Biophysically Based Computational Models Of Astrocyte Neuron Coupling And Their Functional Significance

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Biophysically based Computational Models of Astrocyte ~ Neuron Coupling and their Functional Significance

Author : John Wade
Publisher : Frontiers E-books
ISBN 13 : 2889191788
Total Pages : 140 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Biophysically based Computational Models of Astrocyte ~ Neuron Coupling and their Functional Significance by : John Wade

Download or read book Biophysically based Computational Models of Astrocyte ~ Neuron Coupling and their Functional Significance written by John Wade and published by Frontiers E-books. This book was released on 2014-03-21 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscientists are increasingly becoming more interested in modelling brain functions where capturing the biophysical mechanisms underpinning these functions requires plausible models at the level of neuron cells. However, cell level models are still very much in the embryo stage and therefore there is a need to advance the level of biological realism at the level of neurons/synapses. Recent publications have highlighted that astrocytes continually exchange information with multiple synapses; if we are to fully appreciate this dynamic and coordinated interplay between these cells then more research on bidirectional signalling between astrocytes and neurons is required. A better understanding of astrocyte-neuron cell coupling would provide the building block for studying the regulatory capability of astrocytes networks on a large scale. For example, it is believed that local and global signalling via astrocytes underpins brain functions like synchrony, learning, memory and self repair. This Research Topic aims to report on current research work which focuses on understanding and modelling the interaction between astrocytes and neurons at the cellular level (Bottom up) and at network level (Top down). Understanding astrocytic regulation of neural activity is crucial if we are to capture how information is represented and processed across large neuronal ensembles in humans.

Reproducibility and Rigour in Computational Neuroscience

Author : Sharon Crook
Publisher : Frontiers Media SA
ISBN 13 : 2889638383
Total Pages : 279 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Reproducibility and Rigour in Computational Neuroscience by : Sharon Crook

Download or read book Reproducibility and Rigour in Computational Neuroscience written by Sharon Crook and published by Frontiers Media SA. This book was released on 2020-07-09 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metastable Dynamics of Neural Ensembles

Author : Emili Balaguer-Ballester
Publisher : Frontiers Media SA
ISBN 13 : 2889454371
Total Pages : 152 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Metastable Dynamics of Neural Ensembles by : Emili Balaguer-Ballester

Download or read book Metastable Dynamics of Neural Ensembles written by Emili Balaguer-Ballester and published by Frontiers Media SA. This book was released on 2018-03-19 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: A classical view of neural computation is that it can be characterized in terms of convergence to attractor states or sequential transitions among states in a noisy background. After over three decades, is this still a valid model of how brain dynamics implements cognition? This book provides a comprehensive collection of recent theoretical and experimental contributions addressing the question of stable versus transient neural population dynamics from complementary angles. These studies showcase recent efforts for designing a framework that encompasses the multiple facets of metastability in neural responses, one of the most exciting topics currently in systems and computational neuroscience.

Criticality in Neural Systems

Author : Dietmar Plenz
Publisher : John Wiley & Sons
ISBN 13 : 3527651020
Total Pages : 734 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Criticality in Neural Systems by : Dietmar Plenz

Download or read book Criticality in Neural Systems written by Dietmar Plenz and published by John Wiley & Sons. This book was released on 2014-04-14 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurowissenschaftler suchen nach Antworten auf die Fragen, wie wir lernen und Information speichern, welche Prozesse im Gehirn verantwortlich sind und in welchem Zeitrahmen diese ablaufen. Die Konzepte, die aus der Physik kommen und weiterentwickelt werden, können in Medizin und Soziologie, aber auch in Robotik und Bildanalyse Anwendung finden. Zentrales Thema dieses Buches sind die sogenannten kritischen Phänomene im Gehirn. Diese werden mithilfe mathematischer und physikalischer Modelle beschrieben, mit denen man auch Erdbeben, Waldbrände oder die Ausbreitung von Epidemien modellieren kann. Neuere Erkenntnisse haben ergeben, dass diese selbstgeordneten Instabilitäten auch im Nervensystem auftreten. Dieses Referenzwerk stellt theoretische und experimentelle Befunde internationaler Gehirnforschung vor zeichnet die Perspektiven dieses neuen Forschungsfeldes auf.

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics

Author : Carl Faingold
Publisher : Academic Press
ISBN 13 : 0124158641
Total Pages : 537 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics by : Carl Faingold

Download or read book Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics written by Carl Faingold and published by Academic Press. This book was released on 2013-12-26 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: - How the brain carries out important tasks via networks - How these networks interact in normal brain function - Major mechanisms that control network function - The interaction of the normal networks to produce more complex behaviors - How brain disorders can result from abnormal interactions - How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. - Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant - Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders - Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Artificial Neural Networks and Machine Learning – ICANN 2018

Author : Věra Kůrková
Publisher : Springer
ISBN 13 : 303001424X
Total Pages : 866 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Artificial Neural Networks and Machine Learning – ICANN 2018 by : Věra Kůrková

Download or read book Artificial Neural Networks and Machine Learning – ICANN 2018 written by Věra Kůrková and published by Springer. This book was released on 2018-10-02 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume set LNCS 11139-11141 constitutes the refereed proceedings of the 27th International Conference on Artificial Neural Networks, ICANN 2018, held in Rhodes, Greece, in October 2018. The papers presented in these volumes was carefully reviewed and selected from total of 360 submissions. They are related to the following thematic topics: AI and Bioinformatics, Bayesian and Echo State Networks, Brain Inspired Computing, Chaotic Complex Models, Clustering, Mining, Exploratory Analysis, Coding Architectures, Complex Firing Patterns, Convolutional Neural Networks, Deep Learning (DL), DL in Real Time Systems, DL and Big Data Analytics, DL and Big Data, DL and Forensics, DL and Cybersecurity, DL and Social Networks, Evolving Systems – Optimization, Extreme Learning Machines, From Neurons to Neuromorphism, From Sensation to Perception, From Single Neurons to Networks, Fuzzy Modeling, Hierarchical ANN, Inference and Recognition, Information and Optimization, Interacting with The Brain, Machine Learning (ML), ML for Bio Medical systems, ML and Video-Image Processing, ML and Forensics, ML and Cybersecurity, ML and Social Media, ML in Engineering, Movement and Motion Detection, Multilayer Perceptrons and Kernel Networks, Natural Language, Object and Face Recognition, Recurrent Neural Networks and Reservoir Computing, Reinforcement Learning, Reservoir Computing, Self-Organizing Maps, Spiking Dynamics/Spiking ANN, Support Vector Machines, Swarm Intelligence and Decision-Making, Text Mining, Theoretical Neural Computation, Time Series and Forecasting, Training and Learning.

Astrocytes in (Patho)Physiology of the Nervous System

Author : Vladimir Parpura
Publisher : Springer Science & Business Media
ISBN 13 : 0387794921
Total Pages : 701 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Astrocytes in (Patho)Physiology of the Nervous System by : Vladimir Parpura

Download or read book Astrocytes in (Patho)Physiology of the Nervous System written by Vladimir Parpura and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.

The Role of Astroglia and Oligodendroglia in CNS Development, Plasticity, and Disease – Novel Tools and Investigative Approaches

Author : Enrica Boda
Publisher : Frontiers Media SA
ISBN 13 : 2889762858
Total Pages : 255 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The Role of Astroglia and Oligodendroglia in CNS Development, Plasticity, and Disease – Novel Tools and Investigative Approaches by : Enrica Boda

Download or read book The Role of Astroglia and Oligodendroglia in CNS Development, Plasticity, and Disease – Novel Tools and Investigative Approaches written by Enrica Boda and published by Frontiers Media SA. This book was released on 2022-05-31 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dynamic Coordination in the Brain

Author : Christoph Von Der Malsburg
Publisher : MIT Press
ISBN 13 : 0262289040
Total Pages : 367 pages
Book Rating : 4.2/5 (622 download)

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Book Synopsis Dynamic Coordination in the Brain by : Christoph Von Der Malsburg

Download or read book Dynamic Coordination in the Brain written by Christoph Von Der Malsburg and published by MIT Press. This book was released on 2010-07-09 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of how widely distributed and specialized activities of the brain are flexibly and effectively coordinated. A fundamental shift is occurring in neuroscience and related disciplines. In the past, researchers focused on functional specialization of the brain, discovering complex processing strategies based on convergence and divergence in slowly adapting anatomical architectures. Yet for the brain to cope with ever-changing and unpredictable circumstances, it needs strategies with richer interactive short-term dynamics. Recent research has revealed ways in which the brain effectively coordinates widely distributed and specialized activities to meet the needs of the moment. This book explores these findings, examining the functions, mechanisms, and manifestations of distributed dynamical coordination in the brain and mind across different species and levels of organization. The book identifies three basic functions of dynamic coordination: contextual disambiguation, dynamic grouping, and dynamic routing. It considers the role of dynamic coordination in temporally structured activity and explores these issues at different levels, from synaptic and local circuit mechanisms to macroscopic system dynamics, emphasizing their importance for cognition, behavior, and psychopathology. Contributors Evan Balaban, György Buzsáki, Nicola S. Clayton, Maurizio Corbetta, Robert Desimone, Kamran Diba, Shimon Edelman, Andreas K. Engel, Yves Fregnac, Pascal Fries, Karl Friston, Ann Graybiel, Sten Grillner, Uri Grodzinski, John-Dylan Haynes, Laurent Itti, Erich D. Jarvis, Jon H. Kaas, J.A. Scott Kelso, Peter König, Nancy J. Kopell, Ilona Kovács, Andreas Kreiter, Anders Lansner, Gilles Laurent, Jörg Lücke, Mikael Lundqvist, Angus MacDonald, Kevan Martin, Mayank Mehta, Lucia Melloni, Earl K. Miller, Bita Moghaddam, Hannah Monyer, Edvard I. Moser, May-Britt Moser, Danko Nikolic, William A. Phillips, Gordon Pipa, Constantin Rothkopf, Terrence J. Sejnowski, Steven M. Silverstein, Wolf Singer, Catherine Tallon-Baudry, Roger D. Traub, Jochen Triesch, Peter Uhlhaas, Christoph von der Malsburg, Thomas Weisswange, Miles Whittington, Matthew Wilson

Glial Physiology and Pathophysiology

Author : Alexei Verkhratsky
Publisher : John Wiley & Sons
ISBN 13 : 1118402057
Total Pages : 473 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Glial Physiology and Pathophysiology by : Alexei Verkhratsky

Download or read book Glial Physiology and Pathophysiology written by Alexei Verkhratsky and published by John Wiley & Sons. This book was released on 2013-01-31 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Augmentation of Brain Function: Facts, Fiction and Controversy

Author : Ioan Opris
Publisher : Frontiers Media SA
ISBN 13 : 2889456153
Total Pages : 403 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Augmentation of Brain Function: Facts, Fiction and Controversy by : Ioan Opris

Download or read book Augmentation of Brain Function: Facts, Fiction and Controversy written by Ioan Opris and published by Frontiers Media SA. This book was released on 2018-09-14 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Volume II is entitled “Neurostimulation and pharmacological approaches”. This volume describes augmentation approaches, where improvements in brain functions are achieved by modulation of brain circuits with electrical or optical stimulation, or pharmacological agents. Activation of brain circuits with electrical currents is a conventional approach that includes such methods as (i) intracortical microstimulation (ICMS), (ii) transcranial direct current stimulation (tDCS), and (iii) transcranial magnetic stimulation (TMS). tDCS and TMS are often regarded as noninvasive methods. Yet, they may induce long-lasting plastic changes in the brain. This is why some authors consider the term “noninvasive” misleading when used to describe these and other techniques, such as stimulation with transcranial lasers. The volume further discusses the potential of neurostimulation as a research tool in the studies of perception, cognition and behavior. Additionally, a notion is expressed that brain augmentation with stimulation cannot be described as a net zero sum proposition, where brain resources are reallocated in such a way that gains in one function are balanced by costs elsewhere. In recent years, optogenetic methods have received an increased attention, and several articles in Volume II cover different aspects of this technique. While new optogenetic methods are being developed, the classical electrical stimulation has already been utilized in many clinically relevant applications, like the vestibular implant and tactile neuroprosthesis that utilizes ICMS. As a peculiar usage of neurostimulation and pharmacological methods, Volume II includes several articles on augmented memory. Memory prostheses are a popular recent development in the stimulation-based BMIs. For example, in a hippocampal memory prosthesis, memory content is extracted from hippocampal activity using a multiple-input, multiple-output non-linear dynamical model. As to the pharmacological approaches to augmenting memory and cognition, the pros and cons of using nootropic drugs are discussed.

Dynamical Systems in Neuroscience

Author : Eugene M. Izhikevich
Publisher : MIT Press
ISBN 13 : 0262514206
Total Pages : 459 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Dynamical Systems in Neuroscience by : Eugene M. Izhikevich

Download or read book Dynamical Systems in Neuroscience written by Eugene M. Izhikevich and published by MIT Press. This book was released on 2010-01-22 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.

Receptor-Receptor Interactions

Author : Kjell Fuxe
Publisher : Springer Science & Business Media
ISBN 13 : 1468454153
Total Pages : 577 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Receptor-Receptor Interactions by : Kjell Fuxe

Download or read book Receptor-Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Simulating, Analyzing, and Animating Dynamical Systems

Author : Bard Ermentrout
Publisher : SIAM
ISBN 13 : 0898715067
Total Pages : 298 pages
Book Rating : 4.8/5 (987 download)

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Book Synopsis Simulating, Analyzing, and Animating Dynamical Systems by : Bard Ermentrout

Download or read book Simulating, Analyzing, and Animating Dynamical Systems written by Bard Ermentrout and published by SIAM. This book was released on 2002-01-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Simulating, Analyzing, and Animating Dynamical Systems: A Guide to XPPAUT for Researchers and Students provides sophisticated numerical methods for the fast and accurate solution of a variety of equations, including ordinary differential equations, delay equations, integral equations, functional equations, and some partial differential equations, as well as boundary value problems. It introduces many modeling techniques and methods for analyzing the resulting equations. Instructors, students, and researchers will all benefit from this book, which demonstrates how to use software tools to simulate and study sets of equations that arise in a variety of applications. Instructors will learn how to use computer software in their differential equations and modeling classes, while students will learn how to create animations of their equations that can be displayed on the World Wide Web. Researchers will be introduced to useful tricks that will allow them to take full advantage of XPPAUT's capabilities.

The Tripartite Synapse

Author : Andrea Volterra
Publisher : Oxford University Press, USA
ISBN 13 : 9780198508540
Total Pages : 272 pages
Book Rating : 4.5/5 (85 download)

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Book Synopsis The Tripartite Synapse by : Andrea Volterra

Download or read book The Tripartite Synapse written by Andrea Volterra and published by Oxford University Press, USA. This book was released on 2002 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "additional images, movies, and animated sequences." -- p. [4] of cover.

Spiking Neuron Models

Author : Wulfram Gerstner
Publisher : Cambridge University Press
ISBN 13 : 9780521890793
Total Pages : 498 pages
Book Rating : 4.8/5 (97 download)

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Book Synopsis Spiking Neuron Models by : Wulfram Gerstner

Download or read book Spiking Neuron Models written by Wulfram Gerstner and published by Cambridge University Press. This book was released on 2002-08-15 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurons in the brain communicate by short electrical pulses, the so-called action potentials or spikes. How can we understand the process of spike generation? How can we understand information transmission by neurons? What happens if thousands of neurons are coupled together in a seemingly random network? How does the network connectivity determine the activity patterns? And, vice versa, how does the spike activity influence the connectivity pattern? These questions are addressed in this 2002 introduction to spiking neurons aimed at those taking courses in computational neuroscience, theoretical biology, biophysics, or neural networks. The approach will suit students of physics, mathematics, or computer science; it will also be useful for biologists who are interested in mathematical modelling. The text is enhanced by many worked examples and illustrations. There are no mathematical prerequisites beyond what the audience would meet as undergraduates: more advanced techniques are introduced in an elementary, concrete fashion when needed.

Computational Glioscience

Author : Maurizio De Pittà
Publisher : Springer
ISBN 13 : 3030008177
Total Pages : 505 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Computational Glioscience by : Maurizio De Pittà

Download or read book Computational Glioscience written by Maurizio De Pittà and published by Springer. This book was released on 2019-01-21 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades, the recognition that astrocytes - the predominant type of cortical glial cells - could sense neighboring neuronal activity and release neuroactive agents, has been instrumental in the uncovering of many roles that these cells could play in brain processing and the storage of information. These findings initiated a conceptual revolution that leads to rethinking how brain communication works since they imply that information travels and is processed not just in the neuronal circuitry but in an expanded neuron-glial network. On the other hand the physiological need for astrocyte signaling in brain information processing and the modes of action of these cells in computational tasks remain largely undefined. This is due, to a large extent, both to the lack of conclusive experimental evidence, and to a substantial lack of a theoretical framework to address modeling and characterization of the many possible astrocyte functions. This book that we propose aims at filling this gap, providing the first systematic computational approach to the complex, wide subject of neuron-glia interactions. The organization of the book is unique insofar as it considers a selection of “hot topics” in glia research that ideally brings together both the novelty of the recent experimental findings in the field and the modelling challenge that they bear. A chapter written by experimentalists, possibly in collaboration with theoreticians, will introduce each topic. The aim of this chapter, that we foresee less technical in its style than in conventional reviews, will be to provide a review as clear as possible, of what is “established” and what remains speculative (i.e. the open questions). Each topic will then be presented in its possible different aspects, by 2-3 chapters by theoreticians. These chapters will be edited in order to provide a “priming” reference for modeling neuron-glia interactions, suitable both for the graduate student and the professional researcher.