Botanical Leads For Drug Discovery

Download Botanical Leads For Drug Discovery full books in PDF, epub, and Kindle. Read online Botanical Leads For Drug Discovery ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Botanical Leads for Drug Discovery

Author : Bikarma Singh
Publisher : Springer Nature
ISBN 13 : 9811559171
Total Pages : 481 pages
Book Rating : 4.8/5 (115 download)

DOWNLOAD NOW!

Book Synopsis Botanical Leads for Drug Discovery by : Bikarma Singh

Download or read book Botanical Leads for Drug Discovery written by Bikarma Singh and published by Springer Nature. This book was released on 2020-10-05 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Lead Compounds from Medicinal Plants for the Treatment of Cancer

Author : Christophe Wiart
Publisher : Academic Press
ISBN 13 : 0123983711
Total Pages : 430 pages
Book Rating : 4.1/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Lead Compounds from Medicinal Plants for the Treatment of Cancer by : Christophe Wiart

Phytochemicals as Lead Compounds for New Drug Discovery

Author : Chukwuebuka Egbuna
Publisher : Elsevier
ISBN 13 : 0128178914
Total Pages : 382 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Phytochemicals as Lead Compounds for New Drug Discovery by : Chukwuebuka Egbuna

Download or read book Phytochemicals as Lead Compounds for New Drug Discovery written by Chukwuebuka Egbuna and published by Elsevier. This book was released on 2019-09-07 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Lead Compounds from Medicinal Plants for the Treatment of Cancer

Author : Christophe Wiart
Publisher : Academic Press
ISBN 13 : 0123983827
Total Pages : 432 pages
Book Rating : 4.1/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Lead Compounds from Medicinal Plants for the Treatment of Cancer by : Christophe Wiart

Download or read book Lead Compounds from Medicinal Plants for the Treatment of Cancer written by Christophe Wiart and published by Academic Press. This book was released on 2012-11-23 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lead Compounds from Medicinal Plants for the Treatment of Cancer is the first volume in the series, Pharmaceutical Leads from Medicinal Plants. The plant species described in this reference have been carefully selected based on pharmacological evidence and represent today’s most promising sources of natural products for the discovery of anti-cancer drugs. Containing references to primary source material, over a hundred botanical illustrations, a table of chemical structures and much more, this book is an essential starting point for cancer researchers and those involved in anti-cancer drug discovery helping you identify the best novel lead molecules for further anti-cancer drug development. Provides a compilation of hundreds of medicinal plants from Europe, Asia, North and South America and Africa that contain prominent lead candidates for anti-cancer drug discovery Contains primary source references and hundreds of the most relevant citations from the current literature for additional research Offers cancer researchers and pharmaceutical scientists valuable tools such as chemical structures and promising pharmacological data to help them select the novel lead compounds that will best aid drug discovery.

Plant Natural Products for Human Health

Author : Chun-Tao Che
Publisher : MDPI
ISBN 13 : 3038977128
Total Pages : 514 pages
Book Rating : 4.0/5 (389 download)

DOWNLOAD NOW!

Book Synopsis Plant Natural Products for Human Health by : Chun-Tao Che

Download or read book Plant Natural Products for Human Health written by Chun-Tao Che and published by MDPI. This book was released on 2019-03-21 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs. This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Poisonous Plants and Phytochemicals in Drug Discovery

Author : Andrew G. Mtewa
Publisher : John Wiley & Sons
ISBN 13 : 1119650259
Total Pages : 432 pages
Book Rating : 4.1/5 (196 download)

DOWNLOAD NOW!

Book Synopsis Poisonous Plants and Phytochemicals in Drug Discovery by : Andrew G. Mtewa

Download or read book Poisonous Plants and Phytochemicals in Drug Discovery written by Andrew G. Mtewa and published by John Wiley & Sons. This book was released on 2020-12-04 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Drug Discovery & Development

Author : Bhushan Patwardhan
Publisher : New India Publishing
ISBN 13 : 9788189422295
Total Pages : 368 pages
Book Rating : 4.4/5 (222 download)

DOWNLOAD NOW!

Book Synopsis Drug Discovery & Development by : Bhushan Patwardhan

Download or read book Drug Discovery & Development written by Bhushan Patwardhan and published by New India Publishing. This book was released on 2007 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

Natural Product Chemistry for Drug Discovery

Author : Antony D. Buss
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041931
Total Pages : 459 pages
Book Rating : 4.8/5 (54 download)

DOWNLOAD NOW!

Book Synopsis Natural Product Chemistry for Drug Discovery by : Antony D. Buss

Download or read book Natural Product Chemistry for Drug Discovery written by Antony D. Buss and published by Royal Society of Chemistry. This book was released on 2010 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.

The Plant Hunter

Author : Cassandra Leah Quave
Publisher : Penguin
ISBN 13 : 1984879138
Total Pages : 385 pages
Book Rating : 4.9/5 (848 download)

DOWNLOAD NOW!

Book Synopsis The Plant Hunter by : Cassandra Leah Quave

Download or read book The Plant Hunter written by Cassandra Leah Quave and published by Penguin. This book was released on 2022-06-14 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The uplifting, adventure-filled memoir of one groundbreaking scientist’s quest to develop new ways to fight illness and disease through the healing powers of plants. “A fascinating and deeply personal journey.” —Amy Stewart, author of Wicked Plants and The Drunken Botanist Traveling by canoe, ATV, mule, airboat, and on foot, Dr. Cassandra Quave has conducted field research everywhere from the flooded forests of the remote Amazon to the isolated mountaintops in Albania and Kosovo—all in search of natural compounds, long-known to traditional healers, that could help save us all from the looming crisis of untreatable superbugs. Dr. Quave is a leading medical ethnobotanist—someone who identifies and studies plants that may be able to treat antimicrobial resistance and other threatening illnesses—helping to provide clues for the next generation of advanced medicines. And as a person born with multiple congenital defects of her skeletal system, she's done it all with just one leg. In The Plant Hunter, Dr. Quave weaves together science, botany, and memoir to tell us the extraordinary story of her own journey.

Natural Products and Drug Discovery

Author : Subhash C. Mandal
Publisher : Elsevier
ISBN 13 : 0081021046
Total Pages : 776 pages
Book Rating : 4.0/5 (81 download)

DOWNLOAD NOW!

Book Synopsis Natural Products and Drug Discovery by : Subhash C. Mandal

Download or read book Natural Products and Drug Discovery written by Subhash C. Mandal and published by Elsevier. This book was released on 2018-02-16 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

The Role of Natural Products in Drug Discovery

Author : J. Mulzer
Publisher : Springer Science & Business Media
ISBN 13 : 3662040425
Total Pages : 363 pages
Book Rating : 4.6/5 (62 download)

DOWNLOAD NOW!

Book Synopsis The Role of Natural Products in Drug Discovery by : J. Mulzer

Download or read book The Role of Natural Products in Drug Discovery written by J. Mulzer and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Plant-derived Natural Products

Author : Anne E. Osbourn
Publisher : Springer
ISBN 13 : 9781489983541
Total Pages : 0 pages
Book Rating : 4.9/5 (835 download)

DOWNLOAD NOW!

Book Synopsis Plant-derived Natural Products by : Anne E. Osbourn

Download or read book Plant-derived Natural Products written by Anne E. Osbourn and published by Springer. This book was released on 2014-09-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Plant Bioactives and Drug Discovery

Author : Valdir Cechinel-Filho
Publisher : John Wiley & Sons
ISBN 13 : 1118259920
Total Pages : 600 pages
Book Rating : 4.1/5 (182 download)

DOWNLOAD NOW!

Book Synopsis Plant Bioactives and Drug Discovery by : Valdir Cechinel-Filho

Download or read book Plant Bioactives and Drug Discovery written by Valdir Cechinel-Filho and published by John Wiley & Sons. This book was released on 2012-04-11 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Human-Plant Relations And Future Drug Discovery

Author : Yash Pal Sharma
Publisher : New India Publishing Agency
ISBN 13 : 9389547970
Total Pages : 4 pages
Book Rating : 4.3/5 (895 download)

DOWNLOAD NOW!

Book Synopsis Human-Plant Relations And Future Drug Discovery by : Yash Pal Sharma

Download or read book Human-Plant Relations And Future Drug Discovery written by Yash Pal Sharma and published by New India Publishing Agency. This book was released on 2020-06-26 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: At present, a multifaceted in drug discovery from medicinal plants continues to unravel novel and important cues against various pharmacological targets including cancer, HIV/AIDS, Alzheimer's, malaria, and inflammation. Several plant-based natural product drugs have found their way into the commercial medicines as dietary supplements or as chemo-preventive agents while others are currently under clinical trials. This book gives an insight into the novel approach of integrated drug discovery, where traditional wisdom and traditional documented use can synergize with drug discovery from plant sources.

Synthesis of Medicinal Agents from Plants

Author : Ashish Tewari
Publisher : Elsevier
ISBN 13 : 0081022743
Total Pages : 368 pages
Book Rating : 4.0/5 (81 download)

DOWNLOAD NOW!

Book Synopsis Synthesis of Medicinal Agents from Plants by : Ashish Tewari

Download or read book Synthesis of Medicinal Agents from Plants written by Ashish Tewari and published by Elsevier. This book was released on 2018-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Medicinal Agents from Plants highlights the importance of synthesizing medicinal agents from plants and outlines methods for performing it effectively. Beginning with an introduction to the significance of medicinal plants, the book goes on to provide a historical overview of drug synthesis before exploring how this can be used to successfully replicate and adapt the active agents from natural sources. Chapters then explore the medicinal properties of a number of important plants, before concluding with a discussion of the future of drugs from medicinal plants. Illustrated with real-world examples, it is a practical resource for researchers in this field. In an age of rapid environmental destruction, hundreds of medicinal plants are at risk of extinction from overexploitation and deforestation, limiting the natural resources available for active agent extraction, thereby threatening the discovery of future cures for diseases. Simultaneously, with the increasing population and advances in medical sciences, the demand for drugs is continuously increasing and cannot be met with just plants. The ability to synthetically replicate the active compounds from these plants is essential in creating an ecologically-aware, sustainable future for drug design Includes detailed coverage of therapeutic compound synthesis Uses multiple real-world examples to support content Lays out a sustainable template for the future of developing active agents from natural products

Essentials of Botanical Extraction

Author : Subhash C. Mandal
Publisher : Academic Press
ISBN 13 : 0128025638
Total Pages : 220 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Essentials of Botanical Extraction by : Subhash C. Mandal

Download or read book Essentials of Botanical Extraction written by Subhash C. Mandal and published by Academic Press. This book was released on 2015-02-02 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Botanical Extraction: Principles and Applications provides a unique, single source of valuable information on the various botanical extraction methods available, from conventional to the use of green and modern extraction technologies including ultrasounds, microwaves, pressurized liquids, and supercritical fluids. Most extracts obtained from botanicals are often poorly characterized with unidentified active or inactive constituents. A wise selection of an extraction strategy is vital to drug discovery from medicinal plants as extraction forms the basic first step in medicinal plant research. This book also explores the mathematical hypotheses and innovations in botanical extractions and analyzes different post extraction operations so that dependency on serendipity is reduced and the same be converted into programmed drug discovery. Reviews the history and current state of natural product drug discovery and development, highlighting successes and current issues Explains the application of chemometric tools in extraction process design and method development Introduces process intensification as applied to the processing of medicinal plant extracts for rapid and cost-effective extraction

Ethnobotany and the Search for New Drugs

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470514647
Total Pages : 290 pages
Book Rating : 4.4/5 (75 download)

DOWNLOAD NOW!

Book Synopsis Ethnobotany and the Search for New Drugs by : Derek J. Chadwick

Download or read book Ethnobotany and the Search for New Drugs written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which are used for some of the most potent drugs in Western medicine.