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Biomedical Applications Of Mesoporous Silica Particles
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Book Synopsis Nanoparticles for Biomedical Applications by : Eun Ji Chung
Download or read book Nanoparticles for Biomedical Applications written by Eun Ji Chung and published by Elsevier. This book was released on 2019-11-19 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles for Biomedical Applications: Fundamental Concepts, Biological Interactions and Clinical Applications brings into one place information on the design and biomedical applications of different classes of nanoparticles. While aspects are dealt with in individual journal articles, there is not one source that covers this area comprehensively. This book fills this gap in the literature. - Outlines an in-depth review of biomedical applications of a variety of nanoparticle classes - Discusses the major techniques for designing nanoparticles for use in biomedicine - Explores safety and regulatory aspects for the use of nanoparticles in biomedicine
Book Synopsis Biomedical Applications of Mesoporous Silica Particles by : Cicily J. Ronhovde
Download or read book Biomedical Applications of Mesoporous Silica Particles written by Cicily J. Ronhovde and published by . This book was released on 2017 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica particles are of significant interest for biomedical applications due to their good general biocompatibility compared to other nanoparticle matrices such as quantum dots, high specific surface areas up to 1000 m2/g, and extreme synthetic tunability in terms of particle size, pore size and topology, core material, and surface functionalization. For one application, drug delivery, mesoporous silica nanoparticles (MSNs) of two pore structures, MCM-41 - parallel, hexagonally ordered pores approximately 3 nm in diameter - and wormhole (WO) - interconnected, disordered pores also approximately 3 nm in diameter - were synthesized with particle diameters under 100 nm. Additionally, a magnetic Fe3O4 nanoparticle core was incorporated into Fe3O4-core WO-MS-shell particles. The particles were loaded with doxorubicin, a chemotherapeutic, and the drug release into phosphate buffered saline (PBS, 10 mM, pH 7.4) at 37 °C was monitored by fluorescence spectroscopy. The data were fit to three models: Korsmeyer-Peppas, first order exponential release, and Weibull. The Korsmeyer-Peppas model provided useful information concerning the kinetics and mechanism of drug release from each MSN type. A small but statistically significant difference in the release kinetics was found due to the different pore topologies. A much larger kinetic effect was observed due to the inclusion of an iron oxide core. Applying a static magnetic field to the Fe3O4-core WO-MS shell particles did not have a significant impact on the doxorubicin release. This is the first time that the effects of pore topology and iron oxide core have been isolated from pore diameter and particle size for these materials. In vitro cell studies were conducted to determine the cytotoxicity of the bare and doxorubicin-loaded materials against three cancerous cell lines - A549 human lung carcinoma cells, HEC50CO human endometrial cancer cells, and CT26 mouse colon cancer cells.
Book Synopsis Update on Silica-based Mesoporous Materials for Biomedical Applications by : Luigi Pasqua
Download or read book Update on Silica-based Mesoporous Materials for Biomedical Applications written by Luigi Pasqua and published by Smithers Rapra. This book was released on 2011-11-22 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an insightful understanding of the mesoporous silica structure and its special properties. The details of synthesis and modification strategies are discussed by reviewing the open literature. The discussion concerning the potential of mesoporous silica in modern biomedical applications will be related to a critical analysis in the field of material science. This book will help the reader rapidly develop the necessary tools to follow the design of the different mesoporous silica-based devices presented in the various studies. The structure of the different devices is examined in detail and the relationship between the structure and the expected activity are discussed. It will also assist in the ability to design new therapeutic devices in a field where the applications seem to be without limits.
Book Synopsis Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part A by :
Download or read book Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part A written by and published by Academic Press. This book was released on 2018-09-20 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy and Diagnosis, Part A, Volume 43 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN). - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series - Updated release includes the latest information on Cancer Therapy and Diagnosis
Book Synopsis Modification of Mesoporous Silica Nanoparticles for Biomedical Applications by : 蘇怡帆
Download or read book Modification of Mesoporous Silica Nanoparticles for Biomedical Applications written by 蘇怡帆 and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part B by :
Download or read book Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part B written by and published by Academic Press. This book was released on 2018-10-22 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy and Diagnosis, Part B, Volume 44 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN). - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series - Updated release includes the latest information on Cancer Therapy and Diagnosis
Book Synopsis Biomedical Applications of Mesoporous Ceramics by : María Vallet-Regí
Download or read book Biomedical Applications of Mesoporous Ceramics written by María Vallet-Regí and published by CRC Press. This book was released on 2012-11-28 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments in mesoporous ceramics in drug delivery, nanomedicine, and bone tissue regeneration have opened promising developments in biomedical research, many applicable in the clinic in the near future. Due to the ability to fine-tune the physicochemical properties of these materials, the field has experienced an impressive burst in the number of publications. As controlled drug delivery systems are one of the most promising applications for human health care, it is now necessary to set the milestones of this technology, from the very basic to the most advanced. Biomedical Applications of Mesoporous Ceramics: Drug Delivery, Smart Materials and Bone Tissue Engineering is a comprehensive overview of silica-based mesoporous materials with special attention given to their use in drug delivery systems, sophisticated stimuli-responsive materials, and bone tissue engineering. The book provides a comprehensive overview of the basic aspects of the properties of mesoporous materials, with a focus on textural properties such as surface and porosity. Starting from this consolidated knowledge, it then addresses various aspects of more sophisticated stimuli-responsive materials and bone tissue engineering, detailing the research and development of these biomedical applications.
Book Synopsis Biomedical Applications of Functionalized Nanomaterials by : Bruno Filipe Carmelino Cardoso Sarmento
Download or read book Biomedical Applications of Functionalized Nanomaterials written by Bruno Filipe Carmelino Cardoso Sarmento and published by Elsevier. This book was released on 2018-03-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
Book Synopsis Safety of Nanoparticles by : Thomas J. Webster
Download or read book Safety of Nanoparticles written by Thomas J. Webster and published by Springer Science & Business Media. This book was released on 2008-11-18 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of the potential use of nanomaterials as tissue engineering devices, implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the cytoplasm undetected. The aim of this book is to provide one of the first (if not the first) detailed views of how cells and tissues in the body deal with nanoparticles. This is important not only for implantable devices, but also for the manufacturing of nanophase materials when particles can be inhaled or enter the body through the skin. Only by compiling research at the intersection of nanoparticles and biological processes can we determine if nanophase materials are safe to be manufactured, handled, and/or implanted for various medical applications.
Book Synopsis Biomedical Application of Mesoporous Silica Nanoparticles by : 陳奕平
Download or read book Biomedical Application of Mesoporous Silica Nanoparticles written by 陳奕平 and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomedical Applications of Nanoparticles by : Alexandru Mihai Grumezescu
Download or read book Biomedical Applications of Nanoparticles written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2019-02-28 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Nanoparticles describes the most interesting and investigated biomedical applications of nanoparticles, emphasizing their therapeutic impact. Progress made in the therapy of severe diseases, such as cancer and difficult infections is strictly correlated to the scientific progress and technological development in the field of materials science. Nanoparticles have numerous therapeutic applications, starting with the design of new drugs, delivery systems, therapeutic materials, and their contribution to the development of preventive strategies. The book highlights the impact of nanoparticles on the therapy of infections, antimicrobial effect and also anti-cancer strategies. Successful examples are given throughout the book, along with analysis in order to improve future outcomes of novel therapies. - Highlights the term nanotherapeutics and presents several classifications of nanotherapeutics from different points-of-view - Presents the recent progress related to nanotherapeutics in the oral cavity - Provides the recent progress in the field of biomedical nanoparticles
Book Synopsis Nano Medicine and Nano Safety by : Malay K. Das
Download or read book Nano Medicine and Nano Safety written by Malay K. Das and published by Springer Nature. This book was released on 2020-12-09 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines. The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book’s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies’ efforts to address them.
Book Synopsis Synthesis and Derivatization of Stimuli Responsive Mesoporous Silica Nanoparticles and Biomedical Drug Delivery Application by : Zilu Li
Download or read book Synthesis and Derivatization of Stimuli Responsive Mesoporous Silica Nanoparticles and Biomedical Drug Delivery Application written by Zilu Li and published by . This book was released on 2015 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis involves synthesis, derivatization and biomedical applications of mesoporous silica nanopartilces (MSNs) and Fe3O4@SiO2 core/shell nanoparticles. Chapter 1 introduces the development of MSNs including the mesopores formation mechanism, synthesis conditions and their capability to act as stimuli responsive drug delivery platforms. In chapter 2, the synthesis optimization of different kinds of particles and their surface derivatization are introduced. Chapter 3 & 4 give specific examples of successful optimization and in vitro and in vivo application of MSNs enabled with pH-sensitive nanovalves and disulfide snap-tops for delivering the antibiotic moxifloxacin. It is shown that a high release capacity is necessary to reach a high efficacy ratio, compared with free drug. Chapter 5 discusses the uptake and release capacities of Fe3O4@SiO2 core/shell nanoparticles when modified with a pH-sensitive nanovalves, and its thermally cargo release behavior when surrounding temperature increases or an oscillating magnetic field is applied. In Chapter 6, successful distribution of Fe3O4@SiO2 core/shell nanoparticles in biofilms and on-command release of cargo inside biofilms are shown. Overall, these chapters demonstrate the ability of modifying both the outer surface and interior of MSNs, and their capability to act as a biocompatible controlled release platform that is more effective than equivalent amount of free drug.
Book Synopsis Silica-coated Magnetic Nanoparticles by : Mariela A. Agotegaray
Download or read book Silica-coated Magnetic Nanoparticles written by Mariela A. Agotegaray and published by Springer. This book was released on 2017-01-04 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.
Book Synopsis Multifunctional Magnetic Silica Nanoparticles for Biomedical Applications by : Nathan Bryce Mahany
Download or read book Multifunctional Magnetic Silica Nanoparticles for Biomedical Applications written by Nathan Bryce Mahany and published by . This book was released on 2009 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Either solid or mesoporous silica can be synthesized sufficiently small for biological uses (diameter
Book Synopsis Mesoporous Silica Nanoparticles for Biomedical and Catalytical Applications by : Xiaoxing Sun
Download or read book Mesoporous Silica Nanoparticles for Biomedical and Catalytical Applications written by Xiaoxing Sun and published by . This book was released on 2011 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multifunctional Mesoporous Silica Nanoparticles for Drug and Large Molecule Delivery by : Ruining Wang
Download or read book Multifunctional Mesoporous Silica Nanoparticles for Drug and Large Molecule Delivery written by Ruining Wang and published by . This book was released on 2020 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis involves synthesis, derivatization and biomedical applications of mesoporous silica nanoparticles (MSNs) based delivery systems. Chapter 1 introduces the background of MSNs including the advantages of MSNs, modification on MSNs for multifunctionality; formation mechanism, a typical synthesis condition for MCM-41 and following characterizaitons. In chapter 2 & 3, the synthesis and application of target moiety functionalized MSNs for gene therapy in vitro and in vivo are introduced. Chapters 4, & 5 introduce the relevant studies of utilizing MSN based delivery system for the treatment of infectious disease, from a pharmacokinetic study of moxifloxacin delivered by MSNs via different routes, to the enhanced efficacy of MSN based treatment by materials optimizations via inhalation administration route. Chapter 6 discusses the study of a general synthesis method for pore enlargement in various types of MSNs. In Chapter 7, the design and preparation of a thin film consist of ultra large pore-sized mesoporous silica spheres and polymer template macropores is illustrated. Overall, these chapters demonstrate the successful engineering of mesoporous silica nanoparticles and materials optimization and their enhanced performance in biological applications from in vivo tumor shrinkage by gene delivery to antibiotics delivery for enhanced bacterial killing efficacy in mouse model.
