Biomaterials And Cellular Systems At The Forefront Of Peripheral Nerve Regeneration

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Biomaterials and Cellular Systems at the Forefront of Peripheral Nerve Regeneration

Author : Ana Colette Maur√≠cio
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Biomaterials and Cellular Systems at the Forefront of Peripheral Nerve Regeneration by : Ana Colette Maur√≠cio

Download or read book Biomaterials and Cellular Systems at the Forefront of Peripheral Nerve Regeneration written by Ana Colette Maur√≠cio and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peripheral nerve injuries remain a common clinical complication, and currently available therapies present significant limitations, often resulting in poor and suboptimal outcomes. Despite significant developments in microsurgical approaches in the last decades, no effective treatment options have been disclosed. Current research focuses on the optimization of such microsurgical techniques and on their combination with other pro-regenerative factors, such as mesenchymal stem cells or biomaterials. Mesenchymal stem cells present a remarkable capacity for bioactive molecule production that modulates inflammatory and regenerative processes, stimulating peripheral nerve regeneration. In parallel, efforts have been directed towards the development of biomaterial nerve guidance channels and nerve conduits. These biomaterials have been optimized in terms of biodegradability, ability to release bioactive factors, incorporation of cellular agents, and internal matrix architecture (to enable cellular migration and mimic native tissue morphology and to generate and bear specific electrical activity). The current literature review presents relevant advances in the development of mesenchymal stem cell and biomaterial-based therapeutic approaches aiming at the peripheral nerve tissue regeneration in diverse lesion scenarios, also exploring the advances achieved by our research group in this field in recent years.

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Download Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art PDF Online Free

Author : Sílvia Santos Pedrosa
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art by : Sílvia Santos Pedrosa

Download or read book Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art written by Sílvia Santos Pedrosa and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

Peripheral Nerve Regeneration

Author : Giovanna Gambarotta
Publisher : Frontiers Media SA
ISBN 13 : 2889632687
Total Pages : 302 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Peripheral Nerve Regeneration by : Giovanna Gambarotta

Download or read book Peripheral Nerve Regeneration written by Giovanna Gambarotta and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bio-Systems Engineering for Regulating Nerve Regeneration

Author : Srinivas Madduri
Publisher : Frontiers Media SA
ISBN 13 : 2889749835
Total Pages : 125 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Bio-Systems Engineering for Regulating Nerve Regeneration by : Srinivas Madduri

Download or read book Bio-Systems Engineering for Regulating Nerve Regeneration written by Srinivas Madduri and published by Frontiers Media SA. This book was released on 2022-04-29 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neural Regenerative Nanomedicine

Author : Mehdi Razavi
Publisher : Academic Press
ISBN 13 : 0128202238
Total Pages : 318 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Neural Regenerative Nanomedicine by : Mehdi Razavi

Download or read book Neural Regenerative Nanomedicine written by Mehdi Razavi and published by Academic Press. This book was released on 2020-08-17 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Regenerative Nanomedicine presents novel, significant, experimental results relating to nanoscience and nanotechnology in neural regeneration. As current research is at the forefront of healing the nervous system, the content in the book focuses on basic, translational and clinical research in neural repair and regeneration. Chapters focus on stem cell biology to advance medical therapies for devastating disorders, the complex, delicate structures that make up the nervous system, and neurodegenerative diseases that cause progressive deterioration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis and multiple system atrophy. Presents a multidisciplinary focus on all research areas surrounding the applications of nanotechnology in neural regeneration Provides a guide for physician and scientists, including necessary expertise for bioengineers, materials engineers, those in biomaterials and nanoengineering, stem cell biologists, and chemists Covers many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, neural regenerative medicine, and nanomedicine

Cellular Systems and Biomaterials for Nerve Regeneration in Neurotmesis Injuries

Author : Ana Colette Maurício
Publisher :
ISBN 13 : 9789533076614
Total Pages : pages
Book Rating : 4.0/5 (766 download)

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Book Synopsis Cellular Systems and Biomaterials for Nerve Regeneration in Neurotmesis Injuries by : Ana Colette Maurício

Download or read book Cellular Systems and Biomaterials for Nerve Regeneration in Neurotmesis Injuries written by Ana Colette Maurício and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Peripheral Nerve Tissue Engineering and Regeneration

Author : James B. Phillips
Publisher : Springer
ISBN 13 : 9783030210519
Total Pages : 612 pages
Book Rating : 4.2/5 (15 download)

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Book Synopsis Peripheral Nerve Tissue Engineering and Regeneration by : James B. Phillips

Download or read book Peripheral Nerve Tissue Engineering and Regeneration written by James B. Phillips and published by Springer. This book was released on 2022-05-26 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.

Cell-mediated Contraction & Induced Regeneration of the Injured Peripheral Nerve

Author : Eric C. Soller
Publisher :
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.:/5 (764 download)

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Book Synopsis Cell-mediated Contraction & Induced Regeneration of the Injured Peripheral Nerve by : Eric C. Soller

Download or read book Cell-mediated Contraction & Induced Regeneration of the Injured Peripheral Nerve written by Eric C. Soller and published by . This book was released on 2011 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-mediated mechanical forces drive closure of severe wounds in adult mammalian organs, including the sciatic nerve following neurotmesis. Without experimental intervention the defect closes rapidly via contraction of transected nerve stumps by a thick, cohesive capsule of myofibroblasts (MFB) and subsequent collagen synthesis (scar), leading to a painful neuroma. Despite considerable progress in regenerating injured peripheral nerves with biomaterials, adequate recovery is generally limited to inter-stump gap lengths of about 20-30 mm in humans. Observations of successful induced regeneration in adults coincide with reduced MFB formation, yet the direct effect of the MFB capsule on nerve regeneration is unknown. According to the pressure cuff theory, a transected peripheral nerve could heal by regeneration, rather than MFB-mediated contraction and scar formation, provided the MFB capsule size (and corresponding cellular forces applied) are reduced. A well-characterized library of type I collagen tubular scaffolds with identical chemical composition and pore size, and varying degradation rate was used to evaluate the ability of a porous scaffold to block MFB contraction after injury in a demanding model of peripheral nerve regeneration in the adult rat. At 9 weeks post-neurotmesis, the MFB capsule thickness, 5, around the regenerating nerve was measured and the correlation with several quantitative measures of the quality of nerve regeneration, Q, was evaluated. A negative, statistically significant association was observed between the contractile capsule thickness, 6, and the quality of axonal regeneration, Q, (consisting of measures of regenerate area, the number of myelinated fibers, and the number of largediameter fibers) at 9 weeks post-sciatic neurotmesis. This constitutes the strongest evidence to date that capsules of contractile MFB antagonize induced regeneration of severely injured peripheral nerves in the adult mammal. Collagen devices of intermediate degradation rate minimized 5 and maximized Q. Reduced contractile cell presence and disrupted organization inside moderately cross-linked scaffolds that consequently degraded at an intermediate rate, but not in highly cross-linked scaffolds that degraded at very low rate, support the hypothesis of cell escape from the wound (making use of scaffold permeability) as a mechanism for scaffold regenerative activity.

Peripheral Nerve Disorders and Treatment

Author : Hande Turker
Publisher : BoD – Books on Demand
ISBN 13 : 1789852579
Total Pages : 194 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Peripheral Nerve Disorders and Treatment by : Hande Turker

Download or read book Peripheral Nerve Disorders and Treatment written by Hande Turker and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathies are one of the main neurological problems in everyday life, and they still have many partially understood parts and unknowns both for physicians and patients. Many systemic conditions may exist within them and therefore they may be difficult to treat. In this book we provide current knowledge concerning neuropathies, which we believe you will find interesting. The subject ‘’neuropathies’’ comprises a number of topics, and each and every one could be the subject of a textbook. On the other hand, this book was never designed as one. This book should be read without prejudgment because the content may not be compatible with general but repeated assumptions and guidelines. However, I believe that the book may be an inspiration for many young investigators as well. It contains current approaches and knowledge and we sincerely believe and hope that it will answer your queries regarding new perspectives about neuropathy in general.

Cell Engineering and Regeneration

Author : Heinz Redl
Publisher : Springer
ISBN 13 : 9783319088303
Total Pages : 0 pages
Book Rating : 4.0/5 (883 download)

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Book Synopsis Cell Engineering and Regeneration by : Heinz Redl

Download or read book Cell Engineering and Regeneration written by Heinz Redl and published by Springer. This book was released on 2017-02-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.

Engineering Neural Tissue from Stem Cells

Author : Stephanie Willerth
Publisher : Academic Press
ISBN 13 : 0128113863
Total Pages : 226 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Engineering Neural Tissue from Stem Cells by : Stephanie Willerth

Download or read book Engineering Neural Tissue from Stem Cells written by Stephanie Willerth and published by Academic Press. This book was released on 2017-07-05 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications. Provides readers entering the field with a strong basis of neural tissue engineering processes and real-world applications Discusses the most current clinical trials and their importance of treating nervous system disorders Reviews the structure and immune response of the nervous system, including the brain, spinal cord and their present cells Offers a necessary overview of the natural and synthetic biomaterials used to engineer neural tissue

Peptide-Based Materials

Author : Timothy Deming
Publisher : Springer Science & Business Media
ISBN 13 : 3642271391
Total Pages : 184 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Peptide-Based Materials by : Timothy Deming

Download or read book Peptide-Based Materials written by Timothy Deming and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-

In Situ Tissue Regeneration

Author : Sang Jin Lee
Publisher : Academic Press
ISBN 13 : 012802500X
Total Pages : 460 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis In Situ Tissue Regeneration by : Sang Jin Lee

Download or read book In Situ Tissue Regeneration written by Sang Jin Lee and published by Academic Press. This book was released on 2016-07-17 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Bioinspired Biomaterials

Author : Heung Jae Chun
Publisher : Springer Nature
ISBN 13 : 9811532583
Total Pages : 231 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Bioinspired Biomaterials by : Heung Jae Chun

Download or read book Bioinspired Biomaterials written by Heung Jae Chun and published by Springer Nature. This book was released on 2020-06-29 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

The 11th Edition of the International Meeting of the SPCE-TC: Advances in Stem Cells and Cell Therapies

Author : Susana Solá
Publisher : Frontiers Media SA
ISBN 13 : 2889713210
Total Pages : 240 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The 11th Edition of the International Meeting of the SPCE-TC: Advances in Stem Cells and Cell Therapies by : Susana Solá

Download or read book The 11th Edition of the International Meeting of the SPCE-TC: Advances in Stem Cells and Cell Therapies written by Susana Solá and published by Frontiers Media SA. This book was released on 2021-09-14 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Novel Biomaterials for Regenerative Medicine

Author : Heung Jae Chun
Publisher : Springer
ISBN 13 : 9811309477
Total Pages : 533 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Novel Biomaterials for Regenerative Medicine by : Heung Jae Chun

Download or read book Novel Biomaterials for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.

Cardiac Regeneration

Author : Masaki Ieda
Publisher : Springer
ISBN 13 : 3319561065
Total Pages : 274 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Cardiac Regeneration by : Masaki Ieda

Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.