Brain Iron

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Brain Iron Metabolism and CNS Diseases

Author : Yan-Zhong Chang
Publisher : Springer Nature
ISBN 13 : 9811395896
Total Pages : 194 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Brain Iron Metabolism and CNS Diseases by : Yan-Zhong Chang

Download or read book Brain Iron Metabolism and CNS Diseases written by Yan-Zhong Chang and published by Springer Nature. This book was released on 2019-08-27 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

Iron in Central Nervous System Disorders

Author : Peter Riederer
Publisher : Springer Science & Business Media
ISBN 13 : 3709193222
Total Pages : 277 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Iron in Central Nervous System Disorders by : Peter Riederer

Download or read book Iron in Central Nervous System Disorders written by Peter Riederer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of the metals copper, zinc, magnesium, lead, manganese, mercury, lithium and aluminium in neuropsychiatric disease are well known and has been discussed on several occasions. Yet little attention has been paid to iron, the most abundant transitional metal in the body and the earth's crust. Iron plays a major role as a cofactor of numerous metabolic enzymes, it is important for DNA and protein synthesis, and has a crucial role in the oxygen carrying capacity of haemoglobin. Some of the most devastating diseases of systemic organs are associated with abnormal iron metabolism. Yet only very recently its role in the central nervous system has been considered. Thus nutritional iron defi ciency and iron overload afflict some 500-600 million people. It is also well recognized that too little or too much iron can produce profound effects on the metabolic state of the cell, and therefore the regulation of iron uptake and disposition is tightly relegated by the cell. Its transport into the cell and storage are handled by transferrin, ferritin and haemo siderin. Nowhere are these processes so well recognized as in the case of brain iron metabolism. Iron does not have ready access to the adult brain as it does to other tissues, since it does not cross the blood brain barrier (BBB). All the iron present in brain is deposited before the closure of BBB at an early age where it is sequestered and conserved. Therefore its turnover is extremely slow.

Brain Iron

Author : Moussa B. H. Youdim
Publisher : Taylor & Francis Group
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Brain Iron by : Moussa B. H. Youdim

Download or read book Brain Iron written by Moussa B. H. Youdim and published by Taylor & Francis Group. This book was released on 1988 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text discusses the specific topics that are associated with brain neurotransmitter function and not on the examination of all aspects of iron metabolism and function in the brain. This study is pertinent to the long-term consequences of early iron deficiency on brain development and function.

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Download Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc PDF Online Free

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309072905
Total Pages : 798 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by : Institute of Medicine

Download or read book Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110526980
Total Pages : 640 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by : Peggy L. Carver

Download or read book Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic written by Peggy L. Carver and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Phineas Gage

Author : John Fleischman
Publisher : Houghton Mifflin Harcourt
ISBN 13 : 9780618494781
Total Pages : 100 pages
Book Rating : 4.4/5 (947 download)

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Book Synopsis Phineas Gage by : John Fleischman

Download or read book Phineas Gage written by John Fleischman and published by Houghton Mifflin Harcourt. This book was released on 2002 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phineas Gage was truly a man with a hole in his head. Phineas, a railroad construction foreman, was blasting rock near Cavendish, Vermont, in 1848 when a thirteen-pound iron rod was shot through his brain. Miraculously, he survived to live another eleven years and become a textbook case in brain science. At the time, Phineas Gage seemed to completely recover from his accident. He could walk, talk, work, and travel, but he was changed. Gage "was no longer Gage," said his Vermont doctor, meaning that the old Phineas was dependable and well liked, and the new Phineas was crude and unpredictable. His case astonished doctors in his day and still fascinates doctors today. What happened and what didn't happen inside the brain of Phineas Gage will tell you a lot about how your brain works and how you act human.

Brain-Iron Cross Talk

Author : Wael Mohamed
Publisher : Springer Nature
ISBN 13 : 981197327X
Total Pages : 289 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Brain-Iron Cross Talk by : Wael Mohamed

Download or read book Brain-Iron Cross Talk written by Wael Mohamed and published by Springer Nature. This book was released on 2022-12-16 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors.

Power Foods for the Brain

Author : Neal D Barnard, MD
Publisher : Balance
ISBN 13 : 1455512699
Total Pages : 226 pages
Book Rating : 4.4/5 (555 download)

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Book Synopsis Power Foods for the Brain by : Neal D Barnard, MD

Download or read book Power Foods for the Brain written by Neal D Barnard, MD and published by Balance. This book was released on 2013-02-19 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strengthen your memory with New York Times bestselling author Dr. Neal Barnard’s simple 3-step plan to protecting your brain with your diet. Could your breakfast or lunch be harming your memory? Are you missing out on the foods that could prevent Alzheimer's disease? Everyone knows good nutrition supports your overall health, but few realize that certain foods-power foods-can protect your brain and optimize its function, and even dramatically reduce your risk of Alzheimer's Disease. Now, New York Times bestselling author, clinical researcher and health advocate Dr. Neal Barnard has gathered the most up-to-date research and created a groundbreaking program that can strengthen your memory and protect your brain's health. In this effective 3-step plan Dr. Barnard reveals which foods to increase in your diet and which to avoid, and shows you specific exercises and supplements that can make a difference. It will not only help boost brain health, but it can also reduce your risk of Alzheimer's disease, stroke, and other less serious malfunctions such as low energy, poor sleep patterns, irritability, and lack of focus. You'll discover: The best foods to increase cognitive function Dairy products and meats-the dangers they may pose to your memory The surprising roles alcohol and caffeine play in Alzheimer's risk The latest research on toxic metals, like aluminum found in cookware, soda cans, and common antacids. Plus a detailed menu plan, recipes and time-saving kitchen tips

Iron Physiology and Pathophysiology in Humans

Author : Gregory J. Anderson
Publisher : Springer Science & Business Media
ISBN 13 : 1603274855
Total Pages : 705 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Iron Physiology and Pathophysiology in Humans by : Gregory J. Anderson

Download or read book Iron Physiology and Pathophysiology in Humans written by Gregory J. Anderson and published by Springer Science & Business Media. This book was released on 2012-01-14 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Brain, Behaviour, and Iron in the Infant Diet

Author : John Dobbing
Publisher : Springer Science & Business Media
ISBN 13 : 1447117662
Total Pages : 203 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Brain, Behaviour, and Iron in the Infant Diet by : John Dobbing

Download or read book Brain, Behaviour, and Iron in the Infant Diet written by John Dobbing and published by Springer Science & Business Media. This book was released on 2013-12-14 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron deficiency in infancy is very widespread, even in developed countries and even when there is no general malnutrition. This book examines the question whether iron deficiency in early life leads to deleterious changes in brain and/or behavioural development. Each of the nine contributors comments critically on each of the other eight chapters, so that the book is very extensively peer-reviewed. The evidence is set out so that the reader may make his own informed judgement. Iron deficiency could very easily be prevented; this fact is of prime importance if such deficiency has long-lasting effects on human intellectual capacity and achievement.

From Neurons to Neighborhoods

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309069882
Total Pages : 610 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis From Neurons to Neighborhoods by : National Research Council

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Iron and Neurodegeneration

Author : Isabella Zanella
Publisher : Frontiers Media SA
ISBN 13 : 2889634515
Total Pages : 369 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Iron and Neurodegeneration by : Isabella Zanella

Download or read book Iron and Neurodegeneration written by Isabella Zanella and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Author : Roger N. Rosenberg
Publisher : Elsevier
ISBN 13 : 0124105491
Total Pages : 1465 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by : Roger N. Rosenberg

Download or read book Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease written by Roger N. Rosenberg and published by Elsevier. This book was released on 2014-10-28 with total page 1465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

Neurogenetics, Part I

Author :
Publisher : Elsevier
ISBN 13 : 0444632352
Total Pages : 438 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurogenetics, Part I by :

Download or read book Neurogenetics, Part I written by and published by Elsevier. This book was released on 2018-01-08 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic methodologies are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is evolving rapidly and expected to grow in scope as more disorders are linked to specific genetic markers. Part I covers basic genetic concepts and recurring biological themes, and begins the discussion of movement disorders and neurodevelopmental disorders, leading the way for Part II to cover a combination of neurological, neuromuscular, cerebrovascular, and psychiatric disorders. This volume in the Handbook of Clinical Neurology will provide a comprehensive introduction and reference on neurogenetics for the clinical practitioner and the research neurologist. - Presents a comprehensive coverage of neurogenetics - Details the latest science and impact on our understanding of neurological psychiatric disorders - Provides a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

Supercharge Your Brain

Author : James Goodwin
Publisher : Simon and Schuster
ISBN 13 : 1643138685
Total Pages : 317 pages
Book Rating : 4.6/5 (431 download)

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Book Synopsis Supercharge Your Brain by : James Goodwin

Download or read book Supercharge Your Brain written by James Goodwin and published by Simon and Schuster. This book was released on 2022-01-04 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to keeping your brain healthy for a long and lucid life, by one of the world's leading scientists in the field of brain health and ageing. The brain is our most vital and complex organ. It controls and coordinates our actions, thoughts and interactions with the world around us. It is the source of personality, of our sense of self, and it shapes every aspect of our human experience. Yet most of us know precious little about how our brains actually work, or what we can do to optimise their performance. Whilst cognitive decline is the biggest long-term health worry for many of us, practical knowledge of how to look after our brain is thin on the ground. In this ground-breaking new book, leading expert Professor James Goodwin explains how simple strategies concerning exercise, diet, social life, and sleep can transform your brain health paradigm, and shows how you can keep your brain youthful and stay sharp across your life. Combining the latest scientific research with insightful storytelling and practical advice, Supercharge Your Brain reveals everything you need to know about how your brain functions, and what you can do to keep it in peak condition.

Power Up Your Brain

Author : David Perlmutter, M.D.
Publisher : Hay House, Inc
ISBN 13 : 1401928188
Total Pages : 265 pages
Book Rating : 4.4/5 (19 download)

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Book Synopsis Power Up Your Brain by : David Perlmutter, M.D.

Download or read book Power Up Your Brain written by David Perlmutter, M.D. and published by Hay House, Inc. This book was released on 2012-02-01 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The quest for enlightenment has occupied mankind for millennia. And from the depictions we’ve see—monks sitting on meditation cushions, nuns kneeling in prayer, shamans communing with the universe—it seems that this elusive state is reserved for a chosen few. But now, neuroscientist David Perlmutter and medical anthropologist and shaman Alberto Villoldo have come together to explore the commonalities between their specialties with the aim of making enlightenment possible for anyone. Joining the long-separated worlds of science and spirit, Perlmutter explores the exciting phenomena of neurogenesis and mitochondrial health, while Villoldo brings his vast knowledge of shamanic and spiritual practices. Drawing the most powerful tools from each discipline, Perlmutter and Villoldo guide you through this groundbreaking, five-week program to help you overcome toxic emotions and awaken the power of your higher brain. Power Up Your Brain will show you how to: • reduce your risk of devastating diseases like Alzheimer’s, cancer, heart disease,and Parkinson’s; • overcome painful memories and break unhealthy emotional and behavioralpatterns; and • gain powerful clarity of thought to experience inner peace, creativity, andenlightenment—all without the use of prescription drugs! The nutritional advice, dietary supplements, fasting, and physical exercise outlined will not only help repair parts of your brain that have been affected by stress but also create a fertile environment to grow new brain cells and turn on the genes responsible for longevity, improved immunity, and enhanced brain function. And the shamanic practices, meditation, and visualizations will help bring online brain regions that allow for peace, compassion, innovation, and joy to arise naturally. Following the Power Up Your Brain program will help you clear your mind and healyour body; and open you up to experience the inner peace, vast insight, and extraordinary creativity that define the experience of enlightenment.

The Mouse in Biomedical Research

Author :
Publisher : Elsevier
ISBN 13 : 0080469078
Total Pages : 829 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis The Mouse in Biomedical Research by :

Download or read book The Mouse in Biomedical Research written by and published by Elsevier. This book was released on 2006-12-15 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse's normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.