Calpains

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Calpains

Author : K K W Wang
Publisher : CRC Press
ISBN 13 : 9781560327134
Total Pages : 472 pages
Book Rating : 4.3/5 (271 download)

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Book Synopsis Calpains by : K K W Wang

Download or read book Calpains written by K K W Wang and published by CRC Press. This book was released on 1999-06-17 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers a clear and through examination of the most recent results of thirty years of research on calcium-activated-neutral protease (CANP or Calpain). Coverage includes the implications of the recently gained ability to produce functionally active recombinant calpain in various human disorders such as cerebal ischemia, traumatic brain and spinal cord injury, cataract formation, myocardial infarction, and Alzheimer's disease. The resulting research to find more selective calpain inhibitors is also discussed. With a copy of Calpain: Pharmacology and Toxicology of Calcium Dependent Protease you will better understand why the calpain research area is such an exciting and promising one.

Calpain Methods and Protocols

Author : John S. Elce
Publisher : Springer Science & Business Media
ISBN 13 : 1592590500
Total Pages : 340 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Calpain Methods and Protocols by : John S. Elce

Download or read book Calpain Methods and Protocols written by John S. Elce and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of Calpain Methods and Protocols is quite straightf- ward: it is to present the actual experimental methods used in many different laboratories for the study of calpain. It will provide the vital experimental detail, and the discussion of possible pitfalls, for which the standard journals no longer provide space. This will make it as easy as possible for investi- tors interested in calpain to adopt established methods without repeating old mistakes, and to adapt and apply these methods in novel approaches to the many outstanding calpain questions. These questions range from purely biochemical problems of protein structure and enzyme regulation at the molecular level, through large areas of cell biology, to applied and clinical aspects of calpain function in human d- ease. Within this panoply of topics, a wide range of investigators will find many fascinating and as yet unanswered questions about calpain. Calpain Methods and Protocols will provide instant access to many essential te- niques, while saving them the time and effort involved in developing a new method. In addition to questions relating to the normal physiological roles of the calpains, there is considerable evidence that inappropriate calpain activity may have pathological effects in many tissues, for example, following ischemia. This provides a major stimulus for the development of specific calpain inhi- tors for therapeutic purposes, and for the development of methods to evaluate such inhibitors.

Intracellular Calcium-Dependent Proteolysis

Author : Ronald L. Mellgren
Publisher : CRC Press
ISBN 13 : 9780849365706
Total Pages : 304 pages
Book Rating : 4.3/5 (657 download)

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Book Synopsis Intracellular Calcium-Dependent Proteolysis by : Ronald L. Mellgren

Download or read book Intracellular Calcium-Dependent Proteolysis written by Ronald L. Mellgren and published by CRC Press. This book was released on 1990-08-29 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Calcium-Dependent Proteolysis explains what is now known about calpains, which are intracellular, non-lysosomal enzymes involved in intracellular protein catabolism. The book provides a comprehensive overview of topics ranging from the molecular biology of the calpains and their specific inhibitor protein (calpastatin) to physiologic and pathologic consequences of the presence of this proteolytic system in many model cells and tissues. Several theoretical functions of the calpains are discussed, including their potential roles in muscle protein turnover, platelet activation, membrane fusion, and synaptic plasticity. Intracellular Calcium-Dependent Proteolysis is a valuable source of information for researchers and students interested in the regulation of intracellular protein catabolism and the general effects of Ca2+ on cell function.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Author : Monte Willis
Publisher : Academic Press
ISBN 13 : 0124055257
Total Pages : 339 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Cellular and Molecular Pathobiology of Cardiovascular Disease by : Monte Willis

Download or read book Cellular and Molecular Pathobiology of Cardiovascular Disease written by Monte Willis and published by Academic Press. This book was released on 2013-12-23 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Proteases: Structure and Function

Author : Klaudia Brix
Publisher : Springer Science & Business Media
ISBN 13 : 3709108853
Total Pages : 568 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Proteases: Structure and Function by : Klaudia Brix

Download or read book Proteases: Structure and Function written by Klaudia Brix and published by Springer Science & Business Media. This book was released on 2014-01-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.

Geriatric Oncology

Author : Martine Extermann
Publisher : Springer
ISBN 13 : 9783319574141
Total Pages : 1150 pages
Book Rating : 4.5/5 (741 download)

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Book Synopsis Geriatric Oncology by : Martine Extermann

Download or read book Geriatric Oncology written by Martine Extermann and published by Springer. This book was released on 2020-01-30 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.

Handbook of Proteolytic Enzymes

Author : Alan J. Barrett
Publisher : Academic Press
ISBN 13 : 0123822203
Total Pages : 4097 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Handbook of Proteolytic Enzymes by : Alan J. Barrett

Download or read book Handbook of Proteolytic Enzymes written by Alan J. Barrett and published by Academic Press. This book was released on 2012-10-30 with total page 4097 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. The only comprehensive book on proteolytic enzymes Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features Over 1000 peptidases included

Handbook of Cell Signaling

Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3048 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw

Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Protein Degradation in Health and Disease

Author : Michele Reboud-Ravaux
Publisher : Springer Science & Business Media
ISBN 13 : 3642563732
Total Pages : 152 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Protein Degradation in Health and Disease by : Michele Reboud-Ravaux

Download or read book Protein Degradation in Health and Disease written by Michele Reboud-Ravaux and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Intracellular Calcium-Dependent Proteolysis

Author : Ronald L. Mellgren
Publisher : CRC Press
ISBN 13 : 1351090712
Total Pages : 426 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Intracellular Calcium-Dependent Proteolysis by : Ronald L. Mellgren

Download or read book Intracellular Calcium-Dependent Proteolysis written by Ronald L. Mellgren and published by CRC Press. This book was released on 2019-08-08 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Calcium-Dependent Proteolysis explains what is now known about calpains, which are intracellular, non-lysosomal enzymes involved in intracellular protein catabolism. The book provides a comprehensive overview of topics ranging from the molecular biology of the calpains and their specific inhibitor protein (calpastatin) to physiologic and pathologic consequences of the presence of this proteolytic system in many model cells and tissues. Several theoretical functions of the calpains are discussed, including their potential roles in muscle protein turnover, platelet activation, membrane fusion, and synaptic plasticity. Intracellular Calcium-Dependent Proteolysis is a valuable source of information for researchers and students interested in the regulation of intracellular protein catabolism and the general effects of Ca2+ on cell function.

Disorders of Voluntary Muscle

Author : George Karpati
Publisher : Cambridge University Press
ISBN 13 : 9780521650625
Total Pages : 800 pages
Book Rating : 4.6/5 (56 download)

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Book Synopsis Disorders of Voluntary Muscle by : George Karpati

Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Comprehensive Toxicology

Author :
Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Toxicology by :

Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Brain Neurotrauma

Author : Firas H. Kobeissy
Publisher : CRC Press
ISBN 13 : 9781466565982
Total Pages : 0 pages
Book Rating : 4.5/5 (659 download)

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Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy

Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. In addition, a section is devoted to models of mild CNS injury, including blast and sport-related injuries. This book, with its diverse coherent content, is a valuable and comprehensive reference for individuals interested in the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Mechanisms of Protease Action

Author : Laszlo Polgar
Publisher : CRC Press
ISBN 13 : 9780849369018
Total Pages : 236 pages
Book Rating : 4.3/5 (69 download)

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Book Synopsis Mechanisms of Protease Action by : Laszlo Polgar

Download or read book Mechanisms of Protease Action written by Laszlo Polgar and published by CRC Press. This book was released on 1989-01-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.

Dynamics of Bone and Cartilage Metabolism

Author : Markus J. Seibel
Publisher : Elsevier
ISBN 13 : 9780080456263
Total Pages : 920 pages
Book Rating : 4.4/5 (562 download)

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Book Synopsis Dynamics of Bone and Cartilage Metabolism by : Markus J. Seibel

Download or read book Dynamics of Bone and Cartilage Metabolism written by Markus J. Seibel and published by Elsevier. This book was released on 2006-07-24 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Encyclopedia of Molecular Pharmacology

Author : Stefan Offermanns
Publisher : Springer Science & Business Media
ISBN 13 : 3540389164
Total Pages : 1515 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Molecular Pharmacology by : Stefan Offermanns

Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Proteases New Perspectives

Author : Vito Turk
Publisher : Birkhäuser
ISBN 13 : 303488737X
Total Pages : 238 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Proteases New Perspectives by : Vito Turk

Download or read book Proteases New Perspectives written by Vito Turk and published by Birkhäuser. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.