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Carma Proteins Playing A Hand Of Four Cards
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Book Synopsis CARMA Proteins: Playing a Hand of Four CARDs by : Frédéric Bornancin
Download or read book CARMA Proteins: Playing a Hand of Four CARDs written by Frédéric Bornancin and published by Frontiers Media SA. This book was released on 2019-10-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partner, called Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), was also implicated in the CARD-BCL10 pathway. Since then, the resulting “CBM” complex has been recognized as a key node in signaling cascades leading to NF-κB activation, particularly in immune cells. Mouse models of genetic deficiencies for each CBM component provided the first evidence for their critical role in cell signaling. More recently, studies of human lymphoid malignancies and novel genetic disorders have revealed important new insights. Both gain- and loss-of-function mutations were identified, establishing these CARMA/CARD proteins as key regulators of proliferation and differentiation of immune and non-immune cells, and linking them to human disease. According to the genetic defect involved, dysregulation of CARMA/CARD pathways can lead to a broad spectrum of immune disorders, including severe immune deficiencies, lymphoproliferative disorders, psoriasis and atopy. The aim of this Research Topic is to summarize and update our current understanding of CARMA/CARD protein biology, from initial discoveries to the most recent insights. It focuses on CARD9 and the CARMA proteins CARD10, CARD11 and CARD14, from genetic, signaling and disease perspectives. BCL10 and MALT1 are also reviewed in this context as critical nodes for CBM signal relay and regulation. This Research Topic also aims to delineate the next key questions in the field to guide future research efforts.
Book Synopsis Stiehm's Immune Deficiencies by : Kathleen E. Sullivan
Download or read book Stiehm's Immune Deficiencies written by Kathleen E. Sullivan and published by Academic Press. This book was released on 2020-05-23 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stiehm's Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. - Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians - Fills an increasingly deep gap in the information available to clinicians - Presents both clinical management and scientific advances for immune deficiencies - Provides a primary resource for physicians in the field of immunodeficiencies - Includes website access to a range of videos relevant to the topics discussed
Book Synopsis Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems by : Marc Thiriet
Download or read book Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems written by Marc Thiriet and published by Springer Science & Business Media. This book was released on 2012-09-25 with total page 1071 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.
Download or read book Contact Cards written by Kim Carlsberg and published by Bear. This book was released on 1996 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Divination systems are tools for accessing knowledge that is beyond our ordinary sensory ability. Contact Cards are the specific conduit for extraterrestrial information, initiating the exploration of intergalactic energies, stars, crop circles, and spaceships. For you voyagers seeking universal understanding during your earthly sojourns, playing with Contact Cards expands awareness of inner, as well as outer, space."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 2084 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis This is Your Brain on Music by : Daniel Levitin
Download or read book This is Your Brain on Music written by Daniel Levitin and published by Penguin UK. This book was released on 2019-07-04 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the author of The Changing Mind and The Organized Mind comes a New York Times bestseller that unravels the mystery of our perennial love affair with music ***** 'What do the music of Bach, Depeche Mode and John Cage fundamentally have in common?' Music is an obsession at the heart of human nature, even more fundamental to our species than language. From Mozart to the Beatles, neuroscientist, psychologist and internationally-bestselling author Daniel Levitin reveals the role of music in human evolution, shows how our musical preferences begin to form even before we are born and explains why music can offer such an emotional experience. In This Is Your Brain On Music Levitin offers nothing less than a new way to understand music, and what it can teach us about ourselves. ***** 'Music seems to have an almost wilful, evasive quality, defying simple explanation, so that the more we find out, the more there is to know . . . Daniel Levitin's book is an eloquent and poetic exploration of this paradox' Sting 'You'll never hear music in the same way again' Classic FM magazine 'Music, Levitin argues, is not a decadent modern diversion but something of fundamental importance to the history of human development' Literary Review
Book Synopsis History of Tofu and Tofu Products (965 CE to 2013) by : William Shurtleff
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Download or read book Yoga Journal written by and published by . This book was released on 1991-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 30 years, Yoga Journal has been helping readers achieve the balance and well-being they seek in their everyday lives. With every issue,Yoga Journal strives to inform and empower readers to make lifestyle choices that are healthy for their bodies and minds. We are dedicated to providing in-depth, thoughtful editorial on topics such as yoga, food, nutrition, fitness, wellness, travel, and fashion and beauty.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Out Of Control written by Kevin Kelly and published by Basic Books. This book was released on 2009-04-30 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Out of Control chronicles the dawn of a new era in which the machines and systems that drive our economy are so complex and autonomous as to be indistinguishable from living things.
Book Synopsis The Glory in the Heavens by : Hârun Yahya
Download or read book The Glory in the Heavens written by Hârun Yahya and published by GLOBAL YAYINCILIK. This book was released on 2004 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second book in this series brings to life the wonders of the universe and explains how it all began in a simple yet engaging way. The reader is taken on a fascinating scientific journey from planet earth, through the atmosphere into the solar system and the stars and galaxies beyond. In full colour and recommended for ages 10 and over.
Book Synopsis The World of Animals by : Harun Yahya
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Book Synopsis Let's Learn Our Islam by : Harun Yahya
Download or read book Let's Learn Our Islam written by Harun Yahya and published by GLOBAL YAYINCILIK. This book was released on 2002 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book My New Roots written by Sarah Britton and published by Appetite by Random House. This book was released on 2015-03-31 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holistic nutritionist and highly-regarded blogger Sarah Britton presents a refreshing, straight-forward approach to balancing mind, body, and spirit through a diet made up of whole foods. Sarah Britton's approach to plant-based cuisine is about satisfaction--foods that satiate on a physical, emotional, and spiritual level. Based on her knowledge of nutrition and her love of cooking, Sarah Britton crafts recipes made from organic vegetables, fruits, whole grains, beans, lentils, nuts, and seeds. She explains how a diet based on whole foods allows the body to regulate itself, eliminating the need to count calories. My New Roots draws on the enormous appeal of Sarah Britton's blog, which strikes the perfect balance between healthy and delicious food. She is a "whole food lover," a cook who makes simple accessible plant-based meals that are a pleasure to eat and a joy to make. This book takes its cues from the rhythms of the earth, showcasing 100 seasonal recipes. Sarah simmers thinly sliced celery root until it mimics pasta for Butternut Squash Lasagna, and whips up easy raw chocolate to make homemade chocolate-nut butter candy cups. Her recipes are not about sacrifice, deprivation, or labels--they are about enjoying delicious food that's also good for you.
Download or read book Resources in Education written by and published by . This book was released on 1989 with total page 1222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vegetarian Times written by and published by . This book was released on 1992-04 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: To do what no other magazine does: Deliver simple, delicious food, plus expert health and lifestyle information, that's exclusively vegetarian but wrapped in a fresh, stylish mainstream package that's inviting to all. Because while vegetarians are a great, vital, passionate niche, their healthy way of eating and the earth-friendly values it inspires appeals to an increasingly large group of Americans. VT's goal: To embrace both.
Download or read book Jesus Will Return written by Hârun Yahya and published by GLOBAL YAYINCILIK. This book was released on 2001 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt:
