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Handbook of Chemical and Biological Warfare Agents, Volume 2

Author : D. Hank Ellison
Publisher : CRC Press
ISBN 13 : 1000484343
Total Pages : 621 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Handbook of Chemical and Biological Warfare Agents, Volume 2 by : D. Hank Ellison

Download or read book Handbook of Chemical and Biological Warfare Agents, Volume 2 written by D. Hank Ellison and published by CRC Press. This book was released on 2022-12-09 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Chemical and Biological Warfare Agents, Volume 2: Pathogens, Mid-Spectrum, and Incapacitating Agents, Third Edition provides rapid access to key data to response professionals and decision-makers on a broad range of agents and pathogens. This volume presents information on a wide range of chemical and biological agents. Chemical agents detailed in this volume are those that were developed specifically for their non-lethal potential. The biological agents described are militarily significant pathogens that could be weaponized to pose a threat to people, animals, or crops and other agricultural interests. Mid-spectrum agents, materials that do not fit clearly into either the Chemical or the Biological Weapons Conventions, include toxins and bioregulators. Entomological agents, the final class of agents discussed in volume, are arthropods that could pose a significant threat to a country’s agriculture infrastructure and be used to devastate its economy. They were proposed for inclusion in the Biological Weapons Convention but never adopted. In addition to a discussion of each of these classes of agents, coverage includes detailed information on a broad spectrum of individual agents that have been used on the battlefield, stockpiled as weapons, used or threatened to be used by terrorists, or have been otherwise assessed by qualified law enforcement and response organizations and determined to be agents of significant concern. The information presented in this edition has been updated and expanded to contain more information on toxicology, health effects, presentation of diseases, advances in medical care and treatment, as well as protective actions needed at the scene of an incident. Key Features: Focuses on the key information needed during an emergency response Provides updated toxicology, exposure hazards, physical-chemical data, and treatment of casualties Profiles the presentation of diseases in people, animals and plants Presents updated protective action distances, decontamination, and remediation information All data compiled is gathered from numerous sources and arranged into the current, easy-to-access format. In order to ensure accuracy, all data has been cross-checked over the widest variety of military, scientific and medical sources available. The Handbook of Chemical and Biological Warfare Agents, Volume 2: Pathogens, Mid-Spectrum, and Incapacitating Agents, Third Edition remains the gold-standard reference detailing the widest variety of military, scientific, and medical sources available.

Fundamentals of Industrial Catalytic Processes

Author : C. H. Bartholomew
Publisher : John Wiley & Sons
ISBN 13 : 1118209737
Total Pages : 1224 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Fundamentals of Industrial Catalytic Processes by : C. H. Bartholomew

Download or read book Fundamentals of Industrial Catalytic Processes written by C. H. Bartholomew and published by John Wiley & Sons. This book was released on 2011-11-30 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalysis is central to the chemical industry, as it is directly or involved in the production of almost all useful chemical products. In this book the authors, present the definitive account of industrial catalytic processes. Throughout Fundamentals of Industrial Catalytic Processes the information is illustrated with many case studies and problems. This book is valuable to anyone wanting a clear account of industrial catalytic processes, but is particularly useful to industrial and academic chemists and engineers and graduate working on catalysis. This book also: Covers fundamentals of catalytic processes, including chemistry, catalyst preparation, properties and reaction engineering. Addresses heterogeneous catalytic processes employed by industry. Provides detailed data on existing catalysts and catalytic reactions, process design and chemical engineering. Covers catalysts used in fuel cells.

C18 - Cx

Author :
Publisher :
ISBN 13 : 9780387934860
Total Pages : pages
Book Rating : 4.9/5 (348 download)

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Book Synopsis C18 - Cx by :

Download or read book C18 - Cx written by and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index

Author : Rainer Bohrer
Publisher : Springer Science & Business Media
ISBN 13 : 3662075121
Total Pages : 265 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Index by : Rainer Bohrer

Download or read book Index written by Rainer Bohrer and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The GmeLin Formula Index and its First Supplement covered those volumes of the Eighth Edition of the Gmelin Handbook which had been issued up to the end of 1979. The present Second Supplement updates the Index by inclusion of the volumes which appeared up to the end of 1987. With this Second Supplement all compounds described in the Gmelin Handbook of Inorganic Chemistry in the period between 1924 and 1987 can be located. The basic structure of the Formula Index remains the same as in the previous editions. Computer techniques were employed in the preparation and print of the Second Supple ment. The data acquisition, sorting, and further data handling were performed with the aid of a series of computer programs developed by staff members of the former "Online Group" of the Gmelin Institute, now at Chemplex GmbH, and by the printer" UniversitiHs druckerei H. StUrtz AG, WOrzburg". Whereas the Handbook itself will continue to appear in printed form, the present Second Supplement of the Index is intended to be the last one issued in print. The cumulated contents of the Index and its Supplements are contained in the Gmelin Formula Index (GFI) database which is available to the scientific community via STN. This database will be updated annually to include the published Handbook volumes.

An Introduction to Biological Membranes

Author : William Stillwell
Publisher : Elsevier
ISBN 13 : 0444637907
Total Pages : 592 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis An Introduction to Biological Membranes by : William Stillwell

Download or read book An Introduction to Biological Membranes written by William Stillwell and published by Elsevier. This book was released on 2016-06-30 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Biological Membranes: Composition, Structure and Function, Second Edition is a greatly expanded revision of the first edition that integrates many aspects of complex biological membrane functions with their composition and structure. A single membrane is composed of hundreds of proteins and thousands of lipids, all in constant flux. Every aspect of membrane structural studies involves parameters that are very small and fast. Both size and time ranges are so vast that multiple instrumentations must be employed, often simultaneously. As a result, a variety of highly specialized and esoteric biochemical and biophysical methodologies are often utilized. This book addresses the salient features of membranes at the molecular level, offering cohesive, foundational information for advanced undergraduate students, graduate students, biochemists, and membranologists who seek a broad overview of membrane science. Significantly expanded coverage on function, composition, and structure Brings together complex aspects of membrane research in a universally understandable manner Features profiles of membrane pioneers detailing how contemporary studies originated Includes a timeline of important discoveries related to membrane science

Index

Author : Helga Hartwig
Publisher : Springer Science & Business Media
ISBN 13 : 3662075245
Total Pages : 280 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Index by : Helga Hartwig

Download or read book Index written by Helga Hartwig and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Gmelin Formula Index and its First Supplement covered those volumes of the Eighth Edition of the Gmelin Handbook which had been issued up to the end of 1979. The present Second Supplement updates the Index by inclusion of the volumes which appeared up to the end of 1987. With this Second Supplement all compounds described in the Gmelin Handbook of Inorganic Chemistry in the period between 1924 and 1987 can be located. The basic structure of the Formula Index remains the same as in the previous editions. Computer techniques were employed in the preparation and print of the Second Supple ment. The data acquisition, sorting, and further data handling were performed with the aid of a series of computer programs developed by staff members of the former" Online Group" of the Gmelin Institute, now at Chemplex GmbH, and by the printer" UniversiUits druckerei H. StOrtz AG, WGrzburg". Whereas the Handbook itself will continue to appear in printed form, the present Second Supplement of the Index is intended to be the last one issued in print. The cumulated contents of the Index and its Supplements are contained in the Gmelin Formula Index (GFI) database which is available to the scientific community via STN. This database will be updated annually to include the published Handbook volumes.

Extractables and Leachables

Author : Dennis Jenke
Publisher : John Wiley & Sons
ISBN 13 : 1119605105
Total Pages : 468 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Extractables and Leachables by : Dennis Jenke

Download or read book Extractables and Leachables written by Dennis Jenke and published by John Wiley & Sons. This book was released on 2022-07-14 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: EXTRACTABLES AND LEACHABLES Learn to address the safety aspects of packaged drug products and medical devices Pharmaceutical drug products and medical devices are expected to be effective and safe to use. This includes minimizing patient, user or product exposure to impurities leached from these items when the drug product is administered or when the medical device is used. Clearly, patient or user exposure to leachables must not adversely impact their health and safety. Furthermore, these impurities must not adversely affect key quality attributes of the drug product or medical device, including its manufacturability, stability, efficacy, appearance, shelf-life and conformance to standards. Extractables and leachables are derived from the drug product’s packaging, manufacturing systems and/or delivery systems or from the medical device’s materials of construction. It is imperative to understand and quantify the release of extractables from these items, the accumulation of leachables in drug products and the release of leachables from medical devices. Once extractables and leachables have been discovered, identified and quantified, their effect on the key product or device quality attributes, including safety, must be systematically and scientifically established according to recognized, rigorous and relevant regulatory and compendial standards and industry-driven best practices. In Extractables and Leachables, the chemical compatibility (including safe use) of drugs (and their containers, delivery devices and manufacturing systems) and medical devices is examined at length, focusing particularly on how trace-level extractables and leachables affect the quality and safety of a medical product and how to assess the magnitude of the effect. This is accomplished by addressing the two critical activities required to develop, register and commercialize safe, effective and affordable clinical therapies; measuring extractables and leachables (chemical characterization) and assessing their impact (for example, toxicological safety risk assessment). Each of these activities is addressed in-depth, based on the existing and developing international regulations and guidelines, current published literature and the author’s extensive personal experience. Written by a key contributor to standards, guidelines, recommended practices and the scientific literature, the book provides “insider” insights beyond those gained by merely reading the relevant texts. Given that the rapidly evolving extractables and leachables landscape, this book provides the most current and crucial information on new and forthcoming regulations and best practices. Extractables and Leachables readers will also find: A thorough summary of regulatory and compendial guidelines and the steps required to meet them A detailed and in-depth review of essential scientific principles and recommended best practices for the design, implementation, interpretation and reporting of chemical characterization studies A practical resource for optimizing the development, registration, and commercialization of safe and effective medical products A helpful tool to maximize product development and successful regulatory outcomes Extractables and Leachables is the essential reference for pharmaceutical scientists, analytical chemists, regulatory affairs professionals, engineers, and toxicologists in areas such as product research and development, product registration and approval, regulatory affairs, analytical science, quality control, and manufacturing.

Fundamentals of Pharmacognosy and Phytotherapy E-Book

Author : Michael Heinrich
Publisher : Elsevier Health Sciences
ISBN 13 : 0702070068
Total Pages : 352 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Fundamentals of Pharmacognosy and Phytotherapy E-Book by : Michael Heinrich

Download or read book Fundamentals of Pharmacognosy and Phytotherapy E-Book written by Michael Heinrich and published by Elsevier Health Sciences. This book was released on 2017-11-24 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacognosy (the science of biogenic or nature-derived pharmaceuticals and poisons) has been an established basic pharmaceutical science taught in institutions of pharmacy education for over two centuries. Over the past 20 years though it has become increasingly important given the explosion of new drugs, phytomedicines (plant medicines), nutraceuticals and dietary supplements – all of which need to be fully understood, tested and regulated. From a review of the previous edition: ‘Drawing on their wealth of experience and knowledge in this field, the authors, who are without doubt among the finest minds in pharmacognosy today, provide useful and fascinating insights into the history, botany, chemistry, phytotherapy and importance of medicinal plants in some of today’s healthcare systems. This is a landmark textbook, which carefully brings together relevant data from numerous sources and provides, in an authoritative and exhaustive manner, cutting-edge information that is relevant to pharmacists, pharmacognocists, complementary practitioners, doctors and nurses alike.’ The Pharmaceutical Journal ‘This is an excellent text book which provides fascinating insights into the world of pharmacognosy and the authors masterfully integrated elements of orthodox pharmacognosy and phytotherapy. Both the science student and the non-scientific person interested in phytotherapy will greatly benefit from reading this publication. It is comprehensive, easy to follow and after having read this book, one is so much more aware of the uniqueness of phytomedicines. A must read for any healthcare practitioner.’ Covers the history, biology and chemistry of plant-based medicines Covers pharmaceutical and neutraceuticals derived from plants Covers the role of medicinal plants in worldwide healthcare systems Examines the therapeutics and evidence of plant-based medicines by body system Sections on regulatory information expanded New evidence updates throughout New material covering non-medical supplements Therapeutics updated throughout Now on StudentConsult

Sample Preparation in LC-MS Bioanalysis

Author : Wenkui Li
Publisher : John Wiley & Sons
ISBN 13 : 111927432X
Total Pages : 665 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Sample Preparation in LC-MS Bioanalysis by : Wenkui Li

Download or read book Sample Preparation in LC-MS Bioanalysis written by Wenkui Li and published by John Wiley & Sons. This book was released on 2019-02-25 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitivity and throughput, the value of research/study mentioned above is still heavily dependent on the availability of high-quality data, for which sample preparation plays the critical role. Thus, this text provides researchers in industry, academia, and regulatory agencies with detailed sample preparation techniques and step-by-step protocols on proper extraction of various analyte(s) of interest from biological samples for LC-MS quantification, in accordance with current health authority regulations and industry best practices. The three sections of the book with a total of 26 chapters cover topics that include: Current basic sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction, salting-out assisted liquid-liquid extraction, ultracentrifugation and ultrafiltration, microsampling, sample extraction via electromembranes) Sample preparation techniques for uncommon biological matrices (e.g., tissues, hair, skin, nails, bones, mononuclear cells, cerebrospinal fluid, aqueous humor) Crucial aspects of LC-MS bioanalytical method development (e.g., pre-analytical considerations, derivation strategies, stability, non-specific binding) in addition to sample preparation techniques for challenging molecules (e.g., lipids, peptides, proteins, oligonucleotides, antibody-drug conjugates) Sample Preparation in LC-MS Bioanalysis will prove a practical and highly valuable addition to the reference shelves of scientists and related professionals in a variety of fields, including pharmaceutical and biomedical research, mass spectrometry, and analytical chemistry, as well as practitioners in clinical pharmacology, toxicology, and therapeutic drug monitoring.

Special Report

Author :
Publisher :
ISBN 13 :
Total Pages : 52 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Special Report by :

Download or read book Special Report written by and published by . This book was released on 1988 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Properties and Operations

Author : I. M. Gel'fand
Publisher : Academic Press
ISBN 13 : 148326159X
Total Pages : 442 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Properties and Operations by : I. M. Gel'fand

Download or read book Properties and Operations written by I. M. Gel'fand and published by Academic Press. This book was released on 2014-05-12 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generalized Functions, Volume 1: Properties and Operations provides a systematic development of the theory of generalized functions and problems in analysis connected with it. This book focuses on the concept of a convenient link that connects many aspects of analysis, functional analysis, theory of differential equations, representation theory of locally compact Lie groups, and theory of probability and statistics. This volume is essentially devoted to algorithmic questions of the theory, covering many applications of generalized functions to various problems of analysis. The topics discussed include the local properties of generalized functions, differentiation as a continuous operation, and Fourier Transforms of test functions. The wave equation in space of odd dimension, derivation of Green's theorem, and reducible singular points are also described. This publication is a good reference for mathematicians, researchers, and students concerned with generalized functions.

Fundamentals of Pharmacognosy and Phytotherapy E-Book

Author : Michael Heinrich
Publisher : Elsevier Health Sciences
ISBN 13 : 0323834353
Total Pages : 285 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Fundamentals of Pharmacognosy and Phytotherapy E-Book by : Michael Heinrich

Download or read book Fundamentals of Pharmacognosy and Phytotherapy E-Book written by Michael Heinrich and published by Elsevier Health Sciences. This book was released on 2023-04-27 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacognosy, the science of nature-derived drugs, pharmaceuticals and poisons, played a crucial role in the development of modern medicine, and now has an equally important place in healthcare all over the world. This wide scope ranges from traditional medicine systems and herbal and nutritional therapies, the preparation and use of highly standardised and clinically tested herbal medicines, to the production of potent drugs used only in a purified form. Natural sources mainly focus on plants, fungi and algae, but drug discovery of novel compounds and structures includes bacteria and even marine animals. Fundamentals of Pharmacognosy and Phytotherapy is a landmark textbook that covers this spectrum of medicinal plant use. Written by leading experts in this field, this book takes the reader through the history, identification and quality assurance of plant-based medicines to their therapeutic properties, safety and compatibility and interaction with prescribed drugs. Aimed at students of all healthcare professions, including pharmacy, medicine, nursing and complementary therapies, the comprehensively updated information in this textbook is also relevant to those companies and organisations concerned with the regulation and testing of herbal medicines (phytomedicines), other natural health products, nutraceuticals and dietary supplements. Introduces the concepts and scope of pharmacognosy Examines the scientific evidence of plant-based medicines for a range of health conditions Extended and updated referencing includes recent reviews, WHO and official documents (open access where available) for quick access to further scientific literature New to this edition Antimicrobial natural products: as antibiotics and antiseptics, and their potential as bacterial resistance modifiers Anticancer natural products: scope now includes their role in chemoprevention and associated anti-inflammatory mechanisms New chapter on pharmacovigilance for herbal medicines and related products Quality assurance and pharmacopoeial methods extended, with many new figures and examples Plant medicines of recent scientific interest (popularity, or notoriety) added throughout An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures, and references, with the ability to search, customise your content, make notes and highlights, and have content read aloud Antimicrobial natural products: as antibiotics and antiseptics, and their potential as bacterial resistance modifiers Anticancer natural products: scope now includes their role in chemoprevention and associated anti-inflammatory mechanisms New chapter on pharmacovigilance for herbal medicines and related products Quality assurance and pharmacopoeial methods extended, with many new figures and examples Plant medicines of recent scientific interest (popularity, or notoriety) added throughout

Fourier Analysis on Local Fields. (MN-15)

Author : M. H. Taibleson
Publisher : Princeton University Press
ISBN 13 : 1400871336
Total Pages : 308 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Fourier Analysis on Local Fields. (MN-15) by : M. H. Taibleson

Download or read book Fourier Analysis on Local Fields. (MN-15) written by M. H. Taibleson and published by Princeton University Press. This book was released on 2015-03-08 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a development of the basic facts about harmonic analysis on local fields and the n-dimensional vector spaces over these fields. It focuses almost exclusively on the analogy between the local field and Euclidean cases, with respect to the form of statements, the manner of proof, and the variety of applications. The force of the analogy between the local field and Euclidean cases rests in the relationship of the field structures that underlie the respective cases. A complete classification of locally compact, non-discrete fields gives us two examples of connected fields (real and complex numbers); the rest are local fields (p-adic numbers, p-series fields, and their algebraic extensions). The local fields are studied in an effort to extend knowledge of the reals and complexes as locally compact fields. The author's central aim has been to present the basic facts of Fourier analysis on local fields in an accessible form and in the same spirit as in Zygmund's Trigonometric Series (Cambridge, 1968) and in Introduction to Fourier Analysis on Euclidean Spaces by Stein and Weiss (1971). Originally published in 1975. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Biopolymers

Author : Neal S. Gupta
Publisher : Springer
ISBN 13 : 9400779364
Total Pages : 196 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Biopolymers by : Neal S. Gupta

Download or read book Biopolymers written by Neal S. Gupta and published by Springer. This book was released on 2014-09-16 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview, research compendium and an introduction to the science of molecular paleontology, including literature overview for non-geochemists. Analytical methods employed are included as a part of each chapter that underpin this branch of paleontology and indeed geochemistry. The primary usefulness of this volume is for organic geochemists, molecular palaeontologists, and molecular archeologists. Researchers, graduate students and academics interested in astrobiology from a paleontological perspective may also find this to be valuable.

CQ

Author :
Publisher :
ISBN 13 :
Total Pages : 1388 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis CQ by :

Download or read book CQ written by and published by . This book was released on 1965 with total page 1388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

B2 — Brx

Author : Helga Hartwig
Publisher : Springer Science & Business Media
ISBN 13 : 3662059657
Total Pages : 320 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis B2 — Brx by : Helga Hartwig

Download or read book B2 — Brx written by Helga Hartwig and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The GmeLin Formula Index and its First Supplement covered those volumes of the Eighth Edition of the GmeLin Handbook which had been issued up to the end of 1979. The present Second Supplement updates the Index by inclusion of the volumes which appeared up to the end of 1987. With this Second Supplement all compounds described in the GmeLin Handbook of Inorganic Chemistry in the period between 1924 and 1987 can be located. The basic structure of the Formula Index remains the same as in the previous editions. Computer techniques were employed in the preparation and print of the Second Supple ment. The data acquisition, sorting, and further data handling were performed with the aid of aseries of computer programs developed by statt members of the former "OnLine Group" of the GmeLin Institute, now at Chemplex GmbH, and by the printer" Universitäts druckerei H. Stürtz AG, Würzburg ". Whereas the Handbook itself will continue to appear in printed form, the present Second Supplement of the Index is intended to be the last one issued in print. The cumulated contents of the Index and its Supplements are contained in the GmeLin Formula Index (GFI) database which is available to the scientific community via STN. This database will be updated annually to include the pubLished Handbook volumes.

Index Formula Index

Author : Helga Hartwig
Publisher : Springer Science & Business Media
ISBN 13 : 3662075210
Total Pages : 284 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Index Formula Index by : Helga Hartwig

Download or read book Index Formula Index written by Helga Hartwig and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Gmelin Formula Index and its First Supplement covered those volumes of the Eighth Edition of the Gmelin Handbook which had been issued up to the end of 1979. The present Second Supplement updates the Index by inclusion of the volumes which appeared up to the end of 1987. With this Second Supplement all compounds described in the Gmelin Handbook of Inorganic Chemistry in the period between 1924 and 1987 can be located. The basic structure of the Formula Index remains the same as in the previous editions. Computer techniques were employed in the preparation and print of the Second Supple ment. The data acquisition, sorting, and further data handling were performed with the aid of aseries of computer programs developed by staft members of the former "Online Group" of the Gmelin Institute, now at Chemplex GmbH, and by the printer" Universitäts druckerei H. Stürtz AG, Würzburg ". Whereas the Handbook itself will continue to appear in printed form, the present Second Supplement of the Index is intended to be the last one issued in print. The cumulated contents of the Index and its Supplements are contained in the Gmelin Formula Index (GFI) database which is available to the scientific community via STN. This database will be updated annually to include the published Handbook volumes.