Biomaterials And Bioreactors For Engineering Living Aortic Valve Leaflets

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Biomaterials and Bioreactors for Engineering Living Aortic Valve Leaflets

Author : Daniel Yiu Cheung Cheung
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.:/5 (122 download)

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Book Synopsis Biomaterials and Bioreactors for Engineering Living Aortic Valve Leaflets by : Daniel Yiu Cheung Cheung

Download or read book Biomaterials and Bioreactors for Engineering Living Aortic Valve Leaflets written by Daniel Yiu Cheung Cheung and published by . This book was released on 2019 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart valve disease is an increasing global burden affecting patients of all ages, ranging from pediatrics to the elderly. Unfortunately, there are currently no diagnostics for early detection or therapeutic treatment strategies. The only remedy for end-stage valve disease is a prosthetic heart valve replacement. However, these non-living prostheses do not possess the ability to remodel, integrate, and respond biologically with the patient, leading to life-long medications or multiple resizing surgeries. Tissue engineering offers an enticing strategy to fabricate living, biological heart valve conduits with growth and integration potential. While there has been advances in fabricating tissue engineered heart valves, there remains a challenge of producing a heterogenous valve. The focus of this dissertation was to develop and evaluate biomaterials and a bioreactor system that can better provide environments for cells to grow and remodel. A hybrid hydrogel biomaterial developed by incorporating solubilized decelluarlized aortic leaflets into a bioprintable base material promoted a myofibroblastic phenotype in encapsulated cells and led to more matrix deposition (Chapter 2). Next, a composite biomaterial was produced by conjugating nanocellulose crystalline with methacrylated gelatin. The material enhanced material properties and promoted a chondrogenic-like phenotype in encapsulated HADMSC (Chapter 3). Finally, a bioreactor system was built to capture a wide range of pressures and frequencies found in the pediatric and adult populations (Chapter 4). The system was validated by culturing ex vivo porcine heart valves and conditioning a bioprinted tissue engineered heart valve. Overall, the completion of this work advanced the field of tissue engineering heart valves by providing insights on two types of biomaterials that can modulate stem cell behavior and phenotype. The bioreactor system proved to be useful in future studies involving both engineered and ex vivo heart valves.

Biomaterials, Medical Devices and Tissue Engineering: An Integrated Approach

Author : F.H. Silver
Publisher : Springer Science & Business Media
ISBN 13 : 9401107351
Total Pages : 310 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Biomaterials, Medical Devices and Tissue Engineering: An Integrated Approach by : F.H. Silver

Download or read book Biomaterials, Medical Devices and Tissue Engineering: An Integrated Approach written by F.H. Silver and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: are then selected and must meet the general 'biocompatibility' require ments. Prototypes are built and tested to include biocompatibility evalua tions based on ASTM standard procedures. The device is validated for sterility and freedom from pyrogens before it can be tested on animals or humans. Medical devices are classified as class I, II or III depending on their invasiveness. Class I devices can be marketed by submitting notification to the FDA. Class II and III devices require either that they show equivalence to a device marketed prior to 1976 or that they receive pre-marketing approval. The time from device conception to FDA approval can range from months (class I device) to in excess of ten years (class III device). Therefore, much planning is necessary to pick the best regulatory approach. 2. Wound Dressings and Skin Replacement 2.1 Introduction Wounds to the skin are encountered every day. Minor skin wounds cause some pain, but these wounds will heal by themselves in time. Even though many minor wounds heal effectively without scarring in the absence of treatment, they heal more rapidly if they are kept clean and moist. Devices such as Band-Aids are used to assist in wound healing. For deeper wounds, a variety of wound dressings have been developed including cell cultured artificial skin. These materials are intended to promote healing of skin damaged or removed as a result of skin grafting, ulceration, burns, cancer excision or mechanical trauma.

Bioreactor Systems for Tissue Engineering

Author : Cornelia Kasper
Publisher : Springer Science & Business Media
ISBN 13 : 3540693564
Total Pages : 274 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Bioreactor Systems for Tissue Engineering by : Cornelia Kasper

Download or read book Bioreactor Systems for Tissue Engineering written by Cornelia Kasper and published by Springer Science & Business Media. This book was released on 2009-02-03 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed.

Bioreactors for Tissue Engineering

Author : Julian Chaudhuri
Publisher : Springer Science & Business Media
ISBN 13 : 1402037414
Total Pages : 373 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Bioreactors for Tissue Engineering by : Julian Chaudhuri

Download or read book Bioreactors for Tissue Engineering written by Julian Chaudhuri and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Biomaterials and Devices for the Circulatory System

Author : Terence Gourlay
Publisher : Elsevier
ISBN 13 : 0857090550
Total Pages : 399 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Biomaterials and Devices for the Circulatory System by : Terence Gourlay

Download or read book Biomaterials and Devices for the Circulatory System written by Terence Gourlay and published by Elsevier. This book was released on 2010-10-28 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is one of the leading causes of death in the world today. Thanks to major advances in circulatory biomaterials and medical devices over the past few decades, many complications of this prevalent disease can be managed with great success for prolonged periods.Biomaterials and devices for the circulatory system reviews the latest developments in this important field and how they can be used to improve the success and safety in this industry.Part one discusses physiological responses to biomaterials with chapters on tissue response, blood interface and biocompatibility. Part two then reviews clinical applications including developments in valve technology, percutaneous valve replacement, bypass technologies and cardiovascular stents. Part three covers future developments in the field with topics such as nanomedicine, cardiac restoration therapy, biosensor technology in the treatment of cardiovascular disease and vascular tissue engineering.With its distinguished editors and international team of contributors Biomaterials and devices for the circulatory system is a vital reference for those concerned with bioengineering, medical devices and clinicians within this critical field. - Reviews the latest developments in this important field and how they can be used to improve success and safety in the industry - Both current clinical advances as well as future innovation are assessed taking a progressive view of the role of biomaterials in medical applications - An examination of the physiological responses to biomaterials features tissue responses to implanted materials and strategies to improve the biocompatibility of medical devices

Calcific Aortic Valve Disease

Author : Elena Aikawa
Publisher : BoD – Books on Demand
ISBN 13 : 9535111507
Total Pages : 544 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Calcific Aortic Valve Disease by : Elena Aikawa

Download or read book Calcific Aortic Valve Disease written by Elena Aikawa and published by BoD – Books on Demand. This book was released on 2013-06-12 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Advances in Heart Valve Biomechanics

Author : Michael S. Sacks
Publisher : Springer
ISBN 13 : 3030019934
Total Pages : 487 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Advances in Heart Valve Biomechanics by : Michael S. Sacks

Download or read book Advances in Heart Valve Biomechanics written by Michael S. Sacks and published by Springer. This book was released on 2019-04-08 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students.

Principles of Heart Valve Engineering

Author : Arash Kheradvar
Publisher : Academic Press
ISBN 13 : 0128146621
Total Pages : 414 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Principles of Heart Valve Engineering by : Arash Kheradvar

Download or read book Principles of Heart Valve Engineering written by Arash Kheradvar and published by Academic Press. This book was released on 2019-08-28 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Heart Valve Engineering is the first comprehensive resource for heart valve engineering that covers a wide range of topics, including biology, epidemiology, imaging and cardiovascular medicine. It focuses on valves, therapies, and how to develop safer and more durable artificial valves. The book is suitable for an interdisciplinary audience, with contributions from bioengineers and cardiologists that includes coverage of valvular and potential future developments. This book provides an opportunity for bioengineers to study all topics relating to heart valve engineering in a single book as written by subject matter experts. Covers the depth and breadth of this interdisciplinary area of research Encompasses a wide range of topics, from basic science, to the translational applications of heart valve engineering Contains contributions from leading experts in the field that are heavily illustrated

Bioreactors for Tissue Engineering

Author : Julian Chaudhuri
Publisher : Springer Science & Business Media
ISBN 13 : 9781402037405
Total Pages : 394 pages
Book Rating : 4.0/5 (374 download)

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Book Synopsis Bioreactors for Tissue Engineering by : Julian Chaudhuri

Download or read book Bioreactors for Tissue Engineering written by Julian Chaudhuri and published by Springer Science & Business Media. This book was released on 2005-10-18 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments in tissue engineering for human medicine are increasing rapidly. Advances in stem cell biology, biomaterials science and scaffold design underpin this emerging science. An equally important facet of this field is the rational design and operation of bioreactors to control the nascent tissue growth. For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Biomaterials Science

Author : William R Wagner
Publisher : Academic Press
ISBN 13 : 0128161388
Total Pages : 1612 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biomaterials Science by : William R Wagner

Download or read book Biomaterials Science written by William R Wagner and published by Academic Press. This book was released on 2020-05-23 with total page 1612 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters

Comprehensive Biomaterials II

Author : Kevin Healy
Publisher : Elsevier
ISBN 13 : 0081006926
Total Pages : 4865 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Biomaterials II by : Kevin Healy

Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Novel Biomaterials for Regenerative Medicine

Author : Heung Jae Chun
Publisher : Springer
ISBN 13 : 9811309477
Total Pages : 533 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Novel Biomaterials for Regenerative Medicine by : Heung Jae Chun

Download or read book Novel Biomaterials for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.

Methods of Tissue Engineering

Author : Anthony Atala
Publisher : Gulf Professional Publishing
ISBN 13 : 0124366368
Total Pages : 580 pages
Book Rating : 4.1/5 (243 download)

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Book Synopsis Methods of Tissue Engineering by : Anthony Atala

Download or read book Methods of Tissue Engineering written by Anthony Atala and published by Gulf Professional Publishing. This book was released on 2001-10-12 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book combines the tools, experimental protocols, detailed descriptions and know-how for the successful engineering of tissues and organs in one volume.

Biomaterials Science

Author : Buddy D. Ratner
Publisher : Academic Press
ISBN 13 : 008087780X
Total Pages : 1573 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Biomaterials Science by : Buddy D. Ratner

Download or read book Biomaterials Science written by Buddy D. Ratner and published by Academic Press. This book was released on 2012-12-31 with total page 1573 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank

Aortic Valve Surgery

Author : Noboru Motomura
Publisher : BoD – Books on Demand
ISBN 13 : 9533076003
Total Pages : 260 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Aortic Valve Surgery by : Noboru Motomura

Download or read book Aortic Valve Surgery written by Noboru Motomura and published by BoD – Books on Demand. This book was released on 2011-12-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aortic valve is located at the center of the heart. It is the core of cardiac anatomy and aortic valve surgery has led the field of cardiac surgery. This book describes all aspects of aortic valve surgery and it will help clarify daily questions regarding the clinical practice in aortic valve surgery, as well as induce inspiration and new insights into this field.

Regenerative Pharmacology

Author : George J. Christ
Publisher : Cambridge University Press
ISBN 13 : 0521899494
Total Pages : 361 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Regenerative Pharmacology by : George J. Christ

Download or read book Regenerative Pharmacology written by George J. Christ and published by Cambridge University Press. This book was released on 2013-04-15 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art primer on the role of pharmacological sciences in regenerative medicine, for advanced students, postdoctoral fellows, and researchers.

Stem Cell Manufacturing

Author : Joaquim M.S. Cabral
Publisher : Elsevier
ISBN 13 : 0444632662
Total Pages : 342 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Stem Cell Manufacturing by : Joaquim M.S. Cabral

Download or read book Stem Cell Manufacturing written by Joaquim M.S. Cabral and published by Elsevier. This book was released on 2016-07-24 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders. Presents the first ‘Flowchart‘ of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book