for scientists, students and doctors.
Download or read book Microarrays written by Jang B. Rampal and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 927 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second part in the two-volume work Microarrays details applications and data analysis. It includes insight into non-mammalian vertebrate systems, processes and protocols for high quality glass-based microarrays. Coverage includes applications in DNA, peptide, antibody and carbohydrate microarraying, oligonucleotide microarrays generated from hydrolysis PCR probe sequences, microarray platforms in clinical practice, and screening of cDNA libraries on glass slide microarrays. Authors in this volume also discuss protocols for predicting DNA duplex stability on oligonucleotide arrays and integrated analysis of microarray results.
Book Synopsis Microarray Technology by : Paul C.H. Li
Download or read book Microarray Technology written by Paul C.H. Li and published by Humana. This book was released on 2015-11-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides updates of this established field in both methods and applications, as well as advances in applications of the microarray method to biomarkers such as DNAs, RNAs, proteins, glycans and whole cells. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microarray Technology: Methods and Applications aims to ensure successful results in the further study of this vital field.
Book Synopsis Small Molecule Microarrays: Methods and Protocols by : Mahesh Uttamchandani
Download or read book Small Molecule Microarrays: Methods and Protocols written by Mahesh Uttamchandani and published by Methods in Molecular Biology. This book was released on 2018-12-05 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition by : Robert S. Matson
Download or read book Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition written by Robert S. Matson and published by CRC Press. This book was released on 2013-03-13 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. Updated and revised to reflect recent progress in the field, the second edition discusses: Expanded omics-driven applications, including the areas of metabolomics and chemical biology The commercialization of the microarray platform, with a historical perspective aimed at recognizing key technological developments Solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays Different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented The development of the gene expression microarray and representative applications The development of protein microarray technology, including its history and key applications Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons. Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.
Book Synopsis DNA Microarrays, Part A: Array Platforms and Wet-Bench Protocols by :
Download or read book DNA Microarrays, Part A: Array Platforms and Wet-Bench Protocols written by and published by Elsevier. This book was released on 2011-08-19 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results. Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations. Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician. Provides an overview of platforms Includes experimental design and wet bench protocols Presents statistical and data analysis methods, array databases, data visualization and meta-analysis
Download or read book Bioarrays written by Krishnarao Appasani and published by Springer Science & Business Media. This book was released on 2007-10-04 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an integrated collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. It is the first book to comprehensively integrate molecular diagnostics and molecular pathology. This book serves as an indispensable reference for graduate students, post-docs, and professors as well as an explanatory analysis for executives and scientists in biotechnology and pharmaceutical companies.
Book Synopsis Cellular Microarrays for Interrogation of Cell-cell and Cell-substrate Interactions by : Chaofang Yue
Download or read book Cellular Microarrays for Interrogation of Cell-cell and Cell-substrate Interactions written by Chaofang Yue and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Aside from developing the microarrays based on a commercial substrate, we developed a self-assembled monolayer (SAM)-based substrate as a general platform for protein microarrays. Neutron scattering characterization were conducted, indicating the highly ordered multi-component multi-layer structure of the substrate; preliminary cell binding experiments were performed, showing the great promises of this substrate for specific and uniform cell capture. In addition, a method of immobilizing functionalized magnetic nanoparticles on planar surface to form nanoparticle microarray was reported, which significantly reduced the cost for functional characterization of the particles and further demonstrated its potential as a new small-scale cell sorter.
