Bioreaction Engineering, Bioprocess Monitoring

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Publisher : John Wiley & Sons
ISBN 13 : 0471970611
Total Pages : 500 pages
Book Rating : 4.4/5 (719 download)

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Book Synopsis Bioreaction Engineering, Bioprocess Monitoring by : Karl Schügerl

Download or read book Bioreaction Engineering, Bioprocess Monitoring written by Karl Schügerl and published by John Wiley & Sons. This book was released on 1997-04-03 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 3 of Bioreaction Engineering covers the general principles and techniques of bioprocess monitoring and their application for various bioprocesses. Methods based on the author's long standing experience working with various bioprocesses are applied within the book. In particular, the cultivation of Baker's yeast; production of fusion protein with recombinant E. Coli, alkaline serine protease production with Bacillus licheniformis; production of penicillin V with Penicillin chrysogenum; Cephalosporin C with Acremonium chrysogenum and tetracycline with Streptomyces aureofaciens are considered. This book deals with the monitoring of batch and perfusion cultivations of animal cells and production of monoclonal antibodies with hybridoma cells, Antithrombin III with BHK and CHO cells and ß -galactosidase with insect cells. The topics covered include: Bioprocess monitoring techniques Cultivation of Saccharomyces cerevisiae Production of Fusion Protein with Recombinanat E. coli Alkaline Protease Production with Bacillus licheniformis Antibiotica Production by Fungi and Streptomycetes Continuous Production of Primary Metabolites with Suspended and Immobilized Microorganisms Cultivation of Animal Cells and Production of Proteins Anaerobic Waste Water Treatment Fast Process Monitoring Techniques Image Analysis of Cells and Cell Aggregates Evaluation of Experimental Data to the Calculation of Metabolite Flux in Microorganisms and Animal Cells Signal Evaluation, Automation and Expert Systems for Process Monitoring Bioprocess Monitoring is invaluable for process engineers, analytical chemists and researchers in biotechnological, pharmaceutical, environmnental and chemical industries.

Bioreaction Engineering

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Publisher : Springer Science & Business Media
ISBN 13 : 3642597351
Total Pages : 639 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Bioreaction Engineering by : K. Schügerl

Download or read book Bioreaction Engineering written by K. Schügerl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Bioanalysis and Biosensors for Bioprocess Monitoring

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Publisher : Springer
ISBN 13 : 9783662156377
Total Pages : 264 pages
Book Rating : 4.1/5 (563 download)

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Book Synopsis Bioanalysis and Biosensors for Bioprocess Monitoring by : Bernhard Sonnleitner

Download or read book Bioanalysis and Biosensors for Bioprocess Monitoring written by Bernhard Sonnleitner and published by Springer. This book was released on 2014-01-15 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contributions to this special volume were selected in order to show present trends in the field of bioprocess monitoring and estimation. Established conventional methods are critically discussed and non-conventional ones introduced. Two papers focus on more fuzzy approaches such as electronic noses or advanced chemometric techniques. One contribution illustrates the high potential with the example of cephalosporin production. Three contributions dare to "look" inside the cells, one by the analysis of (microscopic) images, one by trying to estimate the so-called physiological state, and the third by analyzing the metabolic network. This shows how sophisticated (bio)chemical as well as mathematical analytical tools result in better understanding of living systems and bioprocesses.

Bioprocess Engineering Principles

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Publisher : Elsevier
ISBN 13 : 0080528120
Total Pages : 455 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Bioprocess Engineering Principles by : Pauline M. Doran

Download or read book Bioprocess Engineering Principles written by Pauline M. Doran and published by Elsevier. This book was released on 1995-04-03 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts as well as traditional fermentation systems.* * First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists* Explains process analysis from an engineering point of view, but uses worked examples relating to biological systems* Comprehensive, single-authored* 170 problems and worked examples encompass a wide range of applications, involving recombinant plant and animal cell cultures, immobilized catalysts, and traditional fermentation systems* 13 chapters, organized according to engineering sub-disciplines, are groupled in four sections - Introduction, Material and Energy Balances, Physical Processes, and Reactions and Reactors* Each chapter includes a set of problems and exercises for the student, key references, and a list of suggestions for further reading* Includes useful appendices, detailing conversion factors, physical and chemical property data, steam tables, mathematical rules, and a list of symbols used* Suitable for course adoption - follows closely curricula used on most bioprocessing and process biotechnology courses at senior undergraduate and graduate levels.

Biochemical Engineering and Biotechnology

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Publisher : Elsevier
ISBN 13 : 0444633774
Total Pages : 669 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Biochemical Engineering and Biotechnology by : Ghasem Najafpour

Download or read book Biochemical Engineering and Biotechnology written by Ghasem Najafpour and published by Elsevier. This book was released on 2015-02-24 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Engineering and Biotechnology, 2nd Edition, outlines the principles of biochemical processes and explains their use in the manufacturing of every day products. The author uses a diirect approach that should be very useful for students in following the concepts and practical applications. This book is unique in having many solved problems, case studies, examples and demonstrations of detailed experiments, with simple design equations and required calculations. - Covers major concepts of biochemical engineering and biotechnology, including applications in bioprocesses, fermentation technologies, enzymatic processes, and membrane separations, amongst others - Accessible to chemical engineering students who need to both learn, and apply, biological knowledge in engineering principals - Includes solved problems, examples, and demonstrations of detailed experiments with simple design equations and all required calculations - Offers many graphs that present actual experimental data, figures, and tables, along with explanations

Computational Intelligence Techniques for Bioprocess Modelling, Supervision and Control

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Publisher : Springer Science & Business Media
ISBN 13 : 3642018874
Total Pages : 349 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Computational Intelligence Techniques for Bioprocess Modelling, Supervision and Control by : Maria Carmo Nicoletti

Download or read book Computational Intelligence Techniques for Bioprocess Modelling, Supervision and Control written by Maria Carmo Nicoletti and published by Springer Science & Business Media. This book was released on 2009-06-29 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.

Bioprocess Engineering Principles

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Publisher : Academic Press
ISBN 13 : 0080917704
Total Pages : 928 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Bioprocess Engineering Principles by : Pauline M. Doran

Download or read book Bioprocess Engineering Principles written by Pauline M. Doran and published by Academic Press. This book was released on 2012-04-23 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: This welcome new edition discusses bioprocess engineering from the perspective of biology students. It includes a great deal of new material and has been extensively revised and expanded. These updates strengthen the book and maintain its position as the book of choice for senior undergraduates and graduates seeking to move from biochemistry/microbiology/molecular biology to bioprocess engineering. - All chapters thoroughly revised for current developments, with over 200 pgs of new material, including significant new content in: Metabolic Engineering, Sustainable Bioprocessing, Membrane Filtration, Turbulence and Impeller Design, Downstream Processing, Oxygen Transfer Systems - Over 150 new problems and worked examples - More than 100 new illustrations

Bioreactor Engineering Research and Industrial Applications II

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Publisher : Springer
ISBN 13 : 3662483475
Total Pages : 161 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Bioreactor Engineering Research and Industrial Applications II by : Jie Bao

Download or read book Bioreactor Engineering Research and Industrial Applications II written by Jie Bao and published by Springer. This book was released on 2015-11-26 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Control in Bioprocessing

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Publisher : John Wiley & Sons
ISBN 13 : 1119296080
Total Pages : 297 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Control in Bioprocessing by : Pablo A. López Pérez

Download or read book Control in Bioprocessing written by Pablo A. López Pérez and published by John Wiley & Sons. This book was released on 2020-03-03 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.

Bioreaction Engineering Principles

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Publisher : Springer
ISBN 13 : 1461507677
Total Pages : 537 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Bioreaction Engineering Principles by : Jens Nielsen

Download or read book Bioreaction Engineering Principles written by Jens Nielsen and published by Springer. This book was released on 2012-12-06 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of the text "Bioreaction Engineering Principles" by Jens Nielsen and John Villadsen, originally published in 1994 by Plenum Press (now part of Kluwer). Time runs fast in Biotechnology, and when Kluwer Plenum stopped reprinting the first edition and asked us to make a second, revised edition we happily accepted. A text on bioreactions written in the early 1990's will not reflect the enormous development of experimental as well as theoretical aspects of cellular reactions during the past decade. In the preface to the first edition we admitted to be newcomers in the field. One of us (JV) has had 10 more years of job training in biotechnology, and the younger author (IN) has now received international recognition for his work with the hottest topics of "modem" biotechnology. Furthermore we are happy to have induced Gunnar Liden, professor of chemical reaction engineering at our sister university in Lund, Sweden to join us as co-author of the second edition. His contribution, especially on the chemical engineering aspects of "real" bioreactors has been of the greatest value. Chapter 8 of the present edition is largely unchanged from the first edition. We wish to thank professor Martin Hjortso from LSU for his substantial help with this chapter.

Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts

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Publisher : John Wiley & Sons
ISBN 13 : 1118361989
Total Pages : 288 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts by : Claire Komives

Download or read book Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts written by Claire Komives and published by John Wiley & Sons. This book was released on 2018-12-27 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies

Bioprocess Engineering

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Publisher : Newnes
ISBN 13 : 0444595228
Total Pages : 1001 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Bioprocess Engineering by : Shijie Liu

Download or read book Bioprocess Engineering written by Shijie Liu and published by Newnes. This book was released on 2012-11-21 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioprocess Engineering involves the design and development of equipment and processes for the manufacturing of products such as food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials. It also deals with studying various biotechnological processes. "Bioprocess Kinetics and Systems Engineering" first of its kind contains systematic and comprehensive content on bioprocess kinetics, bioprocess systems, sustainability and reaction engineering. Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics-including batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering- introducing key principles that enable bioprocess engineers to engage in the analysis, optimization, design and consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme of this book, while more advanced techniques and applications are covered with some depth. Many theoretical derivations and simplifications are used to demonstrate how empirical kinetic models are applicable to complicated bioprocess systems. - Contains extensive illustrative drawings which make the understanding of the subject easy - Contains worked examples of the various process parameters, their significance and their specific practical use - Provides the theory of bioprocess kinetics from simple concepts to complex metabolic pathways - Incorporates sustainability concepts into the various bioprocesses

Advances in Bioprocess Engineering and Technology

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Publisher : Springer Nature
ISBN 13 : 981157409X
Total Pages : 488 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Advances in Bioprocess Engineering and Technology by : Doraiswami Ramkrishna

Download or read book Advances in Bioprocess Engineering and Technology written by Doraiswami Ramkrishna and published by Springer Nature. This book was released on 2020-09-29 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the select peer-reviewed proceedings of the International Conference on Advances in Bioprocess Engineering and Technology (ICABET 2020). The book covers all aspects of bioprocesses, especially related to fermentation technology, food technology, environmental biotechnology, and sustainable energy. Along with this primary theme, the focus is on recent advances in bioprocessing research such as biosensors, micro-reactors, novel separation techniques, bioprocess control, bio-safety, advanced techniques for waste to wealth generation, and nanobiotechnology. This contents are divided according to the major themes of the conference: (i) Fermentation Technology and Bioreactor, (ii) Food Pharmaceuticals and Health care, (iii) Environment and Agriculture, and (iv) Sustainable Energy. This book is intended to help students, researchers, and industry professionals acquire knowledge on innovative technologies and recent advancements in the field of bioprocess engineering and technology.

Bioreactor Modeling

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Publisher : Elsevier
ISBN 13 : 0081011660
Total Pages : 220 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Bioreactor Modeling by : Jerome Morchain

Download or read book Bioreactor Modeling written by Jerome Morchain and published by Elsevier. This book was released on 2017-10-06 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. - Presents a multiphase description of bioreactor modeling - Includes a combination of concepts issued from different scientific fields to address a practical issue - Provides a detailed description of the population balance concept as applied to biological systems - Covers a set of illustrative examples of the interaction between hydrodynamics and biological response

Introduction to Polyphasic Dispersed Systems Theory

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Publisher : Springer
ISBN 13 : 3319278533
Total Pages : 210 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Introduction to Polyphasic Dispersed Systems Theory by : Jacques Thierie

Download or read book Introduction to Polyphasic Dispersed Systems Theory written by Jacques Thierie and published by Springer. This book was released on 2015-12-30 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces a new paradigm in system description and modelling. The author shows the theoretical and practical successes of his approach, which involves replacing a traditional uniform description with a polyphasic description. This change of perspective reveals new fluxes that are cryptic in the classical description. Several case studies are given in this book, which is of interest of those working with biotechnology and green chemistry.

Putting Biotechnology to Work

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Publisher : National Academies Press
ISBN 13 : 0309047854
Total Pages : 133 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Putting Biotechnology to Work by : National Research Council

Download or read book Putting Biotechnology to Work written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of the United States to sustain a dominant global position in biotechnology lies in maintaining its primacy in basic life-science research and developing a strong resource base for bioprocess engineering and bioproduct manufacturing. This book examines the status of bioprocessing and biotechnology in the United States; current bioprocess technology, products, and opportunities; and challenges of the future and what must be done to meet those challenges. It gives recommendations for action to provide suitable incentives to establish a national program in bioprocess-engineering research, development, education, and technology transfer.

Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing

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Publisher : John Wiley & Sons
ISBN 13 : 3527347690
Total Pages : 404 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing by : Ganapathy Subramanian

Download or read book Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing written by Ganapathy Subramanian and published by John Wiley & Sons. This book was released on 2021-12-20 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. In Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing, distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products. A stand-alone follow-up to the editor’s Continuous Biomanufacturing: Innovative Technologies and Methods published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes: Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.