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Author :
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.:/5 (251 download)
Download or read book Carbohydrate-protein Interaction written by and published by . This book was released on 1979 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M Michael Gromiha
Publisher : World Scientific
ISBN 13 : 9811211884
Total Pages : 424 pages
Book Rating : 4.8/5 (112 download)
Download or read book Protein Interactions: Computational Methods, Analysis And Applications written by M Michael Gromiha and published by World Scientific. This book was released on 2020-03-05 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.
Author : American Chemical Society. Division of Carbohydrate Chemistry
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.:/5 (44 download)
Download or read book Carbohydrate-protein Interaction written by American Chemical Society. Division of Carbohydrate Chemistry and published by . This book was released on 1979 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M Corredig
Publisher : Elsevier
ISBN 13 : 1845697197
Total Pages : 713 pages
Book Rating : 4.8/5 (456 download)
Download or read book Dairy-Derived Ingredients written by M Corredig and published by Elsevier. This book was released on 2009-10-26 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in technologies for the extraction and modification of valuable milk components have opened up new opportunities for the food and nutraceutical industries. New applications for dairy ingredients are also being found. Dairy-derived ingredients reviews the latest research in these dynamic areas.Part one covers modern approaches to the separation of dairy components and manufacture of dairy ingredients. Part two focuses on the significant area of the biological functionality of dairy components and their nutraceutical applications, with chapters on milk oligosaccharides, lactoferrin and the role of dairy in food intake and metabolic regulation, among other topics. The final part of the book surveys the technological functionality of dairy components and their applications in food and non-food products. Dairy ingredients and food flavour, applications in emulsions, nanoemulsions and nanoencapsulation, and value-added ingredients from lactose are among the topics covered.With its distinguished editor and international team of contributors, Dairy-derived ingredients is an essential guide to new developments for the dairy and nutraceutical industries, as well as researchers in these fields. - Summarises modern approaches to the separation of dairy components and the manufacture of dairy ingredients - Assesses advances in both the biological and technological functionality of dairy components - Examines the application of dairy components in both food and non-food products
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Author : Roger Christopher Diehl
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (125 download)
Download or read book CH-[pi] Interactions Play a Central Role in Protein Recognition of Carbohydrates written by Roger Christopher Diehl and published by . This book was released on 2021 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate-protein interactions play a central role in biology, but knowledge of the forces underlying them is limited. Carbohydrates are generally hydrophilic and therefore present unique challenges in their recognition. One underappreciated force involved in carbohydrate-protein interactions is the CH-[pi] interaction, an attractive interaction between the aliphatic protons of a carbohydrate and the [pi] system of an aromatic ring. In this thesis, I examine the fundamental nature, strength, and biological significance of this interaction, largely in the context of a family of carbohydrate-binding proteins known as galectins. In Chapter 1, I review previous knowledge of the forces underlying carbohydrate-binding proteins and the forces they utilize to bind their ligands. In particular, I focus on CH-[pi] interactions and galectins. In Chapter 2, I examine the forces that contribute to CH-[pi] interactions in the context of carbohydrates and aromatic compounds in aqueous solution. I find the CH-[pi] interaction to be electronic in nature, and demonstrate its selectivity between different carbohydrates. In Chapter 3, I determine the contribution of the CH-[pi] interaction to the ligand binding of galectin-3, a human carbohydrate-binding protein of medical significance. The data demonstrate that the CH-[pi] interaction accounts for a majority of the binding energy. In Chapter 4, I explore the biological implications of the CH-[pi] interaction in galectin-3. I demonstrate that the CH-[pi] interaction is critical for the biological activities of galectin-3. In Chapter 5, I propose several directions future researchers could take to extend this work. For three of four directions, I present the progress I have made during my studies. The work contained within this thesis demonstrates that CH-[pi] interactions play a central role in protein-carbohydrate interactions at both a molecular level and a biological level. Understanding the CH-[pi] interaction is key to explaining and predicting the activity of carbohydrate-binding proteins.
Author : Peng George Wang
Publisher :
ISBN 13 : 9780841298989
Total Pages : pages
Book Rating : 4.2/5 (989 download)
Download or read book Glycan-Based Cellular Communication written by Peng George Wang and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author : Yann Chevolot
Publisher : Humana Press
ISBN 13 : 9781617793721
Total Pages : 427 pages
Book Rating : 4.7/5 (937 download)
Download or read book Carbohydrate Microarrays written by Yann Chevolot and published by Humana Press. This book was released on 2011-11-09 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate microarrays emerged as a key technology for the deciphering of the glycospace by providing a multiplex technology where tens to hundreds of carbohydrates/protein interactions can be probed in parallel. Carbohydrate Microarrays: Methods and Protocols aims to give the reader the theoretical and experimental clues necessary for the fabrication and implementation of carbohydrate microarrays. This requires three essential steps: 1) to obtain the carbohydrate probes (monosacharides, oligosacchrides, polysacchairdes, glycoconjugates or glycoclusters), 2) to immobilize these probes, and 3) to implement the protocols for biological/biochemical interaction with the desired target. This volume gives an overview of carbohydrate microarray and carbohydrate chemistry and illustrates different detection techniques and their applications. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Carbohydrate Microarrays: Methods and Protocols compiles a catalogue of protocols on carbohydrate microarrays to span the needs of researchers around the globe.
Author : Thomas Peters
Publisher : Springer Science & Business Media
ISBN 13 : 3540490779
Total Pages : 317 pages
Book Rating : 4.5/5 (44 download)
Download or read book Bioactive Conformation I written by Thomas Peters and published by Springer Science & Business Media. This book was released on 2007-01-05 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : Alain Teboho Laederach
Publisher :
ISBN 13 :
Total Pages : 410 pages
Book Rating : 4.:/5 (539 download)
Download or read book Protein-carbohydrate and Protein-protein Interactions written by Alain Teboho Laederach and published by . This book was released on 2003 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Any molecular recognition event results in a change in the free energy of the system. The extent of this change is related to the association constant, such that the more negative the free energy change is, the tighter the interaction between receptor and ligand. Protein-carbohydrate interactions play a critical role in signal transduction, innate immunity, and metabolism. Modeling these interactions is somewhat complicated by the inherent flexibility of carbohydrates as well as their relatively large number of functional groups. An empirical scoring function for docking carbohydrates to proteins, specifically tailored to predict both the correct binding orientation and free energy of binding of the carbohydrate-ligand/protein-receptor complex, will be presented. This new scoring function can predict free energies of binding to within 1.1 kcal/mol residual standard error, a definite improvement over existing scoring functions that result in standard errors well over 2 kcal/mol. Application of automated docking methodology to determine carbohydrate recognition specificity of the C-type lectin, human surfactant protein D, will also be presented. In the second part of the thesis, the role of [pi]-stacking interactions (e.g. between Tyr side chains) in stabilizing protein folds will be discussed. A 17-residue peptide derived from the naturally occurring anti-microbial peptide tachyplesin I was investigated using NMR spectroscopy. NOE cross-peaks were observed, confirming the existence of this interaction in solution. In the final part of the thesis, a quantitative NMR investigation into the self-association behavior of the regulatory domains of several Tec family member kinases will be presented. Of particular interest, self-association within Bruton's tyrosine kinase (Btk) regulatory domains occurs through the formation of an asymmetric homodimer. Together this work demonstrates the importance of rigorous biophysical characterization of biomolecular recognition events and the interdependence of computational modeling and experimentation.
Author :
Publisher : Academic Press
ISBN 13 : 9780121822125
Total Pages : 748 pages
Book Rating : 4.8/5 (221 download)
Download or read book Sphingolipid Metabolism and Cell Signaling written by and published by Academic Press. This book was released on 1999-11-05 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309260868
Total Pages : 171 pages
Book Rating : 4.3/5 (92 download)
Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hans-Joachim Gabius
Publisher : John Wiley & Sons
ISBN 13 : 3527644946
Total Pages : 560 pages
Book Rating : 4.5/5 (276 download)
Download or read book The Sugar Code written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
Author : Sai Kumar Ramadugu
Publisher :
ISBN 13 :
Total Pages : 113 pages
Book Rating : 4.:/5 (917 download)
Download or read book Carbohydrate-protein Interactions written by Sai Kumar Ramadugu and published by . This book was released on 2013 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roland Schauer
Publisher :
ISBN 13 :
Total Pages : 4 pages
Book Rating : 4.:/5 (248 download)
Download or read book Carbohydrate-protein Interaction Studies by Laser Photo CIDNP NMR Methods written by Roland Schauer and published by . This book was released on 1997 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Irwin J. Goldstein
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.:/5 (251 download)
Download or read book Carbohydrate- Protein Interaction written by Irwin J. Goldstein and published by . This book was released on 1979 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
